Regenerative Medicine

Hans Fischer Senior Fellow Prof. Dietmar W. Hutmacher from Queensland University of Technology, Australia, and his host Prof. Arndt F. Schilling from the TUM Clinic for Plastic Surgery and Hand Surgery worked together in the Focus Group Regenerative Medicine.

The lack of functional integration between tissue-engineered constructs (TECs) and surrounding host tissues is a critical barrier, limiting the effectiveness and clinical translation of current soft tissue interface graft technologies. The overarching goal of this Hans Fischer Senior Fellowship is to address this challenge through the development of highly adaptable platform technologies that enable the engineering of stronger interfaces between TECs and the extracellular matrices that are distinct to particular clinical conditions. Through this project, an international network spanning scientists, engineers, clinicians, industry, and government will be established to accelerate the pace of regenerative medicine research targeting reconstruction of complex soft tissue interface defects and abnormalities. Key outcomes of the Hans Fischer Senior Fellowship will deliver innovative strategies for additive tissue manufacturing for soft tissue interfaces whilst contributing to the education at TUM of a new generation of bioengineers, clinician scientists, and tissue engineers with a strong international profile.

The overall objectives of the Focus Group Regenerative Medicine:

  • To develop a world class tissue engineering/regenerative medicine (TE/RM) program focused on additive tissue manufacturing for the regeneration of soft tissue interfaces, specifically for breast reconstruction.
  • To facilitate efforts to bridge the gap between basic research, bioengineering, and clinical positioning of regenerative therapies at TUM through strong activities supporting research translation and business development in collaboration with regional, national, and international industry partners.
  • To share newly generated scientific knowledge in regenerative medicine with researchers, engineers, clinicians, and the public through educational activities, training, publications, and communication forums at national and international levels, as well as being an active advocate and discussant of ethical aspects of TE/regenerative medicine in general, and of stem cells in particular, to improve public awareness and acceptance.

Postdoc:
Elizabeth Rosado Balmayor, Clinic for Plastic Surgery and Hand Surgery

Publications by the Focus Group

2016

  • Zheng, Huaiyuan; Liu, Juan; Dai, Xinyi; Schilling, Arndt F.: The Distally Based Sural Flap for the Reconstruction of Ankle and Foot Defects in Pediatric Patients. Annals of Plastic Surgery 77 (1), 2016, 97-101 mehr…

2015

  • Chhaya, Mohit P; Poh, Patrina SP; Balmayor, Elizabeth R; van Griensven, Martijn; Schantz, Jan-Thorsten; Hutmacher, Dietmar W: Additive manufacturing in biomedical sciences and the need for definitions and norms. Expert Review of Medical Devices 12 (5), 2015, 537-543 mehr…
  • Chhaya, Mohit Prashant; Melchels, Ferry Petrus Wilhelmus; Holzapfel, Boris Michael; Baldwin, Jeremy Grant; Hutmacher, Dietmar Werner: Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing. Biomaterials 52, 2015, 551-560 mehr…
  • Costa, Pedro F.; Hutmacher, Dietmar W.; Theodoropoulos, Christina; Gomes, Manuela E.; Reis, Rui L.; Vaquette, Cédryck: Additively Manufactured Device for Dynamic Culture of Large Arrays of 3D Tissue Engineered Constructs. Advanced Healthcare Materials 4 (6), 2015, 864-873 mehr…
  • Hutmacher, Dietmar Werner; Holzapfel, Boris Michael; De-Juan-Pardo, Elena Maria; Pereira, Brooke Anne; Ellem, Stuart John; Loessner, Daniela; Risbridger, Gail Petuna: Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance. Current Opinion in Biotechnology 35, 2015, 127-132 mehr…
  • Muerza-Cascante, M. Lourdes; Haylock, David; Hutmacher, Dietmar W.; Dalton, Paul D.: Melt Electrospinning and Its Technologization in Tissue Engineering. Tissue Engineering Part B: Reviews 21 (2), 2015, 187-202 mehr…
  • Visser, Jetze; Melchels, Ferry P.W.; Jeon, June E.; van Bussel, Erik M.; Kimpton, Laura S.; Byrne, Helen M.; Dhert, Wouter J.A.; Dalton, Paul D.; Hutmacher, Dietmar W.; Malda, Jos: Reinforcement of hydrogels using three-dimensionally printed microfibres. Nature Communications 6 (1), 2015 mehr…

2014

  • Brown, Toby D.; Edin, Fredrik; Detta, Nicola; Skelton, Anthony D.; Hutmacher, Dietmar W.; Dalton, Paul D.: Melt electrospinning of poly(ε-caprolactone) scaffolds: Phenomenological observations associated with collection and direct writing. Materials Science and Engineering: C 45, 2014, 698-708 mehr…
  • Costa, Pedro F; Vaquette, Cédryck; Baldwin, Jeremy; Chhaya, Mohit; Gomes, Manuela E; Reis, Rui L; Theodoropoulos, Christina; Hutmacher, Dietmar W: Biofabrication of customized bone grafts by combination of additive manufacturing and bioreactor knowhow. Biofabrication 6 (3), 2014, 035006 mehr…
  • Gao, Guifang; Schilling, Arndt F.; Yonezawa, Tomo; Wang, Jiang; Dai, Guohao; Cui, Xiaofeng: Bioactive nanoparticles stimulate bone tissue formation in bioprinted three-dimensional scaffold and human mesenchymal stem cells. Biotechnology Journal 9 (10), 2014, 1304-1311 mehr…
  • Hadjipanayi, Ektoras; Schilling, Arndt F: Regeneration through autologous hypoxia preconditioned plasma. Organogenesis 10 (2), 2014, 164-169 mehr…
  • Hesami, Parisa; Holzapfel, Boris M.; Taubenberger, Anna; Roudier, Martine; Fazli, Ladan; Sieh, Shirly; Thibaudeau, Laure; Gregory, Laura S.; Hutmacher, Dietmar W.; Clements, Judith A.: A humanized tissue-engineered in vivo model to dissect interactions between human prostate cancer cells and human bone. Clinical & Experimental Metastasis 31 (4), 2014, 435-446 mehr…
  • Holzapfel, Boris M.; Wagner, Ferdinand; Loessner, Daniela; Holzapfel, Nina P.; Thibaudeau, Laure; Crawford, Ross; Ling, Ming-Tat; Clements, Judith A.; Russell, Pamela J.; Hutmacher, Dietmar W.: Species-specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone. Biomaterials 35 (13), 2014, 4108-4115 mehr…
  • Holzapfel, Boris Michael; Pilge, Hakan; Prodinger, Peter Michael; Toepfer, Andreas; Mayer-Wagner, Susanne; Hutmacher, Dietmar Werner; von Eisenhart-Rothe, Ruediger; Rudert, Maximilian; Gradinger, Reiner; Rechl, Hans: Customised osteotomy guides and endoprosthetic reconstruction for periacetabular tumours. International Orthopaedics, 2014 mehr…
  • Jeon, June E.; Vaquette, Cédryck; Theodoropoulos, Christina; Klein, Travis J.; Hutmacher, Dietmar W.: Multiphasic construct studied in an ectopic osteochondral defect model. Journal of The Royal Society Interface 11 (95), 2014, 20140184 mehr…
  • Thibaudeau, Laure; Quent, Verena M.; Holzapfel, Boris M.; Taubenberger, Anna V.; Straub, Melanie; Hutmacher, Dietmar W.: Mimicking breast cancer-induced bone metastasis in vivo: current transplantation models and advanced humanized strategies. Cancer and Metastasis Reviews 33 (2-3), 2014, 721-735 mehr…
  • Winkler, T.; Dai, X. Y.; Mielke, G.; Vogt, S.; Buechner, H.; Schantz, J. T.; Harder, Y.; Machens, H. G.; Morlock, M. M.; Schilling, A. F.: Three-Dimensional Quantification of Calcium Salt-Composite Resorption (CSC) In Vitro by Micro-computed Tomography (Micro-CT). JOM 66 (4), 2014, 559-565 mehr…
  • Wu, Lili; Luthringer, Bérengère J.C.; Feyerabend, Frank; Schilling, Arndt F.; Willumeit, Regine: Effects of extracellular magnesium on the differentiation and function of human osteoclasts. Acta Biomaterialia 10 (6), 2014, 2843-2854 mehr…
  • Zheng, Huaiyuan; Liu, Juan; Dai, Xinyi; Schilling, Arndt F.: Modified Technique for One-Stage Treatment of Proximal Phalangeal Enchondromas With Pathologic Fractures. The Journal of Hand Surgery 39 (9), 2014, 1757-1760 mehr…

2013

  • Holzapfel, Boris Michael; Chhaya, Mohit Prashant; Melchels, Ferry Petrus Wilhelmus; Holzapfel, Nina Pauline; Prodinger, Peter Michael; von Eisenhart-Rothe, Ruediger; van Griensven, Martijn; Schantz, Jan-Thorsten; Rudert, Maximilian; Hutmacher, Dietmar Werner: Can Bone Tissue Engineering Contribute to Therapy Concepts after Resection of Musculoskeletal Sarcoma? Sarcoma 2013, 2013, 1-10 mehr…
  • Holzapfel, Boris Michael; Reichert, Johannes Christian; Schantz, Jan-Thorsten; Gbureck, Uwe; Rackwitz, Lars; Nöth, Ulrich; Jakob, Franz; Rudert, Maximilian; Groll, Jürgen; Hutmacher, Dietmar Werner: How smart do biomaterials need to be? A translational science and clinical point of view. Advanced Drug Delivery Reviews 65 (4), 2013, 581-603 mehr…
  • Hutmacher, Dietmar W.: A road map for a tissue engineering concept for restoring structure and function after limb loss. Journal of Materials Science: Materials in Medicine 24 (11), 2013, 2659-2663 mehr…