Zum Inhalt springen
Menü
Technische Universität München
Technische Universität München

Understanding how cancer drugs work

In the focus group “Understanding how cancer drugs work”, Carl von Linde Senior Fellow Prof. Bernhard Küster and his team at the TUM School of Life Sciences seek to discover the molecular reasons underlying a phenomenon called polypharmacology. In simple terms, polypharmacology describes that a particular drug may have multiple desired or undesired effects. The former may be use to extend the application of a drug to new indications while the latter indicates toxicity. Polypharmacology is quite common but often not understood in terms of the underlying mechanism that are responsible for the one or the other effect.

Proteins are the molecular players that regulate virtually all aspects of life. The human genome encodes for about 20,000 proteins, which e. g. act as catalysts for anabolic or catabolic biochemical reactions inside cells, help to transmit signals via the network of neurons, control cell growth and division and many more. Deregulated proteins can cause severe diseases including heart or liver disorders, Alzheimer’s disease or cancer to name a few.

Because of the fundamental role of proteins in disease, most therapeutic drugs act on proteins with the goal to tone down or increase their activity. Identifying the interaction of a drug with any of the 20,000 human proteins can provide important insights into whether or not a drug works as intended or if it causes toxicity. To study protein-drug interactions systematically, the team of Bernhard Kuster brings together cellular and molecular biologists, bio- and analytical chemists as well as bioinformaticians who have established one of the world’s most powerful proteomic technology platforms. The primary focus is on cancer drugs that often show polypharmacology offering the opportunity to ‘re-purpose’ an existing drug for a new use without having to go through the very long process of discovering new drugs from scratch.

Publications by the Focus Group

2021

  • Alfaro, Javier Antonio; Bohländer, Peggy; Dai, Mingjie; Filius, Mike; Howard, Cecil J.; van Kooten, Xander F.; Ohayon, Shilo; Pomorski, Adam; Schmid, Sonja; Aksimentiev, Aleksei; Anslyn, Eric V.; Bedran, Georges; Cao, Chan; Chinappi, Mauro; Coyaud, Etienne; Dekker, Cees; Dittmar, Gunnar; Drachman, Nicholas; Eelkema, Rienk; Goodlett, David; Hentz, Sébastien; Kalathiya, Umesh; Kelleher, Neil L.; Kelly, Ryan T.; Kelman, Zvi; Kim, Sung Hyun; Kuster, Bernhard; Rodriguez-Larrea, David; Lindsay, Stuart; Maglia, Giovanni; Marcotte, Edward M.; Marino, John P.; Masselon, Christophe; Mayer, Michael; Samaras, Patroklos; Sarthak, Kumar; Sepiashvili, Lusia; Stein, Derek; Wanunu, Meni; Wilhelm, Mathias; Yin, Peng; Meller, Amit; Joo, Chirlmin: The emerging landscape of single-molecule protein sequencing technologies. Nature Methods 18 (6), 2021, 604-617 mehr…
  • Bian, Yangyang; Bayer, Florian P.; Chang, Yun-Chien; Meng, Chen; Hoefer, Stefanie; Deng, Nan; Zheng, Runsheng; Boychenko, Oleksandr; Kuster, Bernhard: Robust Microflow LC-MS/MS for Proteome Analysis: 38 000 Runs and Counting. Analytical Chemistry 93 (8), 2021, 3686-3690 mehr…
  • Breunig, Markus; Merkle, Jessica; Wagner, Martin; Melzer, Michael K.; Barth, Thomas F.E.; Engleitner, Thomas; Krumm, Johannes; Wiedenmann, Sandra; Cohrs, Christian M.; Perkhofer, Lukas; Jain, Gaurav; Krüger, Jana; Hermann, Patrick C.; Schmid, Maximilian; Madácsy, Tamara; Varga, Árpád; Griger, Joscha; Azoitei, Ninel; Müller, Martin; Wessely, Oliver; Robey, Pamela G.; Heller, Sandra; Dantes, Zahra; Reichert, Maximilian; Günes, Cagatay; Bolenz, Christian; Kuhn, Florian; Maléth, József; Speier, Stephan; Liebau, Stefan; Sipos, Bence; Kuster, Bernhard; Seufferlein, Thomas; Rad, Roland; Meier, Matthias; Hohwieler, Meike; Kleger, Alexander: Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells. Cell Stem Cell 28 (6), 2021, 1105-1124.e19 mehr…
  • Dieter, S. M., Siegl, C., Codo, P. L., Huerta, M., Ostermann-Parucha, A. L., Schulz, E., Zowada, M. K., Martin, S., Laaber, K., Nowrouzi, A., Blatter, M., Kreth, S., Westermann, F., Benner, A., Uhrig, U., Putzker, K., Lewis, J., Haegebarth, A., Mumberg, D., Holton, S. J., Weiske, J., Toepper, L.-M., Scheib, U., Siemeister, G., Ball, C. R., Kuster, B., Stoehr, G., Hahne, H., Johannes, S., Lange, M., Herbst, F. & Glimm, H.: Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. , 2021, mehr…
  • Dölle, Anja; Adhikari, Bikash; Krämer, Andreas; Weckesser, Janik; Berner, Nicola; Berger, Lena-Marie; Diebold, Mathias; Szewczyk, Magdalena M.; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Gebel, Jakob; Löhr, Frank; Dötsch, Volker; Eilers, Martin; Heinzlmeir, Stephanie; Kuster, Bernhard; Sotriffer, Christoph; Wolf, Elmar; Knapp, Stefan: Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of Medicinal Chemistry, 2021 mehr…
  • Dölle, Anja; Adhikari, Bikash; Krämer, Andreas; Weckesser, Janik; Berner, Nicola; Berger, Lena-Marie; Diebold, Mathias; Szewczyk, Magdalena M.; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Gebel, Jakob; Löhr, Frank; Dötsch, Volker; Eilers, Martin; Heinzlmeir, Stephanie; Kuster, Bernhard; Sotriffer, Christoph; Wolf, Elmar; Knapp, Stefan: Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of Medicinal Chemistry, 2021 mehr…
  • Heider, Michael; Eichner, Ruth; Stroh, Jacob; Morath, Volker; Kuisl, Anna; Zecha, Jana; Lawatscheck, Jannis; Baek, Kheewoong; Garz, Anne-Kathrin; Rudelius, Martina; Deuschle, Friedrich-Christian; Keller, Ulrich; Lemeer, Simone; Verbeek, Mareike; Götze, Katharina S.; Skerra, Arne; Weber, Wolfgang A.; Buchner, Johannes; Schulman, Brenda A.; Kuster, Bernhard; Fernández-Sáiz, Vanesa; Bassermann, Florian: The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma. Molecular Cell 81 (6), 2021, 1170-1186.e10 mehr…
  • Pal, Jagriti; Becker, Andrea C.; Dhamija, Sonam; Seiler, Jeanette; Abdelkarim, Mahmoud; Sharma, Yogita; Behr, Jürgen; Meng, Chen; Ludwig, Christina; Kuster, Bernhard; Diederichs, Sven: Systematic analysis of migration factors by MigExpress identifies essential cell migration control genes in non‐small cell lung cancer. Molecular Oncology, 2021 mehr…
  • Schmidt, Tobias; Samaras, Patroklos; Dorfer, Viktoria; Panse, Christian; Kockmann, Tobias; Bichmann, Leon; van Puyvelde, Bart; Perez-Riverol, Yasset; Deutsch, Eric W.; Kuster, Bernhard; Wilhelm, Mathias: Universal Spectrum Explorer: A Standalone (Web-)Application for Cross-Resource Spectrum Comparison. Journal of Proteome Research 20 (6), 2021, 3388-3394 mehr…
  • Selkrig, Joel; Stanifer, Megan; Mateus, André; Mitosch, Karin; Barrio‐Hernandez, Inigo; Rettel, Mandy; Kim, Heeyoung; Voogdt, Carlos G P; Walch, Philipp; Kee, Carmon; Kurzawa, Nils; Stein, Frank; Potel, Clément; Jarzab, Anna; Kuster, Bernhard; Bartenschlager, Ralf; Boulant, Steeve; Beltrao, Pedro; Typas, Athanasios; Savitski, Mikhail M: SARS‐CoV‐2 infection remodels the host protein thermal stability landscape. Molecular Systems Biology 17 (2), 2021 mehr…
  • Stukalov, Alexey; Girault, Virginie; Grass, Vincent; Karayel, Ozge; Bergant, Valter; Urban, Christian; Haas, Darya A.; Huang, Yiqi; Oubraham, Lila; Wang, Anqi; Hamad, M. Sabri; Piras, Antonio; Hansen, Fynn M.; Tanzer, Maria C.; Paron, Igor; Zinzula, Luca; Engleitner, Thomas; Reinecke, Maria; Lavacca, Teresa M.; Ehmann, Rosina; Wölfel, Roman; Jores, Jörg; Kuster, Bernhard; Protzer, Ulrike; Rad, Roland; Ziebuhr, John; Thiel, Volker; Scaturro, Pietro; Mann, Matthias; Pichlmair, Andreas: Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature, 2021 mehr…
  • Verbruggen, Steven; Gessulat, Siegfried; Gabriels, Ralf; Matsaroki, Anna; Van de Voorde, Hendrik; Kuster, Bernhard; Degroeve, Sven; Martens, Lennart; Van Criekinge, Wim; Wilhelm, Mathias; Menschaert, Gerben: Spectral prediction features as a solution for the search space size problem in proteogenomics. Molecular & Cellular Proteomics, 2021, 100076 mehr…
  • Wiechmann, Svenja; Ruprecht, Benjamin; Siekmann, Theresa; Zheng, Runsheng; Frejno, Martin; Kunold, Elena; Bajaj, Thomas; Zolg, Daniel P.; Sieber, Stephan A.; Gassen, Nils C.; Kuster, Bernhard: Chemical Phosphoproteomics Sheds New Light on the Targets and Modes of Action of AKT Inhibitors. ACS Chemical Biology 16 (4), 2021, 631-641 mehr…
  • Wilhelm, Mathias; Zolg, Daniel P.; Graber, Michael; Gessulat, Siegfried; Schmidt, Tobias; Schnatbaum, Karsten; Schwencke-Westphal, Celina; Seifert, Philipp; de Andrade Krätzig, Niklas; Zerweck, Johannes; Knaute, Tobias; Bräunlein, Eva; Samaras, Patroklos; Lautenbacher, Ludwig; Klaeger, Susan; Wenschuh, Holger; Rad, Roland; Delanghe, Bernard; Huhmer, Andreas; Carr, Steven A.; Clauser, Karl R.; Krackhardt, Angela M.; Reimer, Ulf; Kuster, Bernhard: Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics. Nature Communications 12 (1), 2021 mehr…

2020

  • Adhikari, B., Bozilovic, J., Diebold, M., Schwarz, J. D., Hofstetter, J., Schröder, M., Wanior, M., Narain, A., Vogt, M., Stankovic, N. D., Baluapuri, A., Schönemann, L., Eing, L., Bhandare, P., Kuster, B., Schlosser, A., Heinzlmeir, S., Sotriffer, C., Knapp, S. & Wolf, E.: Targeted protein degradation discriminates between structural and catalytic functions of AURORA-A kinase. Nat Chem Bio 16, 2020, 1179-1188 mehr…
  • Bian, Yangyang; Zheng, Runsheng; Bayer, Florian P.; Wong, Cassandra; Chang, Yun-Chien; Meng, Chen; Zolg, Daniel P.; Reinecke, Maria; Zecha, Jana; Wiechmann, Svenja; Heinzlmeir, Stephanie; Scherr, Johannes; Hemmer, Bernhard; Baynham, Mike; Gingras, Anne-Claude; Boychenko, Oleksandr; Kuster, Bernhard: Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS. Nature Communications 11 (1), 2020 mehr…
  • Cheung, Tommy K.; Lee, Chien-Yun; Bayer, Florian P.; McCoy, Atticus; Kuster, Bernhard; Rose, Christopher M.: Defining the carrier proteome limit for single-cell proteomics. Nature Methods 18 (1), 2020, 76-83 mehr…
  • Cossa, Giacomo; Roeschert, Isabelle; Prinz, Florian; Baluapuri, Apoorva; Silveira Vidal, Raphael; Schülein-Völk, Christina; Chang, Yun-Chien; Ade, Carsten Patrick; Mastrobuoni, Guido; Girard, Cyrille; Kumar, Amit; Wortmann, Lars; Walz, Susanne; Lührmann, Reinhard; Kempa, Stefan; Kuster, Bernhard; Wolf, Elmar; Mumberg, Dominik; Eilers, Martin: Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription. Molecular Cell 77 (6), 2020, 1322-1339.e11 mehr…
  • Dietinger, Vanessa; García de Durango, Cira R.; Wiechmann, Svenja; Boos, Sophie L.; Michl, Marlies; Neumann, Jens; Hermeking, Heiko; Kuster, Bernhard; Jung, Peter: Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer. Cell Communication and Signaling 18 (1), 2020 mehr…
  • Djukovic, Ana; González-Barberá, Eva M.; Sanz, Jaime; Artacho, Alejandro; Peñaranda, Iván; Herrera, Beatriz; Garzón, María José; Salavert, Miguel; López-Hontangas, José Luis; Xavier, Karina B.; Kuster, Bernhard; Debrauwer, Laurent; Rolain, Jean-Marc; Sanz, Miguel A.; Xavier, Joao B.; Ubeda, Carles: High Heterogeneity of Multidrug-Resistant Enterobacteriaceae Fecal Levels in Hospitalized Patients Is Partially Driven by Intravenous β-Lactams. Antimicrobial Agents and Chemotherapy 64 (2), 2020 mehr…
  • Erhart, Friedrich; Hackl, Matthias; Hahne, Hannes; Buchroithner, Johanna; Meng, Chen; Klingenbrunner, Simone; Reitermaier, René; Fischhuber, Katrin; Skalicky, Susanna; Berger, Walter; Spiegl-Kreinecker, Sabine; Lötsch, Daniela; Ricken, Gerda; Kuster, Bernhard; Wöhrer, Adelheid; Widhalm, Georg; Hainfellner, Johannes; Felzmann, Thomas; Dohnal, Alexander M.; Marosi, Christine; Visus, Carmen: Combined proteomics/miRNomics of dendritic cell immunotherapy-treated glioblastoma patients as a screening for survival-associated factors. npj Vaccines 5 (1), 2020 mehr…
  • Erhart, Friedrich; Hackl, Matthias; Hahne, Hannes; Buchroithner, Johanna; Meng, Chen; Klingenbrunner, Simone; Reitermaier, René; Fischhuber, Katrin; Skalicky, Susanna; Berger, Walter; Spiegl-Kreinecker, Sabine; Lötsch, Daniela; Ricken, Gerda; Kuster, Bernhard; Wöhrer, Adelheid; Widhalm, Georg; Hainfellner, Johannes; Felzmann, Thomas; Dohnal, Alexander M.; Marosi, Christine; Visus, Carmen: Combined proteomics/miRNomics of dendritic cell immunotherapy-treated glioblastoma patients as a screening for survival-associated factors. npj Vaccines 5 (1), 2020 mehr…
  • Flosbach, Markus; Oberle, Susanne G.; Scherer, Stefanie; Zecha, Jana; von Hoesslin, Madlaina; Wiede, Florian; Chennupati, Vijaykumar; Cullen, Jolie G.; List, Markus; Pauling, Josch K.; Baumbach, Jan; Kuster, Bernhard; Tiganis, Tony; Zehn, Dietmar: PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells. Cell Reports 32 (4), 2020, 107957 mehr…
  • Frejno, Martin; Meng, Chen; Ruprecht, Benjamin; Oellerich, Thomas; Scheich, Sebastian; Kleigrewe, Karin; Drecoll, Enken; Samaras, Patroklos; Hogrebe, Alexander; Helm, Dominic; Mergner, Julia; Zecha, Jana; Heinzlmeir, Stephanie; Wilhelm, Mathias; Dorn, Julia; Kvasnicka, Hans-Michael; Serve, Hubert; Weichert, Wilko; Kuster, Bernhard: Proteome activity landscapes of tumor cell lines determine drug responses. Nature Communications 11 (1), 2020 mehr…
  • Hoermann, Bernhard; Kokot, Thomas; Helm, Dominic; Heinzlmeir, Stephanie; Chojnacki, Jeremy E.; Schubert, Thomas; Ludwig, Christina; Berteotti, Anna; Kurzawa, Nils; Kuster, Bernhard; Savitski, Mikhail M.; Köhn, Maja: Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A. Nature Communications 11 (1), 2020 mehr…
  • Jarzab, Anna; Kurzawa, Nils; Hopf, Thomas; Moerch, Matthias; Zecha, Jana; Leijten, Niels; Bian, Yangyang; Musiol, Eva; Maschberger, Melanie; Stoehr, Gabriele; Becher, Isabelle; Daly, Charlotte; Samaras, Patroklos; Mergner, Julia; Spanier, Britta; Angelov, Angel; Werner, Thilo; Bantscheff, Marcus; Wilhelm, Mathias; Klingenspor, Martin; Lemeer, Simone; Liebl, Wolfgang; Hahne, Hannes; Savitski, Mikhail M.; Kuster, Bernhard: Meltome atlas—thermal proteome stability across the tree of life. Nature Methods 17 (5), 2020, 495-503 mehr…
  • Kreutmair, Stefanie; Erlacher, Miriam; Andrieux, Geoffroy; Istvanffy, Rouzanna; Mueller-Rudorf, Alina; Zwick, Melissa; Rückert, Tamina; Pantic, Milena; Poggio, Teresa; Shoumariyeh, Khalid; Mueller, Tony A.; Kawaguchi, Hiroyuki; Follo, Marie; Klingeberg, Cathrin; Wlodarski, Marcin; Baumann, Irith; Pfeifer, Dietmar; Kulinski, Michal; Rudelius, Martina; Lemeer, Simone; Kuster, Bernhard; Dierks, Christine; Peschel, Christian; Cabezas-Wallscheid, Nina; Duque-Afonso, Jesus; Zeiser, Robert; Cleary, Michael L.; Schindler, Detlev; Schmitt-Graeff, Annette; Boerries, Melanie; Niemeyer, Charlotte M.; Oostendorp, Robert A.J.; Duyster, Justus; Illert, Anna Lena: Loss of the Fanconi anemia–associated protein NIPA causes bone marrow failure. Journal of Clinical Investigation 130 (6), 2020, 2827-2844 mehr…
  • Lampl, Sandra; Janas, Marianne K.; Donakonda, Sainitin; Brugger, Marcus; Lohr, Kerstin; Schneider, Annika; Manske, Katrin; Sperl, Laura E.; Kläger, Susan; Küster, Bernhard; Wettmarshausen, Jennifer; Müller, Constanze; Laschinger, Melanie; Hartmann, Daniel; Hüser, Norber; Perocchi, Fabiana; Schmitt-Kopplin, Philippe; Hagn, Franz; Zender, Lars; Hornung, Veit; Borner, Christoph; Pichlmair, Andreas; Kashkar, Hamid; Klingenspor, Martin; Prinz, Marco; Schreiner, Sabrina; Conrad, Marcus; Jost, Philipp J.; Zischka, Hans; Steiger, Katja; Krönke, Martin; Zehn, Dietmar; Protzer, Ulrike; Heikenwälder, Mathias; Knolle, Percy A.; Wohlleber, Dirk: Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes. Journal of Hepatology 73 (6), 2020, 1347-1359 mehr…
  • Mergner, Julia; Frejno, Martin; List, Markus; Papacek, Michael; Chen, Xia; Chaudhary, Ajeet; Samaras, Patroklos; Richter, Sandra; Shikata, Hiromasa; Messerer, Maxim; Lang, Daniel; Altmann, Stefan; Cyprys, Philipp; Zolg, Daniel P.; Mathieson, Toby; Bantscheff, Marcus; Hazarika, Rashmi R.; Schmidt, Tobias; Dawid, Corinna; Dunkel, Andreas; Hofmann, Thomas; Sprunck, Stefanie; Falter-Braun, Pascal; Johannes, Frank; Mayer, Klaus F. X.; Jürgens, Gerd; Wilhelm, Mathias; Baumbach, Jan; Grill, Erwin; Schneitz, Kay; Schwechheimer, Claus; Kuster, Bernhard: Mass-spectrometry-based draft of the Arabidopsis proteome. Nature 579 (7799), 2020, 409-414 mehr…
  • Mergner, Julia; Frejno, Martin; Messerer, Maxim; Lang, Daniel; Samaras, Patroklos; Wilhelm, Mathias; Mayer, Klaus F. X.; Schwechheimer, Claus; Kuster, Bernhard: Proteomic and transcriptomic profiling of aerial organ development in Arabidopsis. Scientific Data 7 (1), 2020 mehr…
  • Montenegro, Raquel Carvalho; Howarth, Alison; Ceroni, Alessandro; Fedele, Vita; Farran, Batoul; Mesquita, Felipe Pantoja; Frejno, Martin; Berger, Benedict-Tilman; Heinzlmeir, Stephanie; Sailem, Heba Z.; Tesch, Roberta; Ebner, Daniel; Knapp, Stefan; Burbano, Rommel; Kuster, Bernhard; Müller, Susanne: Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib. Oncotarget 11 (5), 2020, 535-549 mehr…
  • Schöttl, Theresa; Pachl, Fiona; Giesbertz, Pieter; Daniel, Hannelore; Kuster, Bernhard; Fromme, Tobias; Klingenspor, Martin: Proteomic and Metabolite Profiling Reveals Profound Structural and Metabolic Reorganization of Adipocyte Mitochondria in Obesity. Obesity 28 (3), 2020, 590-600 mehr…
  • Searle, Brian C.; Swearingen, Kristian E.; Barnes, Christopher A.; Schmidt, Tobias; Gessulat, Siegfried; Küster, Bernhard; Wilhelm, Mathias: Generating high quality libraries for DIA MS with empirically corrected peptide predictions. Nature Communications 11 (1), 2020 mehr…
  • Sellmer, Andreas; Pilsl, Bernadette; Beyer, Mandy; Pongratz, Herwig; Wirth, Lukas; Elz, Sigurd; Dove, Stefan; Henninger, Sven Julian; Spiekermann, Karsten; Polzer, Harald; Klaeger, Susan; Kuster, Bernhard; Böhmer, Frank D.; Fiebig, Heinz-Herbert; Krämer, Oliver H.; Mahboobi, Siavosh: A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia. European Journal of Medicinal Chemistry 193, 2020, 112232 mehr…
  • Wiechmann, Svenja; Saupp, Elena; Schilling, Daniela; Heinzlmeir, Stephanie; Schneider, Günter; Schmid, Roland M.; Combs, Stephanie E.; Kuster, Bernhard; Dobiasch, Sophie: Radiosensitization by Kinase Inhibition Revealed by Phosphoproteomic Analysis of Pancreatic Cancer Cells. Molecular & Cellular Proteomics 19 (10), 2020, 1649-1663 mehr…
  • Zecha, Jana; Lee, Chien-Yun; Bayer, Florian P.; Meng, Chen; Grass, Vincent; Zerweck, Johannes; Schnatbaum, Karsten; Michler, Thomas; Pichlmair, Andreas; Ludwig, Christina; Kuster, Bernhard: Data, Reagents, Assays and Merits of Proteomics for SARS-CoV-2 Research and Testing. Molecular & Cellular Proteomics 19 (9), 2020, 1503-1522 mehr…

2019

  • Eraslan, Basak; Wang, Dongxue; Gusic, Mirjana; Prokisch, Holger; Hallström, Björn M; Uhlén, Mathias; Asplund, Anna; Pontén, Frederik; Wieland, Thomas; Hopf, Thomas; Hahne, Hannes; Kuster, Bernhard; Gagneur, Julien: Quantification and discovery of sequence determinants of protein‐per‐mRNA amount in 29 human tissues. Molecular Systems Biology 15 (2), 2019 mehr…
  • Gessulat, Siegfried; Schmidt, Tobias; Zolg, Daniel Paul; Samaras, Patroklos; Schnatbaum, Karsten; Zerweck, Johannes; Knaute, Tobias; Rechenberger, Julia; Delanghe, Bernard; Huhmer, Andreas; Reimer, Ulf; Ehrlich, Hans-Christian; Aiche, Stephan; Kuster, Bernhard; Wilhelm, Mathias: Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning. Nature Methods 16 (6), 2019, 509-518 mehr…
  • Gessulat, Siegfried; Schmidt, Tobias; Zolg, Daniel Paul; Samaras, Patroklos; Schnatbaum, Karsten; Zerweck, Johannes; Knaute, Tobias; Rechenberger, Julia; Delanghe, Bernard; Huhmer, Andreas; Reimer, Ulf; Ehrlich, Hans-Christian; Aiche, Stephan; Kuster, Bernhard; Wilhelm, Mathias: Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning. Nature Methods 16 (6), 2019, 509-518 mehr…
  • Kalde, Monika; Elliott, Liam; Ravikumar, Raksha; Rybak, Katarzyna; Altmann, Melina; Klaeger, Susan; Wiese, Christian; Abele, Miriam; Al, Benjamin; Kalbfuß, Nils; Qi, Xingyun; Steiner, Alexander; Meng, Chen; Zheng, Huanquan; Kuster, Bernhard; Falter‐Braun, Pascal; Ludwig, Christina; Moore, Ian; Assaad, Farhah F.: Interactions between Transport Protein Particle (TRAPP) complexes and RabGTPases in Arabidopsis. The Plant Journal 100 (2), 2019, 279-297 mehr…
  • Khakipoor, Shokoufeh; Giannaki, Marina; Theparambil, Shefeeq M.; Zecha, Jana; Küster, Bernhard; Heermann, Stephan; Deitmer, Joachim W.; Roussa, Eleni: Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255‐257 and regulated by mTOR. Glia 67 (12), 2019, 2264-2278 mehr…
  • Lalaoui, Rym; Djukovic, Ana; Bakour, Sofiane; Sanz, Jaime; Gonzalez-Barbera, Eva M.; Salavert, Miguel; López-Hontangas, Jose Luis; Sanz, Miguel A.; Xavier, Karina B.; Kuster, Bernhard; Debrauwer, Laurent; Ubeda, Carles; Rolain, Jean-Marc: Detection of plasmid-mediated colistin resistance, mcr-1 gene, in Escherichia coli isolated from high-risk patients with acute leukemia in Spain. Journal of Infection and Chemotherapy 25 (8), 2019, 605-609 mehr…
  • Le, Philipp; Kunold, Elena; Macsics, Robert; Rox, Katharina; Jennings, Megan C.; Ugur, Ilke; Reinecke, Maria; Chaves-Moreno, Diego; Hackl, Mathias W.; Fetzer, Christian; Mandl, Franziska A. M.; Lehmann, Johannes; Korotkov, Vadim S.; Hacker, Stephan M.; Kuster, Bernhard; Antes, Iris; Pieper, Dietmar H.; Rohde, Manfred; Wuest, William M.; Medina, Eva; Sieber, Stephan A.: Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms. Nature Chemistry 12 (2), 2019, 145-158 mehr…
  • Meng, Chen; Basunia, Azfar; Peters, Bjoern; Gholami, Amin Moghaddas; Kuster, Bernhard; Culhane, Aedín C.: MOGSA: Integrative Single Sample Gene-set Analysis of Multiple Omics Data. Molecular & Cellular Proteomics 18 (8), 2019, S153-S168 mehr…
  • Meng, Chen; Basunia, Azfar; Peters, Bjoern; Gholami, Amin Moghaddas; Kuster, Bernhard; Culhane, Aedín C.: MOGSA: Integrative Single Sample Gene-set Analysis of Multiple Omics Data. Molecular & Cellular Proteomics 18 (8 suppl 1), 2019, S153--S168 mehr…
  • Mucha, Stefanie; Heinzlmeir, Stephanie; Kriechbaumer, Verena; Strickland, Benjamin; Kirchhelle, Charlotte; Choudhary, Manisha; Kowalski, Natalie; Eichmann, Ruth; Hueckelhoven, Ralph; Grill, Erwin; Kuster, Bernhard; Glawischnig, Erich: The formation of a camalexin-biosynthetic metabolon. The Plant Cell, 2019, tpc.00403.2019 mehr…
  • Rechenberger, Julia; Samaras, Patroklos; Jarzab, Anna; Behr, Juergen; Frejno, Martin; Djukovic, Ana; Sanz, Jaime; González-Barberá, Eva M.; Salavert, Miguel; López-Hontangas, Jose Luis; Xavier, Karina B.; Debrauwer, Laurent; Rolain, Jean-Marc; Sanz, Miguel; Garcia-Garcera, Marc; Wilhelm, Mathias; Ubeda, Carles; Kuster, Bernhard: Challenges in Clinical Metaproteomics Highlighted by the Analysis of Acute Leukemia Patients with Gut Colonization by Multidrug-Resistant Enterobacteriaceae. Proteomes 7 (1), 2019, 2 mehr…
  • Rechenberger, Julia; Samaras, Patroklos; Jarzab, Anna; Behr, Juergen; Frejno, Martin; Djukovic, Ana; Sanz, Jaime; González-Barberá, Eva M.; Salavert, Miguel; López-Hontangas, Jose Luis; Xavier, Karina B.; Debrauwer, Laurent; Rolain, Jean-Marc; Sanz, Miguel; Garcia-Garcera, Marc; Wilhelm, Mathias; Ubeda, Carles; Kuster, Bernhard: Challenges in Clinical Metaproteomics Highlighted by the Analysis of Acute Leukemia Patients with Gut Colonization by Multidrug-Resistant Enterobacteriaceae. Proteomes 7 (1), 2019, 2 mehr…
  • Reinecke, Maria; Heinzlmeir, Stephanie; Wilhelm, Mathias; Médard, Guillaume; Klaeger, Susan; Kuster, Bernhard: Kinobeads: A Chemical Proteomic Approach for Kinase Inhibitor Selectivity Profiling and Target Discovery – 4. In: Target Discovery and Validation. John Wiley & Sons, Ltd, 2019, 97-130 mehr…
  • Reinecke, Maria; Ruprecht, Benjamin; Poser, Sandra; Wiechmann, Svenja; Wilhelm, Mathias; Heinzlmeir, Stephanie; Kuster, Bernhard; Médard, Guillaume: Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors. ACS Chemical Biology 14 (4), 2019, 655-664 mehr…
  • Reinecke, Maria; Ruprecht, Benjamin; Poser, Sandra; Wiechmann, Svenja; Wilhelm, Mathias; Heinzlmeir, Stephanie; Kuster, Bernhard; Médard, Guillaume: Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors. ACS Chemical Biology 14 (4), 2019, 655-664 mehr…
  • Ruschhaupt, Moritz; Mergner, Julia; Mucha, Stefanie; Papacek, Michael; Doch, Isabel; Tischer, Stefanie V; Hemmler, Daniel; Chiasson, David; Edel, Kai H; Kudla, Jörg; Schmitt‐Kopplin, Philippe; Kuster, Bernhard; Grill, Erwin: Rebuilding core abscisic acid signaling pathways of Arabidopsis in yeast. The EMBO Journal 38 (17), 2019 mehr…
  • Samaras, Patroklos; Schmidt, Tobias; Frejno, Martin; Gessulat, Siegfried; Reinecke, Maria; Jarzab, Anna; Zecha, Jana; Mergner, Julia; Giansanti, Piero; Ehrlich, Hans-Christian; Aiche, Stephan; Rank, Johannes; Kienegger, Harald; Krcmar, Helmut; Kuster, Bernhard; Wilhelm, Mathias: ProteomicsDB: a multi-omics and multi-organism resource for life science research. Nucleic Acids Research, 2019 mehr…
  • Samaras, Patroklos; Schmidt, Tobias; Frejno, Martin; Gessulat, Siegfried; Reinecke, Maria; Jarzab, Anna; Zecha, Jana; Mergner, Julia; Giansanti, Piero; Ehrlich, Hans-Christian; Aiche, Stephan; Rank, Johannes; Kienegger, Harald; Krcmar, Helmut; Kuster, Bernhard; Wilhelm, Mathias: ProteomicsDB: a multi-omics and multi-organism resource for life science research. Nucleic Acids Research, 2019 mehr…
  • Samaras, Patroklos; Schmidt, Tobias; Frejno, Martin; Gessulat, Siegfried; Reinecke, Maria; Jarzab, Anna; Zecha, Jana; Mergner, Julia; Giansanti, Piero; Ehrlich, Hans-Christian; Aiche, Stephan; Rank, Johannes; Kienegger, Harald; Krcmar, Helmut; Kuster, Bernhard; Wilhelm, Mathias: ProteomicsDB: a multi-omics and multi-organism resource for life science research. Nucleic Acids Research, 2019 mehr…
  • Schirle, Markus; Bantscheff, Marcus; Kuster, Bernhard: Characterization of Drug-Protein Interactions by Chemoproteomics. In: Proteomics for Biological Discovery. John Wiley & Sons, Inc., 2019 mehr…
  • Schirle, Markus; Bantscheff, Marcus; Kuster, Bernhard: Characterization of Drug-Protein Interactions by Chemoproteomics. In: Proteomics for Biological Discovery. John Wiley & Sons, Inc., 2019 mehr…
  • Seefried, Florian; Schmidt, Tobias; Reinecke, Maria; Heinzlmeir, Stephanie; Kuster, Bernhard; Wilhelm, Mathias: CiRCus: A Framework to Enable Classification of Complex High-Throughput Experiments. Journal of Proteome Research 18 (4), 2019, 1486-1493 mehr…
  • Seefried, Florian; Schmidt, Tobias; Reinecke, Maria; Heinzlmeir, Stephanie; Kuster, Bernhard; Wilhelm, Mathias: CiRCus: A Framework to Enable Classification of Complex High-Throughput Experiments. Journal of Proteome Research 18 (4), 2019, 1486-1493 mehr…
  • Verbruggen, Steven; Ndah, Elvis; Van Criekinge, Wim; Gessulat, Siegfried; Kuster, Bernhard; Wilhelm, Mathias; Van Damme, Petra; Menschaert, Gerben: PROTEOFORMER 2.0: Further Developments in the Ribosome Profiling-assisted Proteogenomic Hunt for New Proteoforms. Molecular & Cellular Proteomics 18 (8), 2019, S126-S140 mehr…
  • Wang, Dongxue; Eraslan, Basak; Wieland, Thomas; Hallström, Björn; Hopf, Thomas; Zolg, Daniel Paul; Zecha, Jana; Asplund, Anna; Li, Li‐hua; Meng, Chen; Frejno, Martin; Schmidt, Tobias; Schnatbaum, Karsten; Wilhelm, Mathias; Ponten, Frederik; Uhlen, Mathias; Gagneur, Julien; Hahne, Hannes; Kuster, Bernhard: A deep proteome and transcriptome abundance atlas of 29 healthy human tissues. Molecular Systems Biology 15 (2), 2019 mehr…
  • Wang, Dongxue; Eraslan, Basak; Wieland, Thomas; Hallström, Björn; Hopf, Thomas; Zolg, Daniel Paul; Zecha, Jana; Asplund, Anna; Li, Li‐hua; Meng, Chen; Frejno, Martin; Schmidt, Tobias; Schnatbaum, Karsten; Wilhelm, Mathias; Ponten, Frederik; Uhlen, Mathias; Gagneur, Julien; Hahne, Hannes; Kuster, Bernhard: A deep proteome and transcriptome abundance atlas of 29 healthy human tissues. Molecular Systems Biology 15 (2), 2019 mehr…
  • Zecha, Jana; Satpathy, Shankha; Kanashova, Tamara; Avanessian, Shayan C.; Kane, M. Harry; Clauser, Karl R.; Mertins, Philipp; Carr, Steven A.; Kuster, Bernhard: TMT Labeling for the Masses: A Robust and Cost-efficient, In-solution Labeling Approach. Molecular & Cellular Proteomics 18 (7), 2019, 1468-1478 mehr…
  • Zecha, Jana; Satpathy, Shankha; Kanashova, Tamara; Avanessian, Shayan C.; Kane, M. Harry; Clauser, Karl R.; Mertins, Philipp; Carr, Steven A.; Kuster, Bernhard: TMT Labeling for the Masses: A Robust and Cost-efficient, In-solution Labeling Approach. Molecular & Cellular Proteomics 18 (7), 2019, 1468-1478 mehr…
  • Zhang, Bing; Kuster, Bernhard: Proteomics Is Not an Island: Multi-omics Integration Is the Key to Understanding Biological Systems. Molecular & Cellular Proteomics 18 (8), 2019, S1-S4 mehr…
  • Zhang, Bing; Kuster, Bernhard: Proteomics Is Not an Island: Multi-omics Integration Is the Key to Understanding Biological Systems. Molecular & Cellular Proteomics 18 (8 suppl 1), 2019, S1-S4 mehr…

2018

  • Bader, Matthias; Dunkel, Andreas; Wenning, Mareike; Kohler, Bernd; Medard, Guillaume; del Castillo, Estela; Gholami, Amin; Kuster, Bernhard; Scherer, Siegfried; Hofmann, Thomas: Dynamic Proteome Alteration and Functional Modulation of Human Saliva Induced by Dietary Chemosensory Stimuli. Journal of Agricultural and Food Chemistry 66 (22), 2018, 5621-5634 mehr…
  • Buhner, Sabine; Hahne, Hannes; Hartwig, Kerstin; Li, Qin; Vignali, Sheila; Ostertag, Daniela; Meng, Chen; Hörmannsperger, Gabriele; Braak, Breg; Pehl, Christian; Frieling, Thomas; Barbara, Giovanni; De Giorgio, Roberto; Demir, Ihsan Ekin; Ceyhan, Güralp Onur; Zeller, Florian; Boeckxstaens, Guy; Haller, Dirk; Kuster, Bernhard; Schemann, Michael: Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients. PLOS ONE 13 (3), 2018, e0193943 mehr…
  • Deutsch, Eric W.; Perez-Riverol, Yasset; Chalkley, Robert J.; Wilhelm, Mathias; Tate, Stephen; Sachsenberg, Timo; Walzer, Mathias; Käll, Lukas; Delanghe, Bernard; Böcker, Sebastian; Schymanski, Emma L.; Wilmes, Paul; Dorfer, Viktoria; Kuster, Bernhard; Volders, Pieter-Jan; Jehmlich, Nico; Vissers, Johannes P. C.; Wolan, Dennis W.; Wang, Ana Y.; Mendoza, Luis; Shofstahl, Jim; Dowsey, Andrew W.; Griss, Johannes; Salek, Reza M.; Neumann, Steffen; Binz, Pierre-Alain; Lam, Henry; Vizcaíno, Juan Antonio; Bandeira, Nuno; Röst, Hannes: Expanding the Use of Spectral Libraries in Proteomics. Journal of Proteome Research 17 (12), 2018, 4051-4060 mehr…
  • Kindt, Alida; Liebisch, Gerhard; Clavel, Thomas; Haller, Dirk; Hörmannsperger, Gabriele; Yoon, Hongsup; Kolmeder, Daniela; Sigruener, Alexander; Krautbauer, Sabrina; Seeliger, Claudine; Ganzha, Alexandra; Schweizer, Sabine; Morisset, Rosalie; Strowig, Till; Daniel, Hannelore; Helm, Dominic; Küster, Bernhard; Krumsiek, Jan; Ecker, Josef: The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice. Nature Communications 9 (1), 2018 mehr…
  • Lee, Chien-Yun; Wang, Dongxue; Wilhelm, Mathias; Zolg, Daniel P.; Schmidt, Tobias; Schnatbaum, Karsten; Reimer, Ulf; Pontén, Fredrik; Uhlén, Mathias; Hahne, Hannes; Kuster, Bernhard: Mining the Human Tissue Proteome for Protein Citrullination. Molecular & Cellular Proteomics 17 (7), 2018, 1378-1391 mehr…
  • Mathew, Nimitha R; Baumgartner, Francis; Braun, Lukas; O'Sullivan, David; Thomas, Simone; Waterhouse, Miguel; Müller, Tony A; Hanke, Kathrin; Taromi, Sanaz; Apostolova, Petya; Illert, Anna L; Melchinger, Wolfgang; Duquesne, Sandra; Schmitt-Graeff, Annette; Osswald, Lena; Yan, Kai-Li; Weber, Arnim; Tugues, Sonia; Spath, Sabine; Pfeifer, Dietmar; Follo, Marie; Claus, Rainer; Lübbert, Michael; Rummelt, Christoph; Bertz, Hartmut; Wäsch, Ralph; Haag, Johanna; Schmidts, Andrea; Schultheiss, Michael; Bettinger, Dominik; Thimme, Robert; Ullrich, Evelyn; Tanriver, Yakup; Vuong, Giang Lam; Arnold, Renate; Hemmati, Philipp; Wolf, Dominik; Ditschkowski, Markus; Jilg, Cordula; Wilhelm, Konrad; Leiber, Christian; Gerull, Sabine; Halter, Jörg; Lengerke, Claudia; Pabst, Thomas; Schroeder, Thomas; Kobbe, Guido; Rösler, Wolf; Doostkam, Soroush; Meckel, Stephan et al.: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nature Medicine 24 (3), 2018, 282-291 mehr…
  • Mulder, Celine; Prust, Nadine; van Doorn, Sander; Reinecke, Maria; Kuster, Bernhard; van Bergen en Henegouwen, Paul; Lemeer, Simone: Adaptive Resistance to EGFR-Targeted Therapy by Calcium Signaling in NSCLC Cells. Molecular Cancer Research 16 (11), 2018, 1773-1784 mehr…
  • Prechtl, Roman M.; Janßen, Dorothee; Behr, Jürgen; Ludwig, Christina; Küster, Bernhard; Vogel, Rudi F.; Jakob, Frank: Sucrose-Induced Proteomic Response and Carbohydrate Utilization of Lactobacillus sakei TMW 1.411 During Dextran Formation. Frontiers in Microbiology 9, 2018 mehr…
  • Tröster, Alix; Heinzlmeir, Stephanie; Berger, Benedict-Tilman; Gande, Santosh L.; Saxena, Krishna; Sreeramulu, Sridhar; Linhard, Verena; Nasiri, Amir H.; Bolte, Michael; Müller, Susanne; Kuster, Bernhard; Médard, Guillaume; Kudlinzki, Denis; Schwalbe, Harald: NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. ChemMedChem 13 (16), 2018, 1629-1633 mehr…
  • Yoon, Hongsup; Schaubeck, Monika; Lagkouvardos, Ilias; Blesl, Andreas; Heinzlmeir, Stephanie; Hahne, Hannes; Clavel, Thomas; Panda, Suchita; Ludwig, Christina; Kuster, Bernhard; Manichanh, Chaysavanh; Kump, Patrizia; Haller, Dirk; Hörmannsperger, Gabriele: Increased Pancreatic Protease Activity in Response to Antibiotics Impairs Gut Barrier and Triggers Colitis. Cellular and Molecular Gastroenterology and Hepatology 6 (3), 2018, 370-388.e3 mehr…
  • Zecha, Jana; Meng, Chen; Zolg, Daniel Paul; Samaras, Patroklos; Wilhelm, Mathias; Kuster, Bernhard: Peptide Level Turnover Measurements Enable the Study of Proteoform Dynamics. Molecular & Cellular Proteomics 17 (5), 2018, 974-992 mehr…
  • Zolg, Daniel Paul; Wilhelm, Mathias; Schmidt, Tobias; Médard, Guillaume; Zerweck, Johannes; Knaute, Tobias; Wenschuh, Holger; Reimer, Ulf; Schnatbaum, Karsten; Kuster, Bernhard: ProteomeTools: Systematic Characterization of 21 Post-translational Protein Modifications by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Using Synthetic Peptides. Molecular & Cellular Proteomics 17 (9), 2018, 1850-1863 mehr…

2017

  • Jiang, Li; Zhang, Bodong; Médard, Guillaume; Seitsonen, Ari Paavo; Haag, Felix; Allegretti, Francesco; Reichert, Joachim; Kuster, Bernhard; Barth, Johannes V.; Papageorgiou, Anthoula C.: N-Heterocyclic carbenes on close-packed coinage metal surfaces: bis-carbene metal adatom bonding scheme of monolayer films on Au, Ag and Cu. Chemical Science 8 (12), 2017, 8301-8308 mehr…
To top