Engineering Cells for Immune Therapie

Rudolf Mößbauer Tenure Track Professor Kathrin Schumann’s research is focused on human immune cell engineering. She uses innovative CRISPR technology to ablate or modify genetic regions in human T cells in order to characterize their role in cellular function and stability. In the long term, this knowledge may help to develop new therapies for the treatment of autoimmune diseases and cancer.

Publications by the Focus Group

2021

Mathewson, Nathan D.; Ashenberg, Orr; Tirosh, Itay; Gritsch, Simon; Perez, Elizabeth M.; Marx, Sascha; Jerby-Arnon, Livnat; Chanoch-Myers, Rony; Hara, Toshiro; Richman, Alyssa R.; Ito, Yoshinaga; Pyrdol, Jason; Friedrich, Mirco; Schumann, Kathrin; Poitras, Michael J.; Gokhale, Prafulla C.; Gonzalez Castro, L. Nicolas; Shore, Marni E.; Hebert, Christine M.; Shaw, Brian; Cahill, Heather L.; Drummond, Matthew; Zhang, Wubing; Olawoyin, Olamide; Wakimoto, Hiroaki; Rozenblatt-Rosen, Orit; Brastianos, Priscilla K.; Liu, X. Shirley; Jones, Pamela S.; Cahill, Daniel P.; Frosch, Matthew P.; Louis, David N.; Freeman, Gordon J.; Ligon, Keith L.; Marson, Alexander; Chiocca, E. Antonio; Reardon, David A.; Regev, Aviv; Suvà, Mario L.; Wucherpfennig, Kai W.: Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell 184 (5), 2021, 1281-1298.e26 mehr…

2020

Schumann, Kathrin; Raju, Siddharth S.; Lauber, Michael; Kolb, Saskia; Shifrut, Eric; Cortez, Jessica T.; Skartsis, Nikolaos; Nguyen, Vinh Q.; Woo, Jonathan M.; Roth, Theodore L.; Yu, Ruby; Nguyen, Michelle L. T.; Simeonov, Dimitre R.; Nguyen, David N.; Targ, Sasha; Gate, Rachel E.; Tang, Qizhi; Bluestone, Jeffrey A.; Spitzer, Matthew H.; Ye, Chun Jimmie; Marson, Alexander: Functional CRISPR dissection of gene networks controlling human regulatory T cell identity. Nature Immunology 21 (11), 2020, 1456-1466 mehr…

2019

Lowe, Margaret M.; Boothby, Ian; Clancy, Sean; Ahn, Richard S.; Liao, Wilson; Nguyen, David N.; Schumann, Kathrin; Marson, Alexander; Mahuron, Kelly M.; Kingsbury, Gillian A.; Liu, Zheng; Munoz Sandoval, Priscila; Rodriguez, Robert Sanchez; Pauli, Mariela L.; Taravati, Keyon; Arron, Sarah T.; Neuhaus, Isaac M.; Harris, Hobart W.; Kim, Esther A.; Shin, Uk Sok; Krummel, Matthew F.; Daud, Adil; Scharschmidt, Tiffany C.; Rosenblum, Michael D.: Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. JCI Insight 4 (24), 2019 mehr…
Schober, Kilian; Müller, Thomas R.; Gökmen, Füsun; Grassmann, Simon; Effenberger, Manuel; Poltorak, Mateusz; Stemberger, Christian; Schumann, Kathrin; Roth, Theodore L.; Marson, Alexander; Busch, Dirk H.: Orthotopic replacement of T-cell receptor α- and β-chains with preservation of near-physiological T-cell function. Nature Biomedical Engineering 3 (12), 2019, 974-984 mehr…

2018

Hultquist, Judd F.; Hiatt, Joseph; Schumann, Kathrin; McGregor, Michael J.; Roth, Theodore L.; Haas, Paige; Doudna, Jennifer A.; Marson, Alexander; Krogan, Nevan J.: CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions. Nature Protocols 14 (1), 2018, 1-27 mehr…
Roth, Theodore L.; Puig-Saus, Cristina; Yu, Ruby; Shifrut, Eric; Carnevale, Julia; Li, P. Jonathan; Hiatt, Joseph; Saco, Justin; Krystofinski, Paige; Li, Han; Tobin, Victoria; Nguyen, David N.; Lee, Michael R.; Putnam, Amy L.; Ferris, Andrea L.; Chen, Jeff W.; Schickel, Jean-Nicolas; Pellerin, Laurence; Carmody, David; Alkorta-Aranburu, Gorka; del Gaudio, Daniela; Matsumoto, Hiroyuki; Morell, Montse; Mao, Ying; Cho, Min; Quadros, Rolen M.; Gurumurthy, Channabasavaiah B.; Smith, Baz; Haugwitz, Michael; Hughes, Stephen H.; Weissman, Jonathan S.; Schumann, Kathrin; Esensten, Jonathan H.; May, Andrew P.; Ashworth, Alan; Kupfer, Gary M.; Greeley, Siri Atma W.; Bacchetta, Rosa; Meffre, Eric; Roncarolo, Maria Grazia; Romberg, Neil; Herold, Kevan C.; Ribas, Antoni; Leonetti, Manuel D.; Marson, Alexander: Reprogramming human T cell function and specificity with non-viral genome targeting. Nature 559 (7714), 2018, 405-409 mehr…

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