How do cells control the structure of the proteins they produce? How are defective proteins recognized and degraded instead of having potentially harmful effects on the organism? Which molecules and mechanisms underlie this molecular quality control? These are major questions that drive the research in the Focus Group for Cellular Protein Biochemistry, which has been headed by Rudolf Mößbauer Tenure Track Professor Matthias J. Feige since March 2015. A particular emphasis of Professor Feige’s work is laid on secretory and membrane proteins. These protein classes play an important role in the interaction of cells with their environment, e.g. in the human immune system, and failures in their biogenesis are involved in many different human pathologies. Insights into the principles of cellular quality control might thus ultimately be translated into new biomedical and biotechnological applications.
TUM-IAS funded doctoral candidates: Stephanie Müller, Cellular Protein Biochemisty Susanne Reitberger, Cellular Protein Biochemistry
Coelho, João P. L.; Stahl, Matthias; Bloemeke, Nicolas; Meighen-Berger, Kevin; Alvira, Carlos Piedrafita; Zhang, Zai-Rong; Sieber, Stephan A.; Feige, Matthias J.: A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration. Nature Communications 10 (1), 2019 mehr…
Meier, Susanne; Bohnacker, Sina; Klose, Carolin J.; Lopez, Abraham; Choe, Christian A.; Schmid, Philipp W. N.; Bloemeke, Nicolas; Rührnößl, Florian; Haslbeck, Martin; Bieren, Julia Esser-von; Sattler, Michael; Huang, Po-Ssu; Feige, Matthias J.: The molecular basis of chaperone-mediated interleukin 23 assembly control. Nature Communications 10 (1), 2019 mehr…
Müller, Stephanie I.; Aschenbrenner, Isabel; Zacharias, Martin; Feige, Matthias J.: An Interspecies Analysis Reveals Molecular Construction Principles of Interleukin 27. Journal of Molecular Biology 431 (12), 2019, 2383-2393 mehr…
Müller, Stephanie I.; Friedl, Antonie; Aschenbrenner, Isabel; Esser-von Bieren, Julia; Zacharias, Martin; Devergne, Odile; Feige, Matthias J.: A folding switch regulates interleukin 27 biogenesis and secretion of its α-subunit as a cytokine. Proceedings of the National Academy of Sciences 116 (5), 2019, 1585-1590 mehr…
Behnke, Julia; Mann, Melissa J.; Scruggs, Fei-Lin; Feige, Matthias J.; Hendershot, Linda M.: Members of the Hsp70 Family Recognize Distinct Types of Sequences to Execute ER Quality Control. Molecular Cell 63 (5), 2016, 739-752 mehr…
2015
Behnke, Julia; Feige, Matthias J.; Hendershot, Linda M.: BiP and Its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions. Journal of Molecular Biology 427 (7), 2015, 1589-1608 mehr…
Feige, Matthias J.; Behnke, Julia; Mittag, Tanja; Hendershot, Linda M.: Dimerization-dependent Folding Underlies Assembly Control of the Clonotypic αβT Cell Receptor Chains. Journal of Biological Chemistry 290 (44), 2015, 26821-26831 mehr…
2012
Vignali, Dario A A; Kuchroo, Vijay K: IL-12 family cytokines: immunological playmakers. Nature Immunology 13 (8), 2012, 722-728 mehr…
