2018
- From a Helix to a Small Cycle: Metadynamics-Inspired αvβ6 Integrin Selective Ligands. Angewandte Chemie International Edition 57 (44), 2018, 14645-14649 mehr…
- Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1. Journal of Medicinal Chemistry 61 (8), 2018, 3674-3684 mehr…
- Therapeutic Radiopharmaceuticals Targeting Integrin αvβ6. ACS Omega 3 (2), 2018, 2428-2436 mehr…
- Combining Adhesive Nanostructured Surfaces and Costimulatory Signals to Increase T Cell Activation. Nano Letters 18 (9), 2018, 5899-5904 mehr…
- Bioconjugation of Supramolecular Metallacages to Integrin Ligands for Targeted Delivery of Cisplatin. Bioconjugate Chemistry 29 (11), 2018, 3856-3865 mehr…
- N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent. Journal of Medicinal Chemistry 61 (6), 2018, 2490-2499 mehr…
- Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme. Journal of Medicinal Chemistry 61 (11), 2018, 4791-4809 mehr…
- Fluorescence imaging of invasive head and neck carcinoma cells with integrin αvβ6-targeting RGD-peptides: an approach to a fluorescence-assisted intraoperative cytological assessment of bony resection margins. British Journal of Oral and Maxillofacial Surgery 56 (10), 2018, 972-978 mehr…
- Orally Active Peptides: Is There a Magic Bullet? Angewandte Chemie International Edition 57 (44), 2018, 14414-14438 mehr…
- Improving oral bioavailability of cyclic peptides by N -methylation. Bioorganic & Medicinal Chemistry 26 (10), 2018, 2766-2773 mehr…
- Enhancing Oral Bioavailability of Cyclic RGD Hexa-peptides by the Lipophilic Prodrug Charge Masking Approach: Redirection of Peptide Intestinal Permeability from a Paracellular to Transcellular Pathway. Molecular Pharmaceutics 15 (8), 2018, 3468-3477 mehr…
2017
- Structural Insights into Selective Ligand–Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists. Biochemistry 56 (32), 2017, 4201-4209 mehr…
- Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands. Scientific Reports 7 (1), 2017 mehr…
- A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins. Scientific Reports 7 (1), 2017 mehr…
- Integrin-Targeted Hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography for Imaging Tumor Progression and Early Response in Non-Small Cell Lung Cancer. Neoplasia 19 (1), 2017, 8-16 mehr…
- Fibronectin promotes directional persistence in fibroblast migration through interactions with both its cell-binding and heparin-binding domains. Scientific Reports 7 (1), 2017 mehr…
- Exploring the Role of RGD-Recognizing Integrins in Cancer. Cancers 9 (12), 2017, 116 mehr…
- Highly Ordered Gold Nanopatterned Indium Tin Oxide Electrodes for Simultaneous Optical and Electrochemical Probing Cell Interactions. Analytical Chemistry 89 (18), 2017, 10054-10062 mehr…
- Focal adhesion stabilization by enhanced integrin-cRGD binding affinity. BioNanoMaterials 18 (1-2), 2017 mehr…
- Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3. Angewandte Chemie International Edition 56 (51), 2017, 16405-16409 mehr…
2016
- αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating. Angewandte Chemie International Edition 55 (25), 2016, 7048-7067 mehr…
- Substrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin. Scientific Reports 6 (1), 2016 mehr…
- In Vivo PET Imaging of the Cancer Integrin αvβ6 Using 68 Ga-Labeled Cyclic RGD Nonapeptides. Journal of Nuclear Medicine 58 (4), 2016, 671-677 mehr…
- Selective binding and lateral clustering of α5β1 and αvβ3 integrins: Unraveling the spatial requirements for cell spreading and focal adhesion assembly. Cell Adhesion & Migration 10 (5), 2016, 505-515 mehr…
2015
- Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors. Journal of Medicinal Chemistry 58 (16), 2015, 6359-6367 mehr…
- In vivo biokinetic and metabolic characterization of the 68Ga-labelled α5β1-selective peptidomimetic FR366. European Journal of Nuclear Medicine and Molecular Imaging 43 (5), 2015, 953-963 mehr…
- Mimicking bone extracellular matrix: Integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium. Colloids and Surfaces B: Biointerfaces 128, 2015, 191-200 mehr…
- Direct prediction of residual dipolar couplings of small molecules in a stretched gel by stochastic molecular dynamics simulations. Magnetic Resonance in Chemistry 53 (3), 2015, 213-217 mehr…
- Synthetische Adhäsion von Integrin-Liposomen als minimales Zellmodell. Angewandte Chemie 127 (42), 2015, 12649-12655 mehr…
- Minimal Synthetic Cells to Study Integrin-Mediated Adhesion. Angewandte Chemie International Edition 54 (42), 2015, 12472-12478 mehr…
- Segregation Versus Colocalization: Orthogonally Functionalized Binary Micropatterned Substrates Regulate the Molecular Distribution in Focal Adhesions. Advanced Materials 27 (25), 2015, 3737-3747 mehr…
- Bioactive compounds immobilized on Ti and TiNbHf: AFM-based investigations of biofunctionalization efficiency and cell adhesion. Colloids and Surfaces B: Biointerfaces 136, 2015, 704-711 mehr…
- Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties. Oncotarget 6 (39), 2015 mehr…
- Small Cause, Great Impact: Modification of the Guanidine Group in the RGD Motif Controls Integrin Subtype Selectivity. Angewandte Chemie International Edition 55 (4), 2015, 1540-1543 mehr…
- Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands. Angewandte Chemie International Edition 55 (4), 2015, 1535-1539 mehr…
- Enantiomeric Cyclic Peptides with Different Caco-2 Permeability Suggest Carrier-Mediated Transport. Chemistry - A European Journal 21 (22), 2015, 8023-8027 mehr…
- cis-Peptide Bonds: A Key for Intestinal Permeability of Peptides? Chemistry - A European Journal 21 (43), 2015, 15148-15152 mehr…
- Complementary, Selective PET Imaging of Integrin Subtypes 5 1 and v 3 Using 68Ga-Aquibeprin and 68Ga-Avebetrin. Journal of Nuclear Medicine 57 (3), 2015, 460-466 mehr…
- Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma. Cell Death & Differentiation 23 (4), 2015, 640-653 mehr…
- Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules. Nature Communications 6 (1), 2015 mehr…
- Disclosing the CXCR4 Expression in Lymphoproliferative Diseases by Targeted Molecular Imaging. Theranostics 5 (6), 2015, 618-630 mehr…
2014
- PET/CT Imaging of Integrin αvβ3 Expression in Human Carotid Atherosclerosis. JACC: Cardiovascular Imaging 7 (2), 2014, 178-187 mehr…
- Protein Folding by Interaction. Structure 22 (7), 2014, 936-937 mehr…
- The Cyclic Cystine Ladder of Theta-Defensins as a Stable, Bifunctional Scaffold: A Proof-of-Concept Study Using the Integrin-Binding RGD Motif. ChemBioChem 15 (3), 2014, 451-459 mehr…
- Rational Improvement of the Affinity and Selectivity of Integrin Binding of Grafted Lasso Peptides. Journal of Medicinal Chemistry 57 (13), 2014, 5829-5834 mehr…
- Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure. Chemistry - A European Journal 20 (44), 2014, 14201-14206 mehr…
- Investigation of early cell–surface interactions of human mesenchymal stem cells on nanopatterned β-type titanium–niobium alloy surfaces. Interface Focus 4 (1), 2014, 20130046 mehr…
- Cytoplasmic salt bridge formation in integrin αvß3 stabilizes its inactive state affecting integrin-mediated cell biological effects. Cellular Signalling 26 (11), 2014, 2493-2503 mehr…
- Pharmacophoric Modifications Lead to Superpotent αvβ3 Integrin Ligands with Suppressed α5β1 Activity. Journal of Medicinal Chemistry 57 (8), 2014, 3410-3417 mehr…
- Single cell tracking assay reveals an opposite effect of selective small non-peptidic α5β1 or αvβ3/β5 integrin antagonists in U87MG glioma cells. Biochimica et Biophysica Acta (BBA) - General Subjects 1840 (9), 2014, 2978-2987 mehr…
- The Integrin Ligandc(RGDf(NMe)Nal) Reduces Neointimal Hyperplasia in a Polymer-Free Drug-Eluting Stent System. ChemMedChem 9 (7), 2014, 1413-1418 mehr…
- Benefits of NOPO As Chelator in Gallium-68 Peptides, Exemplified by Preclinical Characterization of 68Ga-NOPO–c(RGDfK). Molecular Pharmaceutics 11 (5), 2014, 1687-1695 mehr…
2013
- Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids. Journal of Medicinal Chemistry 56 (4), 2013, 1509-1519 mehr…
- FOSL1 Controls the Assembly of Endothelial Cells into Capillary Tubes by Direct Repression of αv and β3 Integrin Transcription. Molecular and Cellular Biology 33 (6), 2013, 1198-1209 mehr…
- Integrin modulators: a patent review. Expert Opinion on Therapeutic Patents 23 (10), 2013, 1273-1295 mehr…
- Comparison of cyclic RGD peptides for αvβ3 integrin detection in a rat model of myocardial infarction. EJNMMI Research 3 (1), 2013, 38 mehr…
- Tumor Targeting via Integrin Ligands. Frontiers in Oncology 3, 2013 mehr…
- The Glycophorin A Transmembrane Sequence within Integrin αvβ3 Creates a Non-Signaling Integrin with Low Basal Affinity That Is Strongly Adhesive under Force. Journal of Molecular Biology 425 (16), 2013, 2988-3006 mehr…
- Selective Imaging of the Angiogenic Relevant Integrins α5β1 and αvβ3. Angewandte Chemie International Edition 52 (44), 2013, 11656-11659 mehr…
- Interface Immobilization Chemistry ofcRGD-based Peptides Regulates Integrin Mediated Cell Adhesion. Advanced Functional Materials 24 (7), 2013, 943-956 mehr…
- Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through αvβ3- or α5β1-Integrins. Advanced Materials 25 (41), 2013, 5869-5874 mehr…
- A Molecular Toolkit for the Functionalization of Titanium-Based Biomaterials That Selectively Control Integrin-Mediated Cell Adhesion. Chemistry - A European Journal 19 (28), 2013, 9218-9223 mehr…
- The Regulatory Domain Stabilizes the p53 Tetramer by Intersubunit Contacts with the DNA Binding Domain. Journal of Molecular Biology 425 (1), 2013, 144-155 mehr…
- A Cyclen-Based Tetraphosphinate Chelator for the Preparation of Radiolabeled Tetrameric Bioconjugates. Chemistry - A European Journal 19 (24), 2013, 7748-7757 mehr…
2012
- N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions. Angewandte Chemie International Edition 52 (1), 2012, 254-269 mehr…
- Behavior of primary human osteoblasts on trimmed and sandblasted Ti6Al4V surfaces functionalized with integrin αvβ3-selective cyclic RGD peptides. Journal of Biomedical Materials Research Part A 101A (1), 2012, 87-97 mehr…
- Functionalizing αvβ3- or α5β1-Selective Integrin Antagonists for Surface Coating: A Method To Discriminate Integrin Subtypes In Vitro. Angewandte Chemie International Edition 52 (5), 2012, 1572-1575 mehr…