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Technische Universität München
Technische Universität München

Biochemistry

Prof. Horst Kessler worked as a Carl von Linde Senior Fellow on organic chemistry and bio chemistry topics at TUM-IAS.The main topics of his research are the development of cell adhesion molecules for improvement of biomaterials and molecular imaging, as well as NMR work, for understanding the function and interaction of proteins. He collaborates with a number of scientists in biochemistry, biophysics, and medicine, as well as with several industrial partners.  

Prof. Franz Hagn was a Hans Fischer Fellow in the Focus Group from April 2013 to September 2014. Since October 2014 he has been Rudolf Mößbauer Tenure Track Assistant Professor of Structural Membrane Biochemistry at TUM.

Publications by the Focus Group

2018

  • Di Leva, Francesco Saverio; Tomassi, Stefano; Di Maro, Salvatore; Reichart, Florian; Notni, Johannes; Dangi, Abha; Marelli, Udaya Kiran; Brancaccio, Diego; Merlino, Francesco; Wester, Hans-Jürgen; Novellino, Ettore; Kessler, Horst; Marinelli, Luciana: From a Helix to a Small Cycle: Metadynamics-Inspired αvβ6 Integrin Selective Ligands. Angewandte Chemie International Edition 57 (44), 2018, 14645-14649 mehr…
  • Durek, Thomas; Cromm, Philipp M.; White, Andrew M.; Schroeder, Christina I.; Kaas, Quentin; Weidmann, Joachim; Ahmad Fuaad, Abdullah; Cheneval, Olivier; Harvey, Peta J.; Daly, Norelle L.; Zhou, Yang; Dellsén, Anita; Österlund, Torben; Larsson, Niklas; Knerr, Laurent; Bauer, Udo; Kessler, Horst; Cai, Minying; Hruby, Victor J.; Plowright, Alleyn T.; Craik, David J.: Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1. Journal of Medicinal Chemistry 61 (8), 2018, 3674-3684 mehr…
  • Färber, Stefanie Felicitas; Wurzer, Alexander; Reichart, Florian; Beck, Roswitha; Kessler, Horst; Wester, Hans-Jürgen; Notni, Johannes: Therapeutic Radiopharmaceuticals Targeting Integrin αvβ6. ACS Omega 3 (2), 2018, 2428-2436 mehr…
  • Guasch, Judith; Hoffmann, Marco; Diemer, Jennifer; Riahinezhad, Hossein; Neubauer, Stefanie; Kessler, Horst; Spatz, Joachim P.: Combining Adhesive Nanostructured Surfaces and Costimulatory Signals to Increase T Cell Activation. Nano Letters 18 (9), 2018, 5899-5904 mehr…
  • Han, Jiaying; Räder, Andreas F. B.; Reichart, Florian; Aikman, Brech; Wenzel, Margot N.; Woods, Ben; Weinmüller, Michael; Ludwig, Beatrice S.; Stürup, Stefan; Groothuis, Geny M. M.; Permentier, Hjalmar P.; Bischoff, Rainer; Kessler, Horst; Horvatovich, Peter; Casini, Angela: Bioconjugation of Supramolecular Metallacages to Integrin Ligands for Targeted Delivery of Cisplatin. Bioconjugate Chemistry 29 (11), 2018, 3856-3865 mehr…
  • Kapp, Tobias G.; Di Leva, Francesco Saverio; Notni, Johannes; Räder, Andreas F. B.; Fottner, Maximilian; Reichart, Florian; Reich, Dominik; Wurzer, Alexander; Steiger, Katja; Novellino, Ettore; Marelli, Udaya Kiran; Wester, Hans-Jürgen; Marinelli, Luciana; Kessler, Horst: N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent. Journal of Medicinal Chemistry 61 (6), 2018, 2490-2499 mehr…
  • Merlino, Francesco; Daniele, Simona; La Pietra, Valeria; Di Maro, Salvatore; Di Leva, Francesco Saverio; Brancaccio, Diego; Tomassi, Stefano; Giuntini, Stefano; Cerofolini, Linda; Fragai, Marco; Luchinat, Claudio; Reichart, Florian; Cavallini, Chiara; Costa, Barbara; Piccarducci, Rebecca; Taliani, Sabrina; Da Settimo, Federico; Martini, Claudia; Kessler, Horst; Novellino, Ettore; Marinelli, Luciana: Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme. Journal of Medicinal Chemistry 61 (11), 2018, 4791-4809 mehr…
  • Nieberler, M.; Reuning, U.; Kessler, H.; Reichart, F.; Weirich, G.; Wolff, K.-D.: Fluorescence imaging of invasive head and neck carcinoma cells with integrin αvβ6-targeting RGD-peptides: an approach to a fluorescence-assisted intraoperative cytological assessment of bony resection margins. British Journal of Oral and Maxillofacial Surgery 56 (10), 2018, 972-978 mehr…
  • Räder, Andreas F. B.; Weinmüller, Michael; Reichart, Florian; Schumacher-Klinger, Adi; Merzbach, Shira; Gilon, Chaim; Hoffman, Amnon; Kessler, Horst: Orally Active Peptides: Is There a Magic Bullet? Angewandte Chemie International Edition 57 (44), 2018, 14414-14438 mehr…
  • Räder, Andreas F.B.; Reichart, Florian; Weinmüller, Michael; Kessler, Horst: Improving oral bioavailability of cyclic peptides by N -methylation. Bioorganic & Medicinal Chemistry 26 (10), 2018, 2766-2773 mehr…
  • Schumacher-Klinger, Adi; Fanous, Joseph; Merzbach, Shira; Weinmüller, Michael; Reichart, Florian; Räder, Andreas F. B.; Gitlin-Domagalska, Agata; Gilon, Chaim; Kessler, Horst; Hoffman, Amnon: Enhancing Oral Bioavailability of Cyclic RGD Hexa-peptides by the Lipophilic Prodrug Charge Masking Approach: Redirection of Peptide Intestinal Permeability from a Paracellular to Transcellular Pathway. Molecular Pharmaceutics 15 (8), 2018, 3468-3477 mehr…

2017

  • Cai, Minying; Marelli, Udaya Kiran; Mertz, Blake; Beck, Johannes G.; Opperer, Florian; Rechenmacher, Florian; Kessler, Horst; Hruby, Victor J.: Structural Insights into Selective Ligand–Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists. Biochemistry 56 (32), 2017, 4201-4209 mehr…
  • Fraioli, Roberta; Tsimbouri, Penelope M.; Fisher, Leanne E.; Nobbs, Angela H.; Su, Bo; Neubauer, Stefanie; Rechenmacher, Florian; Kessler, Horst; Ginebra, Maria-Pau; Dalby, Matthew J.; Manero, José M.; Mas-Moruno, Carlos: Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands. Scientific Reports 7 (1), 2017 mehr…
  • Kapp, Tobias G.; Rechenmacher, Florian; Neubauer, Stefanie; Maltsev, Oleg V.; Cavalcanti-Adam, Elisabetta A.; Zarka, Revital; Reuning, Ute; Notni, Johannes; Wester, Hans-Jürgen; Mas-Moruno, Carlos; Spatz, Joachim; Geiger, Benjamin; Kessler, Horst: A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins. Scientific Reports 7 (1), 2017 mehr…
  • Ma, Xiaopeng; Phi Van, Valerie; Kimm, Melanie A.; Prakash, Jaya; Kessler, Horst; Kosanke, Katja; Feuchtinger, Annette; Aichler, Michaela; Gupta, Aayush; Rummeny, Ernst J.; Eisenblätter, Michel; Siveke, Jens; Walch, Axel K.; Braren, Rickmer; Ntziachristos, Vasilis; Wildgruber, Moritz: Integrin-Targeted Hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography for Imaging Tumor Progression and Early Response in Non-Small Cell Lung Cancer. Neoplasia 19 (1), 2017, 8-16 mehr…
  • Missirlis, Dimitris; Haraszti, Tamás; Kessler, Horst; Spatz, Joachim P.: Fibronectin promotes directional persistence in fibroblast migration through interactions with both its cell-binding and heparin-binding domains. Scientific Reports 7 (1), 2017 mehr…
  • Nieberler, Markus; Reuning, Ute; Reichart, Florian; Notni, Johannes; Wester, Hans-Jürgen; Schwaiger, Markus; Weinmüller, Michael; Räder, Andreas; Steiger, Katja; Kessler, Horst: Exploring the Role of RGD-Recognizing Integrins in Cancer. Cancers 9 (12), 2017, 116 mehr…
  • Pallarola, Diego; Bochen, Alexander; Guglielmotti, Victoria; Oswald, Tabea A.; Kessler, Horst; Spatz, Joachim P.: Highly Ordered Gold Nanopatterned Indium Tin Oxide Electrodes for Simultaneous Optical and Electrochemical Probing Cell Interactions. Analytical Chemistry 89 (18), 2017, 10054-10062 mehr…
  • Pallarola, Diego; Platzman, Ilia; Bochen, Alexander; Cavalcanti-Adam, Elisabetta A.; Axmann, Markus; Kessler, Horst; Geiger, Benjamin; Spatz, Joachim P.: Focal adhesion stabilization by enhanced integrin-cRGD binding affinity. BioNanoMaterials 18 (1-2), 2017 mehr…
  • Weinmüller, Michael; Rechenmacher, Florian; Kiran Marelli, Udaya; Reichart, Florian; Kapp, Tobias G.; Räder, Andreas F. B.; Di Leva, Francesco Saverio; Marinelli, Luciana; Novellino, Ettore; Muñoz-Félix, José M.; Hodivala-Dilke, Kairbaan; Schumacher, Adi; Fanous, Joseph; Gilon, Chaim; Hoffman, Amnon; Kessler, Horst: Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3. Angewandte Chemie International Edition 56 (51), 2017, 16405-16409 mehr…

2016

  • Mas-Moruno, Carlos; Fraioli, Roberta; Rechenmacher, Florian; Neubauer, Stefanie; Kapp, Tobias G.; Kessler, Horst: αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating. Angewandte Chemie International Edition 55 (25), 2016, 7048-7067 mehr…
  • Missirlis, Dimitris; Haraszti, Tamás; Scheele, Catharina v. C.; Wiegand, Tina; Diaz, Carolina; Neubauer, Stefanie; Rechenmacher, Florian; Kessler, Horst; Spatz, Joachim P.: Substrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin. Scientific Reports 6 (1), 2016 mehr…
  • Notni, Johannes; Reich, Dominik; Maltsev, Oleg V.; Kapp, Tobias G.; Steiger, Katja; Hoffmann, Frauke; Esposito, Irene; Weichert, Wilko; Kessler, Horst; Wester, Hans-Jürgen: In Vivo PET Imaging of the Cancer Integrin αvβ6 Using 68 Ga-Labeled Cyclic RGD Nonapeptides. Journal of Nuclear Medicine 58 (4), 2016, 671-677 mehr…
  • Schaufler, Viktoria; Czichos-Medda, Helmi; Hirschfeld-Warnecken, Vera; Neubauer, Stefanie; Rechenmacher, Florian; Medda, Rebecca; Kessler, Horst; Geiger, Benjamin; Spatz, Joachim P.; Cavalcanti-Adam, E. Ada: Selective binding and lateral clustering of α5β1 and αvβ3 integrins: Unraveling the spatial requirements for cell spreading and focal adhesion assembly. Cell Adhesion & Migration 10 (5), 2016, 505-515 mehr…

2015

  • Cai, Minying; Marelli, Udaya Kiran; Bao, Jennifer; Beck, Johannes G.; Opperer, Florian; Rechenmacher, Florian; McLeod, Kaitlyn R.; Zingsheim, Morgan R.; Doedens, Lucas; Kessler, Horst; Hruby, Victor J.: Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors. Journal of Medicinal Chemistry 58 (16), 2015, 6359-6367 mehr…
  • D’Alessandria, Calogero; Pohle, Karolin; Rechenmacher, Florian; Neubauer, Stefanie; Notni, Johannes; Wester, Hans-Jürgen; Schwaiger, Markus; Kessler, Horst; Beer, Ambros J.: In vivo biokinetic and metabolic characterization of the 68Ga-labelled α5β1-selective peptidomimetic FR366. European Journal of Nuclear Medicine and Molecular Imaging 43 (5), 2015, 953-963 mehr…
  • Fraioli, Roberta; Rechenmacher, Florian; Neubauer, Stefanie; Manero, José M.; Gil, Javier; Kessler, Horst; Mas-Moruno, Carlos: Mimicking bone extracellular matrix: Integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium. Colloids and Surfaces B: Biointerfaces 128, 2015, 191-200 mehr…
  • Frank, Andreas O.; Freudenberger, J. Christoph; Shaytan, Alexey K.; Kessler, Horst; Luy, Burkhard: Direct prediction of residual dipolar couplings of small molecules in a stretched gel by stochastic molecular dynamics simulations. Magnetic Resonance in Chemistry 53 (3), 2015, 213-217 mehr…
  • Frohnmayer, Johannes P.; Brüggemann, Dorothea; Eberhard, Christian; Neubauer, Stefanie; Mollenhauer, Christine; Boehm, Heike; Kessler, Horst; Geiger, Benjamin; Spatz, Joachim P.: Synthetische Adhäsion von Integrin-Liposomen als minimales Zellmodell. Angewandte Chemie 127 (42), 2015, 12649-12655 mehr…
  • Frohnmayer, Johannes P.; Brüggemann, Dorothea; Eberhard, Christian; Neubauer, Stefanie; Mollenhauer, Christine; Boehm, Heike; Kessler, Horst; Geiger, Benjamin; Spatz, Joachim P.: Minimal Synthetic Cells to Study Integrin-Mediated Adhesion. Angewandte Chemie International Edition 54 (42), 2015, 12472-12478 mehr…
  • Guasch, Judith; Conings, Bert; Neubauer, Stefanie; Rechenmacher, Florian; Ende, Karen; Rolli, Claudio G.; Kappel, Christian; Schaufler, Viktoria; Micoulet, Alexandre; Kessler, Horst; Boyen, Hans-Gerd; Cavalcanti-Adam, Elisabetta Ada; Spatz, Joachim P.: Segregation Versus Colocalization: Orthogonally Functionalized Binary Micropatterned Substrates Regulate the Molecular Distribution in Focal Adhesions. Advanced Materials 27 (25), 2015, 3737-3747 mehr…
  • Herranz-Diez, C.; Li, Q.; Lamprecht, C.; Mas-Moruno, C.; Neubauer, S.; Kessler, H.; Manero, J.M.; Guillem-Martí, J.; Selhuber-Unkel, C.: Bioactive compounds immobilized on Ti and TiNbHf: AFM-based investigations of biofunctionalization efficiency and cell adhesion. Colloids and Surfaces B: Biointerfaces 136, 2015, 704-711 mehr…
  • Jung, Alain C.; Ray, Anne-Marie; Ramolu, Ludivine; Macabre, Christine; Simon, Florian; Noulet, Fanny; Blandin, Anne-Florence; Renner, Guillaume; Lehmann, Maxime; Choulier, Laurence; Kessler, Horst; Abecassis, Joseph; Dontenwill, Monique; Martin, Sophie: Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties. Oncotarget 6 (39), 2015 mehr…
  • Kapp, Tobias G.; Fottner, Maximilian; Maltsev, Oleg V.; Kessler, Horst: Small Cause, Great Impact: Modification of the Guanidine Group in the RGD Motif Controls Integrin Subtype Selectivity. Angewandte Chemie International Edition 55 (4), 2015, 1540-1543 mehr…
  • Maltsev, Oleg V.; Marelli, Udaya Kiran; Kapp, Tobias G.; Di Leva, Francesco Saverio; Di Maro, Salvatore; Nieberler, Markus; Reuning, Ute; Schwaiger, Markus; Novellino, Ettore; Marinelli, Luciana; Kessler, Horst: Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands. Angewandte Chemie International Edition 55 (4), 2015, 1535-1539 mehr…
  • Marelli, Udaya Kiran; Bezençon, Jacqueline; Puig, Eduard; Ernst, Beat; Kessler, Horst: Enantiomeric Cyclic Peptides with Different Caco-2 Permeability Suggest Carrier-Mediated Transport. Chemistry - A European Journal 21 (22), 2015, 8023-8027 mehr…
  • Marelli, Udaya Kiran; Ovadia, Oded; Frank, Andreas Oliver; Chatterjee, Jayanta; Gilon, Chaim; Hoffman, Amnon; Kessler, Horst: cis-Peptide Bonds: A Key for Intestinal Permeability of Peptides? Chemistry - A European Journal 21 (43), 2015, 15148-15152 mehr…
  • Notni, J.; Steiger, K.; Hoffmann, F.; Reich, D.; Kapp, T. G.; Rechenmacher, F.; Neubauer, S.; Kessler, H.; Wester, H.-J.: Complementary, Selective PET Imaging of Integrin Subtypes  5 1 and  v 3 Using 68Ga-Aquibeprin and 68Ga-Avebetrin. Journal of Nuclear Medicine 57 (3), 2015, 460-466 mehr…
  • Renner, G; Janouskova, H; Noulet, F; Koenig, V; Guerin, E; Bär, S; Nuesch, J; Rechenmacher, F; Neubauer, S; Kessler, H; Blandin, A-F; Choulier, L; Etienne-Selloum, N; Lehmann, M; Lelong-Rebel, I; Martin, S; Dontenwill, M: Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma. Cell Death & Differentiation 23 (4), 2015, 640-653 mehr…
  • Röhl, Alina; Wengler, Daniela; Madl, Tobias; Lagleder, Stephan; Tippel, Franziska; Herrmann, Monika; Hendrix, Jelle; Richter, Klaus; Hack, Gordon; Schmid, Andreas B.; Kessler, Horst; Lamb, Don C.; Buchner, Johannes: Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules. Nature Communications 6 (1), 2015 mehr…
  • Wester, Hans Jürgen; Keller, Ulrich; Schottelius, Margret; Beer, Ambros; Philipp-Abbrederis, Kathrin; Hoffmann, Frauke; Šimeček, Jakub; Gerngross, Carlos; Lassmann, Michael; Herrmann, Ken; Pellegata, Natalia; Rudelius, Martina; Kessler, Horst; Schwaiger, Markus: Disclosing the CXCR4 Expression in Lymphoproliferative Diseases by Targeted Molecular Imaging. Theranostics 5 (6), 2015, 618-630 mehr…

2014

  • Beer, Ambros J.; Pelisek, Jaroslav; Heider, Peter; Saraste, Antti; Reeps, Christian; Metz, Stephan; Seidl, Stefan; Kessler, Horst; Wester, Hans-Jürgen; Eckstein, Hans Henning; Schwaiger, Markus: PET/CT Imaging of Integrin αvβ3 Expression in Human Carotid Atherosclerosis. JACC: Cardiovascular Imaging 7 (2), 2014, 178-187 mehr…
  • Buchner, Johannes; Kessler, Horst: Protein Folding by Interaction. Structure 22 (7), 2014, 936-937 mehr…
  • Conibear, Anne C.; Bochen, Alexander; Rosengren, K. Johan; Stupar, Petar; Wang, Conan; Kessler, Horst; Craik, David J.: The Cyclic Cystine Ladder of Theta-Defensins as a Stable, Bifunctional Scaffold: A Proof-of-Concept Study Using the Integrin-Binding RGD Motif. ChemBioChem 15 (3), 2014, 451-459 mehr…
  • Hegemann, Julian D.; De Simone, Mariarosaria; Zimmermann, Marcel; Knappe, Thomas A.; Xie, Xiulan; Di Leva, Francesco Saverio; Marinelli, Luciana; Novellino, Ettore; Zahler, Stefan; Kessler, Horst; Marahiel, Mohamed A.: Rational Improvement of the Affinity and Selectivity of Integrin Binding of Grafted Lasso Peptides. Journal of Medicinal Chemistry 57 (13), 2014, 5829-5834 mehr…
  • Marelli, Udaya Kiran; Frank, Andreas O.; Wahl, Bernhard; La Pietra, Valeria; Novellino, Ettore; Marinelli, Luciana; Herdtweck, Eberhardt; Groll, Michael; Kessler, Horst: Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure. Chemistry - A European Journal 20 (44), 2014, 14201-14206 mehr…
  • Medda, Rebecca; Helth, Arne; Herre, Patrick; Pohl, Darius; Rellinghaus, Bernd; Perschmann, Nadine; Neubauer, Stefanie; Kessler, Horst; Oswald, Steffen; Eckert, Jürgen; Spatz, Joachim P.; Gebert, Annett; Cavalcanti-Adam, Elisabetta A.: Investigation of early cell–surface interactions of human mesenchymal stem cells on nanopatterned β-type titanium–niobium alloy surfaces. Interface Focus 4 (1), 2014, 20130046 mehr…
  • Müller, Martina A.; Brunie, Leonora; Bächer, Anne-Sophie; Kessler, Horst; Gottschalk, Kay-Eberhard; Reuning, Ute: Cytoplasmic salt bridge formation in integrin αvß3 stabilizes its inactive state affecting integrin-mediated cell biological effects. Cellular Signalling 26 (11), 2014, 2493-2503 mehr…
  • Neubauer, Stefanie; Rechenmacher, Florian; Brimioulle, Richard; Di Leva, Francesco Saverio; Bochen, Alexander; Sobahi, Tariq R.; Schottelius, Margret; Novellino, Ettore; Mas-Moruno, Carlos; Marinelli, Luciana; Kessler, Horst: Pharmacophoric Modifications Lead to Superpotent αvβ3 Integrin Ligands with Suppressed α5β1 Activity. Journal of Medicinal Chemistry 57 (8), 2014, 3410-3417 mehr…
  • Ray, Anne-Marie; Schaffner, Florence; Janouskova, Hana; Noulet, Fanny; Rognan, Didier; Lelong-Rebel, Isabelle; Choulier, Laurence; Blandin, Anne-Florence; Lehmann, Maxime; Martin, Sophie; Kapp, Tobias; Neubauer, Stefanie; Rechenmacher, Florian; Kessler, Horst; Dontenwill, Monique: Single cell tracking assay reveals an opposite effect of selective small non-peptidic α5β1 or αvβ3/β5 integrin antagonists in U87MG glioma cells. Biochimica et Biophysica Acta (BBA) - General Subjects 1840 (9), 2014, 2978-2987 mehr…
  • Rechenmacher, Florian; Steigerwald, Kristin; Laufer, Burkhardt; Neubauer, Stefanie; Kapp, Tobias G.; Li, Liang; Mas-Moruno, Carlos; Joner, Michael; Kessler, Horst: The Integrin Ligandc(RGDf(NMe)Nal) Reduces Neointimal Hyperplasia in a Polymer-Free Drug-Eluting Stent System. ChemMedChem 9 (7), 2014, 1413-1418 mehr…
  • Šimeček, Jakub; Notni, Johannes; Kapp, Tobias G.; Kessler, Horst; Wester, Hans-Jürgen: Benefits of NOPO As Chelator in Gallium-68 Peptides, Exemplified by Preclinical Characterization of 68Ga-NOPO–c(RGDfK). Molecular Pharmaceutics 11 (5), 2014, 1687-1695 mehr…

2013

  • Bochen, Alexander; Marelli, Udaya Kiran; Otto, Elke; Pallarola, Diego; Mas-Moruno, Carlos; Di Leva, Francesco Saverio; Boehm, Heike; Spatz, Joachim P.; Novellino, Ettore; Kessler, Horst; Marinelli, Luciana: Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids. Journal of Medicinal Chemistry 56 (4), 2013, 1509-1519 mehr…
  • Evellin, Sandrine; Galvagni, Federico; Zippo, Alessio; Neri, Francesco; Orlandini, Maurizio; Incarnato, Danny; Dettori, Daniela; Neubauer, Stefanie; Kessler, Horst; Wagner, Erwin F.; Oliviero, Salvatore: FOSL1 Controls the Assembly of Endothelial Cells into Capillary Tubes by Direct Repression of αv and β3 Integrin Transcription. Molecular and Cellular Biology 33 (6), 2013, 1198-1209 mehr…
  • Kapp, Tobias G; Rechenmacher, Florian; Sobahi, Tariq R; Kessler, Horst: Integrin modulators: a patent review. Expert Opinion on Therapeutic Patents 23 (10), 2013, 1273-1295 mehr…
  • Laitinen, Iina; Notni, Johannes; Pohle, Karolin; Rudelius, Martina; Farrell, Eliane; Nekolla, Stephan G; Henriksen, Gjermund; Neubauer, Stefanie; Kessler, Horst; Wester, Hans-Jürgen; Schwaiger, Markus: Comparison of cyclic RGD peptides for αvβ3 integrin detection in a rat model of myocardial infarction. EJNMMI Research 3 (1), 2013, 38 mehr…
  • Marelli, Udaya Kiran; Rechenmacher, Florian; Sobahi, Tariq Rashad Ali; Mas-Moruno, Carlos; Kessler, Horst: Tumor Targeting via Integrin Ligands. Frontiers in Oncology 3, 2013 mehr…
  • Müller, Martina A.; Opfer, Jan; Brunie, Leonora; Volkhardt, Lilli A.; Sinner, Eva-Kathrin; Boettiger, David; Bochen, Alexander; Kessler, Horst; Gottschalk, Kay-Eberhard; Reuning, Ute: The Glycophorin A Transmembrane Sequence within Integrin αvβ3 Creates a Non-Signaling Integrin with Low Basal Affinity That Is Strongly Adhesive under Force. Journal of Molecular Biology 425 (16), 2013, 2988-3006 mehr…
  • Neubauer, Stefanie; Rechenmacher, Florian; Beer, Ambros J.; Curnis, Flavio; Pohle, Karolin; D'Alessandria, Calogero; Wester, Hans-Jürgen; Reuning, Ute; Corti, Angelo; Schwaiger, Markus; Kessler, Horst: Selective Imaging of the Angiogenic Relevant Integrins α5β1 and αvβ3. Angewandte Chemie International Edition 52 (44), 2013, 11656-11659 mehr…
  • Pallarola, Diego; Bochen, Alexander; Boehm, Heike; Rechenmacher, Florian; Sobahi, Tariq R.; Spatz, Joachim P.; Kessler, Horst: Interface Immobilization Chemistry ofcRGD-based Peptides Regulates Integrin Mediated Cell Adhesion. Advanced Functional Materials 24 (7), 2013, 943-956 mehr…
  • Rahmouni, Sabri; Lindner, Aaron; Rechenmacher, Florian; Neubauer, Stefanie; Sobahi, Tariq Rashad Ali; Kessler, Horst; Cavalcanti-Adam, Elisabetta Ada; Spatz, Joachim Pius: Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through αvβ3- or α5β1-Integrins. Advanced Materials 25 (41), 2013, 5869-5874 mehr…
  • Rechenmacher, Florian; Neubauer, Stefanie; Mas-Moruno, Carlos; Dorfner, Petra M.; Polleux, Julien; Guasch, Judith; Conings, Bert; Boyen, Hans-Gerd; Bochen, Alexander; Sobahi, Tariq R.; Burgkart, Rainer; Spatz, Joachim P.; Fässler, Reinhard; Kessler, Horst: A Molecular Toolkit for the Functionalization of Titanium-Based Biomaterials That Selectively Control Integrin-Mediated Cell Adhesion. Chemistry - A European Journal 19 (28), 2013, 9218-9223 mehr…
  • Retzlaff, Marco; Rohrberg, Julia; Küpper, Natascha Jennifer; Lagleder, Stephan; Bepperling, Alexander; Manzenrieder, Florian; Peschek, Jirka; Kessler, Horst; Buchner, Johannes: The Regulatory Domain Stabilizes the p53 Tetramer by Intersubunit Contacts with the DNA Binding Domain. Journal of Molecular Biology 425 (1), 2013, 144-155 mehr…
  • Šimeček, Jakub; Hermann, Petr; Havlíčková, Jana; Herdtweck, Eberhardt; Kapp, Tobias G.; Engelbogen, Nils; Kessler, Horst; Wester, Hans-Jürgen; Notni, Johannes: A Cyclen-Based Tetraphosphinate Chelator for the Preparation of Radiolabeled Tetrameric Bioconjugates. Chemistry - A European Journal 19 (24), 2013, 7748-7757 mehr…

2012

  • Chatterjee, Jayanta; Rechenmacher, Florian; Kessler, Horst: N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions. Angewandte Chemie International Edition 52 (1), 2012, 254-269 mehr…
  • Mas-Moruno, Carlos; Dorfner, Petra M.; Manzenrieder, Florian; Neubauer, Stefanie; Reuning, Ute; Burgkart, Rainer; Kessler, Horst: Behavior of primary human osteoblasts on trimmed and sandblasted Ti6Al4V surfaces functionalized with integrin αvβ3-selective cyclic RGD peptides. Journal of Biomedical Materials Research Part A 101A (1), 2012, 87-97 mehr…
  • Rechenmacher, Florian; Neubauer, Stefanie; Polleux, Julien; Mas-Moruno, Carlos; De Simone, Mariarosaria; Cavalcanti-Adam, Elisabetta Ada; Spatz, Joachim P.; Fässler, Reinhard; Kessler, Horst: Functionalizing αvβ3- or α5β1-Selective Integrin Antagonists for Surface Coating: A Method To Discriminate Integrin Subtypes In Vitro. Angewandte Chemie International Edition 52 (5), 2012, 1572-1575 mehr…
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