The Focus Group Fungal Sensing and Signaling of the Environment involves Hans Fischer Senior Fellow Prof. Gustavo Goldman (University of São Paulo) and host Prof. J. Philipp Benz.
The production of biofuels from plant biomass has gained interest in recent years as an environmental friendly alternative to petroleum-based energy sources. Filamentous fungi, which naturally thrive on decaying plant matter, are of particular interest for this process due to their ability to secrete enzymes required for the deconstruction of lignocellulosic material. A major drawback in fungal hydrolytic enzyme production is the natural repression of the corresponding genes in the presence of easily metabolizable carbon sources such as glucose, a process known as carbon catabolite repression (CCR) which is to a large extend mediated by the transcriptional regulator protein CreA. This is a disadvantage for second-generation (2G) biofuel production that aims to convert non-glucose saccharides from lignocellulosic plant biomass (e.g. xylose, arabinose, and cello- and xylooligosaccharides) to biofuels.
Within the scientific aims of this project, this study will unravel novel mechanistic details underlying CreA-mediated CCR and provide a solid basis for studying additional factors involved in carbon source utilization, which could prove useful for many biotechnological applications utilizing fungi.
Sarikaya Bayram, Özlem; Bayram, Özgür; Karahoda, Betim; Meister, Cindy; Köhler, Anna M.; Thieme, Sabine; Elramli, Nadia; Frawley, Dean; McGowan, Jamie; Fitzpatrick, David A.; Schmitt, Kerstin; de Assis, Leandro Jose; Valerius, Oliver; Goldman, Gustavo H.; Braus, Gerhard H.: F-box receptor mediated control of substrate stability and subcellular location organizes cellular development of Aspergillus nidulans. PLOS Genetics 18 (12), 2022, e1010502 mehr…
2021
Gabriel, Raphael; Thieme, Nils; Liu, Qian; Li, Fangya; Meyer, Lisa T.; Harth, Simon; Jecmenica, Marina; Ramamurthy, Maya; Gorman, Jennifer; Simmons, Blake A.; McCluskey, Kevin; Baker, Scott E.; Tian, Chaoguang; Schuerg, Timo; Singer, Steven W.; Fleißner, André; Benz, J. Philipp: The F-box protein gene <i>exo</i> - <i>1</i> is a target for reverse engineering enzyme hypersecretion in filamentous fungi. Proceedings of the National Academy of Sciences 118 (26), 2021 mehr…
Gabriel, Raphael; Thieme, Nils; Liu, Qian; Li, Fangya; Meyer, Lisa T.; Harth, Simon; Jecmenica, Marina; Ramamurthy, Maya; Gorman, Jennifer; Simmons, Blake A.; McCluskey, Kevin; Baker, Scott E.; Tian, Chaoguang; Schuerg, Timo; Singer, Steven W.; Fleißner, André; Benz, J. Philipp: The F-box protein gene exo-1 is a target for reverse engineering enzyme hypersecretion in filamentous fungi. Proceedings of the National Academy of Sciences 118 (26), 2021, e2025689118 mehr…
de Assis, Leandro José; Silva, Lilian Pereira; Bayram, Ozgur; Dowling, Paul; Kniemeyer, Olaf; Krüger, Thomas; Brakhage, Axel A.; Chen, Yingying; Dong, Liguo; Tan, Kaeling; Wong, Koon Ho; Ries, Laure N. A.; Goldman, Gustavo H.: Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA. mBio 12 (1), 2021 mehr…
2020
Mattos, Eliciane Cevolani; Silva, Lilian Pereira; Valero, Clara; de Castro, Patrícia Alves; dos Reis, Thaila Fernanda; Ribeiro, Liliane F. C.; Marten, Mark R.; Silva-Rocha, Rafael; Westmann, Cauã; da Silva, Carlos Henrique Tomich de Paula; Taft, Carlton Anthony; Al-Furaiji, Narjes; Bromley, Michael; Mortensen, Uffe H.; Benz, J. Philipp; Brown, Neil Andrew; Goldman, Gustavo H.: The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance. mBio 11 (1), 2020 mehr…
de Assis, Leandro José; Silva, Lilian Pereira; Liu, Li; Schmitt, Kerstin; Valerius, Oliver; Braus, Gerhard H.; Ries, Laure Nicolas Annick; Goldman, Gustavo Henrique: The High Osmolarity Glycerol Mitogen-Activated Protein Kinase regulates glucose catabolite repression in filamentous fungi. PLOS Genetics 16 (8), 2020, e1008996 mehr…
2019
Horta, Maria Augusta C.; Thieme, Nils; Gao, Yuqian; Burnum-Johnson, Kristin E.; Nicora, Carrie D.; Gritsenko, Marina A.; Lipton, Mary S.; Mohanraj, Karthikeyan; de Assis, Leandro José; Lin, Liangcai; Tian, Chaoguang; Braus, Gerhard H.; Borkovich, Katherine A.; Schmoll, Monika; Larrondo, Luis F.; Samal, Areejit; Goldman, Gustavo H.; Benz, J. Philipp: Broad Substrate-Specific Phosphorylation Events Are Associated With the Initial Stage of Plant Cell Wall Recognition in Neurospora crassa. Frontiers in Microbiology 10, 2019 mehr…
