Medicinal and Bioinorganic Chemistry

TUM-IAS Hans Fischer Senior Fellow Prof. Angela Casini (Cardiff University) worked in this Focus Group with her host Prof. Fritz E. Kühn (Molecular Catalysis, TUM)

TUM-IAS funded doctoral candidate:
Jens Oberkofler, Molecular Catalysis

Publications by the Focus Group

2019

  • Pöthig, Alexander; Casini, Angela: Recent Developments of Supramolecular Metal-based Structures for Applications in Cancer Therapy and Imaging. Theranostics 9 (11), 2019, 3150-3169 mehr…

2018

  • Casini, Angela; Bonsignore, Riccardo; Oberkofler, Jens: Organometallic Gold-Based Anticancer Therapeutics. In: Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier, 2018 mehr…
  • Han, Jiaying; Räder, Andreas F. B.; Reichart, Florian; Aikman, Brech; Wenzel, Margot N.; Woods, Ben; Weinmüller, Michael; Ludwig, Beatrice S.; Stürup, Stefan; Groothuis, Geny M. M.; Permentier, Hjalmar P.; Bischoff, Rainer; Kessler, Horst; Horvatovich, Peter; Casini, Angela: Bioconjugation of Supramolecular Metallacages to Integrin Ligands for Targeted Delivery of Cisplatin. Bioconjugate Chemistry 29 (11), 2018, 3856-3865 mehr…
  • Jurgens, Sophie; Kuhn, Fritz E.; Casini, Angela: Cyclometalated Complexes of Platinum and Gold with Biological Properties: State-of-the-Art and Future Perspectives. Current Medicinal Chemistry 25 (4), 2018, 437-461 mehr…
  • Wragg, Darren; de Almeida, Andreia; Bonsignore, Riccardo; Kühn, Fritz E.; Leoni, Stefano; Casini, Angela: On the Mechanism of Gold/NHC Compounds Binding to DNA G-Quadruplexes: Combined Metadynamics and Biophysical Methods. Angewandte Chemie International Edition 57 (44), 2018, 14524-14528 mehr…

2017

  • Casini, Angela; Woods, Benjamin; Wenzel, Margot: The Promise of Self-Assembled 3D Supramolecular Coordination Complexes for Biomedical Applications. Inorganic Chemistry 56 (24), 2017, 14715-14729 mehr…
  • Han, J.; Schmidt, A.; Zhang, T.; Permentier, H.; Groothuis, G. M. M.; Bischoff, R.; Kühn, F. E.; Horvatovich, P.; Casini, A.: Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications. Chemical Communications 53 (8), 2017, 1405-1408 mehr…
  • Jürgens, Sophie; Casini, Angela: Mechanistic Insights into Gold Organometallic Compounds and their Biomedical Applications. CHIMIA International Journal for Chemistry 71 (3), 2017, 92-101 mehr…
  • Jürgens, Sophie; Scalcon, Valeria; Estrada-Ortiz, Natalia; Folda, Alessandra; Tonolo, Federica; Jandl, Christian; Browne, Duncan L.; Rigobello, Maria Pia; Kühn, Fritz E.; Casini, Angela: Exploring the C^N^C theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes. Bioorganic & Medicinal Chemistry 25 (20), 2017, 5452-5460 mehr…
  • Karaca, Özden; Meier-Menches, Samuel M.; Casini, Angela; Kühn, Fritz E.: On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging. Chemical Communications 53 (59), 2017, 8249-8260 mehr…
  • Karaca, Özden; Scalcon, Valeria; Meier-Menches, Samuel M.; Bonsignore, Riccardo; Brouwer, Jurriaan M. J. L.; Tonolo, Federica; Folda, Alessandra; Rigobello, Maria Pia; Kühn, Fritz E.; Casini, Angela: Characterization of Hydrophilic Gold(I) N-Heterocyclic Carbene (NHC) Complexes as Potent TrxR Inhibitors Using Biochemical and Mass Spectrometric Approaches. Inorganic Chemistry 56 (22), 2017, 14237-14250 mehr…
  • Rieb, Julia; Dominelli, Bruno; Mayer, David; Jandl, Christian; Drechsel, Jonas; Heydenreuter, Wolfgang; Sieber, Stephan A.; Kühn, Fritz E.: Influence of wing-tip substituents and reaction conditions on the structure, properties and cytotoxicity of Ag(i)– and Au(i)–bis(NHC) complexes. Dalton Transactions 46 (8), 2017, 2722-2735 mehr…
  • Wenzel, Margot; Casini, Angela: Mass spectrometry as a powerful tool to study therapeutic metallodrugs speciation mechanisms: Current frontiers and perspectives. Coordination Chemistry Reviews 352, 2017, 432-460 mehr…

2016

  • Hahn, Eva M.; Estrada-Ortiz, Natalia; Han, Jiaying; Ferreira, Vera F. C.; Kapp, Tobias G.; Correia, João D. G.; Casini, Angela; Kühn, Fritz E.: Functionalization of Ruthenium(II) Terpyridine Complexes with Cyclic RGD Peptides To Target Integrin Receptors in Cancer Cells. European Journal of Inorganic Chemistry 2017 (12), 2016, 1667-1672 mehr…
  • Kühn, Fritz E.; Schmidt, Andrea: Metallkomplexe als Antikrebsmittel. Chemie in unserer Zeit 51 (2), 2016, 86-95 mehr…