Jane A. McKeating

Short CV

Jane A. McKeating received a BSc in Biological Sciences from the University of Warwick in 1982 and a PhD in Virology from the Royal Free Hospital School of Medicine at University College London in 1987. From 1987- 1992, she was a research fellow at the Institute of Cancer Research in London. From 1994-1999, she was a Research Fellow of the Lister Institute of Preventive Medicine as well as an lecturer/reader in Virology at the University of Reading. After working as as a Section Head of Anti-Virals at Pfizer Research Central Research, UK, from 1999-2000, Jane A. McKeating moved to Rockefeller University as an associate professor. From 2005 - 2017, she was a professor of Molecular Virology at the University of Birmingham, a professor of Molecular Virology at the University of Birmingham,where she was the director of the Centre of Human Virology since 2012 and the Deputy Head of the School of Immunity and Infection since 2013. In 2017, Jane A. McKeating transferred to the University of Oxford.

Selected Awards

• 2015, Founders Award for academic excellence – University of Birmingham
• 2010, Oxford University Distinguished Virology Lecture
• 2006, Royal Society Wolfson Merit Award
• 1995, Fleming Award, Society of General Microbiology
• 1994, Research Fellowship of the Lister Institute of Preventive Medicine
• 1990, Medical Research Council Senior AIDS Research Fellowship
• 1988, Herpes Vaccine Research Trust Prize, Society of General Microbiology

Research Interests

Jane A. McKeating’s research focuses on understanding early infection events that define the cellular and tissue tropism of clinically important human viruses to understand viral-associated pathology and to design improved vaccines and anti-viral therapies.

Selected Publications

• Fletcher, Nicola F.; Wilson, Garrick K.; Murray, Jacinta; Hu, Ke; Lewis, Andrew; Reynolds, Gary M.; Stamataki, Zania; Meredith, Luke W.; Rowe, Ian A.; Luo, Guangxiang; Lopez–Ramirez, Miguel A.; Baumert, Thomas F.; Weksler, Babette; Couraud, Pierre–Olivier; Kim, Kwang Sik; Romero, Ignacio A.; Jopling, Catherine; Morgello, Susan; Balfe, Peter; McKeating, Jane A.: Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier. Gastroenterology 142 (3), 2012, 634-643.e6.

• Lupberger, Joachim; Zeisel, Mirjam B; Xiao, Fei; Thumann, Christine; Fofana, Isabel; Zona, Laetitia; Davis, Christopher; Mee, Christopher J; Turek, Marine; Gorke, Sebastian; Royer, Cathy; Fischer, Benoit; Zahid, Muhammad N; Lavillette, Dimitri; Fresquet, Judith; Cosset, François-Loïc; Rothenberg, S Michael; Pietschmann, Thomas; Patel, Arvind H; Pessaux, Patrick; Doffoël, Michel; Raffelsberger, Wolfgang; Poch, Olivier; McKeating, Jane A; Brino, Laurent; Baumert, Thomas F: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nature Medicine 17 (5), 2011, 589-595.

• Harris, Helen J.; Davis, Christopher; Mullins, Jonathan G. L.; Hu, Ke; Goodall, Margaret; Farquhar, Michelle J.; Mee, Christopher J.; McCaffrey, Kitty; Young, Stephen; Drummer, Heidi; Balfe, Peter; McKeating, Jane A.: Claudin Association with CD81 Defines Hepatitis C Virus Entry. Journal of Biological Chemistry 285 (27), 2010, 21092-21102.

• Timpe, Jennifer M.; Stamataki, Zania; Jennings, Adam; Hu, Ke; Farquhar, Michelle J.; Harris, Helen J.; Schwarz, Anne; Desombere, Isabelle; Roels, Geert Leroux; Balfe, Peter; McKeating, Jane A.: Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies. Hepatology 47 (1), 2007, 17-24.

• Evans, Matthew J.; von Hahn, Thomas; Tscherne, Donna M.; Syder, Andrew J.; Panis, Maryline; Wölk, Benno; Hatziioannou, Theodora; McKeating, Jane A.; Bieniasz, Paul D.; Rice, Charles M.: Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature 446 (7137), 2007, 801-805.

• von Hahn, Thomas; Yoon, Joo Chun; Alter, Harvey; Rice, Charles M.; Rehermann, Barbara; Balfe, Peter; McKeating, Jane A.: Hepatitis C Virus Continuously Escapes From Neutralizing Antibody and T-Cell Responses During Chronic Infection In Vivo. Gastroenterology 132 (2), 2007, 667-678.

• Lindenbach, B. D.: Complete Replication of Hepatitis C Virus in Cell Culture. Science 309 (5734), 2005, 623-626.

• Logvinoff, C.; Major, M. E.; Oldach, D.; Heyward, S.; Talal, A.; Balfe, P.; Feinstone, S. M.; Alter, H.; Rice, C. M.; McKeating, J. A.: Neutralizing antibody response during acute and chronic hepatitis C virus infection. Proceedings of the National Academy of Sciences 101 (27), 2004, 10149-10154.

• Hsu, M.; Zhang, J.; Flint, M.; Logvinoff, C.; Cheng-Mayer, C.; Rice, C. M.; McKeating, J. A.: Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Proceedings of the National Academy of Sciences 100 (12), 2003, 7271-7276.

• Blight, K. J.; McKeating, J. A.; Rice, C. M.: Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication. Journal of Virology 76, 2002, 13001-13014.

• Moore, J.; McKeating, J.; Weiss, R.; Sattentau, Q.: Dissociation of gp120 from HIV-1 virions induced by soluble CD4. Science 250 (4984), 1990, 1139-1142.

• McKeating, Jane A.; Griffiths, Paul D.; Weiss, Robin A.: HIV susceptibility conferred to human fibroblasts by cytomegalovirus-induced Fc receptor. Nature 343 (6259), 1990, 659-661.