2019
- Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nature Neuroscience 22 (2), 2019, 191-204 more…
2018
- Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds. Physiological Reviews 98 (4), 2018, 2025-2061 more…
- BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines. Frontiers in Aging Neuroscience 10, 2018 more…
- The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation. The FASEB Journal 32 (7), 2018, 3560-3573 more…
- Prion Replication in the Mammalian Cytosol: Functional Regions within a Prion Domain Driving Induction, Propagation, and Inheritance. Molecular and Cellular Biology 38 (15), 2018 more…
- Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling. Angiogenesis 21 (2), 2018, 335-347 more…
- ADAM10 controls the differentiation of the coronary arterial endothelium. Angiogenesis 22 (2), 2018, 237-250 more…
- Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-a pathway. Blood 132 (10), 2018, 1064-1074 more…
- Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome. Molecular & Cellular Proteomics 17 (8), 2018, 1487-1501 more…
- Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments. The EMBO Journal 37 (15), 2018, e99456 more…
- Shedding of BAFF/APRIL Receptors Controls B Cells. Trends in Immunology 39 (9), 2018, 673-676 more…
- iRhom2 promotes lupus nephritis through TNF-a and EGFR signaling. Journal of Clinical Investigation 128 (4), 2018, 1397-1412 more…
- Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor. Scientific Reports 8 (1), 2018 more…
- A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity. Science Translational Medicine 10 (454), 2018, eaap9527 more…
- BACE2 distribution in major brain cell types and identification of novel substrates. Life Science Alliance 1 (1), 2018, e201800026 more…
- CADASIL brain vessels show a HTRA1 loss-of-function profile. Acta Neuropathologica 136 (1), 2018, 111-125 more…
2017
- Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis. Journal of Cell Science 130 (5), 2017, 868-878 more…
- Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays. Biochemical Journal 474 (9), 2017, 1467-1479 more…
- An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. EMBO Molecular Medicine 9 (10), 2017, 1356-1365 more…
- Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a “TRAP” to increase levels of TIMP-3 in the tissue. Matrix Biology 59, 2017, 69-79 more…
- The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands. Journal of Cellular Physiology 233 (3), 2017, 2247-2256 more…
2016
- ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds. Circulation Research 119 (4), 2016, 519-531 more…
- Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding. Proceedings of the National Academy of Sciences 113 (26), 2016, E3629-E3638 more…
- Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. eLife 5, 2016 more…
- Proteomic Substrate Identification for Membrane Proteases in the Brain. Frontiers in Molecular Neuroscience 9, 2016 more…
- iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice. European Journal of Immunology 46 (12), 2016, 2737-2748 more…
2015
- MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease. Cellular and Molecular Life Sciences 73 (1), 2015, 217-236 more…
- Blood-Induced Arthropathy in Hemophilia: Mechanisms and Heterogeneity. Seminars in Thrombosis and Hemostasis 41 (08), 2015, 832-837 more…
- iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling. Proceedings of the National Academy of Sciences 112 (19), 2015, 6080-6085 more…
- iRhoms in the brain - a new frontier? Cell Cycle 14 (19), 2015, 3003-3004 more…
- Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17. Science Signaling 8 (401), 2015, ra109-ra109 more…
- The Cytoplasmic Domain of A Disintegrin and Metalloproteinase 10 (ADAM10) Regulates Its Constitutive Activity but Is Dispensable for Stimulated ADAM10-dependent Shedding. Journal of Biological Chemistry 290 (12), 2015, 7416-7425 more…
- Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism. Arthritis Research & Therapy 17 (1), 2015 more…
- The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain. Progress in Neurobiology 135, 2015, 1-20 more…
- Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells. The Journal of Cell Biology 211 (3), 2015, 553-567 more…
- The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site. Journal of Biological Chemistry 290 (19), 2015, 12135-12146 more…