Viral Hepatitis

Chronic infection of the liver is a major global health problem, with an estimated 400 million individuals infected with hepatitis B, C or Delta viruses (HBV, HCV, HDV) at risk of progressive liver disease, liver cirrhosis and hepatocellular carcinoma. Viral hepatitis is the major cause of hepatocellular carcinoma for which we have very limited therapeutic options rendering it the 2nd most frequent cause of cancer-related death. This is highlighting the need to increase our understanding of host pathways playing a role in virus control and in viral-associated carcinogenesis.

Hepatitis B is one of the world’s unconquered diseases, with approximately 4% of the world’s population suffering with chronic HBV infection (WHO March 2015). While a prophylactic vaccine exists, current antivirals control HBV but only eliminate the virus in 15% of treated subjects. In contrast, the recently available anti-viral agents for HCV can eliminate the virus in up to 90% of patients, but a vaccine is missing. For Delta virus, no specific treatment exists at all. Thus, new treatments are urgently needed. The high treatment costs for hepatitis C along with the risk for re-infection, highlight the need for continued research to develop new drugs and a hepatitis C vaccine. Our goal is to gain an improved understanding of the molecular pathways allowing virus persistence and involved in disease pathogenesis, and translate this molecular understanding into novel therapies.

In this Focus Group, Hans Fischer Senior Fellow Prof. Jane A. McKeating (University of Birmingham) collaborated with her TUM host Prof. Ulrike Protzer (Virology, TUM) as well as with Dr. Sabrina Schreiner and Prof. em. Michael Roggendorf, also from the Virology group at TUM.

TUM-IAS funded doctoral candidate:
Lisa Wolff, Virology

Publications by the Focus Group

2017

  • Appelman, Monique D.; Chakraborty, Anindita; Protzer, Ulrike; McKeating, Jane A.; van de Graaf, Stan F. J.: N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection. PLOS ONE 12 (1), 2017, e0170419 more…
  • Appelman, Monique D.; Chakraborty, Anindita; Protzer, Ulrike; McKeating, Jane A.; van de Graaf, Stan F. J.: N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection. PLOS ONE 12 (1), 2017, e0170419 more…
  • Burwitz, Benjamin J.; Wettengel, Jochen M.; Mück-Häusl, Martin A.; Ringelhan, Marc; Ko, Chunkyu; Festag, Marvin M.; Hammond, Katherine B.; Northrup, Mina; Bimber, Benjamin N.; Jacob, Thomas; Reed, Jason S.; Norris, Reed; Park, Byung; Moller-Tank, Sven; Esser, Knud; Greene, Justin M.; Wu, Helen L.; Abdulhaqq, Shaheed; Webb, Gabriela; Sutton, William F.; Klug, Alex; Swanson, Tonya; Legasse, Alfred W.; Vu, Tania Q.; Asokan, Aravind; Haigwood, Nancy L.; Protzer, Ulrike; Sacha, Jonah B.: Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques. Nature Communications 8 (1), 2017 more…
  • Farquhar, Michelle J.; Humphreys, Isla S.; Rudge, Simon A.; Wilson, Garrick K.; Bhattacharya, Bishnupriya; Ciaccia, Maria; Hu, Ke; Zhang, Qifeng; Mailly, Laurent; Reynolds, Gary M.; Ashcroft, Margaret; Balfe, Peter; Baumert, Thomas F.; Roessler, Stephanie; Wakelam, Michael J.O.; McKeating, Jane A.: Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication. Journal of Hepatology 66 (5), 2017, 919-929 more…
  • Fletcher, N. F; Clark, A. R; Balfe, P; McKeating, J. A: TNF superfamily members promote hepatitis C virus entry via an NF-kB and myosin light chain kinase dependent pathway. Journal of General Virology 98 (3), 2017, 405-412 more…
  • Golsaz-Shirazi, Forough; Amiri, Mohammad Mehdi; Farid, Samira; Bahadori, Motahareh; Bohne, Felix; Altstetter, Sebastian; Wolff, Lisa; Kazemi, Tohid; Khoshnoodi, Jalal; Hojjat-Farsangi, Mohammad; Chudy, Michael; Jeddi-Tehrani, Mahmood; Protzer, Ulrike; Shokri, Fazel: Construction of a hepatitis B virus neutralizing chimeric monoclonal antibody recognizing escape mutants of the viral surface antigen (HBsAg). Antiviral Research 144, 2017, 153-163 more…
  • Gonçalves-Carneiro, Daniel; McKeating, Jane A.; Bailey, Dalan: The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis. Journal of Virology 91 (7), 2017 more…
  • Hedegaard, Ditte L.; Tully, Damien C.; Rowe, Ian A.; Reynolds, Gary M.; Bean, David J.; Hu, Ke; Davis, Christopher; Wilhelm, Annika; Ogilvie, Colin B.; Power, Karen A.; Tarr, Alexander W.; Kelly, Deirdre; Allen, Todd M.; Balfe, Peter; McKeating, Jane A.: High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end-stage liver disease. Journal of Hepatology 66 (1), 2017, 28-38 more…
  • Hösel, Marianna; Quasdorff, Maria; Ringelhan, Marc; Kashkar, Hamid; Debey-Pascher, Svenja; Sprinzl, Martin F.; Bockmann, Jan-Hendrik; Arzberger, Silke; Webb, Dennis; von Olshausen, Gesa; Weber, Achim; Schultze, Joachim L.; Büning, Hildegard; Heikenwalder, Mathias; Protzer, Ulrike: Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication. Cellular and Molecular Gastroenterology and Hepatology 4 (3), 2017, 339-363 more…
  • Ringehan, Marc; McKeating, Jane A.; Protzer, Ulrike: Viral hepatitis and liver cancer. Philosophical Transactions of the Royal Society B: Biological Sciences 372 (1732), 2017, 20160274 more…
  • Xia, Yuchen; Carpentier, Arnaud; Cheng, Xiaoming; Block, Peter Daniel; Zhao, Yao; Zhang, Zhensheng; Protzer, Ulrike; Liang, T. Jake: Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions. Journal of Hepatology 66 (3), 2017, 494-503 more…
  • Xia, Yuchen; Carpentier, Arnaud; Cheng, Xiaoming; Block, Peter Daniel; Zhao, Yao; Zhang, Zhensheng; Protzer, Ulrike; Liang, T. Jake: Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions. Journal of Hepatology 66 (3), 2017, 494-503 more…
  • Xia, Yuchen; Cheng, Xiaoming; Blossey, Christoph K.; Wisskirchen, Karin; Esser, Knud; Protzer, Ulrike: Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro. Journal of Immunology Research 2017, 2017, 1-12 more…
  • Zhuang, Xiaodong; Rambhatla, Srinivasa Bhargav; Lai, Alvina G.; McKeating, Jane A.: Interplay between circadian clock and viral infection. Journal of Molecular Medicine 95 (12), 2017, 1283-1289 more…

2016

  • Backes, Simone; Jäger, Clemens; Dembek, Claudia J.; Kosinska, Anna D.; Bauer, Tanja; Stephan, Ann-Sophie; Dišlers, Andris; Mutwiri, George; Busch, Dirk H.; Babiuk, Lorne A.; Gasteiger, Georg; Protzer, Ulrike: Protein-prime/modified vaccinia virus Ankara vector-boost vaccination overcomes tolerance in high-antigenemic HBV-transgenic mice. Vaccine 34 (7), 2016, 923-932 more…
  • Desombere, Isabelle; Fafi-Kremer, Samira; Van Houtte, Freya; Pessaux, Patrick; Farhoudi, Ali; Heydmann, Laura; Verhoye, Lieven; Cole, Sarah; McKeating, Jane A.; Leroux-Roels, Geert; Baumert, Thomas F.; Patel, Arvind H.; Meuleman, Philip: Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge. Hepatology 63 (4), 2016, 1120-1134 more…
  • Körber, Nina; Behrends, Uta; Hapfelmeier, Alexander; Protzer, Ulrike; Bauer, Tanja: Validation of an IFNγ/IL2 FluoroSpot assay for clinical trial monitoring. Journal of Translational Medicine 14 (1), 2016 more…
  • Lehmann, J.; Vomacka, J.; Esser, K.; Nodwell, M.; Kolbe, K.; Rämer, P.; Protzer, U.; Reiling, N.; Sieber, S. A.: Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases. MedChemComm 7 (9), 2016, 1797-1801 more…
  • Lucifora, Julie; Protzer, Ulrike: Attacking hepatitis B virus cccDNA – The holy grail to hepatitis B cure. Journal of Hepatology 64 (1), 2016, S41-S48 more…
  • Mayorga, Orlando; Bühler, Silja; Jaeger, Veronika K.; Bally, Seraina; Hatz, Christoph; Frösner, Gert; Protzer, Ulrike; Van Damme, Pierre; Egger, Matthias; Herzog, Christian: Single-Dose Hepatitis A Immunization: 7.5-Year Observational Pilot Study in Nicaraguan Children to Assess Protective Effectiveness and Humoral Immune Memory Response. Journal of Infectious Diseases 214 (10), 2016, 1498-1506 more…
  • Meredith, L. W.; Baumert, T. F.; Balfe, P.; Hu, K.; Protzer, U.; van de Graaf, K. F.; Cheng, X.; McKeating, J. A.; Howard, C. R.: Lentiviral hepatitis B pseudotype entry requires sodium taurocholate co-transporting polypeptide and additional hepatocyte-specific factors. Journal of General Virology 97 (1), 2016, 121-127 more…
  • Meredith, L. W.; Baumert, T. F.; Balfe, P.; Hu, K.; Protzer, U.; van de Graaf, K. F.; Cheng, X.; McKeating, J. A.; Howard, C. R.: Lentiviral hepatitis B pseudotype entry requires sodium taurocholate co-transporting polypeptide and additional hepatocyte-specific factors. Journal of General Virology 97 (1), 2016, 121-127 more…
  • Michler, Thomas; Große, Stefanie; Mockenhaupt, Stefan; Röder, Natalie; Stückler, Ferdinand; Knapp, Bettina; Ko, Chunkyu; Heikenwalder, Mathias; Protzer, Ulrike; Grimm, Dirk: Blocking sense‐strand activity improves potency, safety and specificity of anti‐hepatitis B virus short hairpin RNA. EMBO Molecular Medicine 8 (9), 2016, 1082-1098 more…
  • Protzer, Ulrike; Knolle, Percy: “To Be or Not to Be”: Immune Tolerance in Chronic Hepatitis B. Gastroenterology 151 (5), 2016, 805-806 more…
  • Rowe, Ian A.; Tully, Damien C.; Armstrong, Matthew J.; Parker, Richard; Guo, Kathy; Barton, Darren; Morse, Gene D.; Venuto, Charles S.; Ogilvie, Colin B.; Hedegaard, Ditte L.; McKelvy, Jeffrey F.; Wong-Staal, Flossie; Allen, Todd M.; Balfe, Peter; McKeating, Jane A.; Mutimer, David J.: Effect of scavenger receptor class B type I antagonist ITX5061 in patients with hepatitis C virus infection undergoing liver transplantation. Liver Transplantation 22 (3), 2016, 287-297 more…
  • Saugel, Bernd; Jakobus, Julia; Huber, Wolfgang; Hoffmann, Dieter; Holzapfel, Konstantin; Protzer, Ulrike; Schmid, Roland M.; Umgelter, Andreas: Herpes simplex virus in bronchoalveolar lavage fluid of medical intensive care unit patients: Association with lung injury and outcome. Journal of Critical Care 32, 2016, 138-144 more…
  • Thomsen, Martin K.; Nandakumar, Ramya; Stadler, Daniela; Malo, Antje; Valls, Roser Marin; Wang, Fan; Reinert, Line S.; Dagnaes-Hansen, Frederik; Hollensen, Anne Kruse; Mikkelsen, Jacob Giehm; Protzer, Ulrike; Paludan, Søren R.: Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection. Hepatology 64 (3), 2016, 746-759 more…
  • Tully, Damien C.; Hjerrild, Simon; Leutscher, Peter D.; Renvillard, Signe G.; Ogilvie, Colin B.; Bean, David J.; Videbech, Poul; Allen, Todd M.; McKeating, Jane A.; Fletcher, Nicola F.: Deep sequencing of hepatitis C virus reveals genetic compartmentalization in cerebrospinal fluid from cognitively impaired patients. Liver International 36 (10), 2016, 1418-1424 more…
  • Verrier, Eloi R.; Colpitts, Che C.; Bach, Charlotte; Heydmann, Laura; Zona, Laetitia; Xiao, Fei; Thumann, Christine; Crouchet, Emilie; Gaudin, Raphaël; Sureau, Camille; Cosset, François-Loïc; McKeating, Jane A.; Pessaux, Patrick; Hoshida, Yujin; Schuster, Catherine; Zeisel, Mirjam B.; Baumert, Thomas F.: Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes. Cell Reports 17 (5), 2016, 1357-1368 more…
  • Xia, Yuchen; Stadler, Daniela; Lucifora, Julie; Reisinger, Florian; Webb, Dennis; Hösel, Marianna; Michler, Thomas; Wisskirchen, Karin; Cheng, Xiaoming; Zhang, Ke; Chou, Wen-Min; Wettengel, Jochen M.; Malo, Antje; Bohne, Felix; Hoffmann, Dieter; Eyer, Florian; Thimme, Robert; Falk, Christine S.; Thasler, Wolfgang E.; Heikenwalder, Mathias; Protzer, Ulrike: Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis. Gastroenterology 150 (1), 2016, 194-205 more…
  • Xia, Yuchen; Stadler, Daniela; Lucifora, Julie; Reisinger, Florian; Webb, Dennis; Hösel, Marianna; Michler, Thomas; Wisskirchen, Karin; Cheng, Xiaoming; Zhang, Ke; Chou, Wen-Min; Wettengel, Jochen M.; Malo, Antje; Bohne, Felix; Hoffmann, Dieter; Eyer, Florian; Thimme, Robert; Falk, Christine S.; Thasler, Wolfgang E.; Heikenwalder, Mathias; Protzer, Ulrike: Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis. Gastroenterology 150 (1), 2016, 194-205 more…
  • Zhang, Yong-Hong; Zhao, Yan; Rajapaksa, Ushani S.; Lawrence, Tessa M.; Peng, Yan-Chun; Liu, Jinghua; Xu, Keyi; Hu, Ke; Qin, Ling; Liu, Ning; Sun, Huanqin; Yan, Hui-Ping; Repapi, Emmanouela; Rowland-Jones, Sarah; Thimme, Robert; McKeating, Jane A.; Dong, Tao: A Comprehensive Analysis of the Impact of HIV on HCV Immune Responses and Its Association with Liver Disease Progression in a Unique Plasma Donor Cohort. PLOS ONE 11 (7), 2016, e0158037 more…

2015

  • Böttcher, Jan P.; Beyer, Marc; Meissner, Felix; Abdullah, Zeinab; Sander, Jil; Höchst, Bastian; Eickhoff, Sarah; Rieckmann, Jan C.; Russo, Caroline; Bauer, Tanja; Flecken, Tobias; Giesen, Dominik; Engel, Daniel; Jung, Steffen; Busch, Dirk H.; Protzer, Ulrike; Thimme, Robert; Mann, Matthias; Kurts, Christian; Schultze, Joachim L.; Kastenmüller, Wolfgang; Knolle, Percy A.: Functional classification of memory CD8+ T cells by CX3CR1 expression. Nature Communications 6 (1), 2015 more…
  • Dargel, Christina; Bassani-Sternberg, Michal; Hasreiter, Julia; Zani, Fabio; Bockmann, Jan-Hendrik; Thiele, Frank; Bohne, Felix; Wisskirchen, Karin; Wilde, Susanne; Sprinzl, Martin F.; Schendel, Dolores J.; Krackhardt, Angela M.; Uckert, Wolfgang; Wohlleber, Dirk; Schiemann, Matthias; Stemmer, Kerstin; Heikenwälder, Mathias; Busch, Dirk H.; Richter, Günther; Mann, Matthias; Protzer, Ulrike: T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice. Gastroenterology 149 (4), 2015, 1042-1052 more…
  • Fletcher, Nicola F.; Jennings, Elliott; Lissauer, Samantha; Humphreys, Elizabeth; van IJzendoorn, Sven C. D.; McKeating, Jane A.; Osburn, William; Wilson, Garrick K.; Balfe, Peter; Baumert, Thomas F.; Afford, Simon: Hepatitis C virus infection of cholangiocarcinoma cell lines. Journal of General Virology 96 (6), 2015, 1380-1388 more…
  • Geipel, Andreas; ; Seiz, Pia L; Niekamp, Hauke; Neumann-Fraune, Maria; Zhang, Ke; Kaiser, Rolf; Protzer, Ulrike; Gerlich, Wolfram H; Glebe, Dieter: Entecavir allows an unexpectedly high residual replication of HBV mutants resistant to lamivudine. Antiviral Therapy 20 (8), 2015, 779-787 more…
  • Guidotti, Luca G.; Inverso, Donato; Sironi, Laura; Di Lucia, Pietro; Fioravanti, Jessica; Ganzer, Lucia; Fiocchi, Amleto; Vacca, Maurizio; Aiolfi, Roberto; Sammicheli, Stefano; Mainetti, Marta; Cataudella, Tiziana; Raimondi, Andrea; Gonzalez-Aseguinolaza, Gloria; Protzer, Ulrike; Ruggeri, Zaverio M.; Chisari, Francis V.; Isogawa, Masanori; Sitia, Giovanni; Iannacone, Matteo: Immunosurveillance of the Liver by Intravascular Effector CD8 + T Cells. Cell 161 (3), 2015, 486-500 more…
  • Hoellein, Alexander; Hecker, Judith; Hoffmann, Dieter; Göttle, Franziska; Protzer, Ulrike; Peschel, Christian; Götze, Katharina: Serious outbreak of human metapneumovirus in patients with hematologic malignancies. Leukemia & Lymphoma 57 (3), 2015, 623-627 more…
  • Hoh, Alexander; Heeg, Maximilian; Ni, Yi; Schuch, Anita; Binder, Benedikt; Hennecke, Nadine; Blum, Hubert E.; Nassal, Michael; Protzer, Ulrike; Hofmann, Maike; Urban, Stephan; Thimme, Robert: Hepatitis B Virus-Infected HepG2hNTCPCells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+T CellsIn Vitro. Journal of Virology 89 (14), 2015, 7433-7438 more…
  • Kefalakes, Helenie; Jochum, Christoph; Hilgard, Gudrun; Kahraman, Alisan; Bohrer, Anna Margarethe; El Hindy, Nicolai; Heinemann, Falko Markus; Verheyen, Jens; Gerken, Guido; Roggendorf, Michael; Timm, Joerg: Decades after recovery from hepatitis B and HBsAg clearance the CD8+ T cell response against HBV core is nearly undetectable. Journal of Hepatology 63 (1), 2015, 13-19 more…
  • Lindemann, M; Koldehoff, M; Fiedler, M; Schumann, A; Ottinger, H D; Heinemann, F M; Roggendorf, M; Horn, P A; Beelen, D W: Control of hepatitis B virus infection in hematopoietic stem cell recipients after receiving grafts from vaccinated donors. Bone Marrow Transplantation 51 (3), 2015, 428-431 more…
  • Loffredo-Verde, E.; Abdel-Aziz, I.; Albrecht, J.; El-Guindy, N.; Yacob, M.; Solieman, A.; Protzer, U.; Busch, D. H.; Layland, L. E.; Prazeres da Costa, C. U.: Schistosome infection aggravates HCV-related liver disease and induces changes in the regulatory T-cell phenotype. Parasite Immunology 37 (2), 2015, 97-104 more…
  • Mailly, Laurent; Xiao, Fei; Lupberger, Joachim; Wilson, Garrick K; Aubert, Philippe; Duong, François H T; Calabrese, Diego; Leboeuf, Céline; Fofana, Isabel; Thumann, Christine; Bandiera, Simonetta; Lütgehetmann, Marc; Volz, Tassilo; Davis, Christopher; Harris, Helen J; Mee, Christopher J; Girardi, Erika; Chane-Woon-Ming, Béatrice; Ericsson, Maria; Fletcher, Nicola; Bartenschlager, Ralf; Pessaux, Patrick; Vercauteren, Koen; Meuleman, Philip; Villa, Pascal; Kaderali, Lars; Pfeffer, Sébastien; Heim, Markus H; Neunlist, Michel; Zeisel, Mirjam B; Dandri, Maura; McKeating, Jane A; Robinet, Eric; Baumert, Thomas F: Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody. Nature Biotechnology 33 (5), 2015, 549-554 more…
  • Mathiesen, Christian K.; Prentoe, Jannick; Meredith, Luke W.; Jensen, Tanja B.; Krarup, Henrik; McKeating, Jane A.; Gottwein, Judith M.; Bukh, Jens: Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant. Journal of Virology 89 (15), 2015, 7758-7775 more…
  • Protzer, Ulrike: Epigenetic control of HBV by HBx protein—releasing the break? Nature Reviews Gastroenterology & Hepatology 12 (10), 2015, 558-559 more…
  • Ringelhan, Marc; Protzer, Ulrike: Oncogenic potential of hepatitis B virus encoded proteins. Current Opinion in Virology 14, 2015, 109-115 more…
  • Sautto, Giuseppe A; Wisskirchen, Karin; Clementi, Nicola; Castelli, Matteo; Diotti, Roberta A; Graf, Julia; Clementi, Massimo; Burioni, Roberto; Protzer, Ulrike; Mancini, Nicasio: Chimeric antigen receptor (CAR)-engineered T cells redirected against hepatitis C virus (HCV) E2 glycoprotein. Gut 65 (3), 2015, 512-523 more…
  • Schmid, Sebastian C.; Thümer, Leonore; Schuster, Tibor; Horn, Thomas; Kurtz, Florian; Slotta-Huspenina, Julia; Seebach, Judith; Straub, Michael; Maurer, Tobias; Autenrieth, Michael; Kübler, Hubert; Retz, Margitta; Protzer, Ulrike; Gschwend, Jürgen E.; Hoffmann, Dieter: Human papilloma virus is not detectable in samples of urothelial bladder cancer in a central European population: a prospective translational study. Infectious Agents and Cancer 10 (1), 2015 more…
  • Sprinzl, Martin Franz; Puschnik, Andreas; Schlitter, Anna Melissa; Schad, Arno; Ackermann, Kerstin; Esposito, Irene; Lang, Hauke; Galle, Peter Robert; Weinmann, Arndt; Heikenwälder, Mathias; Protzer, Ulrike: Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion. Journal of Hepatology 62 (4), 2015, 863-870 more…
  • Tawar, Rajiv G.; Colpitts, Che C.; Timm, Jörg; Fehm, Tanja; Roggendorf, Michael; Meisel, Helga; Meyer, Nicolas; Habersetzer, François; Cosset, François-Loïc; Berg, Thomas; Zeisel, Mirjam B.; Baumert, Thomas F.: Acute hepatitis C virus infection induces anti-host cell receptor antibodies with virus-neutralizing properties. Hepatology 62 (3), 2015, 726-736 more…
  • Wilson, Garrick K.; Farquhar, Michelle J.; Dhawan, Anil; McKeating, Jane A.; Balfe, Peter; Meredith, Luke; Mitry, Ragai: Permissivity of primary hepatocytes and hepatoma cell lines to support hepatitis C virus infection. Journal of General Virology 96 (6), 2015, 1369-1373 more…

2014

  • Dembek, Claudia; Protzer, Ulrike: Mouse models for therapeutic vaccination against hepatitis B virus. Medical Microbiology and Immunology 204 (1), 2014, 95-102 more…
  • Protzer, Ulrike; Böhm, Friederike; Longerich, Thomas; Seebach, Judith; Heidary Navid, Mojdeh; Friemel, Juliane; Marques-Maggio, Ewerton; Bawohl, Marion; Heikenwalder, Mathias; Schirmacher, Peter; Dutkowski, Philipp; Clavien, Pierre-Alain; Schemmer, Peter; Schnitzler, Paul; Gotthardt, Daniel; Müllhaupt, Beat; Weber, Achim: Molecular detection of hepatitis E virus (HEV) in liver biopsies after liver transplantation. Modern Pathology 28 (4), 2014, 523-532 more…