Microfluidic Design Automation (MDA)

In the MDA group, Hans Fischer Fellow Prof. Tsung-Yi Ho (National Tsing Hua University) and Hans Fischer Senior Fellow Prof. Krishnendu Chakrabarty (Duke University) work with their host Prof. Ulf Schlichtmann (TUM Department of Electrical and Computer Engineering).

Miniaturized and low-cost microfluidic biochip are revolutionizing a diverse range of applications, e.g., air quality studies, point-of-care clinical diagnostics, drug discovery, and DNA sequencing. Yole development recently predicted a 28% Compound Annual Growth Rate for the microfluidic biochip (“lab-on-chip”) market during 2013-2018 and the market size for lab-on-chip alone (not including microarrays, biosensors, and microreactors) will grow swiftly from $1.4B in 2012 to $5.7B by 2018.

However, continued growth (and larger revenues resulting from technology adoption by pharmaceutical and healthcare companies) depends on advances in chip integration and design-automation tools. In particular, design-automation tools are needed to ensure that biochips are as versatile as the macro-labs that they are intended to replace. Furthermore, as more bioassays are executed concurrently on a biochip, system integration and design complexity are expected to increase dramatically. There is now a need to deliver the same level of computer-aided design (CAD) support to the biochip designer that the semiconductor industry today takes for granted. These CAD tools will allow designers and chip users to harness the new technology that is rapidly emerging for integrated biofluidics. This Focus Group will develop CAD tools for hardware/software co-design and cyberphysical system integration of microfluidic biochips. In addition, it will offer researchers at TUM a bridge between the electronic chip/system design industries on the one hand, and the biomedical and pharmaceutical industries on the other hand.

TUM-IAS funded doctoral candidate:
Yasamin Moradi, Chair of Electronic Design Automation
Chunfeng Liu, Chair of Electronic Design Automation

 

Publications by the Focus Group

2019

  • Bernardini, Alessandro; Liu, Chunfeng; Li, Bing; Schlichtmann, Ulf: Fault Localization in Programmable Microfluidic Devices. 2019 Design, Automation & Test in Europe Conference & Exhibition (DATE), IEEE, 2019 more…
  • Chen, Zhisheng; Huang, Xing; Guo, Wenzhong; Li, Bing; Ho, Tsung-Yi; Schlichtmann, Ulf: Physical Synthesis of Flow-Based Microfluidic Biochips Considering Distributed Channel Storage. 2019 Design, Automation & Test in Europe Conference & Exhibition (DATE), IEEE, 2019 more…
  • Huang, Xing; Ho, Tsung-Yi; Guo, Wenzhong; Li, Bing; Schlichtmann, Ulf: MiniControl. Proceedings of the 56th Annual Design Automation Conference 2019 on - DAC '19, ACM Press, 2019 more…
  • Ibrahim, Mohamed; Chakrabarty, Krishnendu; Schlichtmann, Ulf: Synthesis of a Cyberphysical Hybrid Microfluidic Platform for Single-Cell Analysis. IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems 38 (7), 2019, 1237-1250 more…
  • Ibrahim, Mohamed; Sridhar, Aditya; Chakrabarty, Krishnendu; Schlichtmann, Ulf: Synthesis of Reconfigurable Flow-Based Biochips for Scalable Single-Cell Screening. IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems 38 (12), 2019, 2255-2270 more…
  • Lin, Yu-Huei; Ho, Tsung-Yi; Li, Bing; Schlichtmann, Ulf: Block-Flushing: A Block-based Washing Algorithm for Programmable Microfluidic Devices. 2019 Design, Automation & Test in Europe Conference & Exhibition (DATE), IEEE, 2019 more…
  • Liu, Chunfeng; Li, Bing; Bhattacharya, Bhargab B.; Chakrabarty, Krishnendu; Ho, Tsung-Yi; Schlichtmann, Ulf: Test Generation for Flow-Based Microfluidic Biochips with General Architectures. IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, 2019, 1-1 more…
  • Wang, Qin; Ji, Weiqing; Li, Zeyan; Cheong, Haena; Kwon, Oh-Sun; Yao, Hailong; Ho, Tsung-Yi; Shin, Kwanwoo; Li, Bing; Schlichtmann, Ulf; Cai, Yici: Integrated Control-Fluidic CoDesign Methodology for Paper-Based Digital Microfluidic Biochips. IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, 2019, 1-1 more…
  • Zhu, Ying; Huang, Xing; Li, Bing; Ho, Tsung-Yi; Wang, Qin; Yao, Hailong; Wille, Robert; Schlichtmann, Ulf: MultiControl: Advanced Control Logic Synthesis for Flow-Based Microfluidic Biochips. IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, 2019, 1-1 more…

2018

  • Serr, Isabelle; Scherm, Martin G.; Zahm, Adam M.; Schug, Jonathan; Flynn, Victoria K.; Hippich, Markus; Kälin, Stefanie; Becker, Maike; Achenbach, Peter; Nikolaev, Alexei; Gerlach, Katharina; Liebsch, Nicole; Loretz, Brigitta; Lehr, Claus-Michael; Kirchner, Benedikt; Spornraft, Melanie; Haase, Bettina; Segars, James; Küper, Christoph; Palmisano, Ralf; Waisman, Ari; Willis, Richard A.; Kim, Wan-Uk; Weigmann, Benno; Kaestner, Klaus H.; Ziegler, Anette-Gabriele; Daniel, Carolin: A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes. Science Translational Medicine 10 (422), 2018, eaag1782 more…

2015

  • Tsun-Ming Tseng; Bing Li; Schlichtmann, Ulf; Tsung-Yi Ho: Storage and Caching: Synthesis of Flow-Based Microfluidic Biochips. IEEE Design & Test 32 (6), 2015, 69-75 more…