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Technical University of Munich
Technical University of Munich

Biologically Inspired Materials Science

Prof. Hendrik Dietz (Hans Fischer Tenure Track Fellow), is conducting research toward developing novel scientific devices and methods for applications in biomolecular physics, biological chemistry, and molecular medicine. A central focus of his newly established Laboratory for Biomolecular Nanotechnology is on investigating the physical details of intermolecular interactions, in particular protein-protein and protein-DNA interactions. To overcome critical experimental challenges that one faces when studying low-affinity biomolecular interactions, the Dietz lab is working toward taking advantage of the fine positional control afforded by molecular-self assembly with DNA origami to build nanometer-scale scientific devices that will be used to interface and manipulate target macromolecules and that will enable conformational read-out with single-molecule fluorescence methods and/or with transmission electron microscopy. Since 2016 Prof. Hendrik Dietz has been a Carl von Linde Senior Fellow.

Prof. Zvonimir Dogic of University of California, Santa Barbara, was as a Hans Fischer Senior Fellow working in this Focus Group. Active matter is an assembly of microscopic objects, each of which consumes energy to generate continuous dynamics. Interactions between such objects lead to collective emergent properties that are strikingly different from those of conventional materials assembled from inanimate objects. An example of active matter is the biological cytoskeleton which is built from animate actively propelled molecular motors and other components. Being released from the constraints of the equilibrium the cytoskeleton exhibits remarkable properties such as motility, rapid shape changes and spontaneous internal flows. Our goal is to create biologically inspired far-from-equilibrium polymeric and liquid crystalline materials from purified biological components. Prof. Dogic in collaboration with the groups of his TUM-IAS Hosts Prof. Hendrik Dietz and Prof. Andreas Bausch seeks to deconstruct the complicated cytoskeletal machinery and to identify the simplest set of proteins that reproduce the remarkable material properties of the cytoskeleton.

TUM-IAS funded doctoral candidates:
Felix Keber (PhD in 2017), Molecular & Cellular Biophysics

Publications by the Focus Group

2019

  • Engelhardt, Floris A. S.; Praetorius, Florian; Wachauf, Christian H.; Brüggenthies, Gereon; Kohler, Fabian; Kick, Benjamin; Kadletz, Karoline L.; Pham, Phuong Nhi; Behler, Karl L.; Gerling, Thomas; Dietz, Hendrik: Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds. ACS Nano 13 (5), 2019, 5015-5027 more…
  • Gerling, Thomas; Dietz, Hendrik: Reversible Covalent Stabilization of Stacking Contacts in DNA Assemblies. Angewandte Chemie International Edition 58 (9), 2019, 2680-2684 more…
  • Häußermann, Katharina; Young, Gavin; Kukura, Philipp; Dietz, Hendrik: Dissecting FOXP2 Oligomerization and DNA Binding. Angewandte Chemie International Edition 58 (23), 2019, 7662-7667 more…
  • Lakemeyer, Markus; Bertosin, Eva; Möller, Friederike; Balogh, Dóra; Strasser, Ralf; Dietz, Hendrik; Sieber, Stephan A.: Tailored Peptide Phenyl Esters Block ClpXP Proteolysis by an Unusual Breakdown into a Heptamer-Hexamer Assembly. Angewandte Chemie International Edition 58 (21), 2019, 7127-7132 more…
  • Ramezani, Hamid; Dietz, Hendrik: Building machines with DNA molecules. Nature Reviews Genetics 21 (1), 2019, 5-26 more…
  • Rodrigues, Letícia; Schneider, Fabian; Zhang, Xiaohan; Larsson, Elin; Moodie, Lindon W.K.; Dietz, Hendrik; Papadakis, Christine M.; Winter, Gerhard; Lundmark, Richard; Hubert, Madlen: Cellular uptake of self-assembled phytantriol-based hexosomes is independent of major endocytic machineries. Journal of Colloid and Interface Science 553, 2019, 820-833 more…
  • Schneider, Fabian; Möritz, Natalie; Dietz, Hendrik: The sequence of events during folding of a DNA origami. Science Advances 5 (5), 2019, eaaw1412 more…
  • Sigmund, Felix; Pettinger, Susanne; Kube, Massimo; Schneider, Fabian; Schifferer, Martina; Schneider, Steffen; Efremova, Maria V.; Pujol-Martí, Jesús; Aichler, Michaela; Walch, Axel; Misgeld, Thomas; Dietz, Hendrik; Westmeyer, Gil G.: Iron-Sequestering Nanocompartments as Multiplexed Electron Microscopy Gene Reporters. ACS Nano 13 (7), 2019, 8114-8123 more…
  • Wanzke, Caren; Jussupow, Alexander; Kohler, Fabian; Dietz, Hendrik; Kaila, Ville R. I.; Boekhoven, Job: Dynamic Vesicles Formed By Dissipative Self‐Assembly. ChemSystemsChem 2 (1), 2019 more…

2018

  • Bruetzel, Linda K.; Walker, Philipp U.; Gerling, Thomas; Dietz, Hendrik; Lipfert, Jan: Time-Resolved Small-Angle X-ray Scattering Reveals Millisecond Transitions of a DNA Origami Switch. Nano Letters 18 (4), 2018, 2672-2676 more…
  • Bräuning, Bastian; Bertosin, Eva; Praetorius, Florian; Ihling, Christian; Schatt, Alexandra; Adler, Agnes; Richter, Klaus; Sinz, Andrea; Dietz, Hendrik; Groll, Michael: Structure and mechanism of the two-component a-helical pore-forming toxin YaxAB. Nature Communications 9 (1), 2018 more…
  • Franquelim, Henri G.; Khmelinskaia, Alena; Sobczak, Jean-Philippe; Dietz, Hendrik; Schwille, Petra: Membrane sculpting by curved DNA origami scaffolds. Nature Communications 9 (1), 2018 more…
  • Gerling, Thomas; Kube, Massimo; Kick, Benjamin; Dietz, Hendrik: Sequence-programmable covalent bonding of designed DNA assemblies. Science Advances 4 (8), 2018, eaau1157 more…
  • Ketterer, Philip; Ananth, Adithya N.; Laman Trip, Diederik S.; Mishra, Ankur; Bertosin, Eva; Ganji, Mahipal; van der Torre, Jaco; Onck, Patrick; Dietz, Hendrik; Dekker, Cees: DNA origami scaffold for studying intrinsically disordered proteins of the nuclear pore complex. Nature Communications 9 (1), 2018 more…
  • Schickinger, Matthias; Zacharias, Martin; Dietz, Hendrik: Tethered multifluorophore motion reveals equilibrium transition kinetics of single DNA double helices. Proceedings of the National Academy of Sciences 115 (32), 2018, E7512-E7521 more…

2017

  • Keber, Felix: Dynamics and self-organisation of active cytoskeletal gels. Dissertation, 2017 more…
  • Praetorius, Florian; Dietz, Hendrik: Self-assembly of genetically encoded DNA-protein hybrid nanoscale shapes. Science 355 (6331), 2017, eaam5488 more…
  • Praetorius, Florian; Kick, Benjamin; Behler, Karl L.; Honemann, Maximilian N.; Weuster-Botz, Dirk; Dietz, Hendrik: Biotechnological mass production of DNA origami. Nature 552 (7683), 2017, 84-87 more…
  • Siavashpouri, Mahsa; Wachauf, Christian H.; Zakhary, Mark J.; Praetorius, Florian; Dietz, Hendrik; Dogic, Zvonimir: Molecular engineering of chiral colloidal liquid crystals using DNA origami. Nature Materials 16 (8), 2017, 849-856 more…
  • Wagenbauer, Klaus F.; Engelhardt, Floris A. S.; Stahl, Evi; Hechtl, Vera K.; Stömmer, Pierre; Seebacher, Fabian; Meregalli, Letizia; Ketterer, Philip; Gerling, Thomas; Dietz, Hendrik: How We Make DNA Origami. ChemBioChem 18 (19), 2017, 1873-1885 more…
  • Wagenbauer, Klaus F.; Sigl, Christian; Dietz, Hendrik: Gigadalton-scale shape-programmable DNA assemblies. Nature 552 (7683), 2017, 78-83 more…
  • Willner, Elena M.; Kamada, Yuu; Suzuki, Yuki; Emura, Tomoko; Hidaka, Kumi; Dietz, Hendrik; Sugiyama, Hiroshi; Endo, Masayuki: Single-Molecule Observation of the Photoregulated Conformational Dynamics of DNA Origami Nanoscissors. Angewandte Chemie International Edition 56 (48), 2017, 15324-15328 more…

2016

  • Bruetzel, Linda K.; Gerling, Thomas; Sedlak, Steffen M.; Walker, Philipp U.; Zheng, Wenjun; Dietz, Hendrik; Lipfert, Jan: Conformational Changes and Flexibility of DNA Devices Observed by Small-Angle X-ray Scattering. Nano Letters 16 (8), 2016, 4871-4879 more…
  • Dietz, Hendrik: Toward Applications for DNA Nanotechnology-More Bricks To Build With. ChemBioChem 17 (12), 2016, 1046-1047 more…
  • Funke, Jonas J.; Ketterer, Philip; Lieleg, Corinna; Korber, Philipp; Dietz, Hendrik: Exploring Nucleosome Unwrapping Using DNA Origami. Nano Letters 16 (12), 2016, 7891-7898 more…
  • Funke, Jonas J.; Ketterer, Philip; Lieleg, Corinna; Schunter, Sarah; Korber, Philipp; Dietz, Hendrik: Uncovering the forces between nucleosomes using DNA origami. Science Advances 2 (11), 2016, e1600974 more…
  • Ketterer, Philip; Willner, Elena M.; Dietz, Hendrik: Nanoscale rotary apparatus formed from tight-fitting 3D DNA components. Science Advances 2 (2), 2016, e1501209 more…
  • Kick, Benjamin; Hensler, Samantha; Praetorius, Florian; Dietz, Hendrik; Weuster-Botz, Dirk: Specific growth rate and multiplicity of infection affect high-cell-density fermentation with bacteriophage M13 for ssDNA production. Biotechnology and Bioengineering 114 (4), 2016, 777-784 more…
  • Kilchherr, F.; Wachauf, C.; Pelz, B.; Rief, M.; Zacharias, M.; Dietz, H.: Single-molecule dissection of stacking forces in DNA. Science 353 (6304), 2016, aaf5508-aaf5508 more…
  • Krishnan, Swati; Ziegler, Daniela; Arnaut, Vera; Martin, Thomas G.; Kapsner, Korbinian; Henneberg, Katharina; Bausch, Andreas R.; Dietz, Hendrik; Simmel, Friedrich C.: Molecular transport through large-diameter DNA nanopores. Nature Communications 7 (1), 2016 more…
  • Rodrigues, Letícia; Kyriakos, Konstantinos; Schneider, Fabian; Dietz, Hendrik; Winter, Gerhard; Papadakis, Christine M.; Hubert, Madlen: Characterization of Lipid-Based Hexosomes as Versatile Vaccine Carriers. Molecular Pharmaceutics 13 (11), 2016, 3945-3954 more…
  • Stahl, Evi; Praetorius, Florian; de Oliveira Mann, Carina C.; Hopfner, Karl-Peter; Dietz, Hendrik: Impact of Heterogeneity and Lattice Bond Strength on DNA Triangle Crystal Growth. ACS Nano 10 (10), 2016, 9156-9164 more…

2015

  • Gerling, T.; Wagenbauer, K. F.; Neuner, A. M.; Dietz, H.: Dynamic DNA devices and assemblies formed by shape-complementary, non-base pairing 3D components. Science 347 (6229), 2015, 1446-1452 more…

2014

  • Cui, H; Seubert, B; Stahl, E; Dietz, H; Reuning, U; Moreno-Leon, L; Ilie, M; Hofman, P; Nagase, H; Mari, B; Krüger, A: Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes. Oncogene 34 (28), 2014, 3640-3650 more…
  • Dogic, Zvonimir; Sharma, Prerna; Zakhary, Mark J.: Hypercomplex Liquid Crystals. Annual Review of Condensed Matter Physics 5 (1), 2014, 137-157 more…
  • Elkhatib, Nadia; Neu, Matthew B.; Zensen, Carla; Schmoller, Kurt M.; Louvard, Daniel; Bausch, Andreas R.; Betz, Timo; Vignjevic, Danijela Matic: Fascin Plays a Role in Stress Fiber Organization and Focal Adhesion Disassembly. Current Biology 24 (13), 2014, 1492-1499 more…
  • Huber, Benjamin; Harasim, Markus; Wunderlich, Bernhard; Kröger, Martin; Bausch, Andreas R.: Microscopic Origin of the Non-Newtonian Viscosity of Semiflexible Polymer Solutions in the Semidilute Regime. ACS Macro Letters 3 (2), 2014, 136-140 more…
  • Keber, F. C.; Loiseau, E.; Sanchez, T.; DeCamp, S. J.; Giomi, L.; Bowick, M. J.; Marchetti, M. C.; Dogic, Z.; Bausch, A. R.: Topology and dynamics of active nematic vesicles. Science 345 (6201), 2014, 1135-1139 more…
  • Müller, Kei W.; Bruinsma, Robijn F.; Lieleg, Oliver; Bausch, Andreas R.; Wall, Wolfgang A.; Levine, Alex J.: Rheology of Semiflexible Bundle Networks with Transient Linkers. Physical Review Letters 112 (23), 2014 more…
  • Plesa, Calin; van Loo, Nick; Ketterer, Philip; Dietz, Hendrik; Dekker, Cees: Velocity of DNA during Translocation through a Solid-State Nanopore. Nano Letters 15 (1), 2014, 732-737 more…
  • Shen, Boxuan; Linko, Veikko; Dietz, Hendrik; Toppari, J. Jussi: Dielectrophoretic trapping of multilayer DNA origami nanostructures and DNA origami-induced local destruction of silicon dioxide. ELECTROPHORESIS 36 (2), 2014, 255-262 more…
  • Stahl, Evi; Martin, Thomas G.; Praetorius, Florian; Dietz, Hendrik: Facile and Scalable Preparation of Pure and Dense DNA Origami Solutions. Angewandte Chemie International Edition 53 (47), 2014, 12735-12740 more…
  • Wagenbauer, Klaus F.; Wachauf, Christian H.; Dietz, Hendrik: Quantifying quality in DNA self-assembly. Nature Communications 5 (1), 2014 more…

2013

  • Plesa, Calin; Ananth, Adithya N.; Linko, Veikko; Gülcher, Coen; Katan, Allard J.; Dietz, Hendrik; Dekker, Cees: Ionic Permeability and Mechanical Properties of DNA Origami Nanoplates on Solid-State Nanopores. ACS Nano 8 (1), 2013, 35-43 more…
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