Computational Biomechanics

Patient-specific geometrical models of bones and information on their material properties can be obtained from computed tomography scans. Manipulation of this information by new and advanced numerical methods (high-order non-linear finite elements and the finite cell method) combined with experimentation on bones may have a tremendous impact on the clinical treatment of diseases as osteoporosis and total hip replacement surgery. This capability can also provide medical doctors a comprehensive understanding on the pathological situation of a specific patient and enable an optimal treatment which is unavailable at the moment.

Prof. Zohar Yosibash is the founder and head of the Computational Mechanics Laboratory at the dept. of mechanical engineering at Ben-Gurion University of the Negev in Israel. He has vast experience in high-order finite element methods and has been involved since 2001 with computational biomechanics, especially with the verification of validation of p-FE models of the human femur. As a Hans Fischer Senior Fellow, Prof. Yosibash enhances the long lasting collaboration with Prof. Ernst Rank, head of the Institute of Computational Engineering at TUM. This collaboration is hoped to lead to the development of patient specific computer aided quantitative planning and analysis tool that will assist orthopedists in diagnosis and treatment of bone diseases. Computer simulations of human bones, due to their multiscale and/or stochastic nature, are computationally extremely intensive and therefore require scientific expertise and hardware availability for High Performance Computing, therefore would need to be closely embedded in the research activities of MAC, the newly created Munich Center for Advanced Computing. Several topics will be investigated as:

a) Reliable simulation of femur's mechanical response under a complex loading state.

b) Fracture predictions capabilities for a healthy and osteoporosis affected bone by applying a high-order multi-scale-finite-element/finite-cell approach.

c) Optimization of a total hip replacement (THR) surgery.

d) Quantifying material and geometrical uncertainties by numerical simulations.

Prof. Yosibash is also building multidisciplinary connections with other research groups within TUM (the groups of Prof. Reiner Gradinger - Orthopedic Surgery, Sport Orthopedics and Trauma Surgery and Prof. Rüdiger Westermann - Computer Graphics and Visualization) interested in different aspects of bone simulation and validation.

Doctoral Candidate:
Hagen Wille, Chair for Computation in Engineering

Publications by the Focus Group


  • Yosibash, Zohar; Mayo, Romina Plitman; Milgrom, Charles: Atypical viscous fracture of human femurs. Advances in biomechanics and applications 1 (2), 2014, 77-83 more…
  • Yosibash, Zohar; Plitman Mayo, Romina; Dahan, Gal; Trabelsi, Nir; Amir, Gail; Milgrom, Charles: Predicting the stiffness and strength of human femurs with real metastatic tumors. Bone 69, 2014, 180-190 more…


  • Yosibash, Zohar; Katz, Alon; Milgrom, Charles: Toward verified and validated FE simulations of a femur with a cemented hip prosthesis. Medical Engineering & Physics 35 (7), 2013, 978-987 more…