Carl P. Blobel is Professor of Medicine and of Physiology, Biophysics and Systems Biology at Weill Cornell Medical College, and Chairman of the Arthritis and Tissue Degeneration Program at the Hospital for Special Surgery in New York City. He received an MD degree from the Justus-Liebig University in Giessen, Germany (1984) and a PhD degree in Biochemistry from the University of California, San Francisco (1991). In 1992 he established his lab at the Sloan-Kettering Institute, and has been at the Hospital for Special Surgery at Weill Cornell Medical College in New York since 2004, where he holds the V.F. and W.R. Salomon endowed Chair in Musculoskeletal Research.
Selected Awards
2015, Elected to the Association of American Physicians
2012, Bayer Hemophilia Awards Program
2009, Chair of the Gordon Research Conference on Matrix Metalloproteinases
2004, V.F. and W.R. Salomon Endowed Chair in Musculoskeletal Research (Hospital for Special Surgery)
1996, NIH Shannon Director’s Award
Research Interests
Research in Dr. Blobel’s lab is focused on elucidating the function of cell surface metalloproteinases termed ADAMs (a disintegrin and metalloproteinase) in development and disease. ADAMs have emerged as critical modulators of cell-cell interactions through their ability to regulate the bioavailability of membrane proteins such as the pro-inflammatory cytokine TNFα and ligands of the EGF-receptor (EGFR). Moreover, ADAMs are essential for activating cell surface receptors of the Notch family, which control cell fate decisions during the development of specialized cell types in different tissues, but are also involved in the pathogenesis of cancer. Studies in Dr. Blobel’s lab employ a comprehensive combination of biochemical and cell biological approaches as well as mouse models for disease. They have helped establish ADAM17 as a key regulator of the EGFR signaling pathway, which is essential for maintaining the skin and intestinal barrier, but can cause a variety of human pathologies when it is dysregulated. Moreover, his lab has pioneered studies on the newly discovered iRhom1 and 2 as crucial upstream regulators of ADAM17-dependent EGFR and TNFα-signaling. The medical relevance of Dr. Blobel’s work is significant, since it not only helps understand how exactly iRhoms and ADAM17 can promote EGFR-dependent pathologies such as cancer and TNFα-dependent autoimmune disorders such as rheumatoid arthritis, but it has also revealed new and attractive potential targets for treatment of these diseases.
Selected Publications
Maretzky, Thorsten; McIlwain, David R.; Issuree, Priya Darshinee A; Li, Xue; Malapeira, Jordi; Amin, Sadaf; Lang, Philipp A.; Mak, Tak W.; Blobel, Carl P.: iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding. Proceedings of the National Academy of Sciences of the United States of America 110 (28), 2013, 11433-11438.
Issuree, Priya Darshinee A; Maretzky, Thorsten; McIlwain, David R.; Monette, Sébastien; Qing, Xiaoping; Lang, Philipp A.; Swendeman, Steven L.; Park-Min, Kyung-Hyun; Binder, Nikolaus; Kalliolias, George D.; Yarilina, Anna; Horiuchi, Keisuke; Ivashkiv, Lionel B.; Mak, Tak W.; Salmon, Jane E.; Blobel, Carl P.: iRHOM2 is a critical pathogenic mediator of inflammatory arthritis. The Journal of clinical investigation 123 (2), 2013, 928-932.
McIlwain, David R.; Lang, Philipp A.; Maretzky, Thorsten; Hamada, Koichi; Ohishi, Kazuhito; Maney, Sathish Kumar; Berger, Thorsten; Murthy, Aditya; Duncan, Gordon; Xu, Haifeng C.; Lang, Karl S.; Häussinger, Dieter; Wakeham, Andrew; Itie-Youten, Annick; Khokha, Rama; Ohashi, Pamela S.; Blobel, Carl P.; Mak, Tak W.: iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science (New York, N.Y.) 335 (6065), 2012, 229-232.
Franzke, Claus-Werner; Cobzaru, Cristina; Triantafyllopoulou, Antigoni; Löffek, Stefanie; Horiuchi, Keisuke; Threadgill, David W.; Kurz, Thomas; van Rooijen, Nico; Bruckner-Tuderman, Leena; Blobel, Carl P.: Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. The Journal of experimental medicine 209 (6), 2012, 1105-1119.
Horiuchi, Keisuke; Kimura, Tokuhiro; Miyamoto, Takeshi; Takaishi, Hironari; Okada, Yasunori; Toyama, Yoshiaki; Blobel, Carl P.: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. Journal of immunology (Baltimore, Md. : 1950) 179 (5), 2007, 2686-2689.
Weskamp, Gisela; Ford, Jill W.; Sturgill, Jamie; Martin, Steve; Docherty, Andrew J P; Swendeman, Steven; Broadway, Neil; Hartmann, Dieter; Saftig, Paul; Umland, Shelby; Sehara-Fujisawa, Atsuko; Black, Roy A.; Ludwig, Andreas; Becherer, J. David; Conrad, Daniel H.; Blobel, Carl P.: ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23. Nature immunology 7 (12), 2006, 1293-1298.
Blobel, Carl P.: ADAMs: key components in EGFR signalling and development. Nature reviews. Molecular cell biology 6 (1), 2005, 32-43.
Sahin, Umut; Weskamp, Gisela; Kelly, Kristine; Zhou, Hong-Ming; Higashiyama, Shigeki; Peschon, Jacques; Hartmann, Dieter; Saftig, Paul; Blobel, Carl P.: Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. The Journal of cell biology 164 (5), 2004, 769-779.
Blobel, C. P.; Wolfsberg, T. G.; Turck, C. W.; Myles, D. G.; Primakoff, P.; White, J. M.: A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion. Nature 356 (6366), 1992, 248-252.
Alabi, Rolake O.; Farber, Gregory; Blobel, Carl P.: Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds. Physiological Reviews 98 (4), 2018, 2025-2061 more…BibTeX
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Brummer, Tobias; Pigoni, Martina; Rossello, Armando; Wang, Huanhuan; Noy, Peter J.; Tomlinson, Michael G.; Blobel, Carl P.; Lichtenthaler, Stefan F.: The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation. The FASEB Journal 32 (7), 2018, 3560-3573 more…BibTeX
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Farber, Gregory; Hurtado, Romulo; Loh, Sarah; Monette, Sébastien; Mtui, James; Kopan, Raphael; Quaggin, Susan; Meyer-Schwesinger, Catherine; Herzlinger, Doris; Scott, Rizaldy P.; Blobel, Carl P.: Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling. Angiogenesis 21 (2), 2018, 335-347 more…BibTeX
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Farber, Gregory; Parks, Matthew M.; Lustgarten Guahmich, Nicole; Zhang, Yi; Monette, Sébastien; Blanchard, Scott C.; Di Lorenzo, Annarita; Blobel, Carl P.: ADAM10 controls the differentiation of the coronary arterial endothelium. Angiogenesis 22 (2), 2018, 237-250 more…BibTeX
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Haxaire, Coline; Hakobyan, Narine; Pannellini, Tania; Carballo, Camila; McIlwain, David; Mak, Tak W.; Rodeo, Scott; Acharya, Suchitra; Li, Daniel; Szymonifka, Jackie; Song, Xiangqian; Monette, Sébastien; Srivastava, Alok; Salmon, Jane E.; Blobel, Carl P.: Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-a pathway. Blood 132 (10), 2018, 1064-1074 more…BibTeX
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Qing, Xiaoping; Chinenov, Yurii; Redecha, Patricia; Madaio, Michael; Roelofs, Joris J.T.H.; Farber, Gregory; Issuree, Priya D.; Donlin, Laura; Mcllwain, David R.; Mak, Tak W.; Blobel, Carl P.; Salmon, Jane E.: iRhom2 promotes lupus nephritis through TNF-a and EGFR signaling. Journal of Clinical Investigation 128 (4), 2018, 1397-1412 more…BibTeX
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Shipman, William D.; Chyou, Susan; Ramanathan, Anusha; Izmirly, Peter M.; Sharma, Sneh; Pannellini, Tania; Dasoveanu, Dragos C.; Qing, Xiaoping; Magro, Cynthia M.; Granstein, Richard D.; Lowes, Michelle A.; Pamer, Eric G.; Kaplan, Daniel H.; Salmon, Jane E.; Mehrara, Babak J.; Young, James W.; Clancy, Robert M.; Blobel, Carl P.; Lu, Theresa T.: A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity. Science Translational Medicine 10 (454), 2018, eaap9527 more…BibTeX
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2017
Li, Xue; Maretzky, Thorsten; Perez-Aguilar, Jose Manuel; Monette, Sebastien; Weskamp, Gisela; Le Gall, Sylvain; Beutler, Bruce; Weinstein, Harel; Blobel, Carl P.: Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis. Journal of Cell Science 130 (5), 2017, 868-878 more…BibTeX
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Maretzky, Thorsten; Swendeman, Steven; Mogollon, Elin; Weskamp, Gisela; Sahin, Umut; Reiss, Karina; Blobel, Carl P.: Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays. Biochemical Journal 474 (9), 2017, 1467-1479 more…BibTeX
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Urriola-Muñoz, Paulina; Li, Xue; Maretzky, Thorsten; McIlwain, David R.; Mak, Tak W.; Reyes, Juan G.; Blobel, Carl P.; Moreno, Ricardo D.: The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands. Journal of Cellular Physiology 233 (3), 2017, 2247-2256 more…BibTeX
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2016
Alabi, Rolake O.; Glomski, Krzysztof; Haxaire, Coline; Weskamp, Gisela; Monette, Sébastien; Blobel, Carl P.: ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds. Circulation Research 119 (4), 2016, 519-531 more…BibTeX
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Qing, Xiaoping; D. Rogers, Lindsay; Mortha, Arthur; Lavin, Yonit; Redecha, Patricia; Issuree, Priya D.; Maretzky, Thorsten; Merad, Miriam; R. McIlwain, David; Mak, Tak W.; Overall, Christopher M.; Blobel, Carl P.; Salmon, Jane E.: iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice. European Journal of Immunology 46 (12), 2016, 2737-2748 more…BibTeX
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2015
Haxaire, Coline; Kalliolias, George; DiCarlo, Edward; Salmon, Jane; Srivastava, Alok; Blobel, Carl: Blood-Induced Arthropathy in Hemophilia: Mechanisms and Heterogeneity. Seminars in Thrombosis and Hemostasis 41 (08), 2015, 832-837 more…BibTeX
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Li, Xue; Maretzky, Thorsten; Weskamp, Gisela; Monette, Sébastien; Qing, Xiaoping; Issuree, Priya Darshinee A.; Crawford, Howard C.; McIlwain, David R.; Mak, Tak W.; Salmon, Jane E.; Blobel, Carl P.: iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling. Proceedings of the National Academy of Sciences 112 (19), 2015, 6080-6085 more…BibTeX
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Lichtenthaler, Stefan F; O'Hara, Bruce F; Blobel, Carl P: iRhoms in the brain - a new frontier? Cell Cycle 14 (19), 2015, 3003-3004 more…BibTeX
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Maney, Sathish K.; McIlwain, David R.; Polz, Robin; Pandyra, Aleksandra A.; Sundaram, Balamurugan; Wolff, Dorit; Ohishi, Kazuhito; Maretzky, Thorsten; Brooke, Matthew A.; Evers, Astrid; Vasudevan, Ananda A. Jaguva; Aghaeepour, Nima; Scheller, Jürgen; Münk, Carsten; Häussinger, Dieter; Mak, Tak W.; Nolan, Garry P.; Kelsell, David P.; Blobel, Carl P.; Lang, Karl S.; Lang, Philipp A.: Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17. Science Signaling 8 (401), 2015, ra109-ra109 more…BibTeX
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Maretzky, Thorsten; Evers, Astrid; Le Gall, Sylvain; Alabi, Rolake O.; Speck, Nancy; Reiss, Karina; Blobel, Carl P.: The Cytoplasmic Domain of A Disintegrin and Metalloproteinase 10 (ADAM10) Regulates Its Constitutive Activity but Is Dispensable for Stimulated ADAM10-dependent Shedding. Journal of Biological Chemistry 290 (12), 2015, 7416-7425 more…BibTeX
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Noss, Erika H; Watts, Gerald FM; Zocco, Davide; Keller, Tracy L; Whitman, Malcolm; Blobel, Carl P; Lee, David M; Brenner, Michael B: Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism. Arthritis Research & Therapy 17 (1), 2015 more…BibTeX
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Wong, Eitan; Maretzky, Thorsten; Peleg, Yoav; Blobel, Carl P.; Sagi, Irit: The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site. Journal of Biological Chemistry 290 (19), 2015, 12135-12146 more…BibTeX
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