Carlo Camilloni

Fellowship
Rudolf Mößbauer Tenure Track

Appointment
2015

Institution
University of Milano

Department
Biosciences

Focus Group
Integrative Structural Biology

Short CV

Professor Camilloni studied physics at the University of Milano-Bicocca and in 2008 obtained a PhD in physics from the University of Milano working in the protein-folding lab of Professor Broglia and Dr. Tiana. In 2009, after having worked for six months as an associate researcher at Rottapharm, he was awarded a long-term FEBS fellowship from the Federation of the European Biochemical Societies and joined the biophysics lab of Professor Vendruscolo at the Department of Chemistry of the University of Cambridge. From 2012 to 2015 he was an Intra-European Marie Curie researcher first and then a postdoctoral research associate at the University of Cambridge. In 2015 he took up an appointment as a Rudolf Mößbauer Assistant Professor at TUM where he led the Integrative Structural Biology research group in the Chemistry Faculty before transferring to the University of Milano in spring 2017.


Selected Awards

  • 2013, Clare Hall non-stipendiary Research Fellowship in Science, University of Cambridge
  • 2011, Marie Curie Intra-European Fellowship, European Research Council
  • 2009, Long-term FEBS Fellowship, Federation of the European Biochemical Societies 

Research Interests

Prof. Camilloni research is focused on molecular biophysics and in particular on the development and application of computational techniques for structural biology. He develops simulation techniques to integrate experimental, physical, chemical and statistical information in order to shed light on the molecular basis of biological processes. He also develops free-energy methods and he is one of the developers of PLUMED package. Biological applications include the self-assembly of proteins and nucleic acids and the characterization of the role of multiple conformational states in the regulation of signaling, protein misfolding and aggregation.


Selected Publications

  • Gianni, Stefano; Camilloni, Carlo; Giri, Rajanish; Toto, Angelo; Bonetti, Daniela; Morrone, Angela; Sormanni, Pietro; Brunori, Maurizio; Vendruscolo, Michele: Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein. Proceedings of the National Academy of Sciences 111 (39), 2014, 14141-14146.
  • Camilloni, C.; Sahakyan, A. B.; Holliday, M. J.; Isern, N. G.; Zhang, F.; Eisenmesser, E. Z.; Vendruscolo, M.: Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism. Proceedings of the National Academy of Sciences 111 (28), 2014, 10203-10208.
  • Camilloni, Carlo; Vendruscolo, Michele: Statistical Mechanics of the Denatured State of a Protein Using Replica-Averaged Metadynamics. J. Am. Chem. Soc. 136 (25), 2014, 8982-8991.
  • Tribello, Gareth A.; Bonomi, Massimiliano; Branduardi, Davide; Camilloni, Carlo; Bussi, Giovanni: PLUMED 2: New feathers for an old bird. Computer Physics Communications 185 (2), 2014, 604-613.
  • Granata, D.; Camilloni, C.; Vendruscolo, M.; Laio, A.: Characterization of the free-energy landscapes of proteins by NMR-guided metadynamics. Proceedings of the National Academy of Sciences 110 (17), 2013, 6817-6822.
  • Cavalli, Andrea; Camilloni, Carlo; Vendruscolo, Michele: Molecular dynamics simulations with replica-averaged structural restraints generate structural ensembles according to the maximum entropy principle. The Journal of Chemical Physics 138 (9), 2013, 094112.
  • Camilloni, Carlo; De Simone, Alfonso; Vranken, Wim F.; Vendruscolo, Michele: Determination of Secondary Structure Populations in Disordered States of Proteins Using Nuclear Magnetic Resonance Chemical Shifts. Biochemistry 51 (11), 2012, 2224-2231.
  • Camilloni, Carlo; Robustelli, Paul; Simone, Alfonso De; Cavalli, Andrea; Vendruscolo, Michele: Characterization of the Conformational Equilibrium between the Two Major Substates of RNase A Using NMR Chemical Shifts. J. Am. Chem. Soc. 134 (9), 2012, 3968-3971.

Publications as TUM-IAS-Fellow

2016

  • Bonomi, Massimiliano; Camilloni, Carlo; Cavalli, Andrea; Vendruscolo, Michele: Metainference: A Bayesian inference method for heterogeneous systems. Science Advances 2 (1), 2016, e1501177 more… BibTeX Full text ( DOI )
  • Bonomi, Massimiliano; Camilloni, Carlo; Vendruscolo, Michele: Metadynamic metainference: Enhanced sampling of the metainference ensemble using metadynamics. Scientific Reports 6 (1), 2016 more… BibTeX Full text ( DOI )
  • Cabrita, Lisa D; Cassaignau, Anaïs M E; Launay, Hélène M M; Waudby, Christopher A; Wlodarski, Tomasz; Camilloni, Carlo; Karyadi, Maria-Evangelia; Robertson, Amy L; Wang, Xiaolin; Wentink, Anne S; Goodsell, Luke S; Woolhead, Cheryl A; Vendruscolo, Michele; Dobson, Christopher M; Christodoulou, John: A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding. Nature Structural & Molecular Biology 23 (4), 2016, 278-285 more… BibTeX Full text ( DOI )
  • Camilloni, Carlo; Sala, Benedetta Maria; Sormanni, Pietro; Porcari, Riccardo; Corazza, Alessandra; De Rosa, Matteo; Zanini, Stefano; Barbiroli, Alberto; Esposito, Gennaro; Bolognesi, Martino; Bellotti, Vittorio; Vendruscolo, Michele; Ricagno, Stefano: Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability. Scientific Reports 6 (1), 2016 more… BibTeX Full text ( DOI )
  • Deckert, Annika; Waudby, Christopher A.; Wlodarski, Tomasz; Wentink, Anne S.; Wang, Xiaolin; Kirkpatrick, John P.; Paton, Jack F. S.; Camilloni, Carlo; Kukic, Predrag; Dobson, Christopher M.; Vendruscolo, Michele; Cabrita, Lisa D.; Christodoulou, John: Structural characterization of the interaction of a-synuclein nascent chains with the ribosomal surface and trigger factor. Proceedings of the National Academy of Sciences 113 (18), 2016, 5012-5017 more… BibTeX Full text ( DOI )
  • Meloni, Roberto; Camilloni, Carlo; Tiana, Guido: Properties of low-dimensional collective variables in the molecular dynamics of biopolymers. Physical Review E 94 (5), 2016 more… BibTeX Full text ( DOI )

2015

  • Brewer, Kyle D; Bacaj, Taulant; Cavalli, Andrea; Camilloni, Carlo; Swarbrick, James D; Liu, Jin; Zhou, Amy; Zhou, Peng; Barlow, Nicholas; Xu, Junjie; Seven, Alpay B; Prinslow, Eric A; Voleti, Rashmi; Häussinger, Daniel; Bonvin, Alexandre M J J; Tomchick, Diana R; Vendruscolo, Michele; Graham, Bim; Südhof, Thomas C; Rizo, Josep: Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution. Nat Struct Mol Biol 22 (7), 2015, 555-564 more… BibTeX Full text ( DOI )
  • Camilloni, Carlo; Vendruscolo, Michele: A Tensor-Free Method for the Structural and Dynamical Refinement of Proteins using Residual Dipolar Couplings. The Journal of Physical Chemistry B 119 (3), 2015, 653-661 more… BibTeX Full text ( DOI )