Most cancer drugs modulate the activity of malfunctioning proteins. However, it is often not clear how these drugs work and the molecular heterogeneity of tumors often render drugs ineffective. The goal of this Focus Group is to provide better treatment options to patients based on a detailed understanding of their tumor biology and exploiting the capabilities of existing targeted cancer drugs. full report …
Short CV
After studying chemistry at the University of Cologne, Professor Küster obtained his doctorate in biochemistry at the University of Oxford. He subsequently worked as a postdoctoral researcher in Heidelberg, Germany, and Odense, Denmark. Prior to becoming a full professor at TUM and until 2007 he was Vice President of Cellzome AG, a Heidelberg-based biotech company. Professor Küster is the Chair of the TUM Department of Biosciences, a member of the scientific council of the TUM Graduate School and co-director of the Bavarian Biomolecular Mass Spectrometry Center. He is a member of major research consortia including the SFBs 924, 1309 and 1321, the Excellence Cluster CiPSM, the German Consortium for Translational Cancer Research (DKTK) and the EU project EPIC-XS. Professor Küster is one of the founders of the biotech company OmicScouts GmbH.
Selected Awards
2019, ERC Advanced Grant
2019, Life Science Award of the German Society for mass spectrometry
2018, Carl von Linde Senior Fellow, TUM Institute for Advanced Study
2015, Discovery in Proteomic Sciences Award, Human Proteome Organization
2014, Heinz Maier-Leibnitz Medal, TUM
1998, Long-term fellow, European Molecular Biology Organization
1998, Mattauch-Herzog Award, German Mass Spectrometry Society
Research Interest
Most of our research builds on the powerful combination of chemistry, biochemistry, mass spectrometry and bioinformatics. We develop novel analytical methods for quantitative proteome research notably for high throughput applications and the analysis of post translational protein modifications (PTMs). In our chemical biology efforts, we elucidate the selectivity of drug-target interactions on a proteome-wide scale, investigate the cellular mechanisms by which drugs exert their function and identify mechanisms of cancer therapy resistance. In addition, we investigate phosphoproteomic signaling events as biomarkers for patient stratification, as well as indicators of drug effectiveness and treatment response. Our bioinformatic flagship project is ProteomicsDB that offers open access to data analytics on large-scale proteomics and transcriptomics projects. Right now, we are moving into clinical proteomics with the aim to assist therapeutic decision making in molecular tumor boards.
Alfaro, Javier Antonio; Bohländer, Peggy; Dai, Mingjie; Filius, Mike; Howard, Cecil J.; van Kooten, Xander F.; Ohayon, Shilo; Pomorski, Adam; Schmid, Sonja; Aksimentiev, Aleksei; Anslyn, Eric V.; Bedran, Georges; Cao, Chan; Chinappi, Mauro; Coyaud, Etienne; Dekker, Cees; Dittmar, Gunnar; Drachman, Nicholas; Eelkema, Rienk; Goodlett, David; Hentz, Sébastien; Kalathiya, Umesh; Kelleher, Neil L.; Kelly, Ryan T.; Kelman, Zvi; Kim, Sung Hyun; Kuster, Bernhard; Rodriguez-Larrea, David; Lindsay, Stuart; Maglia, Giovanni; Marcotte, Edward M.; Marino, John P.; Masselon, Christophe; Mayer, Michael; Samaras, Patroklos; Sarthak, Kumar; Sepiashvili, Lusia; Stein, Derek; Wanunu, Meni; Wilhelm, Mathias; Yin, Peng; Meller, Amit; Joo, Chirlmin: The emerging landscape of single-molecule protein sequencing technologies. Nature Methods 18 (6), 2021, 604-617 more…BibTeX
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Bian, Yangyang; Bayer, Florian P.; Chang, Yun-Chien; Meng, Chen; Hoefer, Stefanie; Deng, Nan; Zheng, Runsheng; Boychenko, Oleksandr; Kuster, Bernhard: Robust Microflow LC-MS/MS for Proteome Analysis: 38 000 Runs and Counting. Analytical Chemistry 93 (8), 2021, 3686-3690 more…BibTeX
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Breunig, Markus; Merkle, Jessica; Wagner, Martin; Melzer, Michael K.; Barth, Thomas F.E.; Engleitner, Thomas; Krumm, Johannes; Wiedenmann, Sandra; Cohrs, Christian M.; Perkhofer, Lukas; Jain, Gaurav; Krüger, Jana; Hermann, Patrick C.; Schmid, Maximilian; Madácsy, Tamara; Varga, Árpád; Griger, Joscha; Azoitei, Ninel; Müller, Martin; Wessely, Oliver; Robey, Pamela G.; Heller, Sandra; Dantes, Zahra; Reichert, Maximilian; Günes, Cagatay; Bolenz, Christian; Kuhn, Florian; Maléth, József; Speier, Stephan; Liebau, Stefan; Sipos, Bence; Kuster, Bernhard; Seufferlein, Thomas; Rad, Roland; Meier, Matthias; Hohwieler, Meike; Kleger, Alexander: Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells. Cell Stem Cell 28 (6), 2021, 1105-1124.e19 more…BibTeX
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Dieter, S. M., Siegl, C., Codo, P. L., Huerta, M., Ostermann-Parucha, A. L., Schulz, E., Zowada, M. K., Martin, S., Laaber, K., Nowrouzi, A., Blatter, M., Kreth, S., Westermann, F., Benner, A., Uhrig, U., Putzker, K., Lewis, J., Haegebarth, A., Mumberg, D., Holton, S. J., Weiske, J., Toepper, L.-M., Scheib, U., Siemeister, G., Ball, C. R., Kuster, B., Stoehr, G., Hahne, H., Johannes, S., Lange, M., Herbst, F. & Glimm, H.: Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. , 2021, more…BibTeX
Dölle, Anja; Adhikari, Bikash; Krämer, Andreas; Weckesser, Janik; Berner, Nicola; Berger, Lena-Marie; Diebold, Mathias; Szewczyk, Magdalena M.; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Gebel, Jakob; Löhr, Frank; Dötsch, Volker; Eilers, Martin; Heinzlmeir, Stephanie; Kuster, Bernhard; Sotriffer, Christoph; Wolf, Elmar; Knapp, Stefan: Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of Medicinal Chemistry, 2021 more…BibTeX
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Dölle, Anja; Adhikari, Bikash; Krämer, Andreas; Weckesser, Janik; Berner, Nicola; Berger, Lena-Marie; Diebold, Mathias; Szewczyk, Magdalena M.; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Gebel, Jakob; Löhr, Frank; Dötsch, Volker; Eilers, Martin; Heinzlmeir, Stephanie; Kuster, Bernhard; Sotriffer, Christoph; Wolf, Elmar; Knapp, Stefan: Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of Medicinal Chemistry, 2021 more…BibTeX
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Pal, Jagriti; Becker, Andrea C.; Dhamija, Sonam; Seiler, Jeanette; Abdelkarim, Mahmoud; Sharma, Yogita; Behr, Jürgen; Meng, Chen; Ludwig, Christina; Kuster, Bernhard; Diederichs, Sven: Systematic analysis of migration factors by MigExpress identifies essential cell migration control genes in non‐small cell lung cancer. Molecular Oncology, 2021 more…BibTeX
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Schmidt, Tobias; Samaras, Patroklos; Dorfer, Viktoria; Panse, Christian; Kockmann, Tobias; Bichmann, Leon; van Puyvelde, Bart; Perez-Riverol, Yasset; Deutsch, Eric W.; Kuster, Bernhard; Wilhelm, Mathias: Universal Spectrum Explorer: A Standalone (Web-)Application for Cross-Resource Spectrum Comparison. Journal of Proteome Research 20 (6), 2021, 3388-3394 more…BibTeX
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Selkrig, Joel; Stanifer, Megan; Mateus, André; Mitosch, Karin; Barrio‐Hernandez, Inigo; Rettel, Mandy; Kim, Heeyoung; Voogdt, Carlos G P; Walch, Philipp; Kee, Carmon; Kurzawa, Nils; Stein, Frank; Potel, Clément; Jarzab, Anna; Kuster, Bernhard; Bartenschlager, Ralf; Boulant, Steeve; Beltrao, Pedro; Typas, Athanasios; Savitski, Mikhail M: SARS‐CoV‐2 infection remodels the host protein thermal stability landscape. Molecular Systems Biology 17 (2), 2021 more…BibTeX
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Stukalov, Alexey; Girault, Virginie; Grass, Vincent; Karayel, Ozge; Bergant, Valter; Urban, Christian; Haas, Darya A.; Huang, Yiqi; Oubraham, Lila; Wang, Anqi; Hamad, M. Sabri; Piras, Antonio; Hansen, Fynn M.; Tanzer, Maria C.; Paron, Igor; Zinzula, Luca; Engleitner, Thomas; Reinecke, Maria; Lavacca, Teresa M.; Ehmann, Rosina; Wölfel, Roman; Jores, Jörg; Kuster, Bernhard; Protzer, Ulrike; Rad, Roland; Ziebuhr, John; Thiel, Volker; Scaturro, Pietro; Mann, Matthias; Pichlmair, Andreas: Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature, 2021 more…BibTeX
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Verbruggen, Steven; Gessulat, Siegfried; Gabriels, Ralf; Matsaroki, Anna; Van de Voorde, Hendrik; Kuster, Bernhard; Degroeve, Sven; Martens, Lennart; Van Criekinge, Wim; Wilhelm, Mathias; Menschaert, Gerben: Spectral prediction features as a solution for the search space size problem in proteogenomics. Molecular & Cellular Proteomics, 2021, 100076 more…BibTeX
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Wiechmann, Svenja; Ruprecht, Benjamin; Siekmann, Theresa; Zheng, Runsheng; Frejno, Martin; Kunold, Elena; Bajaj, Thomas; Zolg, Daniel P.; Sieber, Stephan A.; Gassen, Nils C.; Kuster, Bernhard: Chemical Phosphoproteomics Sheds New Light on the Targets and Modes of Action of AKT Inhibitors. ACS Chemical Biology 16 (4), 2021, 631-641 more…BibTeX
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Wilhelm, Mathias; Zolg, Daniel P.; Graber, Michael; Gessulat, Siegfried; Schmidt, Tobias; Schnatbaum, Karsten; Schwencke-Westphal, Celina; Seifert, Philipp; de Andrade Krätzig, Niklas; Zerweck, Johannes; Knaute, Tobias; Bräunlein, Eva; Samaras, Patroklos; Lautenbacher, Ludwig; Klaeger, Susan; Wenschuh, Holger; Rad, Roland; Delanghe, Bernard; Huhmer, Andreas; Carr, Steven A.; Clauser, Karl R.; Krackhardt, Angela M.; Reimer, Ulf; Kuster, Bernhard: Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics. Nature Communications 12 (1), 2021 more…BibTeX
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2020
Adhikari, B., Bozilovic, J., Diebold, M., Schwarz, J. D., Hofstetter, J., Schröder, M., Wanior, M., Narain, A., Vogt, M., Stankovic, N. D., Baluapuri, A., Schönemann, L., Eing, L., Bhandare, P., Kuster, B., Schlosser, A., Heinzlmeir, S., Sotriffer, C., Knapp, S. & Wolf, E.: Targeted protein degradation discriminates between structural and catalytic functions of AURORA-A kinase. Nat Chem Bio 16, 2020, 1179-1188 more…BibTeX
Bian, Yangyang; Zheng, Runsheng; Bayer, Florian P.; Wong, Cassandra; Chang, Yun-Chien; Meng, Chen; Zolg, Daniel P.; Reinecke, Maria; Zecha, Jana; Wiechmann, Svenja; Heinzlmeir, Stephanie; Scherr, Johannes; Hemmer, Bernhard; Baynham, Mike; Gingras, Anne-Claude; Boychenko, Oleksandr; Kuster, Bernhard: Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS. Nature Communications 11 (1), 2020 more…BibTeX
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Cheung, Tommy K.; Lee, Chien-Yun; Bayer, Florian P.; McCoy, Atticus; Kuster, Bernhard; Rose, Christopher M.: Defining the carrier proteome limit for single-cell proteomics. Nature Methods 18 (1), 2020, 76-83 more…BibTeX
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Cossa, Giacomo; Roeschert, Isabelle; Prinz, Florian; Baluapuri, Apoorva; Silveira Vidal, Raphael; Schülein-Völk, Christina; Chang, Yun-Chien; Ade, Carsten Patrick; Mastrobuoni, Guido; Girard, Cyrille; Kumar, Amit; Wortmann, Lars; Walz, Susanne; Lührmann, Reinhard; Kempa, Stefan; Kuster, Bernhard; Wolf, Elmar; Mumberg, Dominik; Eilers, Martin: Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription. Molecular Cell 77 (6), 2020, 1322-1339.e11 more…BibTeX
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Dietinger, Vanessa; García de Durango, Cira R.; Wiechmann, Svenja; Boos, Sophie L.; Michl, Marlies; Neumann, Jens; Hermeking, Heiko; Kuster, Bernhard; Jung, Peter: Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer. Cell Communication and Signaling 18 (1), 2020 more…BibTeX
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Djukovic, Ana; González-Barberá, Eva M.; Sanz, Jaime; Artacho, Alejandro; Peñaranda, Iván; Herrera, Beatriz; Garzón, María José; Salavert, Miguel; López-Hontangas, José Luis; Xavier, Karina B.; Kuster, Bernhard; Debrauwer, Laurent; Rolain, Jean-Marc; Sanz, Miguel A.; Xavier, Joao B.; Ubeda, Carles: High Heterogeneity of Multidrug-Resistant Enterobacteriaceae Fecal Levels in Hospitalized Patients Is Partially Driven by Intravenous β-Lactams. Antimicrobial Agents and Chemotherapy 64 (2), 2020 more…BibTeX
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Erhart, Friedrich; Hackl, Matthias; Hahne, Hannes; Buchroithner, Johanna; Meng, Chen; Klingenbrunner, Simone; Reitermaier, René; Fischhuber, Katrin; Skalicky, Susanna; Berger, Walter; Spiegl-Kreinecker, Sabine; Lötsch, Daniela; Ricken, Gerda; Kuster, Bernhard; Wöhrer, Adelheid; Widhalm, Georg; Hainfellner, Johannes; Felzmann, Thomas; Dohnal, Alexander M.; Marosi, Christine; Visus, Carmen: Combined proteomics/miRNomics of dendritic cell immunotherapy-treated glioblastoma patients as a screening for survival-associated factors. npj Vaccines 5 (1), 2020 more…BibTeX
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Erhart, Friedrich; Hackl, Matthias; Hahne, Hannes; Buchroithner, Johanna; Meng, Chen; Klingenbrunner, Simone; Reitermaier, René; Fischhuber, Katrin; Skalicky, Susanna; Berger, Walter; Spiegl-Kreinecker, Sabine; Lötsch, Daniela; Ricken, Gerda; Kuster, Bernhard; Wöhrer, Adelheid; Widhalm, Georg; Hainfellner, Johannes; Felzmann, Thomas; Dohnal, Alexander M.; Marosi, Christine; Visus, Carmen: Combined proteomics/miRNomics of dendritic cell immunotherapy-treated glioblastoma patients as a screening for survival-associated factors. npj Vaccines 5 (1), 2020 more…BibTeX
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Flosbach, Markus; Oberle, Susanne G.; Scherer, Stefanie; Zecha, Jana; von Hoesslin, Madlaina; Wiede, Florian; Chennupati, Vijaykumar; Cullen, Jolie G.; List, Markus; Pauling, Josch K.; Baumbach, Jan; Kuster, Bernhard; Tiganis, Tony; Zehn, Dietmar: PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells. Cell Reports 32 (4), 2020, 107957 more…BibTeX
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Hoermann, Bernhard; Kokot, Thomas; Helm, Dominic; Heinzlmeir, Stephanie; Chojnacki, Jeremy E.; Schubert, Thomas; Ludwig, Christina; Berteotti, Anna; Kurzawa, Nils; Kuster, Bernhard; Savitski, Mikhail M.; Köhn, Maja: Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A. Nature Communications 11 (1), 2020 more…BibTeX
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Jarzab, Anna; Kurzawa, Nils; Hopf, Thomas; Moerch, Matthias; Zecha, Jana; Leijten, Niels; Bian, Yangyang; Musiol, Eva; Maschberger, Melanie; Stoehr, Gabriele; Becher, Isabelle; Daly, Charlotte; Samaras, Patroklos; Mergner, Julia; Spanier, Britta; Angelov, Angel; Werner, Thilo; Bantscheff, Marcus; Wilhelm, Mathias; Klingenspor, Martin; Lemeer, Simone; Liebl, Wolfgang; Hahne, Hannes; Savitski, Mikhail M.; Kuster, Bernhard: Meltome atlas—thermal proteome stability across the tree of life. Nature Methods 17 (5), 2020, 495-503 more…BibTeX
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Kreutmair, Stefanie; Erlacher, Miriam; Andrieux, Geoffroy; Istvanffy, Rouzanna; Mueller-Rudorf, Alina; Zwick, Melissa; Rückert, Tamina; Pantic, Milena; Poggio, Teresa; Shoumariyeh, Khalid; Mueller, Tony A.; Kawaguchi, Hiroyuki; Follo, Marie; Klingeberg, Cathrin; Wlodarski, Marcin; Baumann, Irith; Pfeifer, Dietmar; Kulinski, Michal; Rudelius, Martina; Lemeer, Simone; Kuster, Bernhard; Dierks, Christine; Peschel, Christian; Cabezas-Wallscheid, Nina; Duque-Afonso, Jesus; Zeiser, Robert; Cleary, Michael L.; Schindler, Detlev; Schmitt-Graeff, Annette; Boerries, Melanie; Niemeyer, Charlotte M.; Oostendorp, Robert A.J.; Duyster, Justus; Illert, Anna Lena: Loss of the Fanconi anemia–associated protein NIPA causes bone marrow failure. Journal of Clinical Investigation 130 (6), 2020, 2827-2844 more…BibTeX
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Mergner, Julia; Frejno, Martin; Messerer, Maxim; Lang, Daniel; Samaras, Patroklos; Wilhelm, Mathias; Mayer, Klaus F. X.; Schwechheimer, Claus; Kuster, Bernhard: Proteomic and transcriptomic profiling of aerial organ development in Arabidopsis. Scientific Data 7 (1), 2020 more…BibTeX
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Montenegro, Raquel Carvalho; Howarth, Alison; Ceroni, Alessandro; Fedele, Vita; Farran, Batoul; Mesquita, Felipe Pantoja; Frejno, Martin; Berger, Benedict-Tilman; Heinzlmeir, Stephanie; Sailem, Heba Z.; Tesch, Roberta; Ebner, Daniel; Knapp, Stefan; Burbano, Rommel; Kuster, Bernhard; Müller, Susanne: Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib. Oncotarget 11 (5), 2020, 535-549 more…BibTeX
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Schöttl, Theresa; Pachl, Fiona; Giesbertz, Pieter; Daniel, Hannelore; Kuster, Bernhard; Fromme, Tobias; Klingenspor, Martin: Proteomic and Metabolite Profiling Reveals Profound Structural and Metabolic Reorganization of Adipocyte Mitochondria in Obesity. Obesity 28 (3), 2020, 590-600 more…BibTeX
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Searle, Brian C.; Swearingen, Kristian E.; Barnes, Christopher A.; Schmidt, Tobias; Gessulat, Siegfried; Küster, Bernhard; Wilhelm, Mathias: Generating high quality libraries for DIA MS with empirically corrected peptide predictions. Nature Communications 11 (1), 2020 more…BibTeX
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Sellmer, Andreas; Pilsl, Bernadette; Beyer, Mandy; Pongratz, Herwig; Wirth, Lukas; Elz, Sigurd; Dove, Stefan; Henninger, Sven Julian; Spiekermann, Karsten; Polzer, Harald; Klaeger, Susan; Kuster, Bernhard; Böhmer, Frank D.; Fiebig, Heinz-Herbert; Krämer, Oliver H.; Mahboobi, Siavosh: A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia. European Journal of Medicinal Chemistry 193, 2020, 112232 more…BibTeX
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Wiechmann, Svenja; Saupp, Elena; Schilling, Daniela; Heinzlmeir, Stephanie; Schneider, Günter; Schmid, Roland M.; Combs, Stephanie E.; Kuster, Bernhard; Dobiasch, Sophie: Radiosensitization by Kinase Inhibition Revealed by Phosphoproteomic Analysis of Pancreatic Cancer Cells. Molecular & Cellular Proteomics 19 (10), 2020, 1649-1663 more…BibTeX
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Zecha, Jana; Lee, Chien-Yun; Bayer, Florian P.; Meng, Chen; Grass, Vincent; Zerweck, Johannes; Schnatbaum, Karsten; Michler, Thomas; Pichlmair, Andreas; Ludwig, Christina; Kuster, Bernhard: Data, Reagents, Assays and Merits of Proteomics for SARS-CoV-2 Research and Testing. Molecular & Cellular Proteomics 19 (9), 2020, 1503-1522 more…BibTeX
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2019
Eraslan, Basak; Wang, Dongxue; Gusic, Mirjana; Prokisch, Holger; Hallström, Björn M; Uhlén, Mathias; Asplund, Anna; Pontén, Frederik; Wieland, Thomas; Hopf, Thomas; Hahne, Hannes; Kuster, Bernhard; Gagneur, Julien: Quantification and discovery of sequence determinants of protein‐per‐mRNA amount in 29 human tissues. Molecular Systems Biology 15 (2), 2019 more…BibTeX
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Gessulat, Siegfried; Schmidt, Tobias; Zolg, Daniel Paul; Samaras, Patroklos; Schnatbaum, Karsten; Zerweck, Johannes; Knaute, Tobias; Rechenberger, Julia; Delanghe, Bernard; Huhmer, Andreas; Reimer, Ulf; Ehrlich, Hans-Christian; Aiche, Stephan; Kuster, Bernhard; Wilhelm, Mathias: Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning. Nature Methods 16 (6), 2019, 509-518 more…BibTeX
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Gessulat, Siegfried; Schmidt, Tobias; Zolg, Daniel Paul; Samaras, Patroklos; Schnatbaum, Karsten; Zerweck, Johannes; Knaute, Tobias; Rechenberger, Julia; Delanghe, Bernard; Huhmer, Andreas; Reimer, Ulf; Ehrlich, Hans-Christian; Aiche, Stephan; Kuster, Bernhard; Wilhelm, Mathias: Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning. Nature Methods 16 (6), 2019, 509-518 more…BibTeX
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Kalde, Monika; Elliott, Liam; Ravikumar, Raksha; Rybak, Katarzyna; Altmann, Melina; Klaeger, Susan; Wiese, Christian; Abele, Miriam; Al, Benjamin; Kalbfuß, Nils; Qi, Xingyun; Steiner, Alexander; Meng, Chen; Zheng, Huanquan; Kuster, Bernhard; Falter‐Braun, Pascal; Ludwig, Christina; Moore, Ian; Assaad, Farhah F.: Interactions between Transport Protein Particle (TRAPP) complexes and RabGTPases in Arabidopsis. The Plant Journal 100 (2), 2019, 279-297 more…BibTeX
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Khakipoor, Shokoufeh; Giannaki, Marina; Theparambil, Shefeeq M.; Zecha, Jana; Küster, Bernhard; Heermann, Stephan; Deitmer, Joachim W.; Roussa, Eleni: Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255‐257 and regulated by mTOR. Glia 67 (12), 2019, 2264-2278 more…BibTeX
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Lalaoui, Rym; Djukovic, Ana; Bakour, Sofiane; Sanz, Jaime; Gonzalez-Barbera, Eva M.; Salavert, Miguel; López-Hontangas, Jose Luis; Sanz, Miguel A.; Xavier, Karina B.; Kuster, Bernhard; Debrauwer, Laurent; Ubeda, Carles; Rolain, Jean-Marc: Detection of plasmid-mediated colistin resistance, mcr-1 gene, in Escherichia coli isolated from high-risk patients with acute leukemia in Spain. Journal of Infection and Chemotherapy 25 (8), 2019, 605-609 more…BibTeX
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Le, Philipp; Kunold, Elena; Macsics, Robert; Rox, Katharina; Jennings, Megan C.; Ugur, Ilke; Reinecke, Maria; Chaves-Moreno, Diego; Hackl, Mathias W.; Fetzer, Christian; Mandl, Franziska A. M.; Lehmann, Johannes; Korotkov, Vadim S.; Hacker, Stephan M.; Kuster, Bernhard; Antes, Iris; Pieper, Dietmar H.; Rohde, Manfred; Wuest, William M.; Medina, Eva; Sieber, Stephan A.: Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms. Nature Chemistry 12 (2), 2019, 145-158 more…BibTeX
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Meng, Chen; Basunia, Azfar; Peters, Bjoern; Gholami, Amin Moghaddas; Kuster, Bernhard; Culhane, Aedín C.: MOGSA: Integrative Single Sample Gene-set Analysis of Multiple Omics Data. Molecular & Cellular Proteomics 18 (8), 2019, S153-S168 more…BibTeX
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Meng, Chen; Basunia, Azfar; Peters, Bjoern; Gholami, Amin Moghaddas; Kuster, Bernhard; Culhane, Aedín C.: MOGSA: Integrative Single Sample Gene-set Analysis of Multiple Omics Data. Molecular & Cellular Proteomics 18 (8 suppl 1), 2019, S153--S168 more…BibTeX
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Mucha, Stefanie; Heinzlmeir, Stephanie; Kriechbaumer, Verena; Strickland, Benjamin; Kirchhelle, Charlotte; Choudhary, Manisha; Kowalski, Natalie; Eichmann, Ruth; Hueckelhoven, Ralph; Grill, Erwin; Kuster, Bernhard; Glawischnig, Erich: The formation of a camalexin-biosynthetic metabolon. The Plant Cell, 2019, tpc.00403.2019 more…BibTeX
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Rechenberger, Julia; Samaras, Patroklos; Jarzab, Anna; Behr, Juergen; Frejno, Martin; Djukovic, Ana; Sanz, Jaime; González-Barberá, Eva M.; Salavert, Miguel; López-Hontangas, Jose Luis; Xavier, Karina B.; Debrauwer, Laurent; Rolain, Jean-Marc; Sanz, Miguel; Garcia-Garcera, Marc; Wilhelm, Mathias; Ubeda, Carles; Kuster, Bernhard: Challenges in Clinical Metaproteomics Highlighted by the Analysis of Acute Leukemia Patients with Gut Colonization by Multidrug-Resistant Enterobacteriaceae. Proteomes 7 (1), 2019, 2 more…BibTeX
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Rechenberger, Julia; Samaras, Patroklos; Jarzab, Anna; Behr, Juergen; Frejno, Martin; Djukovic, Ana; Sanz, Jaime; González-Barberá, Eva M.; Salavert, Miguel; López-Hontangas, Jose Luis; Xavier, Karina B.; Debrauwer, Laurent; Rolain, Jean-Marc; Sanz, Miguel; Garcia-Garcera, Marc; Wilhelm, Mathias; Ubeda, Carles; Kuster, Bernhard: Challenges in Clinical Metaproteomics Highlighted by the Analysis of Acute Leukemia Patients with Gut Colonization by Multidrug-Resistant Enterobacteriaceae. Proteomes 7 (1), 2019, 2 more…BibTeX
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Reinecke, Maria; Heinzlmeir, Stephanie; Wilhelm, Mathias; Médard, Guillaume; Klaeger, Susan; Kuster, Bernhard: Kinobeads: A Chemical Proteomic Approach for Kinase Inhibitor Selectivity Profiling and Target Discovery – 4. In: Target Discovery and Validation. John Wiley & Sons, Ltd, 2019, 97-130 more…BibTeX
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Reinecke, Maria; Ruprecht, Benjamin; Poser, Sandra; Wiechmann, Svenja; Wilhelm, Mathias; Heinzlmeir, Stephanie; Kuster, Bernhard; Médard, Guillaume: Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors. ACS Chemical Biology 14 (4), 2019, 655-664 more…BibTeX
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Reinecke, Maria; Ruprecht, Benjamin; Poser, Sandra; Wiechmann, Svenja; Wilhelm, Mathias; Heinzlmeir, Stephanie; Kuster, Bernhard; Médard, Guillaume: Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors. ACS Chemical Biology 14 (4), 2019, 655-664 more…BibTeX
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Ruschhaupt, Moritz; Mergner, Julia; Mucha, Stefanie; Papacek, Michael; Doch, Isabel; Tischer, Stefanie V; Hemmler, Daniel; Chiasson, David; Edel, Kai H; Kudla, Jörg; Schmitt‐Kopplin, Philippe; Kuster, Bernhard; Grill, Erwin: Rebuilding core abscisic acid signaling pathways of Arabidopsis in yeast. The EMBO Journal 38 (17), 2019 more…BibTeX
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Samaras, Patroklos; Schmidt, Tobias; Frejno, Martin; Gessulat, Siegfried; Reinecke, Maria; Jarzab, Anna; Zecha, Jana; Mergner, Julia; Giansanti, Piero; Ehrlich, Hans-Christian; Aiche, Stephan; Rank, Johannes; Kienegger, Harald; Krcmar, Helmut; Kuster, Bernhard; Wilhelm, Mathias: ProteomicsDB: a multi-omics and multi-organism resource for life science research. Nucleic Acids Research, 2019 more…BibTeX
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Samaras, Patroklos; Schmidt, Tobias; Frejno, Martin; Gessulat, Siegfried; Reinecke, Maria; Jarzab, Anna; Zecha, Jana; Mergner, Julia; Giansanti, Piero; Ehrlich, Hans-Christian; Aiche, Stephan; Rank, Johannes; Kienegger, Harald; Krcmar, Helmut; Kuster, Bernhard; Wilhelm, Mathias: ProteomicsDB: a multi-omics and multi-organism resource for life science research. Nucleic Acids Research, 2019 more…BibTeX
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Samaras, Patroklos; Schmidt, Tobias; Frejno, Martin; Gessulat, Siegfried; Reinecke, Maria; Jarzab, Anna; Zecha, Jana; Mergner, Julia; Giansanti, Piero; Ehrlich, Hans-Christian; Aiche, Stephan; Rank, Johannes; Kienegger, Harald; Krcmar, Helmut; Kuster, Bernhard; Wilhelm, Mathias: ProteomicsDB: a multi-omics and multi-organism resource for life science research. Nucleic Acids Research, 2019 more…BibTeX
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Schirle, Markus; Bantscheff, Marcus; Kuster, Bernhard: Characterization of Drug-Protein Interactions by Chemoproteomics. In: Proteomics for Biological Discovery. John Wiley & Sons, Inc., 2019 more…BibTeX
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Schirle, Markus; Bantscheff, Marcus; Kuster, Bernhard: Characterization of Drug-Protein Interactions by Chemoproteomics. In: Proteomics for Biological Discovery. John Wiley & Sons, Inc., 2019 more…BibTeX
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Seefried, Florian; Schmidt, Tobias; Reinecke, Maria; Heinzlmeir, Stephanie; Kuster, Bernhard; Wilhelm, Mathias: CiRCus: A Framework to Enable Classification of Complex High-Throughput Experiments. Journal of Proteome Research 18 (4), 2019, 1486-1493 more…BibTeX
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Seefried, Florian; Schmidt, Tobias; Reinecke, Maria; Heinzlmeir, Stephanie; Kuster, Bernhard; Wilhelm, Mathias: CiRCus: A Framework to Enable Classification of Complex High-Throughput Experiments. Journal of Proteome Research 18 (4), 2019, 1486-1493 more…BibTeX
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Verbruggen, Steven; Ndah, Elvis; Van Criekinge, Wim; Gessulat, Siegfried; Kuster, Bernhard; Wilhelm, Mathias; Van Damme, Petra; Menschaert, Gerben: PROTEOFORMER 2.0: Further Developments in the Ribosome Profiling-assisted Proteogenomic Hunt for New Proteoforms. Molecular & Cellular Proteomics 18 (8), 2019, S126-S140 more…BibTeX
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Wang, Dongxue; Eraslan, Basak; Wieland, Thomas; Hallström, Björn; Hopf, Thomas; Zolg, Daniel Paul; Zecha, Jana; Asplund, Anna; Li, Li‐hua; Meng, Chen; Frejno, Martin; Schmidt, Tobias; Schnatbaum, Karsten; Wilhelm, Mathias; Ponten, Frederik; Uhlen, Mathias; Gagneur, Julien; Hahne, Hannes; Kuster, Bernhard: A deep proteome and transcriptome abundance atlas of 29 healthy human tissues. Molecular Systems Biology 15 (2), 2019 more…BibTeX
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Wang, Dongxue; Eraslan, Basak; Wieland, Thomas; Hallström, Björn; Hopf, Thomas; Zolg, Daniel Paul; Zecha, Jana; Asplund, Anna; Li, Li‐hua; Meng, Chen; Frejno, Martin; Schmidt, Tobias; Schnatbaum, Karsten; Wilhelm, Mathias; Ponten, Frederik; Uhlen, Mathias; Gagneur, Julien; Hahne, Hannes; Kuster, Bernhard: A deep proteome and transcriptome abundance atlas of 29 healthy human tissues. Molecular Systems Biology 15 (2), 2019 more…BibTeX
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Zecha, Jana; Satpathy, Shankha; Kanashova, Tamara; Avanessian, Shayan C.; Kane, M. Harry; Clauser, Karl R.; Mertins, Philipp; Carr, Steven A.; Kuster, Bernhard: TMT Labeling for the Masses: A Robust and Cost-efficient, In-solution Labeling Approach. Molecular & Cellular Proteomics 18 (7), 2019, 1468-1478 more…BibTeX
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Zecha, Jana; Satpathy, Shankha; Kanashova, Tamara; Avanessian, Shayan C.; Kane, M. Harry; Clauser, Karl R.; Mertins, Philipp; Carr, Steven A.; Kuster, Bernhard: TMT Labeling for the Masses: A Robust and Cost-efficient, In-solution Labeling Approach. Molecular & Cellular Proteomics 18 (7), 2019, 1468-1478 more…BibTeX
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Zhang, Bing; Kuster, Bernhard: Proteomics Is Not an Island: Multi-omics Integration Is the Key to Understanding Biological Systems. Molecular & Cellular Proteomics 18 (8), 2019, S1-S4 more…BibTeX
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Zhang, Bing; Kuster, Bernhard: Proteomics Is Not an Island: Multi-omics Integration Is the Key to Understanding Biological Systems. Molecular & Cellular Proteomics 18 (8 suppl 1), 2019, S1-S4 more…BibTeX
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2018
Bader, Matthias; Dunkel, Andreas; Wenning, Mareike; Kohler, Bernd; Medard, Guillaume; del Castillo, Estela; Gholami, Amin; Kuster, Bernhard; Scherer, Siegfried; Hofmann, Thomas: Dynamic Proteome Alteration and Functional Modulation of Human Saliva Induced by Dietary Chemosensory Stimuli. Journal of Agricultural and Food Chemistry 66 (22), 2018, 5621-5634 more…BibTeX
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Buhner, Sabine; Hahne, Hannes; Hartwig, Kerstin; Li, Qin; Vignali, Sheila; Ostertag, Daniela; Meng, Chen; Hörmannsperger, Gabriele; Braak, Breg; Pehl, Christian; Frieling, Thomas; Barbara, Giovanni; De Giorgio, Roberto; Demir, Ihsan Ekin; Ceyhan, Güralp Onur; Zeller, Florian; Boeckxstaens, Guy; Haller, Dirk; Kuster, Bernhard; Schemann, Michael: Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients. PLOS ONE 13 (3), 2018, e0193943 more…BibTeX
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Deutsch, Eric W.; Perez-Riverol, Yasset; Chalkley, Robert J.; Wilhelm, Mathias; Tate, Stephen; Sachsenberg, Timo; Walzer, Mathias; Käll, Lukas; Delanghe, Bernard; Böcker, Sebastian; Schymanski, Emma L.; Wilmes, Paul; Dorfer, Viktoria; Kuster, Bernhard; Volders, Pieter-Jan; Jehmlich, Nico; Vissers, Johannes P. C.; Wolan, Dennis W.; Wang, Ana Y.; Mendoza, Luis; Shofstahl, Jim; Dowsey, Andrew W.; Griss, Johannes; Salek, Reza M.; Neumann, Steffen; Binz, Pierre-Alain; Lam, Henry; Vizcaíno, Juan Antonio; Bandeira, Nuno; Röst, Hannes: Expanding the Use of Spectral Libraries in Proteomics. Journal of Proteome Research 17 (12), 2018, 4051-4060 more…BibTeX
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Kindt, Alida; Liebisch, Gerhard; Clavel, Thomas; Haller, Dirk; Hörmannsperger, Gabriele; Yoon, Hongsup; Kolmeder, Daniela; Sigruener, Alexander; Krautbauer, Sabrina; Seeliger, Claudine; Ganzha, Alexandra; Schweizer, Sabine; Morisset, Rosalie; Strowig, Till; Daniel, Hannelore; Helm, Dominic; Küster, Bernhard; Krumsiek, Jan; Ecker, Josef: The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice. Nature Communications 9 (1), 2018 more…BibTeX
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Lee, Chien-Yun; Wang, Dongxue; Wilhelm, Mathias; Zolg, Daniel P.; Schmidt, Tobias; Schnatbaum, Karsten; Reimer, Ulf; Pontén, Fredrik; Uhlén, Mathias; Hahne, Hannes; Kuster, Bernhard: Mining the Human Tissue Proteome for Protein Citrullination. Molecular & Cellular Proteomics 17 (7), 2018, 1378-1391 more…BibTeX
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Mulder, Celine; Prust, Nadine; van Doorn, Sander; Reinecke, Maria; Kuster, Bernhard; van Bergen en Henegouwen, Paul; Lemeer, Simone: Adaptive Resistance to EGFR-Targeted Therapy by Calcium Signaling in NSCLC Cells. Molecular Cancer Research 16 (11), 2018, 1773-1784 more…BibTeX
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Prechtl, Roman M.; Janßen, Dorothee; Behr, Jürgen; Ludwig, Christina; Küster, Bernhard; Vogel, Rudi F.; Jakob, Frank: Sucrose-Induced Proteomic Response and Carbohydrate Utilization of Lactobacillus sakei TMW 1.411 During Dextran Formation. Frontiers in Microbiology 9, 2018 more…BibTeX
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Tröster, Alix; Heinzlmeir, Stephanie; Berger, Benedict-Tilman; Gande, Santosh L.; Saxena, Krishna; Sreeramulu, Sridhar; Linhard, Verena; Nasiri, Amir H.; Bolte, Michael; Müller, Susanne; Kuster, Bernhard; Médard, Guillaume; Kudlinzki, Denis; Schwalbe, Harald: NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. ChemMedChem 13 (16), 2018, 1629-1633 more…BibTeX
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Yoon, Hongsup; Schaubeck, Monika; Lagkouvardos, Ilias; Blesl, Andreas; Heinzlmeir, Stephanie; Hahne, Hannes; Clavel, Thomas; Panda, Suchita; Ludwig, Christina; Kuster, Bernhard; Manichanh, Chaysavanh; Kump, Patrizia; Haller, Dirk; Hörmannsperger, Gabriele: Increased Pancreatic Protease Activity in Response to Antibiotics Impairs Gut Barrier and Triggers Colitis. Cellular and Molecular Gastroenterology and Hepatology 6 (3), 2018, 370-388.e3 more…BibTeX
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Zecha, Jana; Meng, Chen; Zolg, Daniel Paul; Samaras, Patroklos; Wilhelm, Mathias; Kuster, Bernhard: Peptide Level Turnover Measurements Enable the Study of Proteoform Dynamics. Molecular & Cellular Proteomics 17 (5), 2018, 974-992 more…BibTeX
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Zecha, Jana; Meng, Chen; Zolg, Daniel Paul; Samaras, Patroklos; Wilhelm, Mathias; Kuster, Bernhard: Peptide Level Turnover Measurements Enable the Study of Proteoform Dynamics. Molecular & Cellular Proteomics 17 (5), 2018, 974-992 more…BibTeX
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Zolg, Daniel Paul; Wilhelm, Mathias; Schmidt, Tobias; Médard, Guillaume; Zerweck, Johannes; Knaute, Tobias; Wenschuh, Holger; Reimer, Ulf; Schnatbaum, Karsten; Kuster, Bernhard: ProteomeTools: Systematic Characterization of 21 Post-translational Protein Modifications by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Using Synthetic Peptides. Molecular & Cellular Proteomics 17 (9), 2018, 1850-1863 more…BibTeX
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2017
Jiang, Li; Zhang, Bodong; Médard, Guillaume; Seitsonen, Ari Paavo; Haag, Felix; Allegretti, Francesco; Reichert, Joachim; Kuster, Bernhard; Barth, Johannes V.; Papageorgiou, Anthoula C.: N-Heterocyclic carbenes on close-packed coinage metal surfaces: bis-carbene metal adatom bonding scheme of monolayer films on Au, Ag and Cu. Chemical Science 8 (12), 2017, 8301-8308 more…BibTeX
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