Skip to content
Technical University of Munich

Horst Kessler

Fellowship
Carl von Linde Senior Fellow

Appointment
2008

Institution
Technical University of Munich

Department
Organic Chemistry and Biochemistry

Focus Group
Biochemistry

Short CV

Horst Kessler was born in Suhl, Thuringia. He studied chemistry in Leipzig and Tübingen. He received his diploma in chemistry in 1963 and he was awarded his Ph.D. in 1966. He earned both degrees at University of Tübingen (dissertation: “Kupfersalz-katalysierte Reaktionen von Diazomethan mit Aromaten”).
Three years later he qualified as a professor (Habilitation) in Organic Chemistry (topic: „Nachweis innermolekularer Beweglichkeit durch NMR-Spektroskopie“). From 1971 to 1988 Kessler worked as Full Professor at J.W. Goethe University in Frankfurt/Main at the Department of Organic Chemistry.
The next twenty years he spent at the Technische Unversität München as Full Professor at the Department of Organic Chemistry and Biochemistry.
Since October 2008 he is a Carl von Linde Professor (Emeritus Professor of Excellence) at the Institute for Advanced Study at TUM. Kessler has also held visiting appointments at several universities in Halifax, Tokyo, Madison, Haifa, Austin and Jerusalem. Moreover he holds several honorary posts and is member of the Editorial Board of renowned chemical journals.

Selected Awards

  • 2009, Honory Member of the Israel Chemical Society
  • 2008, Josef Rudinger Award, European Peptide Society
  • 2005, Burkhardt Helferich Award
  • 2002, Vincent Du Vigneaud Award, American Peptide Society
  • 2002, Hans-Herloff Inhoffen Medal
  • 2002, Honorary doctoral degree, University of Leipzig
  • 2002, Member German Academy of Sciences Leopoldina
  • 2001, Max-Planck-Research Award
  • 1997, Emil Fischer Medal
  • 1996, Member Bavarian Academy of Science
  • 1988, Max-Bergmann-Medal for Peptide Chemistry
  • 1986, Otto-Bayer-Award

Research Interes

The following topics represent the core of Kessler’s research: rational design of molecules on the basis of conformation, the synthesis and structure of peptides and peptidmimetica and the development and application of NMR-techniques and calculation methods for the identification of molecule structures.

Selected Publications

  • Heckmann, Dominik; Meyer, Axel; Marinelli, Luciana; Zahn, Grit; Stragies, Roland; Kessler, Horst: Probing Integrin Selectivity: Rational Design of Highly Active and Selective Ligands for the α5β1 and αvβ3 Integrin Receptor. Angewandte Chemie International Edition 46 (19), 2007, 3571-3574.
  • Meyer, A.; Auernheimer, J.; Modlinger, A.; Kessler, H.: Targeting RGD Recognizing Integrins: Drug Development, Biomaterial Research, Tumor Imaging and Targeting. CPD 12 (22), 2006, 2723-2747.
  • Haubner, Roland; Weber, Wolfgang A; Beer, Ambros J; Vabuliene, Eugenija; Reim, Daniel; Sarbia, Mario; Becker, Karl-Friedrich; Goebel, Michael; Hein, Rüdiger; Wester, Hans-Jürgen; Kessler, Horst; Schwaiger, Markus: Noninvasive Visualization of the Activated αvβ3 Integrin in Cancer Patients by Positron Emission Tomography and [18F]Galacto-RGD. PLoS Med 2 (3), 2005, e70.
  • Hersel, Ulrich; Dahmen, Claudia; Kessler, Horst: RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials 24 (24), 2003, 4385-4415.
  • Dechantsreiter, Michael A.; Planker, Eckart; Mathä, Barbara; Lohof, Elisabeth; Hölzemann, Günter; Jonczyk, Alfred; Goodman, Simon L.; Kessler, Horst: N -Methylated Cyclic RGD Peptides as Highly Active and Selective α V β 3 Integrin Antagonists. J. Med. Chem. 42 (16), 1999, 3033-3040.
  • Kessler, H; Oschkinat, H; Griesinger, C; Bermel, W: Transformation of homonuclear two-dimensional NMR techniques into one-dimensional techniques using Gaussian pulses. Journal of Magnetic Resonance (1969) 70 (1), 1986, 106-133.
  • Kessler, H; Griesinger, C; Zarbock, J; Loosli, H.R: Assignment of carbonyl carbons and sequence analysis in peptides by heteronuclear shift correlation via small coupling constants with broadband decoupling in t1 (COLOC). Journal of Magnetic Resonance (1969) 57 (2), 1984, 331-336.
  • Kessler, Horst: Conformation and Biological Activity of Cyclic Peptides. Angewandte Chemie International Edition in English 21 (7), 1982, 512-523.
  • Kessler, Horst: Detection of Hindered Rotation and Inversion by NMR Spectroscopy. Angewandte Chemie International Edition in English 9 (3), 1970, 219-235.

For a full publication list please see here.

Publications as TUM-IAS-Fellow

2018

  • Di Leva, Francesco Saverio; Tomassi, Stefano; Di Maro, Salvatore; Reichart, Florian; Notni, Johannes; Dangi, Abha; Marelli, Udaya Kiran; Brancaccio, Diego; Merlino, Francesco; Wester, Hans-Jürgen; Novellino, Ettore; Kessler, Horst; Marinelli, Luciana: From a Helix to a Small Cycle: Metadynamics-Inspired αvβ6 Integrin Selective Ligands. Angewandte Chemie International Edition 57 (44), 2018, 14645-14649 more… BibTeX Full text ( DOI )
  • Durek, Thomas; Cromm, Philipp M.; White, Andrew M.; Schroeder, Christina I.; Kaas, Quentin; Weidmann, Joachim; Ahmad Fuaad, Abdullah; Cheneval, Olivier; Harvey, Peta J.; Daly, Norelle L.; Zhou, Yang; Dellsén, Anita; Österlund, Torben; Larsson, Niklas; Knerr, Laurent; Bauer, Udo; Kessler, Horst; Cai, Minying; Hruby, Victor J.; Plowright, Alleyn T.; Craik, David J.: Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1. Journal of Medicinal Chemistry 61 (8), 2018, 3674-3684 more… BibTeX Full text ( DOI )
  • Färber, Stefanie Felicitas; Wurzer, Alexander; Reichart, Florian; Beck, Roswitha; Kessler, Horst; Wester, Hans-Jürgen; Notni, Johannes: Therapeutic Radiopharmaceuticals Targeting Integrin αvβ6. ACS Omega 3 (2), 2018, 2428-2436 more… BibTeX Full text ( DOI )
  • Guasch, Judith; Hoffmann, Marco; Diemer, Jennifer; Riahinezhad, Hossein; Neubauer, Stefanie; Kessler, Horst; Spatz, Joachim P.: Combining Adhesive Nanostructured Surfaces and Costimulatory Signals to Increase T Cell Activation. Nano Letters 18 (9), 2018, 5899-5904 more… BibTeX Full text ( DOI )
  • Kapp, Tobias G.; Di Leva, Francesco Saverio; Notni, Johannes; Räder, Andreas F. B.; Fottner, Maximilian; Reichart, Florian; Reich, Dominik; Wurzer, Alexander; Steiger, Katja; Novellino, Ettore; Marelli, Udaya Kiran; Wester, Hans-Jürgen; Marinelli, Luciana; Kessler, Horst: N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent. Journal of Medicinal Chemistry 61 (6), 2018, 2490-2499 more… BibTeX Full text ( DOI )
  • Merlino, Francesco; Daniele, Simona; La Pietra, Valeria; Di Maro, Salvatore; Di Leva, Francesco Saverio; Brancaccio, Diego; Tomassi, Stefano; Giuntini, Stefano; Cerofolini, Linda; Fragai, Marco; Luchinat, Claudio; Reichart, Florian; Cavallini, Chiara; Costa, Barbara; Piccarducci, Rebecca; Taliani, Sabrina; Da Settimo, Federico; Martini, Claudia; Kessler, Horst; Novellino, Ettore; Marinelli, Luciana: Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme. Journal of Medicinal Chemistry 61 (11), 2018, 4791-4809 more… BibTeX Full text ( DOI )
  • Räder, Andreas F. B.; Weinmüller, Michael; Reichart, Florian; Schumacher-Klinger, Adi; Merzbach, Shira; Gilon, Chaim; Hoffman, Amnon; Kessler, Horst: Orally Active Peptides: Is There a Magic Bullet? Angewandte Chemie International Edition 57 (44), 2018, 14414-14438 more… BibTeX Full text ( DOI )
  • Räder, Andreas F.B.; Reichart, Florian; Weinmüller, Michael; Kessler, Horst: Improving oral bioavailability of cyclic peptides by N -methylation. Bioorganic & Medicinal Chemistry 26 (10), 2018, 2766-2773 more… BibTeX Full text ( DOI )
  • Schumacher-Klinger, Adi; Fanous, Joseph; Merzbach, Shira; Weinmüller, Michael; Reichart, Florian; Räder, Andreas F. B.; Gitlin-Domagalska, Agata; Gilon, Chaim; Kessler, Horst; Hoffman, Amnon: Enhancing Oral Bioavailability of Cyclic RGD Hexa-peptides by the Lipophilic Prodrug Charge Masking Approach: Redirection of Peptide Intestinal Permeability from a Paracellular to Transcellular Pathway. Molecular Pharmaceutics 15 (8), 2018, 3468-3477 more… BibTeX Full text ( DOI )

2017

  • Cai, Minying; Marelli, Udaya Kiran; Mertz, Blake; Beck, Johannes G.; Opperer, Florian; Rechenmacher, Florian; Kessler, Horst; Hruby, Victor J.: Structural Insights into Selective Ligand–Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists. Biochemistry 56 (32), 2017, 4201-4209 more… BibTeX Full text ( DOI )
  • Fraioli, Roberta; Tsimbouri, Penelope M.; Fisher, Leanne E.; Nobbs, Angela H.; Su, Bo; Neubauer, Stefanie; Rechenmacher, Florian; Kessler, Horst; Ginebra, Maria-Pau; Dalby, Matthew J.; Manero, José M.; Mas-Moruno, Carlos: Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands. Scientific Reports 7 (1), 2017 more… BibTeX Full text ( DOI )
  • Kapp, Tobias G.; Rechenmacher, Florian; Neubauer, Stefanie; Maltsev, Oleg V.; Cavalcanti-Adam, Elisabetta A.; Zarka, Revital; Reuning, Ute; Notni, Johannes; Wester, Hans-Jürgen; Mas-Moruno, Carlos; Spatz, Joachim; Geiger, Benjamin; Kessler, Horst: A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins. Scientific Reports 7 (1), 2017 more… BibTeX Full text ( DOI )
  • Ma, Xiaopeng; Phi Van, Valerie; Kimm, Melanie A.; Prakash, Jaya; Kessler, Horst; Kosanke, Katja; Feuchtinger, Annette; Aichler, Michaela; Gupta, Aayush; Rummeny, Ernst J.; Eisenblätter, Michel; Siveke, Jens; Walch, Axel K.; Braren, Rickmer; Ntziachristos, Vasilis; Wildgruber, Moritz: Integrin-Targeted Hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography for Imaging Tumor Progression and Early Response in Non-Small Cell Lung Cancer. Neoplasia 19 (1), 2017, 8-16 more… BibTeX Full text ( DOI )
  • Missirlis, Dimitris; Haraszti, Tamás; Kessler, Horst; Spatz, Joachim P.: Fibronectin promotes directional persistence in fibroblast migration through interactions with both its cell-binding and heparin-binding domains. Scientific Reports 7 (1), 2017 more… BibTeX Full text ( DOI )
  • Nieberler, Markus; Reuning, Ute; Reichart, Florian; Notni, Johannes; Wester, Hans-Jürgen; Schwaiger, Markus; Weinmüller, Michael; Räder, Andreas; Steiger, Katja; Kessler, Horst: Exploring the Role of RGD-Recognizing Integrins in Cancer. Cancers 9 (12), 2017, 116 more… BibTeX Full text ( DOI )
  • Pallarola, Diego; Bochen, Alexander; Guglielmotti, Victoria; Oswald, Tabea A.; Kessler, Horst; Spatz, Joachim P.: Highly Ordered Gold Nanopatterned Indium Tin Oxide Electrodes for Simultaneous Optical and Electrochemical Probing Cell Interactions. Analytical Chemistry 89 (18), 2017, 10054-10062 more… BibTeX Full text ( DOI )
  • Pallarola, Diego; Platzman, Ilia; Bochen, Alexander; Cavalcanti-Adam, Elisabetta A.; Axmann, Markus; Kessler, Horst; Geiger, Benjamin; Spatz, Joachim P.: Focal adhesion stabilization by enhanced integrin-cRGD binding affinity. BioNanoMaterials 18 (1-2), 2017 more… BibTeX Full text ( DOI )
  • Weinmüller, Michael; Rechenmacher, Florian; Kiran Marelli, Udaya; Reichart, Florian; Kapp, Tobias G.; Räder, Andreas F. B.; Di Leva, Francesco Saverio; Marinelli, Luciana; Novellino, Ettore; Muñoz-Félix, José M.; Hodivala-Dilke, Kairbaan; Schumacher, Adi; Fanous, Joseph; Gilon, Chaim; Hoffman, Amnon; Kessler, Horst: Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3. Angewandte Chemie International Edition 56 (51), 2017, 16405-16409 more… BibTeX Full text ( DOI )

2016

  • Enthart, Andreas; Klein, Christian; Dehner, Alexander; Coles, Murray; Gemmecker, Gerd; Kessler, Horst; Hagn, Franz: Solution structure and binding specificity of the p63 DNA binding domain. Scientific Reports 6 (1), 2016 more… BibTeX Full text ( DOI )
  • Mas-Moruno, Carlos; Fraioli, Roberta; Rechenmacher, Florian; Neubauer, Stefanie; Kapp, Tobias G.; Kessler, Horst: αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating. Angewandte Chemie International Edition 55 (25), 2016, 7048-7067 more… BibTeX Full text ( DOI )
  • Missirlis, Dimitris; Haraszti, Tamás; Scheele, Catharina v. C.; Wiegand, Tina; Diaz, Carolina; Neubauer, Stefanie; Rechenmacher, Florian; Kessler, Horst; Spatz, Joachim P.: Substrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin. Scientific Reports 6 (1), 2016 more… BibTeX Full text ( DOI )
  • Notni, Johannes; Reich, Dominik; Maltsev, Oleg V.; Kapp, Tobias G.; Steiger, Katja; Hoffmann, Frauke; Esposito, Irene; Weichert, Wilko; Kessler, Horst; Wester, Hans-Jürgen: In Vivo PET Imaging of the Cancer Integrin αvβ6 Using 68 Ga-Labeled Cyclic RGD Nonapeptides. Journal of Nuclear Medicine 58 (4), 2016, 671-677 more… BibTeX Full text ( DOI )
  • Schaufler, Viktoria; Czichos-Medda, Helmi; Hirschfeld-Warnecken, Vera; Neubauer, Stefanie; Rechenmacher, Florian; Medda, Rebecca; Kessler, Horst; Geiger, Benjamin; Spatz, Joachim P.; Cavalcanti-Adam, E. Ada: Selective binding and lateral clustering of α5β1 and αvβ3 integrins: Unraveling the spatial requirements for cell spreading and focal adhesion assembly. Cell Adhesion & Migration 10 (5), 2016, 505-515 more… BibTeX Full text ( DOI )

2015

  • Cai, Minying; Marelli, Udaya Kiran; Bao, Jennifer; Beck, Johannes G.; Opperer, Florian; Rechenmacher, Florian; McLeod, Kaitlyn R.; Zingsheim, Morgan R.; Doedens, Lucas; Kessler, Horst; Hruby, Victor J.: Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors. Journal of Medicinal Chemistry 58 (16), 2015, 6359-6367 more… BibTeX Full text ( DOI )
  • D’Alessandria, Calogero; Pohle, Karolin; Rechenmacher, Florian; Neubauer, Stefanie; Notni, Johannes; Wester, Hans-Jürgen; Schwaiger, Markus; Kessler, Horst; Beer, Ambros J.: In vivo biokinetic and metabolic characterization of the 68Ga-labelled α5β1-selective peptidomimetic FR366. European Journal of Nuclear Medicine and Molecular Imaging 43 (5), 2015, 953-963 more… BibTeX Full text ( DOI )
  • Fraioli, Roberta; Rechenmacher, Florian; Neubauer, Stefanie; Manero, José M.; Gil, Javier; Kessler, Horst; Mas-Moruno, Carlos: Mimicking bone extracellular matrix: Integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium. Colloids and Surfaces B: Biointerfaces 128, 2015, 191-200 more… BibTeX Full text ( DOI )
  • Frank, Andreas O.; Freudenberger, J. Christoph; Shaytan, Alexey K.; Kessler, Horst; Luy, Burkhard: Direct prediction of residual dipolar couplings of small molecules in a stretched gel by stochastic molecular dynamics simulations. Magnetic Resonance in Chemistry 53 (3), 2015, 213-217 more… BibTeX Full text ( DOI )
  • Frohnmayer, Johannes P.; Brüggemann, Dorothea; Eberhard, Christian; Neubauer, Stefanie; Mollenhauer, Christine; Boehm, Heike; Kessler, Horst; Geiger, Benjamin; Spatz, Joachim P.: Synthetische Adhäsion von Integrin-Liposomen als minimales Zellmodell. Angewandte Chemie 127 (42), 2015, 12649-12655 more… BibTeX Full text ( DOI )
  • Frohnmayer, Johannes P.; Brüggemann, Dorothea; Eberhard, Christian; Neubauer, Stefanie; Mollenhauer, Christine; Boehm, Heike; Kessler, Horst; Geiger, Benjamin; Spatz, Joachim P.: Minimal Synthetic Cells to Study Integrin-Mediated Adhesion. Angewandte Chemie International Edition 54 (42), 2015, 12472-12478 more… BibTeX Full text ( DOI )
  • Herranz-Diez, C.; Li, Q.; Lamprecht, C.; Mas-Moruno, C.; Neubauer, S.; Kessler, H.; Manero, J.M.; Guillem-Martí, J.; Selhuber-Unkel, C.: Bioactive compounds immobilized on Ti and TiNbHf: AFM-based investigations of biofunctionalization efficiency and cell adhesion. Colloids and Surfaces B: Biointerfaces 136, 2015, 704-711 more… BibTeX Full text ( DOI )
  • Jung, Alain C.; Ray, Anne-Marie; Ramolu, Ludivine; Macabre, Christine; Simon, Florian; Noulet, Fanny; Blandin, Anne-Florence; Renner, Guillaume; Lehmann, Maxime; Choulier, Laurence; Kessler, Horst; Abecassis, Joseph; Dontenwill, Monique; Martin, Sophie: Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties. Oncotarget 6 (39), 2015 more… BibTeX Full text ( DOI )
  • Kapp, Tobias G.; Fottner, Maximilian; Maltsev, Oleg V.; Kessler, Horst: Small Cause, Great Impact: Modification of the Guanidine Group in the RGD Motif Controls Integrin Subtype Selectivity. Angewandte Chemie International Edition 55 (4), 2015, 1540-1543 more… BibTeX Full text ( DOI )
  • Maltsev, Oleg V.; Marelli, Udaya Kiran; Kapp, Tobias G.; Di Leva, Francesco Saverio; Di Maro, Salvatore; Nieberler, Markus; Reuning, Ute; Schwaiger, Markus; Novellino, Ettore; Marinelli, Luciana; Kessler, Horst: Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands. Angewandte Chemie International Edition 55 (4), 2015, 1535-1539 more… BibTeX Full text ( DOI )
  • Marelli, Udaya Kiran; Bezençon, Jacqueline; Puig, Eduard; Ernst, Beat; Kessler, Horst: Enantiomeric Cyclic Peptides with Different Caco-2 Permeability Suggest Carrier-Mediated Transport. Chemistry - A European Journal 21 (22), 2015, 8023-8027 more… BibTeX Full text ( DOI )
  • Marelli, Udaya Kiran; Ovadia, Oded; Frank, Andreas Oliver; Chatterjee, Jayanta; Gilon, Chaim; Hoffman, Amnon; Kessler, Horst: cis-Peptide Bonds: A Key for Intestinal Permeability of Peptides? Chemistry - A European Journal 21 (43), 2015, 15148-15152 more… BibTeX Full text ( DOI )
  • Notni, J.; Steiger, K.; Hoffmann, F.; Reich, D.; Kapp, T. G.; Rechenmacher, F.; Neubauer, S.; Kessler, H.; Wester, H.-J.: Complementary, Selective PET Imaging of Integrin Subtypes  5 1 and  v 3 Using 68Ga-Aquibeprin and 68Ga-Avebetrin. Journal of Nuclear Medicine 57 (3), 2015, 460-466 more… BibTeX Full text ( DOI )
  • Renner, G; Janouskova, H; Noulet, F; Koenig, V; Guerin, E; Bär, S; Nuesch, J; Rechenmacher, F; Neubauer, S; Kessler, H; Blandin, A-F; Choulier, L; Etienne-Selloum, N; Lehmann, M; Lelong-Rebel, I; Martin, S; Dontenwill, M: Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma. Cell Death & Differentiation 23 (4), 2015, 640-653 more… BibTeX Full text ( DOI )
  • Röhl, Alina; Wengler, Daniela; Madl, Tobias; Lagleder, Stephan; Tippel, Franziska; Herrmann, Monika; Hendrix, Jelle; Richter, Klaus; Hack, Gordon; Schmid, Andreas B.; Kessler, Horst; Lamb, Don C.; Buchner, Johannes: Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules. Nature Communications 6 (1), 2015 more… BibTeX Full text ( DOI )
  • Wester, Hans Jürgen; Keller, Ulrich; Schottelius, Margret; Beer, Ambros; Philipp-Abbrederis, Kathrin; Hoffmann, Frauke; Šimeček, Jakub; Gerngross, Carlos; Lassmann, Michael; Herrmann, Ken; Pellegata, Natalia; Rudelius, Martina; Kessler, Horst; Schwaiger, Markus: Disclosing the CXCR4 Expression in Lymphoproliferative Diseases by Targeted Molecular Imaging. Theranostics 5 (6), 2015, 618-630 more… BibTeX Full text ( DOI )

2014

  • Beer, Ambros J.; Pelisek, Jaroslav; Heider, Peter; Saraste, Antti; Reeps, Christian; Metz, Stephan; Seidl, Stefan; Kessler, Horst; Wester, Hans-Jürgen; Eckstein, Hans Henning; Schwaiger, Markus: PET/CT Imaging of Integrin αvβ3 Expression in Human Carotid Atherosclerosis. JACC: Cardiovascular Imaging 7 (2), 2014, 178-187 more… BibTeX Full text ( DOI )
  • Buchner, Johannes; Kessler, Horst: Protein Folding by Interaction. Structure 22 (7), 2014, 936-937 more… BibTeX Full text ( DOI )
  • Conibear, Anne C.; Bochen, Alexander; Rosengren, K. Johan; Stupar, Petar; Wang, Conan; Kessler, Horst; Craik, David J.: The Cyclic Cystine Ladder of Theta-Defensins as a Stable, Bifunctional Scaffold: A Proof-of-Concept Study Using the Integrin-Binding RGD Motif. ChemBioChem 15 (3), 2014, 451-459 more… BibTeX Full text ( DOI )
  • Hegemann, Julian D.; De Simone, Mariarosaria; Zimmermann, Marcel; Knappe, Thomas A.; Xie, Xiulan; Di Leva, Francesco Saverio; Marinelli, Luciana; Novellino, Ettore; Zahler, Stefan; Kessler, Horst; Marahiel, Mohamed A.: Rational Improvement of the Affinity and Selectivity of Integrin Binding of Grafted Lasso Peptides. Journal of Medicinal Chemistry 57 (13), 2014, 5829-5834 more… BibTeX Full text ( DOI )
  • Marelli, Udaya Kiran; Frank, Andreas O.; Wahl, Bernhard; La Pietra, Valeria; Novellino, Ettore; Marinelli, Luciana; Herdtweck, Eberhardt; Groll, Michael; Kessler, Horst: Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure. Chemistry - A European Journal 20 (44), 2014, 14201-14206 more… BibTeX Full text ( DOI )
  • Medda, Rebecca; Helth, Arne; Herre, Patrick; Pohl, Darius; Rellinghaus, Bernd; Perschmann, Nadine; Neubauer, Stefanie; Kessler, Horst; Oswald, Steffen; Eckert, Jürgen; Spatz, Joachim P.; Gebert, Annett; Cavalcanti-Adam, Elisabetta A.: Investigation of early cell–surface interactions of human mesenchymal stem cells on nanopatterned β-type titanium–niobium alloy surfaces. Interface Focus 4 (1), 2014, 20130046 more… BibTeX Full text ( DOI )
  • Müller, Martina A.; Brunie, Leonora; Bächer, Anne-Sophie; Kessler, Horst; Gottschalk, Kay-Eberhard; Reuning, Ute: Cytoplasmic salt bridge formation in integrin αvß3 stabilizes its inactive state affecting integrin-mediated cell biological effects. Cellular Signalling 26 (11), 2014, 2493-2503 more… BibTeX Full text ( DOI )
  • Neubauer, Stefanie; Rechenmacher, Florian; Brimioulle, Richard; Di Leva, Francesco Saverio; Bochen, Alexander; Sobahi, Tariq R.; Schottelius, Margret; Novellino, Ettore; Mas-Moruno, Carlos; Marinelli, Luciana; Kessler, Horst: Pharmacophoric Modifications Lead to Superpotent αvβ3 Integrin Ligands with Suppressed α5β1 Activity. Journal of Medicinal Chemistry 57 (8), 2014, 3410-3417 more… BibTeX Full text ( DOI )
  • Ray, Anne-Marie; Schaffner, Florence; Janouskova, Hana; Noulet, Fanny; Rognan, Didier; Lelong-Rebel, Isabelle; Choulier, Laurence; Blandin, Anne-Florence; Lehmann, Maxime; Martin, Sophie; Kapp, Tobias; Neubauer, Stefanie; Rechenmacher, Florian; Kessler, Horst; Dontenwill, Monique: Single cell tracking assay reveals an opposite effect of selective small non-peptidic α5β1 or αvβ3/β5 integrin antagonists in U87MG glioma cells. Biochimica et Biophysica Acta (BBA) - General Subjects 1840 (9), 2014, 2978-2987 more… BibTeX Full text ( DOI )
  • Rechenmacher, Florian; Steigerwald, Kristin; Laufer, Burkhardt; Neubauer, Stefanie; Kapp, Tobias G.; Li, Liang; Mas-Moruno, Carlos; Joner, Michael; Kessler, Horst: The Integrin Ligandc(RGDf(NMe)Nal) Reduces Neointimal Hyperplasia in a Polymer-Free Drug-Eluting Stent System. ChemMedChem 9 (7), 2014, 1413-1418 more… BibTeX Full text ( DOI )
  • Šimeček, Jakub; Notni, Johannes; Kapp, Tobias G.; Kessler, Horst; Wester, Hans-Jürgen: Benefits of NOPO As Chelator in Gallium-68 Peptides, Exemplified by Preclinical Characterization of 68Ga-NOPO–c(RGDfK). Molecular Pharmaceutics 11 (5), 2014, 1687-1695 more… BibTeX Full text ( DOI )

2013

  • Bochen, Alexander; Marelli, Udaya Kiran; Otto, Elke; Pallarola, Diego; Mas-Moruno, Carlos; Di Leva, Francesco Saverio; Boehm, Heike; Spatz, Joachim P.; Novellino, Ettore; Kessler, Horst; Marinelli, Luciana: Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids. Journal of Medicinal Chemistry 56 (4), 2013, 1509-1519 more… BibTeX Full text ( DOI )
  • Evellin, Sandrine; Galvagni, Federico; Zippo, Alessio; Neri, Francesco; Orlandini, Maurizio; Incarnato, Danny; Dettori, Daniela; Neubauer, Stefanie; Kessler, Horst; Wagner, Erwin F.; Oliviero, Salvatore: FOSL1 Controls the Assembly of Endothelial Cells into Capillary Tubes by Direct Repression of αv and β3 Integrin Transcription. Molecular and Cellular Biology 33 (6), 2013, 1198-1209 more… BibTeX Full text ( DOI )
  • Kapp, Tobias G; Rechenmacher, Florian; Sobahi, Tariq R; Kessler, Horst: Integrin modulators: a patent review. Expert Opinion on Therapeutic Patents 23 (10), 2013, 1273-1295 more… BibTeX Full text ( DOI )
  • Laitinen, Iina; Notni, Johannes; Pohle, Karolin; Rudelius, Martina; Farrell, Eliane; Nekolla, Stephan G; Henriksen, Gjermund; Neubauer, Stefanie; Kessler, Horst; Wester, Hans-Jürgen; Schwaiger, Markus: Comparison of cyclic RGD peptides for αvβ3 integrin detection in a rat model of myocardial infarction. EJNMMI Research 3 (1), 2013, 38 more… BibTeX Full text ( DOI )
  • Marelli, Udaya Kiran; Rechenmacher, Florian; Sobahi, Tariq Rashad Ali; Mas-Moruno, Carlos; Kessler, Horst: Tumor Targeting via Integrin Ligands. Frontiers in Oncology 3, 2013 more… BibTeX Full text ( DOI )
  • Müller, Martina A.; Opfer, Jan; Brunie, Leonora; Volkhardt, Lilli A.; Sinner, Eva-Kathrin; Boettiger, David; Bochen, Alexander; Kessler, Horst; Gottschalk, Kay-Eberhard; Reuning, Ute: The Glycophorin A Transmembrane Sequence within Integrin αvβ3 Creates a Non-Signaling Integrin with Low Basal Affinity That Is Strongly Adhesive under Force. Journal of Molecular Biology 425 (16), 2013, 2988-3006 more… BibTeX Full text ( DOI )
  • Neubauer, Stefanie; Rechenmacher, Florian; Beer, Ambros J.; Curnis, Flavio; Pohle, Karolin; D'Alessandria, Calogero; Wester, Hans-Jürgen; Reuning, Ute; Corti, Angelo; Schwaiger, Markus; Kessler, Horst: Selective Imaging of the Angiogenic Relevant Integrins α5β1 and αvβ3. Angewandte Chemie International Edition 52 (44), 2013, 11656-11659 more… BibTeX Full text ( DOI )
  • Pallarola, Diego; Bochen, Alexander; Boehm, Heike; Rechenmacher, Florian; Sobahi, Tariq R.; Spatz, Joachim P.; Kessler, Horst: Interface Immobilization Chemistry ofcRGD-based Peptides Regulates Integrin Mediated Cell Adhesion. Advanced Functional Materials 24 (7), 2013, 943-956 more… BibTeX Full text ( DOI )
  • Rahmouni, Sabri; Lindner, Aaron; Rechenmacher, Florian; Neubauer, Stefanie; Sobahi, Tariq Rashad Ali; Kessler, Horst; Cavalcanti-Adam, Elisabetta Ada; Spatz, Joachim Pius: Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through α v β 3 - or α 5 β 1 -Integrins. Adv. Mater. 25 (41), 2013, 5869-5874 more… BibTeX Full text ( DOI )
  • Rahmouni, Sabri; Lindner, Aaron; Rechenmacher, Florian; Neubauer, Stefanie; Sobahi, Tariq Rashad Ali; Kessler, Horst; Cavalcanti-Adam, Elisabetta Ada; Spatz, Joachim Pius: Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through αvβ3- or α5β1-Integrins. Advanced Materials 25 (41), 2013, 5869-5874 more… BibTeX Full text ( DOI )
  • Rechenmacher, Florian; Neubauer, Stefanie; Mas-Moruno, Carlos; Dorfner, Petra M.; Polleux, Julien; Guasch, Judith; Conings, Bert; Boyen, Hans-Gerd; Bochen, Alexander; Sobahi, Tariq R.; Burgkart, Rainer; Spatz, Joachim P.; Fässler, Reinhard; Kessler, Horst: A Molecular Toolkit for the Functionalization of Titanium-Based Biomaterials That Selectively Control Integrin-Mediated Cell Adhesion. Chemistry - A European Journal 19 (28), 2013, 9218-9223 more… BibTeX Full text ( DOI )
  • Retzlaff, Marco; Rohrberg, Julia; Küpper, Natascha Jennifer; Lagleder, Stephan; Bepperling, Alexander; Manzenrieder, Florian; Peschek, Jirka; Kessler, Horst; Buchner, Johannes: The Regulatory Domain Stabilizes the p53 Tetramer by Intersubunit Contacts with the DNA Binding Domain. Journal of Molecular Biology 425 (1), 2013, 144-155 more… BibTeX Full text ( DOI )
  • Romanelli, Elisa; Sorbara, Catherine D; Nikić, Ivana; Dagkalis, Athanasios; Misgeld, Thomas; Kerschensteiner, Martin: Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes. Nature Protocols 8 (3), 2013, 481-490 more… BibTeX Full text ( DOI )
  • Šimeček, Jakub; Hermann, Petr; Havlíčková, Jana; Herdtweck, Eberhardt; Kapp, Tobias G.; Engelbogen, Nils; Kessler, Horst; Wester, Hans-Jürgen; Notni, Johannes: A Cyclen-Based Tetraphosphinate Chelator for the Preparation of Radiolabeled Tetrameric Bioconjugates. Chemistry - A European Journal 19 (24), 2013, 7748-7757 more… BibTeX Full text ( DOI )

2012

  • Chatterjee, Jayanta; Rechenmacher, Florian; Kessler, Horst: N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions. Angewandte Chemie International Edition 52 (1), 2012, 254-269 more… BibTeX Full text ( DOI )
  • Demmer, Oliver; Frank, Andreas O.; Hagn, Franz; Schottelius, Margret; Marinelli, Luciana; Cosconati, Sandro; Brack-Werner, Ruth; Kremb, Stephan; Wester, Hans-Jürgen; Kessler, Horst: A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity. Angewandte Chemie International Edition 51 (32), 2012, 8110-8113 more… BibTeX Full text ( DOI )
  • Habbaba, Ahmad; Lange, Alex; Plank, Johann: Synthesis and performance of a modified polycarboxylate dispersant for concrete possessing enhanced cement compatibility. Journal of Applied Polymer Science 129 (1), 2012, 346-353 more… BibTeX Full text ( DOI )
  • Mas-Moruno, Carlos; Dorfner, Petra M.; Manzenrieder, Florian; Neubauer, Stefanie; Reuning, Ute; Burgkart, Rainer; Kessler, Horst: Behavior of primary human osteoblasts on trimmed and sandblasted Ti6Al4V surfaces functionalized with integrin αvβ3-selective cyclic RGD peptides. Journal of Biomedical Materials Research Part A 101A (1), 2012, 87-97 more… BibTeX Full text ( DOI )
  • Rechenmacher, Florian; Neubauer, Stefanie; Polleux, Julien; Mas-Moruno, Carlos; De Simone, Mariarosaria; Cavalcanti-Adam, Elisabetta Ada; Spatz, Joachim P.; Fässler, Reinhard; Kessler, Horst: Functionalizing αvβ3- or α5β1-Selective Integrin Antagonists for Surface Coating: A Method To Discriminate Integrin Subtypes In Vitro. Angewandte Chemie International Edition 52 (5), 2012, 1572-1575 more… BibTeX Full text ( DOI )
  • Rechenmacher, Florian; Neubauer, Stefanie; Polleux, Julien; Mas-Moruno, Carlos; De Simone, Mariarosaria; Cavalcanti-Adam, Elisabetta Ada; Spatz, Joachim P.; Fässler, Reinhard; Kessler, Horst: Functionalizing αvβ3- or α5β1-Selective Integrin Antagonists for Surface Coating: A Method To Discriminate Integrin Subtypes In Vitro. Angewandte Chemie International Edition 52 (5), 2012, 1572-1575 more… BibTeX Full text ( DOI )

2011

  • Demmer, Oliver; Dijkgraaf, Ingrid; Schumacher, Udo; Marinelli, Luciana; Cosconati, Sandro; Gourni, Eleni; Wester, Hans-Jürgen; Kessler, Horst: Design, Synthesis, and Functionalization of Dimeric Peptides Targeting Chemokine Receptor CXCR4. J. Med. Chem. 54 (21), 2011, 7648-7662 more… BibTeX Full text ( DOI )
  • Hagn, Franz; Lagleder, Stephan; Retzlaff, Marco; Rohrberg, Julia; Demmer, Oliver; Richter, Klaus; Buchner, Johannes; Kessler, Horst: Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53. Nat Struct Mol Biol 18 (10), 2011, 1086-1093 more… BibTeX Full text ( DOI )

2010

  • Doedens, Lucas; Opperer, Florian; Cai, Minying; Beck, Johannes G.; Dedek, Matt; Palmer, Erin; Hruby, Victor J.; Kessler, Horst: Multiple N -Methylation of MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype hMC1R Selectivity: Pharmacological and Conformational Studies. J. Am. Chem. Soc. 132 (23), 2010, 8115-8128 more… BibTeX Full text ( DOI )
  • Hagn, Franz; Thamm, Christopher; Scheibel, Thomas; Kessler, Horst: pH-Dependent Dimerization and Salt-Dependent Stabilization of the N-terminal Domain of Spider Dragline Silk-Implications for Fiber Formation. Angewandte Chemie International Edition 50 (1), 2010, 310-313 more… BibTeX Full text ( DOI )
  • Welker, Sylvia; Rudolph, Birgit; Frenzel, Elke; Hagn, Franz; Liebisch, Gerhard; Schmitz, Gerd; Scheuring, Johannes; Kerth, Andreas; Blume, Alfred; Weinkauf, Sevil; Haslbeck, Martin; Kessler, Horst; Buchner, Johannes: Hsp12 Is an Intrinsically Unstructured Stress Protein that Folds upon Membrane Association and Modulates Membrane Function. Molecular Cell 39 (4), 2010, 507-520 more… BibTeX Full text ( DOI )

2008

  • Biron, Eric; Chatterjee, Jayanta; Ovadia, Oded; Langenegger, Daniel; Brueggen, Joseph; Hoyer, Daniel; Schmid, Herbert A.; Jelinek, Raz; Gilon, Chaim; Hoffman, Amnon; Kessler, Horst: Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues. Angewandte Chemie International Edition 47 (14), 2008, 2595-2599 more… BibTeX Full text ( DOI )
To top