Dietmar W. Hutmacher

Fellowship
Hans Fischer Senior Fellow

Institution
Queensland University of Technology

Department
Health and Biomedical Innovation

Host
Arndt Schilling

Focus Group
Regenerative Medicine

Short CV

Professor Hutmacher’s background is a strong combination of academic and industrial. His expertise is in biomaterials, biomechanics, medical devices and tissue engineering. He is one of the few academics to take a holistic bone engineering concept to clinical application. More than 400 patients have been treated with the FDA-approved bone engineering scaffolds developed by Professor Hutmacher’s Singapore-based interdisciplinary research group. Regenerative medicine/tissue engineering is a rapidly growing multidisciplinary field involving the life, physical and engineering sciences and seeks to develop functional cell, tissue and organ substitutes to repair, replace or enhance biological function that has been lost due to congenital abnormalities, injury, disease or aging. It includes both the regeneration of tissues in vitro for subsequent implantation in vivo as well as regeneration directly in vivo. In addition to having a therapeutic application, tissue engineering can have a diagnostic application where the engineered tissue is used as a biosensor. Engineered tissues can also be used for the development of drugs including screening for novel drug candidates, identifying novel genes as drug targets, and testing for drug metabolism, uptake, and toxicity. Over the last 4 years, Professor Hutmacher has developed an international track record in adult stem cell research related to regenerative medicine.


Selected Awards

  • 2012, ARC Future Fellowship
  • 2012, International College of Fellows Biomaterials Science and Engineering
  • 2012, Australasian Society for Biomaterials & Tissue Engineering (ASBTE) Research Excellence Award
  • 2012, Founding member of the International Fellows of Tissue Engineering and Regenerative Medicine Society

Research Interests

Professor Hutmacher has three main areas of research:

  • Cartilage
  • Bone Graft
  • 3D Cell Cultures

Publications as TUM-IAS-Fellow

2015

  • Chhaya, Mohit P; Poh, Patrina SP; Balmayor, Elizabeth R; van Griensven, Martijn; Schantz, Jan-Thorsten; Hutmacher, Dietmar W: Additive manufacturing in biomedical sciences and the need for definitions and norms. Expert Review of Medical Devices 12 (5), 2015, 537-543 mehr… BibTeX Volltext ( DOI )
  • Chhaya, Mohit Prashant; Melchels, Ferry Petrus Wilhelmus; Holzapfel, Boris Michael; Baldwin, Jeremy Grant; Hutmacher, Dietmar Werner: Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing. Biomaterials 52, 2015, 551-560 mehr… BibTeX Volltext ( DOI )
  • Costa, Pedro F.; Hutmacher, Dietmar W.; Theodoropoulos, Christina; Gomes, Manuela E.; Reis, Rui L.; Vaquette, Cédryck: Additively Manufactured Device for Dynamic Culture of Large Arrays of 3D Tissue Engineered Constructs. Advanced Healthcare Materials 4 (6), 2015, 864-873 mehr… BibTeX Volltext ( DOI )
  • Hutmacher, Dietmar Werner; Holzapfel, Boris Michael; De-Juan-Pardo, Elena Maria; Pereira, Brooke Anne; Ellem, Stuart John; Loessner, Daniela; Risbridger, Gail Petuna: Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance. Current Opinion in Biotechnology 35, 2015, 127-132 mehr… BibTeX Volltext ( DOI )
  • Muerza-Cascante, M. Lourdes; Haylock, David; Hutmacher, Dietmar W.; Dalton, Paul D.: Melt Electrospinning and Its Technologization in Tissue Engineering. Tissue Engineering Part B: Reviews 21 (2), 2015, 187-202 mehr… BibTeX Volltext ( DOI )
  • Visser, Jetze; Melchels, Ferry P.W.; Jeon, June E.; van Bussel, Erik M.; Kimpton, Laura S.; Byrne, Helen M.; Dhert, Wouter J.A.; Dalton, Paul D.; Hutmacher, Dietmar W.; Malda, Jos: Reinforcement of hydrogels using three-dimensionally printed microfibres. Nature Communications 6 (1), 2015 mehr… BibTeX Volltext ( DOI )

2014

  • Brown, Toby D.; Edin, Fredrik; Detta, Nicola; Skelton, Anthony D.; Hutmacher, Dietmar W.; Dalton, Paul D.: Melt electrospinning of poly(ε-caprolactone) scaffolds: Phenomenological observations associated with collection and direct writing. Materials Science and Engineering: C 45, 2014, 698-708 mehr… BibTeX Volltext ( DOI )
  • Costa, Pedro F; Vaquette, Cédryck; Baldwin, Jeremy; Chhaya, Mohit; Gomes, Manuela E; Reis, Rui L; Theodoropoulos, Christina; Hutmacher, Dietmar W: Biofabrication of customized bone grafts by combination of additive manufacturing and bioreactor knowhow. Biofabrication 6 (3), 2014, 035006 mehr… BibTeX Volltext ( DOI )
  • Hesami, Parisa; Holzapfel, Boris M.; Taubenberger, Anna; Roudier, Martine; Fazli, Ladan; Sieh, Shirly; Thibaudeau, Laure; Gregory, Laura S.; Hutmacher, Dietmar W.; Clements, Judith A.: A humanized tissue-engineered in vivo model to dissect interactions between human prostate cancer cells and human bone. Clinical & Experimental Metastasis 31 (4), 2014, 435-446 mehr… BibTeX Volltext ( DOI )
  • Holzapfel, Boris M.; Wagner, Ferdinand; Loessner, Daniela; Holzapfel, Nina P.; Thibaudeau, Laure; Crawford, Ross; Ling, Ming-Tat; Clements, Judith A.; Russell, Pamela J.; Hutmacher, Dietmar W.: Species-specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone. Biomaterials 35 (13), 2014, 4108-4115 mehr… BibTeX Volltext ( DOI )
  • Holzapfel, Boris Michael; Pilge, Hakan; Prodinger, Peter Michael; Toepfer, Andreas; Mayer-Wagner, Susanne; Hutmacher, Dietmar Werner; von Eisenhart-Rothe, Ruediger; Rudert, Maximilian; Gradinger, Reiner; Rechl, Hans: Customised osteotomy guides and endoprosthetic reconstruction for periacetabular tumours. International Orthopaedics, 2014 mehr… BibTeX Volltext ( DOI )
  • Jeon, June E.; Vaquette, Cédryck; Theodoropoulos, Christina; Klein, Travis J.; Hutmacher, Dietmar W.: Multiphasic construct studied in an ectopic osteochondral defect model. Journal of The Royal Society Interface 11 (95), 2014, 20140184 mehr… BibTeX Volltext ( DOI )
  • Taubenberger, Anna V.; Hutmacher, Dietmar W.; Muller, Daniel J.: Single-Cell Force Spectroscopy, an Emerging Tool to Quantify Cell Adhesion to Biomaterials. Tissue Engineering Part B: Reviews 20 (1), 2014, 40-55 mehr… BibTeX Volltext ( DOI )
  • Thibaudeau, Laure; Quent, Verena M.; Holzapfel, Boris M.; Taubenberger, Anna V.; Straub, Melanie; Hutmacher, Dietmar W.: Mimicking breast cancer-induced bone metastasis in vivo: current transplantation models and advanced humanized strategies. Cancer and Metastasis Reviews 33 (2-3), 2014, 721-735 mehr… BibTeX Volltext ( DOI )
  • Yong, Mostyn R.N.O.; Saifzadeh, Siamak; Askin, Geoffrey N.; Labrom, Robert D.; Hutmacher, Dietmar W.; Adam, Clayton J.: Establishment and Characterization of an Open Mini-Thoracotomy Surgical Approach to an Ovine Thoracic Spine Fusion Model. Tissue Engineering Part C: Methods 20 (1), 2014, 19-27 mehr… BibTeX Volltext ( DOI )

2013

  • Berner, A.; Reichert, J.C.; Woodruff, M.A.; Saifzadeh, S.; Morris, A.J.; Epari, D.R.; Nerlich, M.; Schuetz, M.A.; Hutmacher, D.W.: Autologous vs. allogenic mesenchymal progenitor cells for the reconstruction of critical sized segmental tibial bone defects in aged sheep. Acta Biomaterialia 9 (8), 2013, 7874-7884 mehr… BibTeX Volltext ( DOI )
  • Clark, Ashlee K.; Taubenberger, Anna V.; Taylor, Renea A.; Niranjan, Birunthi; Chea, Zhen Y.; Zotenko, Elena; Sieh, Shirly; Pedersen, John S.; Norden, Sam; Frydenberg, Mark; Grummet, Jeremy P.; Pook, David W.; Stirzaker, Clare; Clark, Susan J.; Lawrence, Mitchell G.; Ellem, Stuart J.; Hutmacher, Dietmar W.; Risbridger, Gail P.: A bioengineered microenvironment to quantitatively measure the tumorigenic properties of cancer-associated fibroblasts in human prostate cancer. Biomaterials 34 (20), 2013, 4777-4785 mehr… BibTeX Volltext ( DOI )
  • Farrugia, Brooke L; Brown, Toby D; Upton, Zee; Hutmacher, Dietmar W; Dalton, Paul D; Dargaville, Tim R: Dermal fibroblast infiltration of poly(ε-caprolactone) scaffolds fabricated by melt electrospinning in a direct writing mode. Biofabrication 5 (2), 2013, 025001 mehr… BibTeX Volltext ( DOI )
  • Holzapfel, Boris Michael; Chhaya, Mohit Prashant; Melchels, Ferry Petrus Wilhelmus; Holzapfel, Nina Pauline; Prodinger, Peter Michael; von Eisenhart-Rothe, Ruediger; van Griensven, Martijn; Schantz, Jan-Thorsten; Rudert, Maximilian; Hutmacher, Dietmar Werner: Can Bone Tissue Engineering Contribute to Therapy Concepts after Resection of Musculoskeletal Sarcoma? Sarcoma 2013, 2013, 1-10 mehr… BibTeX Volltext ( DOI )
  • Holzapfel, Boris Michael; Reichert, Johannes Christian; Schantz, Jan-Thorsten; Gbureck, Uwe; Rackwitz, Lars; Nöth, Ulrich; Jakob, Franz; Rudert, Maximilian; Groll, Jürgen; Hutmacher, Dietmar Werner: How smart do biomaterials need to be? A translational science and clinical point of view. Advanced Drug Delivery Reviews 65 (4), 2013, 581-603 mehr… BibTeX Volltext ( DOI )
  • Holzapfel, Boris Michael; Thibaudeau, Laure; Hesami, Parisa; Taubenberger, Anna; Holzapfel, Nina Pauline; Mayer-Wagner, Susanne; Power, Carl; Clements, Judith; Russell, Pamela; Hutmacher, Dietmar Werner: Humanised xenograft models of bone metastasis revisited: novel insights into species-specific mechanisms of cancer cell osteotropism. Cancer Metastasis Rev 32 (1-2), 2013, 129-145 mehr… BibTeX Volltext ( DOI )
  • Hutmacher, Dietmar W.: A road map for a tissue engineering concept for restoring structure and function after limb loss. Journal of Materials Science: Materials in Medicine 24 (11), 2013, 2659-2663 mehr… BibTeX Volltext ( DOI )
  • Loessner, D.; Flegg, J. A.; Byrne, H. M.; Clements, J. A.; Hutmacher, D. W.: Growth of confined cancer spheroids: a combined experimental and mathematical modelling approach. Integr. Biol. 5 (3), 2013, 597 mehr… BibTeX Volltext ( DOI )
  • Malda, Jos; Visser, Jetze; Melchels, Ferry P.; Jüngst, Tomasz; Hennink, Wim E.; Dhert, Wouter J. A.; Groll, Jürgen; Hutmacher, Dietmar W.: 25th Anniversary Article: Engineering Hydrogels for Biofabrication. Adv. Mater. 25 (36), 2013, 5011-5028 mehr… BibTeX Volltext ( DOI )
  • Reichert, J.C.; Gohlke, J.; Friis, T.E.; Quent, V.M.C.; Hutmacher, D.W.: Mesodermal and neural crest derived ovine tibial and mandibular osteoblasts display distinct molecular differences. Gene 525 (1), 2013, 99-106 mehr… BibTeX Volltext ( DOI )
  • Schrobback, Karsten; Wrobel, Jana; Hutmacher, Dietmar W.; Woodfield, Tim B.F.; Klein, Travis J.: Stage-Specific Embryonic Antigen-4 Is Not a Marker for Chondrogenic and Osteogenic Potential in Cultured Chondrocytes and Mesenchymal Progenitor Cells. Tissue Engineering Part A 19 (11-12), 2013, 1316-1326 mehr… BibTeX Volltext ( DOI )
  • Schuurman, Wouter; Levett, Peter A.; Pot, Michiel W.; van Weeren, Paul René; Dhert, Wouter J. A.; Hutmacher, Dietmar W.; Melchels, Ferry P. W.; Klein, Travis J.; Malda, Jos: Gelatin-Methacrylamide Hydrogels as Potential Biomaterials for Fabrication of Tissue-Engineered Cartilage Constructs. Macromol. Biosci. 13 (5), 2013, 551-561 mehr… BibTeX Volltext ( DOI )
  • Taubenberger, Anna V; Quent, Verena M; Thibaudeau, Laure; Clements, Judith A; Hutmacher, Dietmar W: Delineating breast cancer cell interactions with engineered bone microenvironments. J Bone Miner Res 28 (6), 2013, 1399-1411 mehr… BibTeX Volltext ( DOI )
  • Vaquette, Cédryck; Ivanovski, Saso; Hamlet, Stephen M.; Hutmacher, Dietmar W.: Effect of culture conditions and calcium phosphate coating on ectopic bone formation. Biomaterials 34 (22), 2013, 5538-5551 mehr… BibTeX Volltext ( DOI )
  • Volpato, Fabio Zomer; Führmann, Tobias; Migliaresi, Claudio; Hutmacher, Dietmar W.; Dalton, Paul D.: Using extracellular matrix for regenerative medicine in the spinal cord. Biomaterials 34 (21), 2013, 4945-4955 mehr… BibTeX Volltext ( DOI )

2012

  • Woodruff, Maria Ann; Lange, Claudia; Chen, Fulin; Fratzl, Peter; Hutmacher, Dietmar Werner: Nano- to Macroscale Remodeling of Functional Tissue-Engineered Bone. Advanced Healthcare Materials 2 (4), 2012, 546-551 mehr… BibTeX Volltext ( DOI )