Matthias Feige

Short CV

Professor Matthias Feige studied biochemistry at the Swiss Federal Institute of Technology (ETH Zurich) and TUM. In 2009, he obtained his PhD in biochemistry under the supervision of Johannes Buchner at TUM. As a postdoctoral fellow in the laboratory of Linda Hendershot at the St. Jude Children’s Research Hospital, Memphis, TN, USA, he expanded his research toward cell biology and now heads the laboratory for cellular protein biochemistry at TUM.

Selected Awards

  • 2016, Fellow of the Daimler and Benz Foundation
  • 2012, Rainer Rudolph Foundation, Rainer Rudolph Award
  • 2011-2014, Fellow of the German Academy of Sciences Leopoldina
  • 2011, Management Engineers Presidential Award, Management Engineers and TUM
  • 2010-2011, Paul Barrett Fellowship, St. Jude Children’s Research Hospital
  • 2010, Hans Fischer Award, Hans Fischer Society
  • 2010, PhD Award, TUM Graduate School
  • 2005, Jürgen Manchot Award, Jürgen Manchot Foundation
  • 2003-2009, Fellow of the German National Academic Foundation

Research Interests

Matthias Feige’s laboratory aims at understanding how cells control and maintain the integrity of their proteome. He is particularly interested in proteins of the secretory pathway – proteins that are ultimately secreted or localized on the cell surface and allow cells to interact with their environment. Using an interdisciplinary approach from protein biochemistry to cell biology, he analyzes the machinery and mechanisms that monitor cellular protein biogenesis. By focusing on proteins of immunological and biomedical relevance, he seeks a molecular understanding of fundamental biological processes that at the same time may help in developing new approaches for protein engineering and human therapy.

Selected Publications

  • Feige, Matthias J.; Buchner, Johannes: Principles and engineering of antibody folding and assembly. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1844 (11), 2014, 2024-2031.
  • Feige, M. J.; Grawert, M. A.; Marcinowski, M.; Hennig, J.; Behnke, J.; Auslander, D.; Herold, E. M.; Peschek, J.; Castro, C. D.; Flajnik, M.; Hendershot, L. M.; Sattler, M.; Groll, M.; Buchner, J.: The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins. Proceedings of the National Academy of Sciences 111 (22), 2014, 8155-8160.
  • Feige, Matthias J.; Hendershot, Linda M.: Quality Control of Integral Membrane Proteins by Assembly-Dependent Membrane Integration. Molecular Cell 51 (3), 2013, 297-309.
  • Feige, Matthias J.; Groscurth, Sandra; Marcinowski, Moritz; Shimizu, Yuichiro; Kessler, Horst; Hendershot, Linda M.; Buchner, Johannes: An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies. Molecular Cell 34 (5), 2009, 569-579.
  • Feige, M. J.; Groscurth, S.; Marcinowski, M.; Yew, Z. T.; Truffault, V.; Paci, E.; Kessler, H.; Buchner, J.: The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity. Proceedings of the National Academy of Sciences 105 (36), 2008, 13373-13378.

Publications as TUM-IAS-Fellow


  • Fauser, Joel; Gulen, Burak; Pogenberg, Vivian; Pett, Christian; Pourjafar-Dehkordi, Danial; Krisp, Christoph; Höpfner, Dorothea; König, Gesa; Schlüter, Hartmut; Feige, Matthias J.; Zacharias, Martin; Hedberg, Christian; Itzen, Aymelt: Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD. Nature Communications 12 (1), 2021 mehr… BibTeX Volltext ( DOI )
  • Schlagintweit, Jonas F.; Jakob, Christian H. G.; Meighen-Berger, Kevin; Gronauer, Thomas F.; Weigert Muñoz, Angela; Weiß, Vanessa; Feige, Matthias J.; Sieber, Stephan A.; Correia, João D. G.; Kühn, Fritz E.: Fluorescent palladium(ii) and platinum(ii) NHC/1,2,3-triazole complexes: antiproliferative activity and selectivity against cancer cells. Dalton Transactions 50 (6), 2021, 2158-2166 mehr… BibTeX Volltext ( DOI )


  • Bohnacker, Sina; Hildenbrand, Karen; Aschenbrenner, Isabel; Müller, Stephanie I.; Bieren, Julia Esser-von; Feige, Matthias J.: Influence of glycosylation on IL-12 family cytokine biogenesis and function. Molecular Immunology 126, 2020, 120-128 mehr… BibTeX Volltext ( DOI )
  • Cavé, Marie‐Charlotte; Maillard, Solène; Hildenbrand, Karen; Mamelonet, Claire; Feige, Matthias J; Devergne, Odile: Glycosaminoglycans bind human IL‐27 and regulate its activity. European Journal of Immunology 50 (10), 2020, 1484-1499 mehr… BibTeX Volltext ( DOI )
  • Coelho, Joao PL; Feige, Matthias J: In case of stress, hold tight: phosphorylation switches PDI from an oxidoreductase to a holdase, tuning ER proteostasis. The EMBO Journal 39 (10), 2020 mehr… BibTeX Volltext ( DOI )
  • Mideksa, Yonatan G.; Fottner, Maximilian; Braus, Sebastian; Weiß, Caroline A. M.; Nguyen, Tuan‐Anh; Meier, Susanne; Lang, Kathrin; Feige, Matthias J.: Site‐Specific Protein Labeling with Fluorophores as a Tool To Monitor Protein Turnover. ChemBioChem 21 (13), 2020, 1861-1867 mehr… BibTeX Volltext ( DOI )
  • Niu, Zheng; Prade, Elke; Malideli, Eleni; Hille, Kathleen; Jussupow, Alexander; Mideksa, Yonatan G.; Yan, Li‐Mei; Qian, Chen; Fleisch, Markus; Messias, Ana C.; Sarkar, Riddhiman; Sattler, Michael; Lamb, Don C.; Feige, Matthias J.; Camilloni, Carlo; Kapurniotu, Aphrodite; Reif, Bernd: Structural Insight into IAPP‐Derived Amyloid Inhibitors and Their Mechanism of Action. Angewandte Chemie International Edition 59 (14), 2020, 5771-5781 mehr… BibTeX Volltext ( DOI )
  • de los Reyes Jiménez, Marta; Lechner, Antonie; Alessandrini, Francesca; Bohnacker, Sina; Schindela, Sonja; Trompette, Aurélien; Haimerl, Pascal; Thomas, Dominique; Henkel, Fiona; Mourão, André; Geerlof, Arie; da Costa, Clarissa Prazeres; Chaker, Adam M.; Brüne, Bernhard; Nüsing, Rolf; Jakobsson, Per-Johan; Nockher, Wolfgang A.; Feige, Matthias J.; Haslbeck, Martin; Ohnmacht, Caspar; Marsland, Benjamin J.; Voehringer, David; Harris, Nicola L.; Schmidt-Weber, Carsten B.; Esser-von Bieren, Julia: An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products. Science Translational Medicine 12 (540), 2020, eaay0605 mehr… BibTeX Volltext ( DOI )


  • Hohl, Adrian; Mideksa, Yonatan G; Karan, Ram; Akal, Anastassja; Vogler, Malvina; Groll, Michael; Rueping, Magnus; Lang, Kathrin; Feige, Matthias J; Eppinger, Jörg: Genetically encoded biotin analogs: Incorporation and application in bacterial and mammalian cells. ChemBioChem, 2019 mehr… BibTeX Volltext ( DOI )
  • Meier, Susanne; Bohnacker, Sina; Klose, Carolin J.; Lopez, Abraham; Choe, Christian A.; Schmid, Philipp W. N.; Bloemeke, Nicolas; Rührnößl, Florian; Haslbeck, Martin; Bieren, Julia Esser-von; Sattler, Michael; Huang, Po-Ssu; Feige, Matthias J.: The molecular basis of chaperone-mediated interleukin 23 assembly control. Nature Communications 10 (1), 2019 mehr… BibTeX Volltext ( DOI )
  • Müller, Stephanie I.; Aschenbrenner, Isabel; Zacharias, Martin; Feige, Matthias J.: An Interspecies Analysis Reveals Molecular Construction Principles of Interleukin 27. Journal of Molecular Biology 431 (12), 2019, 2383-2393 mehr… BibTeX Volltext ( DOI )
  • Müller, Stephanie I.; Friedl, Antonie; Aschenbrenner, Isabel; Esser-von Bieren, Julia; Zacharias, Martin; Devergne, Odile; Feige, Matthias J.: A folding switch regulates interleukin 27 biogenesis and secretion of its α-subunit as a cytokine. Proceedings of the National Academy of Sciences 116 (5), 2019, 1585-1590 mehr… BibTeX Volltext ( DOI )


  • Grötsch, Raphael K.; Angı, Arzu; Mideksa, Yonatan G.; Wanzke, Caren; Tena-Solsona, Marta; Feige, Matthias J.; Rieger, Bernhard; Boekhoven, Job: Dissipative Self-Assembly of Photoluminescent Silicon Nanocrystals. Angewandte Chemie International Edition 57 (44), 2018, 14608-14612 mehr… BibTeX Volltext ( DOI )
  • Matthias Feige: Oxidative Folding of Proteins. Royal Society of Chemistry, 2018 mehr… BibTeX Volltext ( DOI )
  • Rodriguez Camargo, Diana C.; Garg, Divita; Buday, Katalin; Franko, Andras; Rodriguez Camargo, Andres; Schmidt, Fabian; Cox, Sarah J.; Suladze, Saba; Haslbeck, Martin; Mideksa, Yonatan G.; Gemmecker, Gerd; Aichler, Michaela; Mettenleiter, Gabriele; Schulz, Michael; Walch, Axel Karl; Hrabě de Angelis, Martin; Feige, Matthias J.; Sierra, Cesar A.; Conrad, Marcus; Tripsianes, Konstantinos; Ramamoorthy, Ayyalusamy; Reif, Bernd: hIAPP forms toxic oligomers in plasma. Chemical Communications 54 (43), 2018, 5426-5429 mehr… BibTeX Volltext ( DOI )


  • Reitberger, Susanne; Haimerl, Pascal; Aschenbrenner, Isabel; Esser-von Bieren, Julia; Feige, Matthias J.: Assembly-induced folding regulates interleukin 12 biogenesis and secretion. Journal of Biological Chemistry 292 (19), 2017, 8073-8081 mehr… BibTeX Volltext ( DOI )


  • Behnke, Julia; Mann, Melissa J.; Scruggs, Fei-Lin; Feige, Matthias J.; Hendershot, Linda M.: Members of the Hsp70 Family Recognize Distinct Types of Sequences to Execute ER Quality Control. Molecular Cell 63 (5), 2016, 739-752 mehr… BibTeX Volltext ( DOI )


  • Behnke, Julia; Feige, Matthias J.; Hendershot, Linda M.: BiP and Its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions. Journal of Molecular Biology 427 (7), 2015, 1589-1608 mehr… BibTeX Volltext ( DOI )
  • Feige, Matthias J.; Behnke, Julia; Mittag, Tanja; Hendershot, Linda M.: Dimerization-dependent Folding Underlies Assembly Control of the Clonotypic αβT Cell Receptor Chains. Journal of Biological Chemistry 290 (44), 2015, 26821-26831 mehr… BibTeX Volltext ( DOI )