Stanley Riddell received his M.D. from the University of Manitoba in Winnipeg, Canada. He trained in Medical Oncology and Immunology at the Fred Hutchinson Cancer Research Center and the University of Washington from 1985 – 1990. He subsequently joined the faculty at these institutions, and is currently Member and Associate Program Head of the Program in Immunology at the Fred Hutchinson Cancer Research Center and Professor, Department of Medicine at the University of Washington.
Selected Awards
2008, Elected Fellow of the American College of Physicians
2004, Gerald Goldenberg Lecture, University of Toronto, Toronto, Canada
2003, Gerhardt Schmidt Memorial Lecture, City of Hope National Medical Center
2002, Woodward Visiting Professor, Memorial Sloan Kettering Cancer Center
2000, Japan Health Sciences Foundation Fellowship Visiting Scientist
1992-1996, Cancer Research Institute Partridge Foundation Investigator Award
Research Interests
The Riddell lab has focused on the development and clinical evaluation of cellular therapeutics with antigen-specific T cell lymphocytes for human viral infections and malignancy. The research effort in this area encompasses the identification of appropriate target antigens on infected and malignant cells, and the development of methods for selecting and expanding therapeutic T cells of the correct specificity. Recent studies have been directed at understanding the genetic programming of distinct memory T cell subsets that enable some cells to survive long-term in vivo and to reestablish immunologic memory after adoptive transfer.
Selected Publications
Berger, Carolina; Jensen, Michael C.; Lansdorp, Peter M.; Gough, Mike; Elliott, Carole; Riddell, Stanley R.: Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. Journal of Clinical Investigation 118 (1), 2008, 294-305.
Warren, E. H.; Vigneron, N. J.; Gavin, M. A.; Coulie, P. G.; Stroobant, V.; Dalet, A.; Tykodi, S. S.; Xuereb, S. M.; Mito, J. K.; Riddell, S. R.; Van den Eynde, B. J.: An Antigen Produced by Splicing of Noncontiguous Peptides in the Reverse Order. Science 313 (5792), 2006, 1444-1447.
Bleakley, Marie; Riddell, Stanley R.: Molecules and mechanisms of the graft-versus-leukaemia effect. Nature Reviews Cancer 4 (5), 2004, 371-380.
Yee, C.; Thompson, J.A.; Roche, P.; Byrd, D.R.; Lee, P.P.; Piepkorn, M.; Kenyon, K.; Davis, M.M.; Riddell, S.R.; Greenberg, P.D.: Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of T cell-mediated vitiligo. Journal of Experimental Medicine 192, 2000, 1637-1634.
Bonnet, D.; Warren, E. H.; Greenberg, P. D.; Dick, J. E.; Riddell, S. R.: CD8+ minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells. Proceedings of the National Academy of Sciences 96 (15), 1999, 8639-8644.
Greenberg, P.D.; Riddell, S.R.;: Cellular Immunodeficiencies: Finding and fixing the defects. Science 285, 1999, 546-551.
Walter, Elizabeth A.; Greenberg, Philip D.; Gilbert, Mark J.; Finch, Rosalynde J.; Watanabe, Käthe S.; Thomas, E. Donnall; Riddell, Stanley R.: Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor. New England Journal of Medicine 333 (16), 1995, 1038-1044.
Riddell, S.R.; Watanabe, K.S.; Goodrich, J.M; Li, C.R.; Agha, M.E.; P.D. Greenberg, P.D.: Restoration of viral immunity in immunocompromised humans by adoptive transfer of T cell clones. Science 257, 1992, 238-241.
Busch, Dirk H.; Fräßle, Simon P.; Sommermeyer, Daniel; Buchholz, Veit R.; Riddell, Stanley R.: Role of memory T cell subsets for adoptive immunotherapy. Seminars in Immunology 28 (1), 2016, 28-34 mehr…BibTeX
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Liu, Lingfeng; Sommermeyer, Daniel; Cabanov, Alexandra; Kosasih, Paula; Hill, Tyler; Riddell, Stanley R: Inclusion of Strep-tag II in design of antigen receptors for T-cell immunotherapy. Nature Biotechnology 34 (4), 2016, 430-434 mehr…BibTeX
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Paszkiewicz, Paulina J.; Fräßle, Simon P.; Srivastava, Shivani; Sommermeyer, Daniel; Hudecek, Michael; Drexler, Ingo; Sadelain, Michel; Liu, Lingfeng; Jensen, Michael C.; Riddell, Stanley R.; Busch, Dirk H.: Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia. Journal of Clinical Investigation 126 (11), 2016, 4262-4272 mehr…BibTeX
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Turtle, Cameron J.; Hanafi, Laïla-Aïcha; Berger, Carolina; Gooley, Theodore A.; Cherian, Sindhu; Hudecek, Michael; Sommermeyer, Daniel; Melville, Katherine; Pender, Barbara; Budiarto, Tanya M.; Robinson, Emily; Steevens, Natalia N.; Chaney, Colette; Soma, Lorinda; Chen, Xueyan; Yeung, Cecilia; Wood, Brent; Li, Daniel; Cao, Jianhong; Heimfeld, Shelly; Jensen, Michael C.; Riddell, Stanley R.; Maloney, David G.: CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients. Journal of Clinical Investigation 126 (6), 2016, 2123-2138 mehr…BibTeX
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2015
Sommermeyer, D; Hudecek, M; Kosasih, P L; Gogishvili, T; Maloney, D G; Turtle, C J; Riddell, S R: Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo. Leukemia 30 (2), 2015, 492-500 mehr…BibTeX
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2014
Berger, C.; Sommermeyer, D.; Hudecek, M.; Berger, M.; Balakrishnan, A.; Paszkiewicz, P. J.; Kosasih, P. L.; Rader, C.; Riddell, S. R.: Safety of Targeting ROR1 in Primates with Chimeric Antigen Receptor-Modified T Cells. Cancer Immunology Research 3 (2), 2014, 206-216 mehr…BibTeX
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Bleakley, Marie; Heimfeld, Shelly; Jones, Lori A.; Turtle, Cameron; Krause, Diane; Riddell, Stanley R.; Shlomchik, Warren: Engineering Human Peripheral Blood Stem Cell Grafts that Are Depleted of Naïve T Cells and Retain Functional Pathogen-Specific Memory T Cells. Biology of Blood and Marrow Transplantation 20 (5), 2014, 705-716 mehr…BibTeX
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Graef, Patricia; Buchholz, Veit R.; Stemberger, Christian; Flossdorf, Michael; Henkel, Lynette; Schiemann, Matthias; Drexler, Ingo; Höfer, Thomas; Riddell, Stanley R.; Busch, Dirk H.: Serial Transfer of Single-Cell-Derived Immunocompetence Reveals Stemness of CD8+ Central Memory T Cells. Immunity 41 (1), 2014, 116-126 mehr…BibTeX
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Hudecek, M.; Sommermeyer, D.; Kosasih, P. L.; Silva-Benedict, A.; Liu, L.; Rader, C.; Jensen, M. C.; Riddell, S. R.: The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity. Cancer Immunology Research 3 (2), 2014, 125-135 mehr…BibTeX
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Pollack, Seth M; Jones, Robin L; Farrar, Erik A; Lai, Ivy P; Lee, Sylvia M; Cao, Jianhong; Pillarisetty, Venu G; Hoch, Benjamin L; Gullett, Ashley; Bleakley, Marie; Conrad, Ernest U; Eary, Janet F; Shibuya, Kendall C; Warren, Edus H; Carstens, Jason N; Heimfeld, Shelly; Riddell, Stanley R; Yee, Cassian: Tetramer guided, cell sorter assisted production of clinical grade autologous NY-ESO-1 specific CD8+ T cells. Journal for ImmunoTherapy of Cancer 2 (1), 2014 mehr…BibTeX
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Riddell, Stanley R.; Sommermeyer, Daniel; Berger, Carolina; Liu, Lingfeng (Steven); Balakrishnan, Ashwini; Salter, Alex; Hudecek, Michael; Maloney, David G.; Turtle, Cameron J.: Adoptive Therapy With Chimeric Antigen Receptor–Modified T Cells of Defined Subset Composition. The Cancer Journal 20 (2), 2014, 141-144 mehr…BibTeX
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Shibuya, Kendall C.; Goel, Vikas K.; Xiong, Wei; Sham, Jonathan G.; Pollack, Seth M.; Leahy, Allison M.; Whiting, Samuel H.; Yeh, Matthew M.; Yee, Cassian; Riddell, Stanley R.; Pillarisetty, Venu G.: Pancreatic Ductal Adenocarcinoma Contains an Effector and Regulatory Immune Cell Infiltrate that Is Altered by Multimodal Neoadjuvant Treatment. PLoS ONE 9 (5), 2014, e96565 mehr…BibTeX
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2013
Buchholz, V. R.; Flossdorf, M.; Hensel, I.; Kretschmer, L.; Weissbrich, B.; Graf, P.; Verschoor, A.; Schiemann, M.; Hofer, T.; Busch, D. H.: Disparate Individual Fates Compose Robust CD8+ T Cell Immunity. Science 340 (6132), 2013, 630-635 mehr…BibTeX
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Jensen, Michael C.; Riddell, Stanley R.: Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells. Immunological Reviews 257 (1), 2013, 127-144 mehr…BibTeX
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Nauerth, M.; Weissbrich, B.; Knall, R.; Franz, T.; Dossinger, G.; Bet, J.; Paszkiewicz, P. J.; Pfeifer, L.; Bunse, M.; Uckert, W.; Holtappels, R.; Gillert-Marien, D.; Neuenhahn, M.; Krackhardt, A.; Reddehase, M. J.; Riddell, S. R.; Busch, D. H.: TCR-Ligand koff Rate Correlates with the Protective Capacity of Antigen-Specific CD8+ T Cells for Adoptive Transfer. Science Translational Medicine 5 (192), 2013, 192ra87-192ra87 mehr…BibTeX
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Nauerth, M.; Weissbrich, B.; Knall, R.; Franz, T.; Dossinger, G.; Bet, J.; Paszkiewicz, P. J.; Pfeifer, L.; Bunse, M.; Uckert, W.; Holtappels, R.; Gillert-Marien, D.; Neuenhahn, M.; Krackhardt, A.; Reddehase, M. J.; Riddell, S. R.; Busch, D. H.: TCR-Ligand koff Rate Correlates with the Protective Capacity of Antigen-Specific CD8+ T Cells for Adoptive Transfer. Science Translational Medicine 5 (192), 2013, 192ra87-192ra87 mehr…BibTeX
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2012
Stemberger, Christian; Dreher, Stefan; Tschulik, Claudia; Piossek, Christine; Bet, Jeannette; Yamamoto, Tori N.; Schiemann, Matthias; Neuenhahn, Michael; Martin, Klaus; Schlapschy, Martin; Skerra, Arne; Schmidt, Thomas; Edinger, Matthias; Riddell, Stanley R.; Germeroth, Lothar; Busch, Dirk H.: Novel Serial Positive Enrichment Technology Enables Clinical Multiparameter Cell Sorting. PLoS ONE 7 (4), 2012, e35798 mehr…BibTeX
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2011
Terakura, S.; Yamamoto, T. N.; Gardner, R. A.; Turtle, C. J.; Jensen, M. C.; Riddell, S. R.: Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells. Blood 119 (1), 2011, 72-82 mehr…BibTeX
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2009
Berger, Carolina; Turtle, Cameron J; Jensen, Michael C; Riddell, Stanley R: Adoptive transfer of virus-specific and tumor-specific T cell immunity. Current Opinion in Immunology 21 (2), 2009, 224-232 mehr…BibTeX
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Turtle, Cameron J.; Swanson, Hillary M.; Fujii, Nobuharu; Estey, Elihu H.; Riddell, Stanley R.: A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy. Immunity 31 (5), 2009, 834-844 mehr…BibTeX
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