Synthetic Biochemistry

Kathrin Lang has been a Rudolf Mößbauer Tenure Track Assistant Professor since April 2014.

Professor Lang conducts research in the interdisciplinary area of chemical biology, applying concepts from organic chemistry to develop new tools to study fundamental biological questions. Her research focuses on the targeted chemical synthesis of new artificial biomolecules (amino acids, proteins, nucleotides, oligonucleotides) tailored to investigate and manipulate complex cellular processes in in vitro and in vivo biological systems.

Postdoctoral researcher Mathias Enderle, doctoral candidate Susanne Mayer and master student Thorsten Müller also work in this Focus Group.

TUM-IAS funded doctoral candidate:
Marko Cigler, Synthetic Biochemistry

Publications by the Focus Group

2019

  • Fottner, Maximilian; Brunner, Andreas-David; Bittl, Verena; Horn-Ghetko, Daniel; Jussupow, Alexander; Kaila, Ville R. I.; Bremm, Anja; Lang, Kathrin: Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase. Nature Chemical Biology 15 (3), 2019, 276-284 mehr…
  • Hohl, Adrian; Mideksa, Yonatan G; Karan, Ram; Akal, Anastassja; Vogler, Malvina; Groll, Michael; Rueping, Magnus; Lang, Kathrin; Feige, Matthias J; Eppinger, Jörg: Genetically encoded biotin analogs: Incorporation and application in bacterial and mammalian cells. ChemBioChem, 2019 mehr…
  • Reille-Seroussi, Marie; Mayer, Susanne V.; Dörner, Wolfgang; Lang, Kathrin; Mootz, Henning D.: Expanding the genetic code with a lysine derivative bearing an enzymatically removable phenylacetyl group. Chemical Communications 55 (33), 2019, 4793-4796 mehr…

2018

  • Cigler, Marko; Nguyen, Tuan-Anh; Lang, Kathrin: CHAPTER 5.2. Genetic Code Expansion Approaches to Introduce Artificial Covalent Bonds into Proteins In Vivo. In: Oxidative Folding of Proteins. Royal Society of Chemistry, 2018 mehr…
  • Nguyen, Tuan-Anh; Cigler, Marko; Lang, Kathrin: Expanding the Genetic Code to Study Protein-Protein Interactions. Angewandte Chemie International Edition 57 (44), 2018, 14350-14361 mehr…

2017

  • Cigler, Marko; Müller, Thorsten G.; Horn-Ghetko, Daniel; von Wrisberg, Marie-Kristin; Fottner, Maximilian; Goody, Roger S.; Itzen, Aymelt; Müller, Matthias P.; Lang, Kathrin: Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo. Angewandte Chemie International Edition 56 (49), 2017, 15737-15741 mehr…
  • Lang, Kathrin: Building Peptide Bonds in Haifa: The Seventh Chemical Protein Synthesis (CPS) Meeting. ChemBioChem 19 (2), 2017, 115-120 mehr…
  • Lang, Kathrin: Biochemie 2016: Chemie bringt Zellen im Innern zum Leuchten. Nachrichten aus der Chemie 65 (3), 2017, 305-309 mehr…

2016

  • Jiao, Lei; Lang, Kathrin: The 6th Sino-German Frontiers of Chemistry Symposium. Chemistry - An Asian Journal 11 (23), 2016, 3292-3296 mehr…
  • Lang, Kathrin; Mayer, Susanne: Tetrazines in Inverse-Electron-Demand Diels–Alder Cycloadditions and Their Use in Biology. Synthesis 49 (04), 2016, 830-848 mehr…
  • Mayer, Susanne; Lang, Kathrin: Chemie in lebenden Systemen. Nachrichten aus der Chemie 64 (3), 2016, 301-305 mehr…

2015

  • Machida, Takuya; Lang, Kathrin; Xue, Lin; Chin, Jason W.; Winssinger, Nicolas: Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne. Bioconjugate Chemistry 26 (5), 2015, 802-806 mehr…
  • Tsai, Yu-Hsuan; Essig, Sebastian; James, John R.; Lang, Kathrin; Chin, Jason W.: Selective, rapid and optically switchable regulation of protein function in live mammalian cells. Nature Chemistry 7 (7), 2015, 554-561 mehr…
  • Uttamapinant, Chayasith; Howe, Jonathan D.; Lang, Kathrin; Beránek, Václav; Davis, Lloyd; Mahesh, Mohan; Barry, Nicholas P.; Chin, Jason W.: Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins. Journal of the American Chemical Society 137 (14), 2015, 4602-4605 mehr…

2014

  • Elliott, Thomas S; Townsley, Fiona M; Bianco, Ambra; Ernst, Russell J; Sachdeva, Amit; Elsässer, Simon J; Davis, Lloyd; Lang, Kathrin; Pisa, Rudolf; Greiss, Sebastian; Lilley, Kathryn S; Chin, Jason W: Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal. Nature Biotechnology 32 (5), 2014, 465-472 mehr…
  • Lang, Kathrin; Chin, Jason W.: Bioorthogonal Reactions for Labeling Proteins. ACS Chemical Biology 9 (1), 2014, 16-20 mehr…
  • Lang, Kathrin; Chin, Jason W.: Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins. Chemical Reviews 114 (9), 2014, 4764-4806 mehr…
  • Lang, Kathrin; Davis, Lloyd; Chin, Jason W.: Genetic Encoding of Unnatural Amino Acids for Labeling Proteins. In: Site-Specific Protein Labeling. Springer New York, 2014 mehr…
  • Perez-Fernandez, Déborah; Shcherbakov, Dmitri; Matt, Tanja; Leong, Ng Chyan; Kudyba, Iwona; Duscha, Stefan; Boukari, Heithem; Patak, Rashmi; Dubbaka, Srinivas Reddy; Lang, Kathrin; Meyer, Martin; Akbergenov, Rashid; Freihofer, Pietro; Vaddi, Swapna; Thommes, Pia; Ramakrishnan, V.; Vasella, Andrea; Böttger, Erik C.: 4′-O-substitutions determine selectivity of aminoglycoside antibiotics. Nature Communications 5 (1), 2014 mehr…
  • Wang, Kaihang; Sachdeva, Amit; Cox, Daniel J.; Wilf, Nabil M.; Lang, Kathrin; Wallace, Stephen; Mehl, Ryan A.; Chin, Jason W.: Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET. Nature Chemistry 6 (5), 2014, 393-403 mehr…