Multiple sclerosis: Degeneration of long nerve fibers due to influx of calcium ions


In patients with Multiple sclerosis the central nervous system is attacked. This leads to problems in perception and movement. The extent of degeneration of long nerve fibers critically influences the degree for these neurological deficits. A scientific team of Technical University of Munich (TUM) and Ludwig-Maximilians-Universität München (LMU), among them Prof. Thomas Misgeld, TUM-IAS Alumnus Hans Fischer Tenure Track Fellow and currently Host of the Focus Group Subcellular Dynamics in Neurons, identified a putative mechanism for this destruction. They have shown that minuscule ruptures in the cell membrane allow calcium ions to percolate into the neuron and disrupting the ionic balance.

A full press release can be found here.