Intestinal inflammation, anastomotic healing and fibrosis

This group, including Albrecht Struppler Clinician Scientist Fellow PD Dr. Philipp-Alexander Neumann (Clinic and Polyclinic for Surgery, TUM university hospital Klinikum Rechts der Isar), doctoral student Annalisa Buck, and TUM collaboration partner Dr. Dirk Haller (Nutrition and Immunology, TUM), focuses on delineating the impact of the gut’s microbiome and the WNT-pathway on fibrosis development in Crohn’s disease. A novel combination of classic intestinal inflammation models, combined with surgical procedures and molecular analysis, shall bring new insights into the mechanism behind intestinal anastomotic healing and fibrosis in IBD.

TUM-IAS funded doctoral candidate:
Annalisa Buck, Clinic and Polyclinic for Surgery, TUM university hospital Klinikum Rechts der Isar

Publications by the Focus Group

2025

Berlet, Maximilian; Cira, Kamacay; Jell, Alissa; Stoess, Christian; Friess, Helmut; Wilhelm, Dirk; Reim, Daniel; Weber, Marie-Christin; Neumann, Philipp-Alexander: Trends in surgical treatment for ulcerative colitis in the era of biologics – A population-based study using German diagnosis-related groups data. Surgery 185, 2025, 109511 mehr…
Cira, Kamacay; Neumann, Philipp-Alexander: Machine Learning for Anastomotic Leak Prediction in Colorectal Surgery—Between Validation and Clinical Implementation. JAMA Network Open 8 (10), 2025, e2538274 mehr…
Cira, Kamacay; Richter, Sebastian; Friess, Helmut; Neumann, Philipp-Alexander; Reim, Daniel: Timing of Antibiotic Prophylaxis Prior to Abdominal Surgery Has No Impact on Infectious Complications. Annals of Surgery, 2025 mehr…
Cira, Kamacay; Vieregge, Vincent; Pollak, Sebastian; Lee, Jong Hyun; Reischl, Stefan; Walter, Robert Leon; Clees, Zoe; Kasajima, Atsuko; Metzler, Thomas; Friess, Helmut; Kamaly, Nazila; Neumann, Philipp-Alexander: Perioperative Collagen IV-Targeted Ac2-26 Nanoparticles Enhance Anastomotic Healing in Acute Crohn’s Disease-Like Colitis. Annals of Surgery, 2025 mehr…
Jorek, Nicolas; Weber, Marie-Christin; Kasajima, Atsuko; Reischl, Stefan; Jefferies, Benedict; Feith, Marcus; Dimpel, Rebekka; Reim, Daniel; Friess, Helmut; Novotny, Alexander; Neumann, Philipp-Alexander: Configuration of anastomotic doughnuts of stapled anastomoses in upper gastrointestinal surgery is associated with anastomotic leakage. European Journal of Surgical Oncology 51 (1), 2025, 109460 mehr…
Mueller, Tara C; Trefzer, Charlotte; Reischl, Stefan; Friess, Helmut; Martignoni, Marc E.; Neumann, Philipp-Alexander; Cira, Kamacay: Low HS-Omega-3 index as a predictor of severe postoperative complications in abdominal surgery: a prospective observational study. International Journal of Surgery 111 (11), 2025, 8050-8059 mehr…
Schellack, Sophie Klara; Breidenbach, Clara; Kowalski, Christoph; Wedding, Ulrich; van Oorschot, Birgitt; Seufferlein, Thomas; Benz, Stefan; Schnell, Martin; Köninger, Jörg; Klein, Christina; Ockenga, Johann; Freitag, Björn; Wittel, Uwe A.; Wahba, Roger; Kim, Mia; Elhabash, Saleem; Piso, Pompiliu; Weyhe, Dirk; Bunse, Jörg; Riechmann, Maren; von Strauss, Marco; Petzoldt, Sebastian; Neumann, Philipp-Alexander; Kolb, Vanessa; Sibert, Nora Tabea: Pain and overall quality of life in palliatively treated colorectal cancer patients 1 year after diagnosis– results from the EDIUM cohort. Journal of Cancer Research and Clinical Oncology 151 (4), 2025 mehr…
Sibert, N.T.; Breidenbach, C.; Benz, S.R.; Post, S.; Seufferlein, T.; Ackermann, C.; Blossey, R.D.; Böhm, G.; Brennfleck, F.; Bunse, J.; Dahlke, M.-H.; Egetemeyer, J.; Elhabash, S.; Emmanouilidis, N.; Flemming, S.; Freitag, B.; Goetzky, K.; von Haeften, E.; Henschel, M.; Hollerbach, S.; Höppner, J.; Kim, M.; Klein, C.; Klinik, C.; Klump, B.; Köninger, J.; Lee, L.D.-G.; Mirow, L.; Ockenga, J.; Petzoldt, S.; Neumann, P.A.; Piso, P.; Reißfelder, C.; Rickenberger, A.; Riechmann, M.; Rolinger, J.; Rosenberg, R.; Schilawa, D.; Schmidt, J.; Schnell, M.W.; Steinemann, D.; Varga-Szabó, D.; Wahba, R.; Weyhe, D.; Willeke, F.; Wirth, U.; Wittel, U.; Zielinski, C.B.; Kolb, V.; Kowalski, C.: Self-reported financial difficulties of colorectal cancer patients 1 year after start of treatment. ESMO Open 10 (5), 2025, 105078 mehr…
Siegel, Robert; Sibert, Nora Tabea; Breidenbach, Clara; Gani, Cihan; Neumann, Philipp Alexander; Benz, Stefan Rolf; Post, Stefan; Seufferlein, Thomas; Kolb, Vanessa; Behrend, Matthias; Blossey, Richard David; Bunse, Jörg; Dahlke, Marc; Diller, Ricarda; Emmanouilidis, Nikos; Ettrich, Thomas J.; Fahlke, Jörg; Flemming, Sven; Freitag, Björn; Fuchs, Martin; Haeder, Lars; Hollerbach, Stephan; Höppner, Jens; Kim, Mia; Klink, Christian; Knuth, Jürgen; Koeppen, Stefan; Köninger, Jörg; Kolbe, Ernst Wolfgang; Kühn, Florian; Mussa, Shueb; Oehring, Robert; Petzoldt, Sebastian; Piso, Pompiliu; Prause, Christian; Prinz, Christian; Reißfelder, Christoph; Riechmann, Maren; Ritz, Jörg‐Peter; Rolinger, Jens; Rosenberg, Robert; Scheuerlein, Hubert; Schilawa, Dustin; Schneider, Paul Magnus; Schwandner, Thilo; Siech, Marco; Steinemann, Daniel; Stöltzing, Oliver; von Haeften, Elke; Weihs, Dominik et al.: Impact of preoperative radiotherapy on patient‐reported outcomes in rectal cancer. Colorectal Disease 27 (7), 2025 mehr…
Weber, Marie-Christin; Jorek, Nicolas; Neumann, Philipp-Alexander; Bachmann, Jeannine; Dimpel, Rebekka; Martignoni, Marc; Feith, Marcus; Friess, Helmut; Novotny, Alexander; Berlet, Maximilian; Reim, Daniel: Incidence and treatment of anastomotic leakage after esophagectomy in German acute care hospitals: a retrospective cohort study. International Journal of Surgery 111 (4), 2025, 2953-2961 mehr…

2024

Buck, Annalisa; Weber, Marie-Christin; Widemann, Kristina; Friess, Helmut; Neumann, Philipp-Alexander: Tu1181 BREAKING THE FIBROTIC BARRIER: REVEALING WNT-SIGNALLING PATHWAY PHARMACOLOGICAL TARGETING AND METABOLIC RESTORATION AS INNOVATIVE APPROACHES IN THE MANAGEMENT OF CROHN'S DISEASE. Gastroenterology 166 (5), 2024, S-1272 mehr…
Weber, Marie-Christin; Clees, Zoé; Buck, Annalisa; Fischer, Adrian; Steffani, Marcella; Wilhelm, Dirk; Martignoni, Marc; Friess, Helmut; Rinkevich, Yuval; Neumann, Philipp-Alexander: Role of the serosa in intestinal anastomotic healing: insights from in-depth histological analysis of human and murine anastomoses. BJS Open 8 (5), 2024 mehr…
Weber, Marie-Christin; Schmidt, Konstantin; Buck, Annalisa; Kasajima, Atsuko; Becker, Simon; Li, Chunqiao; Reischl, Stefan; Wilhelm, Dirk; Steiger, Katja; Friess, Helmut; Neumann, Philipp-Alexander: Fractal analysis of extracellular matrix for observer-independent quantification of intestinal fibrosis in Crohn’s disease. Scientific Reports 14 (1), 2024 mehr…

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