Small infections can be fatal: Millions of people die each year from sepsis, an overreaction of the immune system. A new immune signaling molecule, designed by a research team with Rudolf Mößbauer Tenure Track Professor Matthias Feige, now provides the basis for potential new approaches in sepsis therapy.
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Relevant publication:
Stephanie I. Müller, Antonie Friedl, Isabel Aschenbrenner, Julia Esser-von Bieren, Martin Zacharias, Odile Devergne, Matthias J Feige: A folding switch regulates interleukin 27 biogenesis and secretion of its alpha subunit as a cytokine PNAS, 16.01.2019 – DOI: 10.1073/pnas.1816698116.