Organization:
Focus Group Proteases in the Brain: Hans Fischer Senior Fellow Prof. Carl Blobel (Hospital of Special Surgery, Weill Cornell Medical School, Cornell University), Prof. Stefan Lichtenthalter (Neuroproteomics, TUM).
Date:
Thursday, November 19, 2015
Location:
German Center for Neurodegenerative Diseases, conference room U1 155
Contact Information:
Carl Blobel, blobelc@hss.edu
Stefan Lichtenthaler, stefan.lichtenthaler@dzne.de
Program
Session 1: Neuroinflammation
13:00 Welcome and introduction
Stefan Lichtenthaler, Carl Blobel
13:10 Mouse models of traumatic brain injury
Nikolaus Plesnila
13:25 Discussion
13:35 Potential roles of iRhom2 in neuroinflammation
Carl Blobel
13:50 Discussion
14:00 Ex vivo studies of neuroinflammation
Sabina Tahirovic
14:15 Discussion
14:25 Substrate repertoire and function of iRhom2/ADAM17 in microglia and macrophages
Simone Scilabra
14:35 Discussion
14:45 The role of TREM2 in neurodegeneration
Christian Haas
15:00 Discussion
15:10 Coffee Break
Session 2: Structural and Biochemical Studies of Proteolysis of Membrane Proteins
15:50 Structure/function analysis of the iRhom/ADAM17 signaling axis
Carl Blobel
16:00 Discussion
16:10 Nanodisc NMR, a novel approach to study membrane protein structure and function
Franz Hagn
16:25 Discussion
16:35 Proteomic analysis of protease activity in the brain
Stefan Lichtenthaler
16:45 Discussion
16:50 Analysis of the substrate repertoire of iRhom1/ADAM17 in the brain
Johanna Tueshaus
17:00 Discussion
17:10 Understanding intramembrane proteolysis
Dieter Langosch
17:25 Discussion
17:35 Intramembrane Proteolysis by Alzheimer´s disease γ-Secretase
Harald Steiner
17:50 Discussion
18:00 Closing Remarks
Stefan Lichtenthaler, Carl Blobel
Please join us for dinner around 18:30, if possible!