Jane A. McKeating

Fellowship
Hans Fischer Senior Fellow

Institution
University of Oxford

Department
Nuffield Department of Medicine

Host
Ulrike Protzer

Focus Group
Viral Hepatitis

Short CV

Jane A. McKeating received a BSc in Biological Sciences from the University of Warwick in 1982 and a PhD in Virology from the Royal Free Hospital School of Medicine at University College London in 1987. From 1987- 1992, she was a research fellow at the Institute of Cancer Research in London. From 1994-1999, she was a Research Fellow of the Lister Institute of Preventive Medicine as well as an lecturer/reader in Virology at the University of Reading. After working as as a Section Head of Anti-Virals at Pfizer Research Central Research, UK, from 1999-2000, Jane A. McKeating moved to Rockefeller University as an associate professor. From 2005 - 2017, she was a professor of Molecular Virology at the University of Birmingham, a professor of Molecular Virology at the University of Birmingham,where she was the director of the Centre of Human Virology since 2012 and the Deputy Head of the School of Immunity and Infection since 2013. In 2017, Jane A. McKeating transferred to the University of Oxford.


Selected Awards

  • 2015, Founders Award for academic excellence – University of Birmingham
  • 2010, Oxford University Distinguished Virology Lecture
  • 2006, Royal Society Wolfson Merit Award
  • 1995, Fleming Award, Society of General Microbiology
  • 1994, Research Fellowship of the Lister Institute of Preventive Medicine
  • 1990, Medical Research Council Senior AIDS Research Fellowship
  • 1988, Herpes Vaccine Research Trust Prize, Society of General Microbiology

Research Interests

Jane A. McKeating’s research focuses on understanding early infection events that define the cellular and tissue tropism of clinically important human viruses to understand viral-associated pathology and to design improved vaccines and anti-viral therapies.


Selected Publications

  • Fletcher, Nicola F.; Wilson, Garrick K.; Murray, Jacinta; Hu, Ke; Lewis, Andrew; Reynolds, Gary M.; Stamataki, Zania; Meredith, Luke W.; Rowe, Ian A.; Luo, Guangxiang; Lopez–Ramirez, Miguel A.; Baumert, Thomas F.; Weksler, Babette; Couraud, Pierre–Olivier; Kim, Kwang Sik; Romero, Ignacio A.; Jopling, Catherine; Morgello, Susan; Balfe, Peter; McKeating, Jane A.: Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier. Gastroenterology 142 (3), 2012, 634-643.e6.
  • Lupberger, Joachim; Zeisel, Mirjam B; Xiao, Fei; Thumann, Christine; Fofana, Isabel; Zona, Laetitia; Davis, Christopher; Mee, Christopher J; Turek, Marine; Gorke, Sebastian; Royer, Cathy; Fischer, Benoit; Zahid, Muhammad N; Lavillette, Dimitri; Fresquet, Judith; Cosset, François-Loïc; Rothenberg, S Michael; Pietschmann, Thomas; Patel, Arvind H; Pessaux, Patrick; Doffoël, Michel; Raffelsberger, Wolfgang; Poch, Olivier; McKeating, Jane A; Brino, Laurent; Baumert, Thomas F: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nature Medicine 17 (5), 2011, 589-595.
  • Harris, Helen J.; Davis, Christopher; Mullins, Jonathan G. L.; Hu, Ke; Goodall, Margaret; Farquhar, Michelle J.; Mee, Christopher J.; McCaffrey, Kitty; Young, Stephen; Drummer, Heidi; Balfe, Peter; McKeating, Jane A.: Claudin Association with CD81 Defines Hepatitis C Virus Entry. Journal of Biological Chemistry 285 (27), 2010, 21092-21102.
  • Timpe, Jennifer M.; Stamataki, Zania; Jennings, Adam; Hu, Ke; Farquhar, Michelle J.; Harris, Helen J.; Schwarz, Anne; Desombere, Isabelle; Roels, Geert Leroux; Balfe, Peter; McKeating, Jane A.: Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies. Hepatology 47 (1), 2007, 17-24.
  • Evans, Matthew J.; von Hahn, Thomas; Tscherne, Donna M.; Syder, Andrew J.; Panis, Maryline; Wölk, Benno; Hatziioannou, Theodora; McKeating, Jane A.; Bieniasz, Paul D.; Rice, Charles M.: Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature 446 (7137), 2007, 801-805.
  • von Hahn, Thomas; Yoon, Joo Chun; Alter, Harvey; Rice, Charles M.; Rehermann, Barbara; Balfe, Peter; McKeating, Jane A.: Hepatitis C Virus Continuously Escapes From Neutralizing Antibody and T-Cell Responses During Chronic Infection In Vivo. Gastroenterology 132 (2), 2007, 667-678.
  • Lindenbach, B. D.: Complete Replication of Hepatitis C Virus in Cell Culture. Science 309 (5734), 2005, 623-626.
  • Logvinoff, C.; Major, M. E.; Oldach, D.; Heyward, S.; Talal, A.; Balfe, P.; Feinstone, S. M.; Alter, H.; Rice, C. M.; McKeating, J. A.: Neutralizing antibody response during acute and chronic hepatitis C virus infection. Proceedings of the National Academy of Sciences 101 (27), 2004, 10149-10154.
  • Hsu, M.; Zhang, J.; Flint, M.; Logvinoff, C.; Cheng-Mayer, C.; Rice, C. M.; McKeating, J. A.: Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Proceedings of the National Academy of Sciences 100 (12), 2003, 7271-7276.
  • Blight, K. J.; McKeating, J. A.; Rice, C. M.: Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication. Journal of Virology 76, 2002, 13001-13014.
  • Moore, J.; McKeating, J.; Weiss, R.; Sattentau, Q.: Dissociation of gp120 from HIV-1 virions induced by soluble CD4. Science 250 (4984), 1990, 1139-1142.
  • McKeating, Jane A.; Griffiths, Paul D.; Weiss, Robin A.: HIV susceptibility conferred to human fibroblasts by cytomegalovirus-induced Fc receptor. Nature 343 (6259), 1990, 659-661.

Publications as TUM-IAS-Fellow

2017

  • Appelman, Monique D.; Chakraborty, Anindita; Protzer, Ulrike; McKeating, Jane A.; van de Graaf, Stan F. J.: N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection. PLOS ONE 12 (1), 2017, e0170419 mehr… BibTeX Volltext ( DOI )
  • Appelman, Monique D.; Chakraborty, Anindita; Protzer, Ulrike; McKeating, Jane A.; van de Graaf, Stan F. J.: N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection. PLOS ONE 12 (1), 2017, e0170419 mehr… BibTeX Volltext ( DOI )
  • Farquhar, Michelle J.; Humphreys, Isla S.; Rudge, Simon A.; Wilson, Garrick K.; Bhattacharya, Bishnupriya; Ciaccia, Maria; Hu, Ke; Zhang, Qifeng; Mailly, Laurent; Reynolds, Gary M.; Ashcroft, Margaret; Balfe, Peter; Baumert, Thomas F.; Roessler, Stephanie; Wakelam, Michael J.O.; McKeating, Jane A.: Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication. Journal of Hepatology 66 (5), 2017, 919-929 mehr… BibTeX Volltext ( DOI )
  • Fletcher, N. F; Clark, A. R; Balfe, P; McKeating, J. A: TNF superfamily members promote hepatitis C virus entry via an NF-kB and myosin light chain kinase dependent pathway. Journal of General Virology 98 (3), 2017, 405-412 mehr… BibTeX Volltext ( DOI )
  • Fletcher, N. F; Clark, A. R; Balfe, P; McKeating, J. A: TNF superfamily members promote hepatitis C virus entry via an NF-kB and myosin light chain kinase dependent pathway. Journal of General Virology 98 (3), 2017, 405-412 mehr… BibTeX Volltext ( DOI )
  • Gonçalves-Carneiro, Daniel; McKeating, Jane A.; Bailey, Dalan: The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis. Journal of Virology 91 (7), 2017 mehr… BibTeX Volltext ( DOI )
  • Hedegaard, Ditte L.; Tully, Damien C.; Rowe, Ian A.; Reynolds, Gary M.; Bean, David J.; Hu, Ke; Davis, Christopher; Wilhelm, Annika; Ogilvie, Colin B.; Power, Karen A.; Tarr, Alexander W.; Kelly, Deirdre; Allen, Todd M.; Balfe, Peter; McKeating, Jane A.: High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end-stage liver disease. Journal of Hepatology 66 (1), 2017, 28-38 mehr… BibTeX Volltext ( DOI )
  • Ringehan, Marc; McKeating, Jane A.; Protzer, Ulrike: Viral hepatitis and liver cancer. Philosophical Transactions of the Royal Society B: Biological Sciences 372 (1732), 2017, 20160274 mehr… BibTeX Volltext ( DOI )
  • Zhuang, Xiaodong; Rambhatla, Srinivasa Bhargav; Lai, Alvina G.; McKeating, Jane A.: Interplay between circadian clock and viral infection. Journal of Molecular Medicine 95 (12), 2017, 1283-1289 mehr… BibTeX Volltext ( DOI )

2016

  • Desombere, Isabelle; Fafi-Kremer, Samira; Van Houtte, Freya; Pessaux, Patrick; Farhoudi, Ali; Heydmann, Laura; Verhoye, Lieven; Cole, Sarah; McKeating, Jane A.; Leroux-Roels, Geert; Baumert, Thomas F.; Patel, Arvind H.; Meuleman, Philip: Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge. Hepatology 63 (4), 2016, 1120-1134 mehr… BibTeX Volltext ( DOI )
  • Meredith, L. W.; Baumert, T. F.; Balfe, P.; Hu, K.; Protzer, U.; van de Graaf, K. F.; Cheng, X.; McKeating, J. A.; Howard, C. R.: Lentiviral hepatitis B pseudotype entry requires sodium taurocholate co-transporting polypeptide and additional hepatocyte-specific factors. Journal of General Virology 97 (1), 2016, 121-127 mehr… BibTeX Volltext ( DOI )
  • Rowe, Ian A.; Tully, Damien C.; Armstrong, Matthew J.; Parker, Richard; Guo, Kathy; Barton, Darren; Morse, Gene D.; Venuto, Charles S.; Ogilvie, Colin B.; Hedegaard, Ditte L.; McKelvy, Jeffrey F.; Wong-Staal, Flossie; Allen, Todd M.; Balfe, Peter; McKeating, Jane A.; Mutimer, David J.: Effect of scavenger receptor class B type I antagonist ITX5061 in patients with hepatitis C virus infection undergoing liver transplantation. Liver Transplantation 22 (3), 2016, 287-297 mehr… BibTeX Volltext ( DOI )
  • Tully, Damien C.; Hjerrild, Simon; Leutscher, Peter D.; Renvillard, Signe G.; Ogilvie, Colin B.; Bean, David J.; Videbech, Poul; Allen, Todd M.; McKeating, Jane A.; Fletcher, Nicola F.: Deep sequencing of hepatitis C virus reveals genetic compartmentalization in cerebrospinal fluid from cognitively impaired patients. Liver International 36 (10), 2016, 1418-1424 mehr… BibTeX Volltext ( DOI )
  • Verrier, Eloi R.; Colpitts, Che C.; Bach, Charlotte; Heydmann, Laura; Zona, Laetitia; Xiao, Fei; Thumann, Christine; Crouchet, Emilie; Gaudin, Raphaël; Sureau, Camille; Cosset, François-Loïc; McKeating, Jane A.; Pessaux, Patrick; Hoshida, Yujin; Schuster, Catherine; Zeisel, Mirjam B.; Baumert, Thomas F.: Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes. Cell Reports 17 (5), 2016, 1357-1368 mehr… BibTeX Volltext ( DOI )
  • Zhang, Yong-Hong; Zhao, Yan; Rajapaksa, Ushani S.; Lawrence, Tessa M.; Peng, Yan-Chun; Liu, Jinghua; Xu, Keyi; Hu, Ke; Qin, Ling; Liu, Ning; Sun, Huanqin; Yan, Hui-Ping; Repapi, Emmanouela; Rowland-Jones, Sarah; Thimme, Robert; McKeating, Jane A.; Dong, Tao: A Comprehensive Analysis of the Impact of HIV on HCV Immune Responses and Its Association with Liver Disease Progression in a Unique Plasma Donor Cohort. PLOS ONE 11 (7), 2016, e0158037 mehr… BibTeX Volltext ( DOI )

2015

  • Fletcher, Nicola F.; Jennings, Elliott; Lissauer, Samantha; Humphreys, Elizabeth; van IJzendoorn, Sven C. D.; McKeating, Jane A.; Osburn, William; Wilson, Garrick K.; Balfe, Peter; Baumert, Thomas F.; Afford, Simon: Hepatitis C virus infection of cholangiocarcinoma cell lines. Journal of General Virology 96 (6), 2015, 1380-1388 mehr… BibTeX Volltext ( DOI )
  • Mailly, Laurent; Xiao, Fei; Lupberger, Joachim; Wilson, Garrick K; Aubert, Philippe; Duong, François H T; Calabrese, Diego; Leboeuf, Céline; Fofana, Isabel; Thumann, Christine; Bandiera, Simonetta; Lütgehetmann, Marc; Volz, Tassilo; Davis, Christopher; Harris, Helen J; Mee, Christopher J; Girardi, Erika; Chane-Woon-Ming, Béatrice; Ericsson, Maria; Fletcher, Nicola; Bartenschlager, Ralf; Pessaux, Patrick; Vercauteren, Koen; Meuleman, Philip; Villa, Pascal; Kaderali, Lars; Pfeffer, Sébastien; Heim, Markus H; Neunlist, Michel; Zeisel, Mirjam B; Dandri, Maura; McKeating, Jane A; Robinet, Eric; Baumert, Thomas F: Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody. Nature Biotechnology 33 (5), 2015, 549-554 mehr… BibTeX Volltext ( DOI )
  • Mathiesen, Christian K.; Prentoe, Jannick; Meredith, Luke W.; Jensen, Tanja B.; Krarup, Henrik; McKeating, Jane A.; Gottwein, Judith M.; Bukh, Jens: Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant. Journal of Virology 89 (15), 2015, 7758-7775 mehr… BibTeX Volltext ( DOI )
  • Wilson, Garrick K.; Farquhar, Michelle J.; Dhawan, Anil; McKeating, Jane A.; Balfe, Peter; Meredith, Luke; Mitry, Ragai: Permissivity of primary hepatocytes and hepatoma cell lines to support hepatitis C virus infection. Journal of General Virology 96 (6), 2015, 1369-1373 mehr… BibTeX Volltext ( DOI )