Peer-Hendrik Kuhn studied medicine from 2001 until 2008 at Ludwig-Maximilians-Universität (LMU) in Munich. During his medical studies he was a scholarship holder of the Molecular Medicine program of LMU. He joined the laboratory of Christian Haass at the Adolf-Butenandt-Institute to study the role of proteases in Alzheimer’s disease. His state examination in medicine in 2008 was followed by the granting of a medical doctorate in 2009. After his medical studies, he joined the Medical Life Science and Technology program of the Technische-Universität München (TUM) and as well as the German Center of Neurodegenerative Diseases within the Hemholtz Association (DZNE) in Munich. In 2012 he received his doctorade. He has been a Carl von Linde Junior Fellow at TUM-IAS since the middle of 2013.
Selected Awards
2003-2005, Stipend of the Molecular Medicine MD program (FöFoLe of Ludwig-Maximilians University Munich)
Research Interests
In the past Peer-Hendrik Kuhn worked on the neurodegenerative disorder Alzheimer’s disease. During his research he especially focused his efforts on developing novel methods to answer important biological questions in the field. He developed a novel method called Secretome protein enrichment with click sugars (SPECS) which involves mass spectrometry, metabolic labeling of cells and bioorthogonal chemistry to analyze the secretome of primary cortical neurons. This in the end allowed the identification of substrates of the aspartylprotease BACE1 which is intimately linked to the pathogenesis of Alzheimer’s disease due to its initiative role in the generation of the neurotoxic peptide Aβ. Now that he has received the Carl von Linde Junior Fellowship he wants to develop this method further and apply it to other scientific fields like neoplasias of the hematopoietic system. This will allow a better understanding of cancer biology and additionally aid biomarker identification. Additionally these results might aid in therapeutic decisions in the near future. Furthermore he plans to develop additional methods which allow analyzing secreted and cell surface proteins directly from patient specimens.
Kuhn, Peer-Hendrik; Wang, Huanhuan; Dislich, Bastian; Colombo, Alessio; Zeitschel, Ulrike; Ellwart, Joachim W; Kremmer, Elisabeth; Roßner, Steffen; Lichtenthaler, Stefan F: ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons. EMBO J 29 (17), 2010, 3020-3032.
Kuhn, P.-H.; Marjaux, E.; Imhof, A.; De Strooper, B.; Haass, C.; Lichtenthaler, S. F.: Regulated Intramembrane Proteolysis of the Interleukin-1 Receptor II by -, beta-, and -Secretase. Journal of Biological Chemistry 282 (16), 2007, 11982-11995.
Friedmann, Elena; Hauben, Ehud; Maylandt, Kerstin; Schleeger, Simone; Vreugde, Sarah; Lichtenthaler, Stefan F.; Kuhn, Peer-Hendrik; Stauffer, Daniela; Rovelli, Giorgio; Martoglio, Bruno: SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production. Nature Cell Biology 8 (8), 2006, 843-848.
Serdaroglu, Alperen; Müller, Stephan A.; Schepers, Ute; Bräse, Stefan; Weichert, Wilko; Lichtenthaler, Stefan F.; Kuhn, Peer-Hendrik: An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome. PROTEOMICS 17 (5), 2017, 1600423 mehr…BibTeX
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2016
Höfling, Corinna; Morawski, Markus; Zeitschel, Ulrike; Zanier, Elisa R.; Moschke, Katrin; Serdaroglu, Alperen; Canneva, Fabio; von Hörsten, Stephan; De Simoni, Maria-Grazia; Forloni, Gianluigi; Jäger, Carsten; Kremmer, Elisabeth; Roßner, Steffen; Lichtenthaler, Stefan F.; Kuhn, Peer-Hendrik: Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies. Aging Cell 15 (5), 2016, 953-963 mehr…BibTeX
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Kretner, Benedikt; Trambauer, Johannes; Fukumori, Akio; Mielke, Janina; Kuhn, Peer‐Hendrik; Kremmer, Elisabeth; Giese, Armin; Lichtenthaler, Stefan F; Haass, Christian; Arzberger, Thomas; Steiner, Harald: Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease. EMBO Molecular Medicine 8 (5), 2016, 458-465 mehr…BibTeX
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Kuhn, Peer-Hendrik; Colombo, Alessio Vittorio; Schusser, Benjamin; Dreymueller, Daniela; Wetzel, Sebastian; Schepers, Ute; Herber, Julia; Ludwig, Andreas; Kremmer, Elisabeth; Montag, Dirk; Müller, Ulrike; Schweizer, Michaela; Saftig, Paul; Bräse, Stefan; Lichtenthaler, Stefan F: Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. eLife 5, 2016 mehr…BibTeX
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Pigoni, Martina; Wanngren, Johanna; Kuhn, Peer-Hendrik; Munro, Kathryn M.; Gunnersen, Jenny M.; Takeshima, Hiroshi; Feederle, Regina; Voytyuk, Iryna; De Strooper, Bart; Levasseur, Mikail D.; Hrupka, Brian J.; Müller, Stephan A.; Lichtenthaler, Stefan F.: Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons. Molecular Neurodegeneration 11 (1), 2016 mehr…BibTeX
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Schwenk, Benjamin M; Hartmann, Hannelore; Serdaroglu, Alperen; Schludi, Martin H; Hornburg, Daniel; Meissner, Felix; Orozco, Denise; Colombo, Alessio; Tahirovic, Sabina; Michaelsen, Meike; Schreiber, Franziska; Haupt, Simone; Peitz, Michael; Brüstle, Oliver; Küpper, Clemens; Klopstock, Thomas; Otto, Markus; Ludolph, Albert C; Arzberger, Thomas; Kuhn, Peer‐Hendrik; Edbauer, Dieter: TDP‐43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons. The EMBO Journal 35 (21), 2016, 2350-2370 mehr…BibTeX
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2015
Dislich, Bastian; Wohlrab, Felix; Bachhuber, Teresa; Müller, Stephan A.; Kuhn, Peer-Hendrik; Hogl, Sebastian; Meyer-Luehmann, Melanie; Lichtenthaler, Stefan F.: Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo. Molecular & Cellular Proteomics 14 (10), 2015, 2550-2563 mehr…BibTeX
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Hadjipanayi, Ektoras; Kuhn, Peer-Hendrik; Moog, Philipp; Bauer, Anna-Theresa; Kuekrek, Haydar; Mirzoyan, Lilit; Hummel, Anja; Kirchhoff, Katharina; Salgin, Burak; Isenburg, Sarah; Dornseifer, Ulf; Ninkovic, Milomir; Machens, Hans-Günther; Schilling, Arndt F.: The Fibrin Matrix Regulates Angiogenic Responses within the Hemostatic Microenvironment through Biochemical Control. PLOS ONE 10 (8), 2015, e0135618 mehr…BibTeX
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Kuhn, Peer-Hendrik; Voss, Matthias; Haug-Kröper, Martina; Schröder, Bernd; Schepers, Ute; Bräse, Stefan; Haass, Christian; Lichtenthaler, Stefan F.; Fluhrer, Regina: Secretome Analysis Identifies Novel Signal Peptide Peptidase-Like 3 (SPPL3) Substrates and Reveals a Role of SPPL3 in Multiple Golgi Glycosylation Pathways. Molecular & Cellular Proteomics 14 (6), 2015, 1584-1598 mehr…BibTeX
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Wagner, M.; Oelsner, M.; Moore, A.; Gotte, F.; Kuhn, P.-H.; Haferlach, T.; Fiegl, M.; Bogner, C.; Baxter, E. J.; Peschel, C.; Follows, G. A.; Ringshausen, I.: Integration of innate into adaptive immune responses in ZAP-70-positive chronic lymphocytic leukemia. Blood 127 (4), 2015, 436-448 mehr…BibTeX
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2014
Hoffmann, Franziska S.; Kuhn, Peer-Hendrik; Laurent, Sarah A.; Hauck, Stefanie M.; Berer, Kerstin; Wendlinger, Simone A.; Krumbholz, Markus; Khademi, Mohsen; Olsson, Tomas; Dreyling, Martin; Pfister, Hans-Walter; Alexander, Tobias; Hiepe, Falk; Kümpfel, Tania; Crawford, Howard C.; Wekerle, Hartmut; Hohlfeld, Reinhard; Lichtenthaler, Stefan F.; Meinl, Edgar: The Immunoregulator Soluble TACI Is Released by ADAM10 and Reflects B Cell Activation in Autoimmunity. The Journal of Immunology 194 (2), 2014, 542-552 mehr…BibTeX
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Vassar, Robert; Kuhn, Peer-Hendrik; Haass, Christian; Kennedy, Matthew E.; Rajendran, Lawrence; Wong, Philip C.; Lichtenthaler, Stefan F.: Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. Journal of Neurochemistry 130 (1), 2014, 4-28 mehr…BibTeX
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Voss, Matthias; Künzel, Ulrike; Higel, Fabian; Kuhn, Peer‐Hendrik; Colombo, Alessio; Fukumori, Akio; Haug‐Kröper, Martina; Klier, Bärbel; Grammer, Gudula; Seidl, Andreas; Schröder, Bernd; Obst, Reinhard; Steiner, Harald; Lichtenthaler, Stefan F; Haass, Christian; Fluhrer, Regina: Shedding of glycan‐modifying enzymes by signal peptide peptidase‐like 3 ( SPPL 3) regulates cellular N‐glycosylation. The EMBO Journal 33 (24), 2014, 2890-2905 mehr…BibTeX
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2013
Colombo, Alessio; Wang, Huanhuan; Kuhn, Peer-Hendrik; Page, Richard; Kremmer, Elisabeth; Dempsey, Peter J.; Crawford, Howard C.; Lichtenthaler, Stefan F.: Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines. Neurobiology of Disease 49, 2013, 137-147 mehr…BibTeX
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Hogl, Sebastian; van Bebber, Frauke; Dislich, Bastian; Kuhn, Peer-Hendrik; Haass, Christian; Schmid, Bettina; Lichtenthaler, Stefan F.: Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics 13 (9), 2013, 1519-1527 mehr…BibTeX
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Ivankov, D.N.; Bogatyreva, N.S.; Hönigschmid, P.; Dislich, B.; Hogl, S.; Kuhn, P.H.; Frishman, D.; Lichtenthaler, S.F.: QARIP, pp. a web server for quantitative proteomic analysis of regulated intramembrane proteolysis. Nucleic Acids Research 41, 2013 mehr…BibTeX
Müller-Rischart, Anne Kathrin; Pilsl, Anna; Beaudette, Patrick; Patra, Maria; Hadian, Kamyar; Funke, Maria; Peis, Regina; Deinlein, Alexandra; Schweimer, Carolin; Kuhn, Peer-Hendrik; Lichtenthaler, Stefan F.; Motori, Elisa; Hrelia, Silvana; Wurst, Wolfgang; Trümbach, Dietrich; Langer, Thomas; Krappmann, Daniel; Dittmar, Gunnar; Tatzelt, Jörg; Winklhofer, Konstanze F.: The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO. Molecular Cell 49 (5), 2013, 908-921 mehr…BibTeX
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