Gustavo H. Goldman received his BSc in Biology at Federal University of Rio de Janeiro, Brazil (1983). After his undergraduation, he worked at the National Institute of Research in Amazon (INPA, 1983-1986), Manaus, Brazil. Subsequently, he got his MSc. in Microbiology at University of São Paulo, Brazil (1988), his Ph.D. in Molecular Biology at Rijksuniversiteit Gent, in Belgium (1993), and his post-doctoral training at the University of Medicine and Dentistry of New Jersey, USA (1994). He followed his academic career at the School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo as Assistant Professor (1994-1997), Associate Professor (1998-2001), and Professor (2002 to date). He is a Researcher (Category 1A) from the National Council of Research and Technology (CNPq), Brazil (1994 to date) and a visiting Professor at the University of Minho, School of Health, Portugal (2009 to date) and University Nova de Lisboa, Portugal (2017 to date). He has been serving the International Union of Microbiological Societies as a Vice-Chair (2014- 2017) and Chair (2017-2020) in Eukaryotic Microbiology and Mycology, and the Brazilian Society of Microbiology as a Secretary (2014-2015) and Vice-President (2015-2019). He is currently Editor in Chief, Frontiers in Microbiology, Fungi and their interactions since 2018 and Associate Editor for mBio, Fungal Genetics and Biology, and Fungal Biology.
Selected Awards
2017, Member of the American Academy of Microbiology
2007, “Fellow” John Simon Guggenheim Memorial Foundation, USA
2000, Medal of Scientific and Technological Merit, Government of São Paulo State, Brazil
Research Interests
Signal transduction mechanisms that are involved in virulence and pathogenicity in the pathogenic filamentous fungus Aspergillus fumigatus
Signal transduction mechanisms for carbon catabolite repression in filamentous fungi
Selected Publications
Simpson AJG et al. (2000) The genome sequence of the plant pathogen Xylella fastidiosa. Nature, 406: 151-157.
Nierman WC et al. (2005) Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature, 438 (7071):1151-6.
Galagan JE et al. (2005) Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature, 438 (7071):1105-15.
Lind AL, Wisecaver JH, Lameiras C, Wiemann P, Palmer JM, Keller NP, Rodrigues F, Goldman GH, Rokas A. (2017) Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species. PLoS Biol. 15(11):e2003583.
Brown NA, Schrevens S, van Dijck P, Goldman GH. (2018) Fungal G-protein-coupled receptors: mediators of pathogenesis and targets for disease control. Nature Microbiol. 3(4):402-414.
Ries LN, Beattie SR, Espeso EA, Cramer RA, Goldman GH. (2016) Diverse Regulation of the CreA Carbon Catabolite Repressor in Aspergillus nidulans. Genetics. 203(1):335-52.
Mariné M, Brown NA, Riaño-Pachón DM, Goldman GH (2015) On and under the skin: emerging basidiomycetous yeast infections caused by Trichosporon species. PLoS Pathogens 11:e1004982.
Ries LNA, Rocha MC, de Castro PA, Silva-Rocha R, Silva RN, Freitas FZ, de Assis LJ, Bertolini MC, Malavazi I, Goldman GH. (2017) The Aspergillus fumigatus CrzA Transcription Factor Activates Chitin Synthase Gene Expression during the Caspofungin Paradoxical Effect. MBio 13;8(3). pii: e00705-17.
Beattie SR, Mark KMK, Thammahong A, Ries LNA, Dhingra S, Caffrey-Carr AK,Cheng C, Black CC, Bowyer P, Bromley MJ, Obar JJ, Goldman GH, Cramer RA. (2017) Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression. PLoS Pathog. 13(4):e1006340.
de Assis LJ, Ulas M, Ries LNA, El Ramli NAM, Sarikaya-Bayram O, Braus GH, Bayram O, Goldman GH. (2018) Regulation of Aspergillus nidulans CreA-Mediated Catabolite Repression by the F-Box Proteins Fbx23 and Fbx47. MBio 9(3). pii: e00840-18.
Sarikaya Bayram, Özlem; Bayram, Özgür; Karahoda, Betim; Meister, Cindy; Köhler, Anna M.; Thieme, Sabine; Elramli, Nadia; Frawley, Dean; McGowan, Jamie; Fitzpatrick, David A.; Schmitt, Kerstin; de Assis, Leandro Jose; Valerius, Oliver; Goldman, Gustavo H.; Braus, Gerhard H.: F-box receptor mediated control of substrate stability and subcellular location organizes cellular development of Aspergillus nidulans. PLOS Genetics 18 (12), 2022, e1010502 mehr…
2021
Gabriel, Raphael; Thieme, Nils; Liu, Qian; Li, Fangya; Meyer, Lisa T.; Harth, Simon; Jecmenica, Marina; Ramamurthy, Maya; Gorman, Jennifer; Simmons, Blake A.; McCluskey, Kevin; Baker, Scott E.; Tian, Chaoguang; Schuerg, Timo; Singer, Steven W.; Fleißner, André; Benz, J. Philipp: The F-box protein gene <i>exo</i> - <i>1</i> is a target for reverse engineering enzyme hypersecretion in filamentous fungi. Proceedings of the National Academy of Sciences 118 (26), 2021 mehr…
de Assis, Leandro José; Silva, Lilian Pereira; Bayram, Ozgur; Dowling, Paul; Kniemeyer, Olaf; Krüger, Thomas; Brakhage, Axel A.; Chen, Yingying; Dong, Liguo; Tan, Kaeling; Wong, Koon Ho; Ries, Laure N. A.; Goldman, Gustavo H.: Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA. mBio 12 (1), 2021 mehr…
2020
Mattos, Eliciane Cevolani; Silva, Lilian Pereira; Valero, Clara; de Castro, Patrícia Alves; dos Reis, Thaila Fernanda; Ribeiro, Liliane F. C.; Marten, Mark R.; Silva-Rocha, Rafael; Westmann, Cauã; da Silva, Carlos Henrique Tomich de Paula; Taft, Carlton Anthony; Al-Furaiji, Narjes; Bromley, Michael; Mortensen, Uffe H.; Benz, J. Philipp; Brown, Neil Andrew; Goldman, Gustavo H.: The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance. mBio 11 (1), 2020 mehr…
de Assis, Leandro José; Silva, Lilian Pereira; Liu, Li; Schmitt, Kerstin; Valerius, Oliver; Braus, Gerhard H.; Ries, Laure Nicolas Annick; Goldman, Gustavo Henrique: The High Osmolarity Glycerol Mitogen-Activated Protein Kinase regulates glucose catabolite repression in filamentous fungi. PLOS Genetics 16 (8), 2020, e1008996 mehr…
2019
Horta, Maria Augusta C.; Thieme, Nils; Gao, Yuqian; Burnum-Johnson, Kristin E.; Nicora, Carrie D.; Gritsenko, Marina A.; Lipton, Mary S.; Mohanraj, Karthikeyan; de Assis, Leandro José; Lin, Liangcai; Tian, Chaoguang; Braus, Gerhard H.; Borkovich, Katherine A.; Schmoll, Monika; Larrondo, Luis F.; Samal, Areejit; Goldman, Gustavo H.; Benz, J. Philipp: Broad Substrate-Specific Phosphorylation Events Are Associated With the Initial Stage of Plant Cell Wall Recognition in Neurospora crassa. Frontiers in Microbiology 10, 2019 mehr…
