Hendrik Dietz

Fellowship
Carl von Linde Senior Fellow

Appointment
2016

Institution
Technical University of Munich

Department
Biomolecular Nanotechnology

Focus Group
Biologically Inspired Material Science

Short CV

Hendrik Dietz was born in 1977 in Dresden. He studied physics at the University of Paderborn, Universidad de Zaragoza (Spain), and the University of Munich and received a physics diploma in 2004 from the latter place. In early 2007 he was awarded a doctoral degree from the Physics Department of the Technische Universität München for his work on development and application of novel single-molecule methods for the mechanical and structural analysis of protein molecules. Hendrik Dietz then turned from proteins to DNA and joined a team of nanotechnology enthusiasts located at the Dana-Farber Cancer Institute at Harvard Medical School in Boston in order to conduct postdoctoral research.
In June 2009 Dietz returned to the Physics Department at the Technische Universität München as an assistant professor for biological physics and established the "Laboratory for Biomolecular Nanotechnology". In 2014, Hendrik Dietz was appointed as associate professor at the Physics Department of TUM.

Selected Awards

2015, Gottfried Wilhelm Leibniz Prize of the German Research Foundation (DFG)
2012, Hoechst Dozentenstipendium, Aventis Foundation
2010, European Research Council (ERC) Starting Grant
2010, "Arnold Sommerfeld-Preis" of the Bavarian Academy of Sciences and Humanities
2007-2008, Feodor-Lynen Fellow
2008, Deutscher Studienpreis
2006, Chorafas-Award
2005, Scientific Award BMW Group
2004, IDK-NBT Fellow, Elite Netzwerk Bayern
2000, ERASMUS Fellow

Research Interests

Dietz's newly founded 'Laboratory for Biomolecular Nanotechnology' develops novel scientific devices and methods for applications in biomolecular physics, biological chemistry, and molecular medicine. A central focus is on investigating the physical details of intermolecular interactions, in particular protein-protein and protein-DNA interactions. To overcome persistent experimental challenges that one faces when studying low-affinity biomolecular interactions, the Dietz lab is working towards taking advantage of the fine positional control afforded by molecular-self assembly with DNA origami to build nanometer-scale scientific devices that are used to interface and manipulate target macromolecules and that enable conformational read-out with single-molecule fluorescence methods and/or with transmission electron microscopy.

Selected Publications

Dietz, H.; Douglas, S. M.; Shih, W. M.: Folding DNA into Twisted and Curved Nanoscale Shapes. Science 325 (5941), 2009, 725-730.

Douglas, Shawn M.; Dietz, Hendrik; Liedl, Tim; Högberg, Björn; Graf, Franziska; Shih, William M.: Self-assembly of DNA into nanoscale three-dimensional shapes. Nature 459 (7245), 2009, 414-418.

Dietz, Hendrik; Rief, Matthias: Elastic Bond Network Model for Protein Unfolding Mechanics. Phys. Rev. Lett. 100 (9), 2008.

Dietz, H.; Berkemeier, F.; Bertz, M.; Rief, M.: Anisotropic deformation response of single protein molecules. Proceedings of the National Academy of Sciences 103 (34), 2006, 12724-12728.

Dietz, H.; Rief, M.: Protein structure by mechanical triangulation. Proceedings of the National Academy of Sciences 103 (5), 2006, 1244-1247.

Dietz, H.; Rief, M.: Exploring the energy landscape of GFP by single-molecule mechanical experiments. Proceedings of the National Academy of Sciences 101 (46), 2004, 16192-16197.

Publications as TUM-IAS-Fellow

2019
2018
2017
2016
2015
2014
2013
2012
2011

2019

Engelhardt, Floris A. S.; Praetorius, Florian; Wachauf, Christian H.; Brüggenthies, Gereon; Kohler, Fabian; Kick, Benjamin; Kadletz, Karoline L.; Pham, Phuong Nhi; Behler, Karl L.; Gerling, Thomas; Dietz, Hendrik: Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds. ACS Nano 13 (5), 2019, 5015-5027 mehr… BibTeX Volltext ( DOI )
Gerling, Thomas; Dietz, Hendrik: Reversible Covalent Stabilization of Stacking Contacts in DNA Assemblies. Angewandte Chemie International Edition 58 (9), 2019, 2680-2684 mehr… BibTeX Volltext ( DOI )
Häußermann, Katharina; Young, Gavin; Kukura, Philipp; Dietz, Hendrik: Dissecting FOXP2 Oligomerization and DNA Binding. Angewandte Chemie International Edition 58 (23), 2019, 7662-7667 mehr… BibTeX Volltext ( DOI )
Lakemeyer, Markus; Bertosin, Eva; Möller, Friederike; Balogh, Dóra; Strasser, Ralf; Dietz, Hendrik; Sieber, Stephan A.: Tailored Peptide Phenyl Esters Block ClpXP Proteolysis by an Unusual Breakdown into a Heptamer-Hexamer Assembly. Angewandte Chemie International Edition 58 (21), 2019, 7127-7132 mehr… BibTeX Volltext ( DOI )
Ramezani, Hamid; Dietz, Hendrik: Building machines with DNA molecules. Nature Reviews Genetics 21 (1), 2019, 5-26 mehr… BibTeX Volltext ( DOI )
Rodrigues, Letícia; Schneider, Fabian; Zhang, Xiaohan; Larsson, Elin; Moodie, Lindon W.K.; Dietz, Hendrik; Papadakis, Christine M.; Winter, Gerhard; Lundmark, Richard; Hubert, Madlen: Cellular uptake of self-assembled phytantriol-based hexosomes is independent of major endocytic machineries. Journal of Colloid and Interface Science 553, 2019, 820-833 mehr… BibTeX Volltext ( DOI )
Schneider, Fabian; Möritz, Natalie; Dietz, Hendrik: The sequence of events during folding of a DNA origami. Science Advances 5 (5), 2019, eaaw1412 mehr… BibTeX Volltext ( DOI )
Sigmund, Felix; Pettinger, Susanne; Kube, Massimo; Schneider, Fabian; Schifferer, Martina; Schneider, Steffen; Efremova, Maria V.; Pujol-Martí, Jesús; Aichler, Michaela; Walch, Axel; Misgeld, Thomas; Dietz, Hendrik; Westmeyer, Gil G.: Iron-Sequestering Nanocompartments as Multiplexed Electron Microscopy Gene Reporters. ACS Nano 13 (7), 2019, 8114-8123 mehr… BibTeX Volltext ( DOI )
Wanzke, Caren; Jussupow, Alexander; Kohler, Fabian; Dietz, Hendrik; Kaila, Ville R. I.; Boekhoven, Job: Dynamic Vesicles Formed By Dissipative Self‐Assembly. ChemSystemsChem 2 (1), 2019 mehr… BibTeX Volltext ( DOI )

2018

Bruetzel, Linda K.; Walker, Philipp U.; Gerling, Thomas; Dietz, Hendrik; Lipfert, Jan: Time-Resolved Small-Angle X-ray Scattering Reveals Millisecond Transitions of a DNA Origami Switch. Nano Letters 18 (4), 2018, 2672-2676 mehr… BibTeX Volltext ( DOI )
Bräuning, Bastian; Bertosin, Eva; Praetorius, Florian; Ihling, Christian; Schatt, Alexandra; Adler, Agnes; Richter, Klaus; Sinz, Andrea; Dietz, Hendrik; Groll, Michael: Structure and mechanism of the two-component a-helical pore-forming toxin YaxAB. Nature Communications 9 (1), 2018 mehr… BibTeX Volltext ( DOI )
Franquelim, Henri G.; Khmelinskaia, Alena; Sobczak, Jean-Philippe; Dietz, Hendrik; Schwille, Petra: Membrane sculpting by curved DNA origami scaffolds. Nature Communications 9 (1), 2018 mehr… BibTeX Volltext ( DOI )
Gerling, Thomas; Kube, Massimo; Kick, Benjamin; Dietz, Hendrik: Sequence-programmable covalent bonding of designed DNA assemblies. Science Advances 4 (8), 2018, eaau1157 mehr… BibTeX Volltext ( DOI )
Ketterer, Philip; Ananth, Adithya N.; Laman Trip, Diederik S.; Mishra, Ankur; Bertosin, Eva; Ganji, Mahipal; van der Torre, Jaco; Onck, Patrick; Dietz, Hendrik; Dekker, Cees: DNA origami scaffold for studying intrinsically disordered proteins of the nuclear pore complex. Nature Communications 9 (1), 2018 mehr… BibTeX Volltext ( DOI )
Schickinger, Matthias; Zacharias, Martin; Dietz, Hendrik: Tethered multifluorophore motion reveals equilibrium transition kinetics of single DNA double helices. Proceedings of the National Academy of Sciences 115 (32), 2018, E7512-E7521 mehr… BibTeX Volltext ( DOI )

2017

Praetorius, Florian; Dietz, Hendrik: Self-assembly of genetically encoded DNA-protein hybrid nanoscale shapes. Science 355 (6331), 2017, eaam5488 mehr… BibTeX Volltext ( DOI )
Praetorius, Florian; Kick, Benjamin; Behler, Karl L.; Honemann, Maximilian N.; Weuster-Botz, Dirk; Dietz, Hendrik: Biotechnological mass production of DNA origami. Nature 552 (7683), 2017, 84-87 mehr… BibTeX Volltext ( DOI )
Siavashpouri, Mahsa; Wachauf, Christian H.; Zakhary, Mark J.; Praetorius, Florian; Dietz, Hendrik; Dogic, Zvonimir: Molecular engineering of chiral colloidal liquid crystals using DNA origami. Nature Materials 16 (8), 2017, 849-856 mehr… BibTeX Volltext ( DOI )
Wagenbauer, Klaus F.; Engelhardt, Floris A. S.; Stahl, Evi; Hechtl, Vera K.; Stömmer, Pierre; Seebacher, Fabian; Meregalli, Letizia; Ketterer, Philip; Gerling, Thomas; Dietz, Hendrik: How We Make DNA Origami. ChemBioChem 18 (19), 2017, 1873-1885 mehr… BibTeX Volltext ( DOI )
Wagenbauer, Klaus F.; Sigl, Christian; Dietz, Hendrik: Gigadalton-scale shape-programmable DNA assemblies. Nature 552 (7683), 2017, 78-83 mehr… BibTeX Volltext ( DOI )
Willner, Elena M.; Kamada, Yuu; Suzuki, Yuki; Emura, Tomoko; Hidaka, Kumi; Dietz, Hendrik; Sugiyama, Hiroshi; Endo, Masayuki: Single-Molecule Observation of the Photoregulated Conformational Dynamics of DNA Origami Nanoscissors. Angewandte Chemie International Edition 56 (48), 2017, 15324-15328 mehr… BibTeX Volltext ( DOI )

2016

Bruetzel, Linda K.; Gerling, Thomas; Sedlak, Steffen M.; Walker, Philipp U.; Zheng, Wenjun; Dietz, Hendrik; Lipfert, Jan: Conformational Changes and Flexibility of DNA Devices Observed by Small-Angle X-ray Scattering. Nano Letters 16 (8), 2016, 4871-4879 mehr… BibTeX Volltext ( DOI )
Dietz, Hendrik: Toward Applications for DNA Nanotechnology-More Bricks To Build With. ChemBioChem 17 (12), 2016, 1046-1047 mehr… BibTeX Volltext ( DOI )
Funke, Jonas J.; Ketterer, Philip; Lieleg, Corinna; Korber, Philipp; Dietz, Hendrik: Exploring Nucleosome Unwrapping Using DNA Origami. Nano Letters 16 (12), 2016, 7891-7898 mehr… BibTeX Volltext ( DOI )
Funke, Jonas J.; Ketterer, Philip; Lieleg, Corinna; Schunter, Sarah; Korber, Philipp; Dietz, Hendrik: Uncovering the forces between nucleosomes using DNA origami. Science Advances 2 (11), 2016, e1600974 mehr… BibTeX Volltext ( DOI )
Ketterer, Philip; Willner, Elena M.; Dietz, Hendrik: Nanoscale rotary apparatus formed from tight-fitting 3D DNA components. Science Advances 2 (2), 2016, e1501209 mehr… BibTeX Volltext ( DOI )
Kick, Benjamin; Hensler, Samantha; Praetorius, Florian; Dietz, Hendrik; Weuster-Botz, Dirk: Specific growth rate and multiplicity of infection affect high-cell-density fermentation with bacteriophage M13 for ssDNA production. Biotechnology and Bioengineering 114 (4), 2016, 777-784 mehr… BibTeX Volltext ( DOI )
Kilchherr, F.; Wachauf, C.; Pelz, B.; Rief, M.; Zacharias, M.; Dietz, H.: Single-molecule dissection of stacking forces in DNA. Science 353 (6304), 2016, aaf5508-aaf5508 mehr… BibTeX Volltext ( DOI )
Krishnan, Swati; Ziegler, Daniela; Arnaut, Vera; Martin, Thomas G.; Kapsner, Korbinian; Henneberg, Katharina; Bausch, Andreas R.; Dietz, Hendrik; Simmel, Friedrich C.: Molecular transport through large-diameter DNA nanopores. Nature Communications 7 (1), 2016 mehr… BibTeX Volltext ( DOI )
Martin, Thomas G.; Bharat, Tanmay A. M.; Joerger, Andreas C.; Bai, Xiao-chen; Praetorius, Florian; Fersht, Alan R.; Dietz, Hendrik; Scheres, Sjors H. W.: Design of a molecular support for cryo-EM structure determination. Proceedings of the National Academy of Sciences 113 (47), 2016, E7456-E7463 mehr… BibTeX Volltext ( DOI )
Rodrigues, Letícia; Kyriakos, Konstantinos; Schneider, Fabian; Dietz, Hendrik; Winter, Gerhard; Papadakis, Christine M.; Hubert, Madlen: Characterization of Lipid-Based Hexosomes as Versatile Vaccine Carriers. Molecular Pharmaceutics 13 (11), 2016, 3945-3954 mehr… BibTeX Volltext ( DOI )
Stahl, Evi; Praetorius, Florian; de Oliveira Mann, Carina C.; Hopfner, Karl-Peter; Dietz, Hendrik: Impact of Heterogeneity and Lattice Bond Strength on DNA Triangle Crystal Growth. ACS Nano 10 (10), 2016, 9156-9164 mehr… BibTeX Volltext ( DOI )

2015

Gerling, T.; Wagenbauer, K. F.; Neuner, A. M.; Dietz, H.: Dynamic DNA devices and assemblies formed by shape-complementary, non-base pairing 3D components. Science 347 (6229), 2015, 1446-1452 mehr… BibTeX Volltext ( DOI )

2014

Cui, H; Seubert, B; Stahl, E; Dietz, H; Reuning, U; Moreno-Leon, L; Ilie, M; Hofman, P; Nagase, H; Mari, B; Krüger, A: Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes. Oncogene 34 (28), 2014, 3640-3650 mehr… BibTeX Volltext ( DOI )
Plesa, Calin; van Loo, Nick; Ketterer, Philip; Dietz, Hendrik; Dekker, Cees: Velocity of DNA during Translocation through a Solid-State Nanopore. Nano Letters 15 (1), 2014, 732-737 mehr… BibTeX Volltext ( DOI )
Shen, Boxuan; Linko, Veikko; Dietz, Hendrik; Toppari, J. Jussi: Dielectrophoretic trapping of multilayer DNA origami nanostructures and DNA origami-induced local destruction of silicon dioxide. ELECTROPHORESIS 36 (2), 2014, 255-262 mehr… BibTeX Volltext ( DOI )
Stahl, Evi; Martin, Thomas G.; Praetorius, Florian; Dietz, Hendrik: Facile and Scalable Preparation of Pure and Dense DNA Origami Solutions. Angewandte Chemie International Edition 53 (47), 2014, 12735-12740 mehr… BibTeX Volltext ( DOI )
Wagenbauer, Klaus F.; Wachauf, Christian H.; Dietz, Hendrik: Quantifying quality in DNA self-assembly. Nature Communications 5 (1), 2014 mehr… BibTeX Volltext ( DOI )

2013

Linko, Veikko; Dietz, Hendrik: The enabled state of DNA nanotechnology. Current Opinion in Biotechnology 24 (4), 2013, 555-561 mehr… BibTeX Volltext ( DOI )
Pfitzner, Emanuel; Wachauf, Christian; Kilchherr, Fabian; Pelz, Benjamin; Shih, William M.; Rief, Matthias; Dietz, Hendrik: Rigid DNA Beams for High-Resolution Single-Molecule Mechanics. Angewandte Chemie International Edition 52 (30), 2013, 7766-7771 mehr… BibTeX Volltext ( DOI )
Plesa, Calin; Ananth, Adithya N.; Linko, Veikko; Gülcher, Coen; Katan, Allard J.; Dietz, Hendrik; Dekker, Cees: Ionic Permeability and Mechanical Properties of DNA Origami Nanoplates on Solid-State Nanopores. ACS Nano 8 (1), 2013, 35-43 mehr… BibTeX Volltext ( DOI )

2012

Bai, X.-c.; Martin, T. G.; Scheres, S. H. W.; Dietz, H.: Cryo-EM structure of a 3D DNA-origami object. Proceedings of the National Academy of Sciences 109 (49), 2012, 20012-20017 mehr… BibTeX Volltext ( DOI )
Langecker, M.; Arnaut, V.; Martin, T. G.; List, J.; Renner, S.; Mayer, M.; Dietz, H.; Simmel, F. C.: Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures. Science 338 (6109), 2012, 932-936 mehr… BibTeX Volltext ( DOI )
Martin, Thomas G.; Dietz, Hendrik: Magnesium-free self-assembly of multi-layer DNA objects. Nature Communications 3, 2012, 1103 mehr… BibTeX Volltext ( DOI )
Sobczak, J.-P. J.; Martin, T. G.; Gerling, T.; Dietz, H.: Rapid Folding of DNA into Nanoscale Shapes at Constant Temperature. Science 338 (6113), 2012, 1458-1461 mehr… BibTeX Volltext ( DOI )
Wei, Ruoshan; Martin, Thomas G.; Rant, Ulrich; Dietz, Hendrik: DNA Origami Gatekeepers for Solid-State Nanopores. Angewandte Chemie International Edition 51 (20), 2012, 4864-4867 mehr… BibTeX Volltext ( DOI )

2011

Castro, Carlos Ernesto; Kilchherr, Fabian; Kim, Do-Nyun; Shiao, Enrique Lin; Wauer, Tobias; Wortmann, Philipp; Bathe, Mark; Dietz, Hendrik: A primer to scaffolded DNA origami. Nature Methods 8 (3), 2011, 221-229 mehr… BibTeX Volltext ( DOI )