Scientific Report on TUM-IAS Fellowship
Prenatal exposure to maternal psychosocial stress confers a lifelong risk for behavioral alterations that last beyond childhood. Our aim is to identify non-invasive biomarkers of the childdevelopmental outcome to offer a precise and truly personalized prediction and new possibilities for designing interventions to improve neurodevelopmental outcomes of pregnancy affected by prenatal stress. full report …
Short CV
Marta C. Antonelli received her Biochemist and PhD degree in Neurochemistry from the University of Buenos Aires, Argentina. Upon receiving her PhD degree, she moved to Seattle, WA, USA for a postdoctoral stay at the Veterans Administration Medical Center/University of Washington. Back in Buenos Aires, she is currently head of the Laboratory of Perinatal Programming of Neurodevelopment at the Faculty of Medicine, University of Buenos Aires and holds a position as Principal Researcher of the CONICET (National Research Council). Since 2021, she has been President of the Executive Council of the Argentine Society for Neuroscience (SAN). The focus of her research is centered in the study of the offspring outcome in a rodent model of prenatal restraint stress. For two consecutive periods, she was recipient of the August-Wilhelm Scheer Visiting Professorship Program (Technische Universität München) to develop a translational project at the Frauenklinik und Poliklinik, Klinikum rechts der Isar, Munich, Germany, to investigate the long term effect of prenatal stress on children outcome and identify potential biomarkers to orient early interventional programs in humans.
Selected Awards
- 2016, August-Wilhelm Scheer Visiting Professorship Program (TUM)
- 2009, President of the International Society for Neurotoxicity
- 1987, Postdoctoral Fellowship (International), CONICET. Argentina
- 1984, Postdoctoral Fellowship (National), CONICET. Argentina
- 1979, Doctoral Fellowship. CONICET. Argentina
Research Interests
Prenatal stress, dopamine, glutamate, corticolimbic system, rats, crossfostering, cortisol, HPA axis, autonomic nervous system, biomarkers, neurodevelopment, epigenetics, DNA methylation, plasticity, substance use disorders, early stimulation.
Selected Publications
- “Unravelling the Link Between Prenatal Stress, Dopamine and Substance Use Disorder”. V. Pastor , MC. Antonelli, ME. Pallares. Neurotox Res.31(1):169-186. 2017.(doi: 10.1007/s12640-016-9674-9)
- ¨Long-Term consequences of prenatal insults on neurodevelopment¨. MC. Antonelli, ME. Pallarés, S. Ceccatelli, S. Spulber. Progress in Neurobiology. 155: 21–35. 2017. (doi: 10.1016/j.pneurobio.2016.05.005).
- “Prenatal stress increases adult vulnerability to cocaine reward without affecting pubertal anxiety or novelty response”. V. Pastor, ME. Pallarés, MC. Antonelli. Behav Brain Res. 339:186-194. 2018. (doi: 10.1016/j.bbr.2017.11.035).
- “In Vivo and in Vitro Neuronal Plasticity Modulation by Epigenetic Regulators”. MC. Monteleone, ME. Pallarés, SC. Billi, MC. Antonelli, MA. Brocco. J.Mol. Neurosci. 2018. 65(3):301-311. (doi: 10.1007/s12031-018-1101-7).
- “Microglial memory of early life stress and inflammation: susceptibility to neurodegeneration in adulthood”. P. Desplats, AM. Gutierrez, MC. Antonelli, MG. Frasch. Neuroscience & Biobehavioral Reviews. 2020. 117:232-242. doi.org/10.1016/j.neubiorev. 2019.10.013.
- “Prefrontal cortex alpha 7 nicotinic receptors are necessary for cocaine-associated memory acquisition and retrieval”. V. Pastor; F. Castillo Díaz; VC. Sanabria; JF. Dalto; MC. Antonelli; JH. Medina. Behavioural Brain Research. 2021. doi: 10.1016/j.bbr.2021.113212.
Publications as TUM-IAS Fellow
