Medications often have unwanted side-effects. One reason is that they reach not only the unhealthy cells for which they are intended, but also reach and have an impact on healthy cells. Researchers at the Technical University of Munich (TUM), including Prof. Oliver Lieleg, and working together with the KTH Royal Institute of Technology in Stockholm, have developed a stable nano-carrier for medications. On November 25, 2020, Prof. Oliver Lieleg will explain how a special mechanism makes sure the drugs are only released in diseased cells. (TUM press release).
Ceren Kimna, Theresa Monika Lutz, Hongji Yan, Jian Song, Thomas Crouzier, and Oliver Lieleg: DNA Strands Trigger the Intracellular Release of Drugs from Mucin-Based Nanocarriers, ACS Nano, doi/abs/10.1021/acsnano.0c04035.
Ceren Kimna, Oliver Lieleg, Engineering an orchestrated release avalanche from hydrogels using DNA-nanotechnology, Journal of Controlled Release, Volume 304, 28 June 2019, Pages 19-28, doi.org/10.1016/j.jconrel.2019.04.028.
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