Intra-Operative Therapy

The Focus Group Intra-Operative Therapy of Rudolf Diesel Industry Fellow Prof. Dr. Michael Friebe were focusing on the combination of minimal-invasive therapy techniques, including the application of intra-operative radiation therapy, with advanced diagnostic imaging devices.

An initial development goal was to use advanced MRI imaging to find and localize small pathologies and subsequently perform minimal-invasive therapy with a small radiation source and continuous intra-operative imaging for visualization and navigation. A small radiation source needs to be build, combined with intra-operative imaging technologies (e.g. US, SPECT, Fluorescence), and guided by separate navigation techniques and pre-operative imaging data (CT, MRI, PET).

To achieve that translational goal a close and intensive interdisciplinary collaboration between the clinical specialists / users (Surgical Oncology, Radiation Therapy, Gynecology, Dermatology, Urology, Minimal Invasive Surgery, Radiology, Nuclear Medicine ...) and the technical faculties (Medical Technology, Physics, Informatics, Medical Physics, ...) is needed.

There are great synergies with the existing Focus Groups Biomedical Engineering (Prof. Kucharczyk and Prof. Haase) and Molecular Imaging (Prof. Aime, Prof. Schwaiger).

The Intra-Operative Therapy group was hosted by Prof. Nassir Navab, the head of the Chair for Computer Aided Medical Procedures & Augmented Reality (CAMPAR).

TUM-IAS funded doctoral candidate:
Philipp Matthies, Chair for Computer Aided Medical Procedures & Augmented Reality

2015

A. Boese, T. Hoffmann, M. Skalej, and M. Friebe: Changing the stiffness of vascular catheters intra interventional. Interventional Neuroradiology 21, 2015, 182-183 more…
A. van Oepen, A. Boese, and M. Friebe: Novel device for minimally-invasive tumor removal. 27nd International Conference of the Society for Medical Innovation and Technology, 2015, 61 more…
A. van Oepen, A. Boese, and M. Friebe: Minimally invasive tumor extraction combined with subsequent intraoperative radiation. Image-Guided Interventions Conference, 2015 more…
Friebe, Michael; Traub, Jörg: Image guided surgery innovation with graduate students - a new lecture format. Current Directions in Biomedical Engineering 1 (1), 2015 more…
J. Gardiazabal, B. Frisch, P. Matthies, J. Vogel, S. Ziegler, N. Navab, and T. Lasser: List-mode reconstruction for continuous freehand SPECT acquisitions. 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, 2015 more…
J. Gardiazabal, J. Vogel, P. Matthies, M. Wieczorek, B. Frisch, N. Navab, S. Ziegler, and T. Lasser: Fully 3D thyroid imaging with mini gamma cameras. Proceedings International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, 2015 more…
Lasser, Tobias; Gardiazabal, José; Wieczorek, Matthias; Matthies, Philipp; Vogel, Jakob; Frisch, Benjamin; Navab, Nassir: Towards 3D Thyroid Imaging Using Robotic Mini Gamma Cameras. In: Informatik aktuell. Springer Berlin Heidelberg, 2015 more…
M. Friebe and A. Boese: Image guided double-balloon brachytherapy concept. International Journal of Computer Assisted Radiology and Surgery 10, 2015, 183-184 more…
M. Friebe and J. Traub: Pathway to MedTec entrepreneurship - image guided surgery translation. European Biomedical Engineering Innovation, Design and Entrepreneurship Alliance, 2015 more…
M. Horn, S. Paepke, E. Klein, T. Wendler, and M. Friebe: Hybrid interventional imaging for non-surgical sentinel lymph node staging. International Journal of Computer Assisted Radiology and Surgery 10 (1), 2015, 36 more…
P. Matthies, B. Frisch, J. Vogel, T. Lasser, M. Friebe, and N. Navab: Inside-out tracking for flexible hand-held nuclear tomographic imaging. 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, 2015 more…

2014

E. Nasonova, M. Durst, C. Gringen, E. Farreif, and M. Friebe: Reconstruction of carbon-13 metabolic MR images using constrained optimization. SMRM/ESMRMB, 2014 more…
E. Nasonova, M. Durst, C. Gringeri, E. V Farrell, M. Friebe, A. Haase, M. Schwaiger, and R. F. Schulte: Reconstruction of carbon-13 metabolic MR images using constrained optimisation. International Society for Magnetic Resonance in Medicine 491 (2011), 2014, 3794 more…
E. Nasonova, M. Durst, C. Gringeri, E. V. Farrell, M. Friebe, A. Haase, M. Schwaiger, and R. F. Schulte: Compensating for metabolite dynamics in 13C chemical shift separation. International Society for Magnetic Resonance in Medicine 202 (1), 2014, 3792 more…
Friebe, Michael; Katouzian, Amin; Krombach, Gabriele; Heinz-Werner Henke: MRI biopsy with semi–automated biopsy needle in Slicer 3D environment. Unpublished, 2014 more…
Friebe, Michael; Traub, Jörg; Wendler, Thomas; Wiesner, Stefan: Hybrid interventional imaging for non-surgical SLNB Staging. Unpublished, 2014 more…
M. Friebe, A. Katouzian, S. O. Cho, and P. Matthies: Miniaturized cold emission low energy X-ray tubes for MRI guided intraoperative radiation therapy - A technical feasibility study. IGIC 2014, 2014 more…
M. Friebe, P. Matthies, and S. O. Cho: low energy radiation therapy - feasibility of using a field emission miniature X-ray tube for intraoperative treatments under MRI guidance. International Journal of Computer Assisted Radiology and Surgery 9, 2014, 65-70 more…
Matthies, Philipp; Gardiazabal, José; Okur, Aslı; Vogel, Jakob; Lasser, Tobias; Navab, Nassir: Mini gamma cameras for intra-operative nuclear tomographic reconstruction. Medical Image Analysis 18 (8), 2014, 1329-1336 more…
P. Matthies, J. Gardiazabal, A. Okur, T. Lasser, and N. Navab: Accuracy evaluation of interventional nuclear tomographic reconstruction using mini gamma cameras. In: G.-Z. Yang and A. Darzi (Ed.): The Hamlyn Symposium on Medical Robotics: Proceedings. UK-Robotics and Autonomous Systems Network, 2014 more…

2013

Matthies, P.; Cho, S.O.; Friebe, M.: Integration of a low energy radiation source in MRI environment for intraoperative applications - a feasibility evaluation. 25th Int. Conf. of the Int. Society for Medical Innovation and Technology, 2013 more…
Matthies, Philipp; Okur, Asli; Wendler, Thomas; Navab, Nassir; Friebe, Michael: Combination of intra-operative freehand SPECT imaging with MR images for guidance and navigation. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), IEEE, 2013 more…
Matthies, Philipp; Sharma, Kanishka; Okur, Aslı; Gardiazabal, José; Vogel, Jakob; Lasser, Tobias; Navab, Nassir: First Use of Mini Gamma Cameras for Intra-operative Robotic SPECT Reconstruction. In: Advanced Information Systems Engineering. Springer Berlin Heidelberg, 2013 more…