The Focus Group around Rudolf Mößbauer Tenure Track Professor Ruben Portugues works on understanding the brain circuitry that underlies behavior, how this is established during development, and how it is affected during natural processes such as learning and disease or injury. We use a highly interdisciplinary approach that stems from neuroimaging experiments we perform, during which we monitor the activity of all 100,000 individual neurons in a larval zebrafish, with single-cell resolution and at a rate of two brains per second. By designing virtual reality environments and behavioral assays during which we present stimuli and monitor behavior, we probe processes such as decision-making, learning, navigation, and attention. These experiments generate large data sets that we analyze and use to generate circuit hypotheses, which we further probe with electrophysiology, optogenetics, modeling, and behavioral experiments. These experiments offer a unique possibility within vertebrate model organisms to investigate neuronal processing from sensory perception to motor action, across scales that range from individual synapses to the whole brain and across multiple behavioral paradigms, while retaining the ability to perturb these circuits and assess their robustness and recovery.
Claudi, Federico; Tyson, Adam L; Petrucco, Luigi; Margrie, Troy W; Portugues, Ruben; Branco, Tiago: Visualizing anatomically registered data with brainrender. eLife 10, 2021 more…
Odstrcil, Iris; Petkova, Mariela D.; Haesemeyer, Martin; Boulanger-Weill, Jonathan; Nikitchenko, Maxim; Gagnon, James A.; Oteiza, Pablo; Schalek, Richard; Peleg, Adi; Portugues, Ruben; Lichtman, Jeff; Engert, Florian: Functional and ultrastructural analysis of reafferent mechanosensation in larval zebrafish. bioRxiv, 2021 more…
Xiao, Yan; Hoodless, Laura J; Petrucco, Luigi; Portugues, Ruben; Czopka, Tim: Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling. bioRxiv, 2021 more…
2020
Barykina, Natalia V.; Sotskov, Vladimir P.; Gruzdeva, Anna M.; Wu, You Kure; Portugues, Ruben; Subach, Oksana M.; Chefanova, Elizaveta S.; Plusnin, Viktor V.; Ivashkina, Olga I.; Anokhin, Konstantin V.; Vlaskina, Anna V.; Korzhenevskiy, Dmitry A.; Nikolaeva, Alena Y.; Boyko, Konstantin M.; Rakitina, Tatiana V.; Varizhuk, Anna M.; Pozmogova, Galina E.; Subach, Fedor V.: FGCaMP7, an Improved Version of Fungi-Based Ratiometric Calcium Indicator for In Vivo Visualization of Neuronal Activity. International Journal of Molecular Sciences 21 (8), 2020, 3012 more…
Claudi, Federico; Petrucco, Luigi; Tyson, Adam; Branco, Tiago; Margrie, Troy; Portugues, Ruben: BrainGlobe Atlas API: a common interface for neuroanatomical atlases. Journal of Open Source Software 5 (54), 2020, 2668 more…
Markov, Daniil A.; Petrucco, Luigi; Kist, Andreas M.; Portugues, Ruben: A cerebellar internal model calibrates a feedback controller involved in sensorimotor control. bioRxiv, 2020 more…
Siju, K.P.; Štih, Vilim; Aimon, Sophie; Gjorgjieva, Julijana; Portugues, Ruben; Grunwald Kadow, Ilona C.: Valence and State-Dependent Population Coding in Dopaminergic Neurons in the Fly Mushroom Body. Current Biology 30 (11), 2020, 2104-2115.e4 more…
Yildizoglu, Tugce; Riegler, Clemens; Fitzgerald, James E.; Portugues, Ruben: A Neural Representation of Naturalistic Motion-Guided Behavior in the Zebrafish Brain. Current Biology 30 (12), 2020, 2321-2333.e6 more…
