Christian Stemberger

Fellowship
Carl von Linde Junior Fellow

Institution
Technische Universität München

Department
Medical Microbiology, Immunology and Hygiene

Host
Dirk Busch

Focus Group
Clinical Cell Processing and Purification

Short CV

Christian Stemberger studied Biology and received his Diploma (in Molecular Biology and Biochemistry) in 2004 from TUM. From 2004 to 2008 he performed his PhD thesis work in immunology at TUM (dissertation: Origin of CD8+T cell subsets; Thesis Advisor Prof. Dirk Busch). After finishing his thesis he continued working as a postdoctorate at the Institute for Medical Microbiology, Immunology and Hygiene.


Research Interests

Christian Stemberger´s research interests focus on the development of cellular therapeutics for infections as well as certain forms of cancer and other immunologically related diseases. His special interest lies in the generation of molecular methods that allow for highly specific and reversible selection, as well as purification of immunologically relevant cells such as antigen-specific CD8+ T cells, NK cells and/or regulatory T cells. Together with the development of technically advanced selection and processing techniques (like magnetic cell sorting and flow cytometry) GMP-grade cellular products should be generated for future clinical applications. Further studies involve the understanding of the generation of robust and long-lasting T cell responses in vivo and their implication for adoptive T cell therapy.


Selected Publications

  • 2009, Huster, K. M.; Stemberger, C.; Gasteiger, G.; Kastenmuller, W.; Drexler, I.; Busch, D. H.: Cutting Edge: Memory CD8 T Cell Compartment Grows in Size with Immunological Experience but Nevertheless Can Lose Function. The Journal of Immunology 183 (11), 6898-6902.
  • 2009, Stemberger, Christian; Neuenhahn, Michael; Gebhardt, Friedemann E.; Schiemann, Matthias; Buchholz, Veit R.; Busch, Dirk H.: Stem cell-like plasticity of naïve and distinct memory CD8+ T cell subsets. Seminars in Immunology 21 (2), 62-68.
  • 2007, Stemberger, Christian; Huster, Katharina M.; Koffler, Martina; Anderl, Florian; Schiemann, Matthias; Wagner, Hermann; Busch, Dirk H.: A Single Naive CD8+ T Cell Precursor Can Develop into Diverse Effector and Memory Subsets. Immunity 27 (6), 985-997.
  • 2007, Stemberger, C.; Neuenhahn, M.; Buchholz, V.R.; Busch, D.H.: Origin of CD8+ Effector and Memory T Cell Subsets. Cellular and Molecular Immunology 4, 399-405.
  • 2006, Neuenhahn, Michael; Kerksiek, Kristen M.; Nauerth, Magdalena; Suhre, Michael H.; Schiemann, Matthias; Gebhardt, Friedemann E.; Stemberger, Christian; Panthel, Klaus; Schröder, Samira; Chakraborty, Trinad; Jung, Steffen; Hochrein, Hubertus; Rüssmann, Holger; Brocker, Thomas; Busch, Dirk H.: CD8α+ Dendritic Cells Are Required for Efficient Entry of Listeria monocytogenes into the Spleen. Immunity 25 (4), 619-630.
  • 2006, Huster, Katharina M.; Koffler, Martina; Stemberger, Christian; Schiemann, Matthias; Wagner, Hermann; Busch, Dirk H.: Unidirectional development of CD8+ central memory T cells into protectiveListeria-specific effector memory T cells. European Journal of Immunology 36 (6), 453-1464.
  • 2006, Stemberger, C.; Huster, K.M.; Busch, D.H.: Defining correlates of T cell protection against infection. Discover Medicine, 148-152.
  • 2005, Kriegeskorte, A. K.; Gebhardt, F. E.; Porcellini, S.; Schiemann, M.; Stemberger, C.; Franz, T. J.; Huster, K. M.; Carayannopoulos, L. N.; Yokoyama, W. M.; Colonna, M.; Siccardi, A. G.; Bauer, S.; Busch, D. H.: NKG2D-independent suppression of T cell proliferation by H60 and MICA. Proceedings of the National Academy of Sciences 102 (33), 11805-11810.

Publications as TUM-IAS-Fellow

2012

  • Stemberger, Christian; Dreher, Stefan; Tschulik, Claudia; Piossek, Christine; Bet, Jeannette; Yamamoto, Tori N.; Schiemann, Matthias; Neuenhahn, Michael; Martin, Klaus; Schlapschy, Martin; Skerra, Arne; Schmidt, Thomas; Edinger, Matthias; Riddell, Stanley R.; Germeroth, Lothar; Busch, Dirk H.: Novel Serial Positive Enrichment Technology Enables Clinical Multiparameter Cell Sorting. PLoS ONE 7 (4), 2012, e35798 more… BibTeX Full text ( DOI )