Thaddeus Stappenbeck

Short CV

Thaddeus Stappenbeck received his B.A. degree as a member of the Integrated Science Program at Northwestern University. He obtained and M.D. and Ph.D. from Northwestern University Medical School. He trained in anatomic pathology at Washington University School of Medicine and is board certified in this specialty. He studied host-microbial interactions in the intestine as a postdoctoral fellow with Jeffrey Gordon at Washington University. He was appointed as an Assistant Professor in 2003 in the Department of Pathology and Immunology at Washington University. He was promoted to Professor in 2013 and received a named professorship in 2016. He became Division Chief of Lab and Genomic Medicine at Washington University Pathology and Immunology in 2016. He moved to Cleveland Clinic in 2019 and is currently the chair of Inflammation and Immunity.

Selected Awards

• 2019, Organizer, Keystone Conference on Organoids
• 2018, American Association of Physicians
• 2016, CCFA Scientific Achievement in IBD Basic Science Award
• 2013, Organizer, Gastrointestinal Tract XV: FASEB conference
• 2012, American Gastroenterological Association (AGA) Fellowship
• 2010, Kavli Fellow
• 2009, American Society for Clinical Investigation
• 2005, Pew Scholar

Research Interests

Thaddeus Stappenbeck’s investigations aim to understand combinations of genetic and environmental factors that affect specific epithelial cell functions that predispose individuals to develop active intestinal inflammation. His research areas include inflammation, infection, wound repair, microbiome, epithelium and host defense.

Selected Publications

• Wang Y, Chiang IL, Ohara TE, Fujii S, Cheng J, Muegge BD, Ver Heul A, Han ND, Lu Q, Xiong S, Chen F, Lai CW, Janova H, Wu R, Whitehurst CE, VanDussen KL, Liu TC, Gordon JI, Sibley LD, Stappenbeck TS. Long-Term culture captures injury-repair cycles of colonic stem cells. Cell. 2019 Nov 14;179(5):1144-1159. PMID: 31708126
   
• Kaiko GE, Chen F, Lai CW, Chiang IL, Perriqoue J, Stojmirovic A, Li K, Muegge BD, Jain U, VanDussen KL, Googins BJ, Kelley S, Weaver J, Foster PS Lawrence DA, Liu TC, Stappenbeck TS. PAI-1 augments mucosal damage in colitis.  Sci Transl Med. 2019 Mar 6; 11(482).  PMCID: PMC6779314
   
• White JP, Xiong S, Malvin P, Khoury-Hanold W, Heuckeroth RO, Stappenbeck TS, Diamond MD. Intestinal Dysmotility Syndromes following Systemic Infection by Flaviviruses. Cell, 2018 Nov 15; 175(5): 1198-1212. PMCID: PMC6309989
   
• Liu TC, Kern JT, VanDussen KL, Xiong S, Kaiko GE, Wilen CB, Rajala MW, Caruso R, Holtzman MJ, Gao F, McGovern DP, Nunez G, Head, RD, Stappenbeck TS.  Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn’s disease.  J Clin Invest. 2018 Nov 1; 128(11): 5110-5122.  PMCID: PC6205411
   
• Jain U, Lai CW, Xiong S, Goodwin VM, Lu Q, Muegge BD, Christophi GP, VanDussen KL, Cummings BP, Young E, Hambor J, Stappenbeck TS.  Temporal Reulation of the Bacterial Metabolite Deoxycholate during Colonic Repair is critical for Crypt Regeneration. Cell Host Microbe. 2018 Sep 12;24(3): 353-363. PMCID: PMC6555552
   
• Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS.  The microbial metabolite desaminotyrosine protects from influenza through type I interferon.  Science 2017; 357 (6350); PMCID: PMC5753406
   
• Miyoshi, H, VanDussen KL, Malvin NP, Ryu SH, Wang Y, Sonnek NM, Lai CW, Stappenbeck TS. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. EMBO J. 2017; 36(1):5-24. PMCID: PMC5210160
   
• Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS.  The colonic crypt protects stem cells from microbiota-derived metabolites. Cell.  2016; 165(7): 1708:20. PMCID: PMC5026192
   
• Moon C, Baldridge MT, Wallace MA, Burnham CA, Virgin HW, Stappenbeck TS.  Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation.  Nature 2015;  521(7550): 90-3.  PMCID: PMC4425643
   
• Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck, TS.  Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury. Science, 2012; 338(6103):108-113. PMCID: PMC3706630