Prof. Schumann studied Biochemistry at the University of Tübingen and obtained her PhD at the Max Planck Institute for Biochemistry in Martinsried. After a research stay at Novartis Institutes for Biomedical Research, Basel, she continued her research at the University of California San Francisco. In the labs of Alex Marson and Jeffrey Bluestone she developed CRISPR-engineering of primary human T cells. In 2018 she was appointed as a Rudolf Mößbauer Tenure Track Assistant Professor of “Engineering Immune Cells for Therapy” at the TUM School of Medicine.
Selected Awards
2016, DFG Research Fellowship
2015, C. Garrison Fathman Fund Award
Research Interests
Prof. Kathrin Schumann´s research is focusing on cell engineering of human immune cells. She is using novel CRISPR technologies to ablate or modify genetic regions in human T cells to characterize their role in cellular function and stability. In the long-term this knowledge can potentially help to develop novel therapies for autoimmune disease and cancer.
Selected Publications
Rupp, Levi J.; Schumann, Kathrin; Roybal, Kole T.; Gate, Rachel E.; Ye, Chun J.; Lim, Wendell A.; Marson, Alexander: CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Scientific Reports 7 (1), 2017.
Hultquist, Judd F.; Schumann, Kathrin; Woo, Jonathan M.; Manganaro, Lara; McGregor, Michael J.; Doudna, Jennifer; Simon, Viviana; Krogan, Nevan J.; Marson, Alexander: A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Reports 17 (5), 2016, 1438-1452.
Schumann, Kathrin; Lin, Steven; Boyer, Eric; Simeonov, Dimitre R.; Subramaniam, Meena; Gate, Rachel E.; Haliburton, Genevieve E.; Ye, Chun J.; Bluestone, Jeffrey A.; Doudna, Jennifer A.; Marson, Alexander: Generation of knock-in primary human T cells using Cas9 ribonucleoproteins. Proceedings of the National Academy of Sciences 112 (33), 2015, 10437-10442.
Mathewson, Nathan D.; Ashenberg, Orr; Tirosh, Itay; Gritsch, Simon; Perez, Elizabeth M.; Marx, Sascha; Jerby-Arnon, Livnat; Chanoch-Myers, Rony; Hara, Toshiro; Richman, Alyssa R.; Ito, Yoshinaga; Pyrdol, Jason; Friedrich, Mirco; Schumann, Kathrin; Poitras, Michael J.; Gokhale, Prafulla C.; Gonzalez Castro, L. Nicolas; Shore, Marni E.; Hebert, Christine M.; Shaw, Brian; Cahill, Heather L.; Drummond, Matthew; Zhang, Wubing; Olawoyin, Olamide; Wakimoto, Hiroaki; Rozenblatt-Rosen, Orit; Brastianos, Priscilla K.; Liu, X. Shirley; Jones, Pamela S.; Cahill, Daniel P.; Frosch, Matthew P.; Louis, David N.; Freeman, Gordon J.; Ligon, Keith L.; Marson, Alexander; Chiocca, E. Antonio; Reardon, David A.; Regev, Aviv; Suvà, Mario L.; Wucherpfennig, Kai W.: Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell 184 (5), 2021, 1281-1298.e26 more…BibTeX
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2020
Schumann, Kathrin; Raju, Siddharth S.; Lauber, Michael; Kolb, Saskia; Shifrut, Eric; Cortez, Jessica T.; Skartsis, Nikolaos; Nguyen, Vinh Q.; Woo, Jonathan M.; Roth, Theodore L.; Yu, Ruby; Nguyen, Michelle L. T.; Simeonov, Dimitre R.; Nguyen, David N.; Targ, Sasha; Gate, Rachel E.; Tang, Qizhi; Bluestone, Jeffrey A.; Spitzer, Matthew H.; Ye, Chun Jimmie; Marson, Alexander: Functional CRISPR dissection of gene networks controlling human regulatory T cell identity. Nature Immunology 21 (11), 2020, 1456-1466 more…BibTeX
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2019
Lowe, Margaret M.; Boothby, Ian; Clancy, Sean; Ahn, Richard S.; Liao, Wilson; Nguyen, David N.; Schumann, Kathrin; Marson, Alexander; Mahuron, Kelly M.; Kingsbury, Gillian A.; Liu, Zheng; Munoz Sandoval, Priscila; Rodriguez, Robert Sanchez; Pauli, Mariela L.; Taravati, Keyon; Arron, Sarah T.; Neuhaus, Isaac M.; Harris, Hobart W.; Kim, Esther A.; Shin, Uk Sok; Krummel, Matthew F.; Daud, Adil; Scharschmidt, Tiffany C.; Rosenblum, Michael D.: Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. JCI Insight 4 (24), 2019 more…BibTeX
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Schober, Kilian; Müller, Thomas R.; Gökmen, Füsun; Grassmann, Simon; Effenberger, Manuel; Poltorak, Mateusz; Stemberger, Christian; Schumann, Kathrin; Roth, Theodore L.; Marson, Alexander; Busch, Dirk H.: Orthotopic replacement of T-cell receptor α- and β-chains with preservation of near-physiological T-cell function. Nature Biomedical Engineering 3 (12), 2019, 974-984 more…BibTeX
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2018
Hultquist, Judd F.; Hiatt, Joseph; Schumann, Kathrin; McGregor, Michael J.; Roth, Theodore L.; Haas, Paige; Doudna, Jennifer A.; Marson, Alexander; Krogan, Nevan J.: CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions. Nature Protocols 14 (1), 2018, 1-27 more…BibTeX
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Roth, Theodore L.; Puig-Saus, Cristina; Yu, Ruby; Shifrut, Eric; Carnevale, Julia; Li, P. Jonathan; Hiatt, Joseph; Saco, Justin; Krystofinski, Paige; Li, Han; Tobin, Victoria; Nguyen, David N.; Lee, Michael R.; Putnam, Amy L.; Ferris, Andrea L.; Chen, Jeff W.; Schickel, Jean-Nicolas; Pellerin, Laurence; Carmody, David; Alkorta-Aranburu, Gorka; del Gaudio, Daniela; Matsumoto, Hiroyuki; Morell, Montse; Mao, Ying; Cho, Min; Quadros, Rolen M.; Gurumurthy, Channabasavaiah B.; Smith, Baz; Haugwitz, Michael; Hughes, Stephen H.; Weissman, Jonathan S.; Schumann, Kathrin; Esensten, Jonathan H.; May, Andrew P.; Ashworth, Alan; Kupfer, Gary M.; Greeley, Siri Atma W.; Bacchetta, Rosa; Meffre, Eric; Roncarolo, Maria Grazia; Romberg, Neil; Herold, Kevan C.; Ribas, Antoni; Leonetti, Manuel D.; Marson, Alexander: Reprogramming human T cell function and specificity with non-viral genome targeting. Nature 559 (7714), 2018, 405-409 more…BibTeX
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