Short CV
Stanley Riddell received his M.D. from the University of Manitoba in Winnipeg, Canada. He trained in Medical Oncology and Immunology at the Fred Hutchinson Cancer Research Center and the University of Washington from 1985 – 1990. He subsequently joined the faculty at these institutions, and is currently Member and Associate Program Head of the Program in Immunology at the Fred Hutchinson Cancer Research Center and Professor, Department of Medicine at the University of Washington.
Selected Awards
- 2008, Elected Fellow of the American College of Physicians
- 2004, Gerald Goldenberg Lecture, University of Toronto, Toronto, Canada
- 2003, Gerhardt Schmidt Memorial Lecture, City of Hope National Medical Center
- 2002, Woodward Visiting Professor, Memorial Sloan Kettering Cancer Center
- 2000, Japan Health Sciences Foundation Fellowship Visiting Scientist
- 1992-1996, Cancer Research Institute Partridge Foundation Investigator Award
Research Interests
The Riddell lab has focused on the development and clinical evaluation of cellular therapeutics with antigen-specific T cell lymphocytes for human viral infections and malignancy. The research effort in this area encompasses the identification of appropriate target antigens on infected and malignant cells, and the development of methods for selecting and expanding therapeutic T cells of the correct specificity. Recent studies have been directed at understanding the genetic programming of distinct memory T cell subsets that enable some cells to survive long-term in vivo and to reestablish immunologic memory after adoptive transfer.
Selected Publications
- Berger, Carolina; Jensen, Michael C.; Lansdorp, Peter M.; Gough, Mike; Elliott, Carole; Riddell, Stanley R.: Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. Journal of Clinical Investigation 118 (1), 2008, 294-305.
- Warren, E. H.; Vigneron, N. J.; Gavin, M. A.; Coulie, P. G.; Stroobant, V.; Dalet, A.; Tykodi, S. S.; Xuereb, S. M.; Mito, J. K.; Riddell, S. R.; Van den Eynde, B. J.: An Antigen Produced by Splicing of Noncontiguous Peptides in the Reverse Order. Science 313 (5792), 2006, 1444-1447.
- Bleakley, Marie; Riddell, Stanley R.: Molecules and mechanisms of the graft-versus-leukaemia effect. Nature Reviews Cancer 4 (5), 2004, 371-380.
- Yee, C.; Thompson, J.A.; Roche, P.; Byrd, D.R.; Lee, P.P.; Piepkorn, M.; Kenyon, K.; Davis, M.M.; Riddell, S.R.; Greenberg, P.D.: Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of T cell-mediated vitiligo. Journal of Experimental Medicine 192, 2000, 1637-1634.
- Bonnet, D.; Warren, E. H.; Greenberg, P. D.; Dick, J. E.; Riddell, S. R.: CD8+ minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells. Proceedings of the National Academy of Sciences 96 (15), 1999, 8639-8644.
- Greenberg, P.D.; Riddell, S.R.;: Cellular Immunodeficiencies: Finding and fixing the defects. Science 285, 1999, 546-551.
- Walter, Elizabeth A.; Greenberg, Philip D.; Gilbert, Mark J.; Finch, Rosalynde J.; Watanabe, Käthe S.; Thomas, E. Donnall; Riddell, Stanley R.: Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor. New England Journal of Medicine 333 (16), 1995, 1038-1044.
- Riddell, S.R.; Watanabe, K.S.; Goodrich, J.M; Li, C.R.; Agha, M.E.; P.D. Greenberg, P.D.: Restoration of viral immunity in immunocompromised humans by adoptive transfer of T cell clones. Science 257, 1992, 238-241.
Publications as TUM-IAS-Fellow
