Kick-off Workshop: Proteases in the Brain

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Focus Group Proteases in the Brain: Hans Fischer Senior Fellow Prof. Carl Blobel (Hospital of Special Surgery, Weill Cornell Medical School, Cornell University), Prof. Stefan Lichtenthalter (Neuroproteomics, TUM).

Thursday, November 19, 2015

German Center for Neurodegenerative Diseases, conference room U1 155

Contact Information:

Carl Blobel,
Stefan Lichtenthaler,


Session 1: Neuroinflammation

13:00 Welcome and introduction
Stefan Lichtenthaler, Carl Blobel

13:10 Mouse models of traumatic brain injury
Nikolaus Plesnila

13:25 Discussion

13:35 Potential roles of iRhom2 in neuroinflammation
Carl Blobel

13:50 Discussion

14:00 Ex vivo studies of neuroinflammation
Sabina Tahirovic

14:15 Discussion

14:25 Substrate repertoire and function of iRhom2/ADAM17 in microglia and macrophages
Simone Scilabra

14:35 Discussion

14:45 The role of TREM2 in neurodegeneration
Christian Haas

15:00 Discussion

15:10 Coffee Break

 Session 2: Structural and Biochemical Studies of Proteolysis of Membrane Proteins

15:50 Structure/function analysis of the iRhom/ADAM17 signaling axis
Carl Blobel

16:00 Discussion

16:10 Nanodisc NMR, a novel approach to study membrane protein structure and function
Franz Hagn

16:25 Discussion

16:35 Proteomic analysis of protease activity in the brain
Stefan Lichtenthaler

16:45 Discussion

16:50 Analysis of the substrate repertoire of iRhom1/ADAM17 in the brain
Johanna Tueshaus

17:00 Discussion

17:10 Understanding intramembrane proteolysis
Dieter Langosch

17:25 Discussion

17:35 Intramembrane Proteolysis by Alzheimer´s disease γ-Secretase
Harald Steiner

17:50 Discussion

18:00 Closing Remarks
Stefan Lichtenthaler, Carl Blobel

Please join us for dinner around 18:30, if possible!