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Technical University of Munich
Technical University of Munich

Hendrik Dietz

Fellowship
Carl von Linde Senior Fellow

Appointment
2016

Institution
Technical University of Munich

Department
Biomolecular Nanotechnology

Focus Group
Biologically Inspired Material Science

Short CV

Hendrik Dietz was born in 1977 in Dresden. He studied physics at the University of Paderborn, Universidad de Zaragoza (Spain), and the University of Munich and received a physics diploma in 2004 from the latter place. In early 2007 he was awarded a doctoral degree from the Physics Department of the Technische Universität München for his work on development and application of novel single-molecule methods for the mechanical and structural analysis of protein molecules. Hendrik Dietz then turned from proteins to DNA and joined a team of nanotechnology enthusiasts located at the Dana-Farber Cancer Institute at Harvard Medical School in Boston in order to conduct postdoctoral research.
In June 2009 Dietz returned to the Physics Department at the Technische Universität München as an assistant professor for biological physics and established the "Laboratory for Biomolecular Nanotechnology". In 2014, Hendrik Dietz was appointed as associate professor at the Physics Department of TUM.

Selected Awards

  • 2015, Gottfried Wilhelm Leibniz Prize of the German Research Foundation (DFG)
  • 2012, Hoechst Dozentenstipendium, Aventis Foundation
  • 2010, European Research Council (ERC) Starting Grant
  • 2010, "Arnold Sommerfeld-Preis" of the Bavarian Academy of Sciences and Humanities
  • 2007-2008, Feodor-Lynen Fellow
  • 2008, Deutscher Studienpreis
  • 2006, Chorafas-Award
  • 2005, Scientific Award BMW Group
  • 2004, IDK-NBT Fellow, Elite Netzwerk Bayern
  • 2000, ERASMUS Fellow

Research Interests

Dietz's newly founded 'Laboratory for Biomolecular Nanotechnology' develops novel scientific devices and methods for applications in biomolecular physics, biological chemistry, and molecular medicine. A central focus is on investigating the physical details of intermolecular interactions, in particular protein-protein and protein-DNA interactions. To overcome persistent experimental challenges that one faces when studying low-affinity biomolecular interactions, the Dietz lab is working towards taking advantage of the fine positional control afforded by molecular-self assembly with DNA origami to build nanometer-scale scientific devices that are used to interface and manipulate target macromolecules and that enable conformational read-out with single-molecule fluorescence methods and/or with transmission electron microscopy.

Selected Publications

  • Dietz, H.; Douglas, S. M.; Shih, W. M.: Folding DNA into Twisted and Curved Nanoscale Shapes. Science 325 (5941), 2009, 725-730.
  • Douglas, Shawn M.; Dietz, Hendrik; Liedl, Tim; Högberg, Björn; Graf, Franziska; Shih, William M.: Self-assembly of DNA into nanoscale three-dimensional shapes. Nature 459 (7245), 2009, 414-418.
  • Dietz, Hendrik; Rief, Matthias: Elastic Bond Network Model for Protein Unfolding Mechanics. Phys. Rev. Lett. 100 (9), 2008.
  • Dietz, H.; Berkemeier, F.; Bertz, M.; Rief, M.: Anisotropic deformation response of single protein molecules. Proceedings of the National Academy of Sciences 103 (34), 2006, 12724-12728.
  • Dietz, H.; Rief, M.: Protein structure by mechanical triangulation. Proceedings of the National Academy of Sciences 103 (5), 2006, 1244-1247.
  • Dietz, H.; Rief, M.: Exploring the energy landscape of GFP by single-molecule mechanical experiments. Proceedings of the National Academy of Sciences 101 (46), 2004, 16192-16197.

Publications as TUM-IAS-Fellow

2019

  • Engelhardt, Floris A. S.; Praetorius, Florian; Wachauf, Christian H.; Brüggenthies, Gereon; Kohler, Fabian; Kick, Benjamin; Kadletz, Karoline L.; Pham, Phuong Nhi; Behler, Karl L.; Gerling, Thomas; Dietz, Hendrik: Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds. ACS Nano 13 (5), 2019, 5015-5027 more… BibTeX Full text ( DOI )
  • Gerling, Thomas; Dietz, Hendrik: Reversible Covalent Stabilization of Stacking Contacts in DNA Assemblies. Angewandte Chemie International Edition 58 (9), 2019, 2680-2684 more… BibTeX Full text ( DOI )
  • Häußermann, Katharina; Young, Gavin; Kukura, Philipp; Dietz, Hendrik: Dissecting FOXP2 Oligomerization and DNA Binding. Angewandte Chemie International Edition 58 (23), 2019, 7662-7667 more… BibTeX Full text ( DOI )
  • Lakemeyer, Markus; Bertosin, Eva; Möller, Friederike; Balogh, Dóra; Strasser, Ralf; Dietz, Hendrik; Sieber, Stephan A.: Tailored Peptide Phenyl Esters Block ClpXP Proteolysis by an Unusual Breakdown into a Heptamer-Hexamer Assembly. Angewandte Chemie International Edition 58 (21), 2019, 7127-7132 more… BibTeX Full text ( DOI )
  • Ramezani, Hamid; Dietz, Hendrik: Building machines with DNA molecules. Nature Reviews Genetics 21 (1), 2019, 5-26 more… BibTeX Full text ( DOI )
  • Rodrigues, Letícia; Schneider, Fabian; Zhang, Xiaohan; Larsson, Elin; Moodie, Lindon W.K.; Dietz, Hendrik; Papadakis, Christine M.; Winter, Gerhard; Lundmark, Richard; Hubert, Madlen: Cellular uptake of self-assembled phytantriol-based hexosomes is independent of major endocytic machineries. Journal of Colloid and Interface Science 553, 2019, 820-833 more… BibTeX Full text ( DOI )
  • Schneider, Fabian; Möritz, Natalie; Dietz, Hendrik: The sequence of events during folding of a DNA origami. Science Advances 5 (5), 2019, eaaw1412 more… BibTeX Full text ( DOI )
  • Sigmund, Felix; Pettinger, Susanne; Kube, Massimo; Schneider, Fabian; Schifferer, Martina; Schneider, Steffen; Efremova, Maria V.; Pujol-Martí, Jesús; Aichler, Michaela; Walch, Axel; Misgeld, Thomas; Dietz, Hendrik; Westmeyer, Gil G.: Iron-Sequestering Nanocompartments as Multiplexed Electron Microscopy Gene Reporters. ACS Nano 13 (7), 2019, 8114-8123 more… BibTeX Full text ( DOI )
  • Wanzke, Caren; Jussupow, Alexander; Kohler, Fabian; Dietz, Hendrik; Kaila, Ville R. I.; Boekhoven, Job: Dynamic Vesicles Formed By Dissipative Self‐Assembly. ChemSystemsChem 2 (1), 2019 more… BibTeX Full text ( DOI )

2018

  • Bruetzel, Linda K.; Walker, Philipp U.; Gerling, Thomas; Dietz, Hendrik; Lipfert, Jan: Time-Resolved Small-Angle X-ray Scattering Reveals Millisecond Transitions of a DNA Origami Switch. Nano Letters 18 (4), 2018, 2672-2676 more… BibTeX Full text ( DOI )
  • Bräuning, Bastian; Bertosin, Eva; Praetorius, Florian; Ihling, Christian; Schatt, Alexandra; Adler, Agnes; Richter, Klaus; Sinz, Andrea; Dietz, Hendrik; Groll, Michael: Structure and mechanism of the two-component a-helical pore-forming toxin YaxAB. Nature Communications 9 (1), 2018 more… BibTeX Full text ( DOI )
  • Franquelim, Henri G.; Khmelinskaia, Alena; Sobczak, Jean-Philippe; Dietz, Hendrik; Schwille, Petra: Membrane sculpting by curved DNA origami scaffolds. Nature Communications 9 (1), 2018 more… BibTeX Full text ( DOI )
  • Gerling, Thomas; Kube, Massimo; Kick, Benjamin; Dietz, Hendrik: Sequence-programmable covalent bonding of designed DNA assemblies. Science Advances 4 (8), 2018, eaau1157 more… BibTeX Full text ( DOI )
  • Ketterer, Philip; Ananth, Adithya N.; Laman Trip, Diederik S.; Mishra, Ankur; Bertosin, Eva; Ganji, Mahipal; van der Torre, Jaco; Onck, Patrick; Dietz, Hendrik; Dekker, Cees: DNA origami scaffold for studying intrinsically disordered proteins of the nuclear pore complex. Nature Communications 9 (1), 2018 more… BibTeX Full text ( DOI )
  • Schickinger, Matthias; Zacharias, Martin; Dietz, Hendrik: Tethered multifluorophore motion reveals equilibrium transition kinetics of single DNA double helices. Proceedings of the National Academy of Sciences 115 (32), 2018, E7512-E7521 more… BibTeX Full text ( DOI )

2017

  • Praetorius, Florian; Dietz, Hendrik: Self-assembly of genetically encoded DNA-protein hybrid nanoscale shapes. Science 355 (6331), 2017, eaam5488 more… BibTeX Full text ( DOI )
  • Praetorius, Florian; Kick, Benjamin; Behler, Karl L.; Honemann, Maximilian N.; Weuster-Botz, Dirk; Dietz, Hendrik: Biotechnological mass production of DNA origami. Nature 552 (7683), 2017, 84-87 more… BibTeX Full text ( DOI )
  • Siavashpouri, Mahsa; Wachauf, Christian H.; Zakhary, Mark J.; Praetorius, Florian; Dietz, Hendrik; Dogic, Zvonimir: Molecular engineering of chiral colloidal liquid crystals using DNA origami. Nature Materials 16 (8), 2017, 849-856 more… BibTeX Full text ( DOI )
  • Wagenbauer, Klaus F.; Engelhardt, Floris A. S.; Stahl, Evi; Hechtl, Vera K.; Stömmer, Pierre; Seebacher, Fabian; Meregalli, Letizia; Ketterer, Philip; Gerling, Thomas; Dietz, Hendrik: How We Make DNA Origami. ChemBioChem 18 (19), 2017, 1873-1885 more… BibTeX Full text ( DOI )
  • Wagenbauer, Klaus F.; Sigl, Christian; Dietz, Hendrik: Gigadalton-scale shape-programmable DNA assemblies. Nature 552 (7683), 2017, 78-83 more… BibTeX Full text ( DOI )
  • Willner, Elena M.; Kamada, Yuu; Suzuki, Yuki; Emura, Tomoko; Hidaka, Kumi; Dietz, Hendrik; Sugiyama, Hiroshi; Endo, Masayuki: Single-Molecule Observation of the Photoregulated Conformational Dynamics of DNA Origami Nanoscissors. Angewandte Chemie International Edition 56 (48), 2017, 15324-15328 more… BibTeX Full text ( DOI )

2016

  • Bruetzel, Linda K.; Gerling, Thomas; Sedlak, Steffen M.; Walker, Philipp U.; Zheng, Wenjun; Dietz, Hendrik; Lipfert, Jan: Conformational Changes and Flexibility of DNA Devices Observed by Small-Angle X-ray Scattering. Nano Letters 16 (8), 2016, 4871-4879 more… BibTeX Full text ( DOI )
  • Dietz, Hendrik: Toward Applications for DNA Nanotechnology-More Bricks To Build With. ChemBioChem 17 (12), 2016, 1046-1047 more… BibTeX Full text ( DOI )
  • Funke, Jonas J.; Ketterer, Philip; Lieleg, Corinna; Korber, Philipp; Dietz, Hendrik: Exploring Nucleosome Unwrapping Using DNA Origami. Nano Letters 16 (12), 2016, 7891-7898 more… BibTeX Full text ( DOI )
  • Funke, Jonas J.; Ketterer, Philip; Lieleg, Corinna; Schunter, Sarah; Korber, Philipp; Dietz, Hendrik: Uncovering the forces between nucleosomes using DNA origami. Science Advances 2 (11), 2016, e1600974 more… BibTeX Full text ( DOI )
  • Ketterer, Philip; Willner, Elena M.; Dietz, Hendrik: Nanoscale rotary apparatus formed from tight-fitting 3D DNA components. Science Advances 2 (2), 2016, e1501209 more… BibTeX Full text ( DOI )
  • Kick, Benjamin; Hensler, Samantha; Praetorius, Florian; Dietz, Hendrik; Weuster-Botz, Dirk: Specific growth rate and multiplicity of infection affect high-cell-density fermentation with bacteriophage M13 for ssDNA production. Biotechnology and Bioengineering 114 (4), 2016, 777-784 more… BibTeX Full text ( DOI )
  • Kilchherr, F.; Wachauf, C.; Pelz, B.; Rief, M.; Zacharias, M.; Dietz, H.: Single-molecule dissection of stacking forces in DNA. Science 353 (6304), 2016, aaf5508-aaf5508 more… BibTeX Full text ( DOI )
  • Krishnan, Swati; Ziegler, Daniela; Arnaut, Vera; Martin, Thomas G.; Kapsner, Korbinian; Henneberg, Katharina; Bausch, Andreas R.; Dietz, Hendrik; Simmel, Friedrich C.: Molecular transport through large-diameter DNA nanopores. Nature Communications 7 (1), 2016 more… BibTeX Full text ( DOI )
  • Martin, Thomas G.; Bharat, Tanmay A. M.; Joerger, Andreas C.; Bai, Xiao-chen; Praetorius, Florian; Fersht, Alan R.; Dietz, Hendrik; Scheres, Sjors H. W.: Design of a molecular support for cryo-EM structure determination. Proceedings of the National Academy of Sciences 113 (47), 2016, E7456-E7463 more… BibTeX Full text ( DOI )
  • Rodrigues, Letícia; Kyriakos, Konstantinos; Schneider, Fabian; Dietz, Hendrik; Winter, Gerhard; Papadakis, Christine M.; Hubert, Madlen: Characterization of Lipid-Based Hexosomes as Versatile Vaccine Carriers. Molecular Pharmaceutics 13 (11), 2016, 3945-3954 more… BibTeX Full text ( DOI )
  • Stahl, Evi; Praetorius, Florian; de Oliveira Mann, Carina C.; Hopfner, Karl-Peter; Dietz, Hendrik: Impact of Heterogeneity and Lattice Bond Strength on DNA Triangle Crystal Growth. ACS Nano 10 (10), 2016, 9156-9164 more… BibTeX Full text ( DOI )

2015

  • Gerling, T.; Wagenbauer, K. F.; Neuner, A. M.; Dietz, H.: Dynamic DNA devices and assemblies formed by shape-complementary, non-base pairing 3D components. Science 347 (6229), 2015, 1446-1452 more… BibTeX Full text ( DOI )

2014

  • Cui, H; Seubert, B; Stahl, E; Dietz, H; Reuning, U; Moreno-Leon, L; Ilie, M; Hofman, P; Nagase, H; Mari, B; Krüger, A: Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes. Oncogene 34 (28), 2014, 3640-3650 more… BibTeX Full text ( DOI )
  • Plesa, Calin; van Loo, Nick; Ketterer, Philip; Dietz, Hendrik; Dekker, Cees: Velocity of DNA during Translocation through a Solid-State Nanopore. Nano Letters 15 (1), 2014, 732-737 more… BibTeX Full text ( DOI )
  • Shen, Boxuan; Linko, Veikko; Dietz, Hendrik; Toppari, J. Jussi: Dielectrophoretic trapping of multilayer DNA origami nanostructures and DNA origami-induced local destruction of silicon dioxide. ELECTROPHORESIS 36 (2), 2014, 255-262 more… BibTeX Full text ( DOI )
  • Stahl, Evi; Martin, Thomas G.; Praetorius, Florian; Dietz, Hendrik: Facile and Scalable Preparation of Pure and Dense DNA Origami Solutions. Angewandte Chemie International Edition 53 (47), 2014, 12735-12740 more… BibTeX Full text ( DOI )
  • Wagenbauer, Klaus F.; Wachauf, Christian H.; Dietz, Hendrik: Quantifying quality in DNA self-assembly. Nature Communications 5 (1), 2014 more… BibTeX Full text ( DOI )

2013

  • Linko, Veikko; Dietz, Hendrik: The enabled state of DNA nanotechnology. Current Opinion in Biotechnology 24 (4), 2013, 555-561 more… BibTeX Full text ( DOI )
  • Pfitzner, Emanuel; Wachauf, Christian; Kilchherr, Fabian; Pelz, Benjamin; Shih, William M.; Rief, Matthias; Dietz, Hendrik: Rigid DNA Beams for High-Resolution Single-Molecule Mechanics. Angewandte Chemie International Edition 52 (30), 2013, 7766-7771 more… BibTeX Full text ( DOI )
  • Plesa, Calin; Ananth, Adithya N.; Linko, Veikko; Gülcher, Coen; Katan, Allard J.; Dietz, Hendrik; Dekker, Cees: Ionic Permeability and Mechanical Properties of DNA Origami Nanoplates on Solid-State Nanopores. ACS Nano 8 (1), 2013, 35-43 more… BibTeX Full text ( DOI )

2012

  • Bai, X.-c.; Martin, T. G.; Scheres, S. H. W.; Dietz, H.: Cryo-EM structure of a 3D DNA-origami object. Proceedings of the National Academy of Sciences 109 (49), 2012, 20012-20017 more… BibTeX Full text ( DOI )
  • Langecker, M.; Arnaut, V.; Martin, T. G.; List, J.; Renner, S.; Mayer, M.; Dietz, H.; Simmel, F. C.: Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures. Science 338 (6109), 2012, 932-936 more… BibTeX Full text ( DOI )
  • Martin, Thomas G.; Dietz, Hendrik: Magnesium-free self-assembly of multi-layer DNA objects. Nature Communications 3, 2012, 1103 more… BibTeX Full text ( DOI )
  • Sobczak, J.-P. J.; Martin, T. G.; Gerling, T.; Dietz, H.: Rapid Folding of DNA into Nanoscale Shapes at Constant Temperature. Science 338 (6113), 2012, 1458-1461 more… BibTeX Full text ( DOI )
  • Wei, Ruoshan; Martin, Thomas G.; Rant, Ulrich; Dietz, Hendrik: DNA Origami Gatekeepers for Solid-State Nanopores. Angewandte Chemie International Edition 51 (20), 2012, 4864-4867 more… BibTeX Full text ( DOI )

2011

  • Castro, Carlos Ernesto; Kilchherr, Fabian; Kim, Do-Nyun; Shiao, Enrique Lin; Wauer, Tobias; Wortmann, Philipp; Bathe, Mark; Dietz, Hendrik: A primer to scaffolded DNA origami. Nature Methods 8 (3), 2011, 221-229 more… BibTeX Full text ( DOI )
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