Hendrik Dietz

Carl von Linde Senior Fellow

Technical University of Munich

Biomolecular Nanotechnology

Focus Group
Biologically Inspired Material Science

Short CV

Hendrik Dietz was born in 1977 in Dresden. He studied physics at the University of Paderborn, Universidad de Zaragoza (Spain), and the University of Munich and received a physics diploma in 2004 from the latter place. In early 2007 he was awarded a doctoral degree from the Physics Department of the Technische Universität München for his work on development and application of novel single-molecule methods for the mechanical and structural analysis of protein molecules. Hendrik Dietz then turned from proteins to DNA and joined a team of nanotechnology enthusiasts located at the Dana-Farber Cancer Institute at Harvard Medical School in Boston in order to conduct postdoctoral research.
In June 2009 Dietz returned to the Physics Department at the Technische Universität München as an assistant professor for biological physics and established the "Laboratory for Biomolecular Nanotechnology". In 2014, Hendrik Dietz was appointed as associate professor at the Physics Department of TUM.

Selected Awards

2015 Gottfried Wilhelm Leibniz Prize of the German Research Foundation (DFG)

2012 Hoechst Dozentenstipendium, Aventis Foundation

2010 European Research Council (ERC) Starting Grant

2010 "Arnold Sommerfeld-Preis" of the Bavarian Academy of Sciences and Humanities

2007-2008 Feodor-Lynen Fellow

2008 Deutscher Studienpreis

2006 Chorafas-Award

2005 Scientific Award BMW Group

2004 IDK-NBT Fellow, Elite Netzwerk Bayern

2000 ERASMUS Fellow

Research Interests

Dietz's newly founded 'Laboratory for Biomolecular Nanotechnology' develops novel scientific devices and methods for applications in biomolecular physics, biological chemistry, and molecular medicine. A central focus is on investigating the physical details of intermolecular interactions, in particular protein-protein and protein-DNA interactions. To overcome persistent experimental challenges that one faces when studying low-affinity biomolecular interactions, the Dietz lab is working towards taking advantage of the fine positional control afforded by molecular-self assembly with DNA origami to build nanometer-scale scientific devices that are used to interface and manipulate target macromolecules and that enable conformational read-out with single-molecule fluorescence methods and/or with transmission electron microscopy.

Selected Publications

  • Sobczak, J.-P. J.; Martin, T. G.; Gerling, T.; Dietz, H.: Rapid Folding of DNA into Nanoscale Shapes at Constant Temperature. Science 338 (6113), 2012, 1458-1461.
  • Bai, X.-c.; Martin, T. G.; Scheres, S. H. W.; Dietz, H.: Cryo-EM structure of a 3D DNA-origami object. Proceedings of the National Academy of Sciences 109 (49), 2012, 20012-20017.
  • Langecker, M.; Arnaut, V.; Martin, T. G.; List, J.; Renner, S.; Mayer, M.; Dietz, H.; Simmel, F. C.: Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures. Science 338 (6109), 2012, 932-936.
  • Martin, Thomas G.; Dietz, Hendrik: Magnesium-free self-assembly of multi-layer DNA objects. Nature Communications 3, 2012, 1103.
  • Wei, Ruoshan; Martin, Thomas G.; Rant, Ulrich; Dietz, Hendrik: DNA Origami Gatekeepers for Solid-State Nanopores. Angewandte Chemie International Edition 51 (20), 2012, 4864-4867.
  • Castro, Carlos Ernesto; Kilchherr, Fabian; Kim, Do-Nyun; Shiao, Enrique Lin; Wauer, Tobias; Wortmann, Philipp; Bathe, Mark; Dietz, Hendrik: A primer to scaffolded DNA origami. Nature Methods 8 (3), 2011, 221-229.
  • Dietz, H.; Douglas, S. M.; Shih, W. M.: Folding DNA into Twisted and Curved Nanoscale Shapes. Science 325 (5941), 2009, 725-730.
  • Douglas, Shawn M.; Dietz, Hendrik; Liedl, Tim; Högberg, Björn; Graf, Franziska; Shih, William M.: Self-assembly of DNA into nanoscale three-dimensional shapes. Nature 459 (7245), 2009, 414-418.
  • Dietz, Hendrik; Rief, Matthias: Elastic Bond Network Model for Protein Unfolding Mechanics. Phys. Rev. Lett. 100 (9), 2008.
  • Dietz, H.; Berkemeier, F.; Bertz, M.; Rief, M.: Anisotropic deformation response of single protein molecules. Proceedings of the National Academy of Sciences 103 (34), 2006, 12724-12728.
  • Dietz, H.; Rief, M.: Protein structure by mechanical triangulation. Proceedings of the National Academy of Sciences 103 (5), 2006, 1244-1247.
  • Dietz, H.; Rief, M.: Exploring the energy landscape of GFP by single-molecule mechanical experiments. Proceedings of the National Academy of Sciences 101 (46), 2004, 16192-16197.