Kathrin Lang

Rudolf Mößbauer Tenure Track

Technical University of Munich

Synthetic Biochemistry

Focus Group
Synthetic Biochemistry

Short CV

Professor Lang studied chemistry at the University of Innsbruck where she obtained a PhD in bioorganic chemistry under the supervision of Professor Micura in 2008. She subsequently worked as a postdoctoral and investigator scientist at the Medical Research Council – Laboratory of Molecular Biology in Cambridge, UK, in the research groups of Dr. Ramakrishnan (ribosome crystallography) and Professor Chin (chemical and synthetic biology). She now heads the synthetic biochemistry research group in the Chemistry Faculty.

Selected Awards

2012 Anton Paar Science Award of the Austrian Chemical Society, GÖCH

2012 MRC Centenary Early Career Award, Medical Research Council – Laboratory of Molecular Biology, Cambridge, UK

2010 Young Investigator Award of the Zonta Club Bolzano/Bozen, Italy

2009 Karl Schlögl Award of the Austrian Academy of Sciences, ÖAW

2009 Georg and Christine Sosnovsky Award, Innsbruck, Austria

Research Interests

Professor Lang (b. 1979) conducts research in the interdisciplinary area of chemical biology, applying concepts from organic chemistry to develop new tools to study fundamental biological questions. Her research focuses on the targeted chemical synthesis of new artificial biomolecules (amino acids, proteins, nucleotides, oligonucleotides) tailored to investigate and manipulate complex cellular processes in in vitro and in vivo biological systems.

Selected Publications

  • Nguyen, Tuan-Anh; Cigler, Marko; Lang, Kathrin: Expanding the Genetic Code to Study Protein-Protein Interactions. Angewandte Chemie International Edition 57 (44), 2018, 14350-14361 more… BibTeX Full text ( DOI )
  • Cigler, Marko; Nguyen, Tuan-Anh; Lang, Kathrin: CHAPTER 5.2. Genetic Code Expansion Approaches to Introduce Artificial Covalent Bonds into Proteins In Vivo. In: Oxidative Folding of Proteins. Royal Society of Chemistry, 2018 more… BibTeX Full text ( DOI )
  • Lang, Kathrin: Building Peptide Bonds in Haifa: The Seventh Chemical Protein Synthesis (CPS) Meeting. ChemBioChem 19 (2), 2017, 115-120 more… BibTeX Full text ( DOI )
  • Cigler, Marko; Müller, Thorsten G.; Horn-Ghetko, Daniel; von Wrisberg, Marie-Kristin; Fottner, Maximilian; Goody, Roger S.; Itzen, Aymelt; Müller, Matthias P.; Lang, Kathrin: Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo. Angewandte Chemie International Edition 56 (49), 2017, 15737-15741 more… BibTeX Full text ( DOI )
  • Lang, Kathrin: Biochemie 2016: Chemie bringt Zellen im Innern zum Leuchten. Nachrichten aus der Chemie 65 (3), 2017, 305-309 more… BibTeX Full text ( DOI )
  • Lang, Kathrin; Mayer, Susanne: Tetrazines in Inverse-Electron-Demand Diels–Alder Cycloadditions and Their Use in Biology. Synthesis 49 (04), 2016, 830-848 more… BibTeX Full text ( DOI )
  • Lang, Kathrin; Davis, Lloyd; Wallace, Stephen; Mahesh, Mohan; Cox, Daniel J.; Blackman, Melissa L.; Fox, Joseph M.; Chin, Jason W.: Genetic Encoding of Bicyclononynes and trans -Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions. J. Am. Chem. Soc. 134 (25), 2012, 10317-10320 more… BibTeX Full text ( DOI )
  • Lang, Kathrin; Davis, Lloyd; Torres-Kolbus, Jessica; Chou, Chungjung; Deiters, Alexander; Chin, Jason W.: Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction. Nature Chemistry 4 (4), 2012, 298-304 more… BibTeX Full text ( DOI )
  • Ng, C Leong; Lang, Kathrin; Meenan, Nicola A G; Sharma, Amit; Kelley, Ann C; Kleanthous, Colin; Ramakrishnan, V: Structural basis for 16S ribosomal RNA cleavage by the cytotoxic domain of colicin E3. Nat Struct Mol Biol 17 (10), 2010, 1241-1246 more… BibTeX Full text ( DOI )
  • Lang, Kathrin; Erlacher, Matthias; Wilson, Daniel N.; Micura, Ronald; Polacek, Norbert: The Role of 23S Ribosomal RNA Residue A2451 in Peptide Bond Synthesis Revealed by Atomic Mutagenesis. Chemistry & Biology 15 (5), 2008, 485-492 more… BibTeX Full text ( DOI )
  • Lang, K.; Rieder, R.; Micura, R.: Ligand-induced folding of the thiM TPP riboswitch investigated by a structure-based fluorescence spectroscopic approach. Nucleic Acids Research 35 (16), 2007, 5370-5378 more… BibTeX Full text ( DOI )