Tamas Horvath

Short CV

Dr. Horvath graduated from the University of Veterinary Sciences, Budapest, Hungary, in 1992, where he received a degree of Doctor of Veterinary Medicine. He received a PhD in neurobiology from University of Szeged in 2000. Dr. Horvath was a postdoctoral fellow at Yale University School of Medicine between 1992 and 1994. Since 2005, he has been the Jean and David W. Wallace Professor of Biomedical Research endowed Chair of the Section of Comparative Medicine, which is a free standing academic department of Yale Medical School focusing on animal models of human diseases. In 2009 he founded the Yale Program in Integrative Cell Signaling and Neurobiology of Metabolism. Since 1986, the major goal of his research is to determine the signaling flow and regulatory relationship within and between neuronal circuits that underlie the maintenance of physiological and pathological homeostatic conditions with particular emphasis on metabolic disorders, such as obesity, and neurodegeneration. As recognition of his research accomplishments, he has received various honors, including The Albert Szent-Gyorgyi Prize, Honorary Diplomat, Faculty of Veterinary Sciences, Szent Istvan University, Budapest, Hungary, Ideas of 2006 by the New York Times Magazine, the NIH Director's Pioneer Award (2010) and the Ernts Oppenheimer Award from The Endocrine Society (2012).

Awards

2013 Honorary Doctorate, Szent Istvan University, Faculty of Veterinary Sciences, Budapest, Hungary

2012 The Ernst Oppenheimer Award, The Endocrine Society

2010 Jean and David W. Wallace Professor of Biomedical Research, Yale University, School of Medicine

2010 The NIH Director’s Pioneer Award

2009 Finalist; Blavatnik Award; The New York Academy of Sciences

2008 Alexander von Humboldt Professorship (by the Ministry of Science of the Republic of Germany)

2008 BBVA Chair in Biomedicine, The Cajal Institute, Madrid, Spain

2007 Jerzy Olszewski Lecture, Killam Lecture Series, McGill University, Montreal, Canada (April 18)

2005 Key Lecture at the Annual Meeting of The Obesity Society (previously known as NAASO), Vancouver, Canada (October)

2002 The Albert Szent-Gyorgyi Fellowship (by the Ministry of Education of the Republic of Hungary)

2002 Key Note Speaker at the Annual Meeting of the Massachusetts Endocrine Society, Amherst, MA (October).

Research Interests

Tamas Horvath’s laboratory has been studying the relationship between peripheral hormones and circuits of the central nervous system that, in turn, regulate complex, goal-oriented behaviors and whole body energy metabolism. They have been analyzing the regulatory principles of hypothalamic circuits and their effects on complex behaviors. From these studies, they assert that hypothalamic circuit activity during development and adulthood has critical relevance in the etiology of symptomatology associated with anorexia nervosa.

Selected Publications

  • Vogt, Merly C.; Paeger, Lars; Hess, Simon; Steculorum, Sophie M.; Awazawa, Motoharu; Hampel, Brigitte; Neupert, Susanne; Nicholls, Hayley T.; Mauer, Jan; Hausen, A. Christine; Predel, Reinhard; Kloppenburg, Peter; Horvath, Tamas L.; Brüning, Jens C.: Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding. Cell 156 (3), 2014, 495-509 more… BibTeX Full text ( DOI )
  • Dietrich, Marcelo O.; Liu, Zhong-Wu; Horvath, Tamas L.: Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity. Cell 155 (1), 2013, 188-199 more… BibTeX Full text ( DOI )
  • Dietrich, Marcelo O; Bober, Jeremy; Ferreira, Jozélia G; Tellez, Luis A; Mineur, Yann S; Souza, Diogo O; Gao, Xiao-Bing; Picciotto, Marina R; Araújo, Ivan; Liu, Zhong-Wu; Horvath, Tamas L: AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nature Neuroscience 15 (8), 2012, 1108-1110 more… BibTeX Full text ( DOI )
  • Diano, Sabrina; Liu, Zhong-Wu; Jeong, Jin Kwon; Dietrich, Marcelo O; Ruan, Hai-Bin; Kim, Esther; Suyama, Shigetomo; Kelly, Kaitlin; Gyengesi, Erika; Arbiser, Jack L; Belsham, Denise D; Sarruf, David A; Schwartz, Michael W; Bennett, Anton M; Shanabrough, Marya; Mobbs, Charles V; Yang, Xiaoyong; Gao, Xiao-Bing; Horvath, Tamas L: Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nature Medicine 17 (9), 2011, 1121-1127 more… BibTeX Full text ( DOI )
  • Andrews, Z. B.; Erion, D.; Beiler, R.; Liu, Z.-W.; Abizaid, A.; Zigman, J.; Elsworth, J. D.; Savitt, J. M.; DiMarchi, R.; Tschop, M.; Roth, R. H.; Gao, X.-B.; Horvath, T. L.: Ghrelin Promotes and Protects Nigrostriatal Dopamine Function via a UCP2-Dependent Mitochondrial Mechanism. Journal of Neuroscience 29 (45), 2009, 14057-14065 more… BibTeX Full text ( DOI )
  • Andrews, Zane B.; Liu, Zhong-Wu; Walllingford, Nicholas; Erion, Derek M.; Borok, Erzsebet; Friedman, Jeffery M.; Tschöp, Matthias H.; Shanabrough, Marya; Cline, Gary; Shulman, Gerald I.; Coppola, Anna; Gao, Xiao-Bing; Horvath, Tamas L.; Diano, Sabrina: UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals. Nature 454 (7206), 2008, 846-851 more… BibTeX Full text ( DOI )
  • Gao, Qian; Mezei, Gabor; Nie, Yongzhan; Rao, Yan; Choi, Cheol Soo; Bechmann, Ingo; Leranth, Csaba; Toran-Allerand, Dominique; Priest, Catherine A; Roberts, James L; Gao, Xiao-Bing; Mobbs, Charles; Shulman, Gerald I; Diano, Sabrina; Horvath, Tamas L: Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nature Medicine 13 (1), 2006, 89-94 more… BibTeX Full text ( DOI )
  • Abizaid, Alfonso; Liu, Zhong-Wu; Andrews, Zane B.; Shanabrough, Marya; Borok, Erzsebet; Elsworth, John D.; Roth, Robert H.; Sleeman, Mark W.; Picciotto, Marina R.; Tschöp, Matthias H.; Gao, Xiao-Bing; Horvath, Tamas L.: Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. Journal of Clinical Investigation 116 (12), 2006, 3229-3239 more… BibTeX Full text ( DOI )
  • Diano, Sabrina; Farr, Susan A; Benoit, Stephen C; McNay, Ewan C; da Silva, Ivaldo; Horvath, Balazs; Gaskin, F Spencer; Nonaka, Naoko; Jaeger, Laura B; Banks, William A; Morley, John E; Pinto, Shirly; Sherwin, Robert S; Xu, Lin; Yamada, Kelvin A; Sleeman, Mark W; Tschöp, Matthias H; Horvath, Tamas L: Ghrelin controls hippocampal spine synapse density and memory performance. Nature Neuroscience 9 (3), 2006, 381-388 more… BibTeX Full text ( DOI )
  • Pinto, S.: Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin. Science 304 (5667), 2004, 110-115 more… BibTeX Full text ( DOI )