Matthias Feige

Rudolf Mößbauer Tenure Track

Technical University of Munich

Cellular Protein Biochemistry

Focus Group
Cellular Protein Biochemistry

Short CV

Professor Matthias Feige studied biochemistry at the Swiss Federal Institute of Technology (ETH Zurich) and TUM. In 2009, he obtained his PhD in biochemistry under the supervision of Johannes Buchner at TUM. As a postdoctoral fellow in the laboratory of Linda Hendershot at the St. Jude Children’s Research Hospital, Memphis, TN, USA, he expanded his research toward cell biology and now heads the laboratory for cellular protein biochemistry at TUM.

Selected Awards

2012 Rainer Rudolph Foundation, Rainer Rudolph Award

2011-2014 Fellow of the German Academy of Sciences Leopoldina

2011 Management Engineers Presidential Award, Management Engineers and TUM

2010-2011 Paul Barrett Fellowship, St. Jude Children’s Research Hospital

2010 Hans Fischer Award, Hans Fischer Society

2010 PhD Award, TUM Graduate School

2005 Jürgen Manchot Award, Jürgen Manchot Foundation

2003-2009 Fellow of the German National Academic Foundation

Research Interests

Matthias Feige’s laboratory aims at understanding how cells control and maintain the integrity of their proteome. He is particularly interested in proteins of the secretory pathway – proteins that are ultimately secreted or localized on the cell surface and allow cells to interact with their environment. Using an interdisciplinary approach from protein biochemistry to cell biology, he analyzes the machinery and mechanisms that monitor cellular protein biogenesis. By focusing on proteins of immunological and biomedical relevance, he seeks a molecular understanding of fundamental biological processes that at the same time may help in developing new approaches for protein engineering and human therapy.

Selected Publications

  • Feige, Matthias J.; Buchner, Johannes: Principles and engineering of antibody folding and assembly. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1844 (11), 2014, 2024-2031.
  • Feige, M. J.; Grawert, M. A.; Marcinowski, M.; Hennig, J.; Behnke, J.; Auslander, D.; Herold, E. M.; Peschek, J.; Castro, C. D.; Flajnik, M.; Hendershot, L. M.; Sattler, M.; Groll, M.; Buchner, J.: The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins. Proceedings of the National Academy of Sciences 111 (22), 2014, 8155-8160.
  • Feige, Matthias J.; Hendershot, Linda M.: Quality Control of Integral Membrane Proteins by Assembly-Dependent Membrane Integration. Molecular Cell 51 (3), 2013, 297-309.
  • Feige, Matthias J.; Groscurth, Sandra; Marcinowski, Moritz; Shimizu, Yuichiro; Kessler, Horst; Hendershot, Linda M.; Buchner, Johannes: An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies. Molecular Cell 34 (5), 2009, 569-579.
  • Feige, M. J.; Groscurth, S.; Marcinowski, M.; Yew, Z. T.; Truffault, V.; Paci, E.; Kessler, H.; Buchner, J.: The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity. Proceedings of the National Academy of Sciences 105 (36), 2008, 13373-13378.