Matthias Feige

Rudolf Mößbauer Tenure Track

Technical University of Munich

Cellular Protein Biochemistry

Focus Group
Cellular Protein Biochemistry

Short CV

Professor Matthias Feige studied biochemistry at the Swiss Federal Institute of Technology (ETH Zurich) and TUM. In 2009, he obtained his PhD in biochemistry under the supervision of Johannes Buchner at TUM. As a postdoctoral fellow in the laboratory of Linda Hendershot at the St. Jude Children’s Research Hospital, Memphis, TN, USA, he expanded his research toward cell biology and now heads the laboratory for cellular protein biochemistry at TUM.

Selected Awards

2012 Rainer Rudolph Foundation, Rainer Rudolph Award

2011-2014 Fellow of the German Academy of Sciences Leopoldina

2011 Management Engineers Presidential Award, Management Engineers and TUM

2010-2011 Paul Barrett Fellowship, St. Jude Children’s Research Hospital

2010 Hans Fischer Award, Hans Fischer Society

2010 PhD Award, TUM Graduate School

2005 Jürgen Manchot Award, Jürgen Manchot Foundation

2003-2009 Fellow of the German National Academic Foundation

Research Interests

Matthias Feige’s laboratory aims at understanding how cells control and maintain the integrity of their proteome. He is particularly interested in proteins of the secretory pathway – proteins that are ultimately secreted or localized on the cell surface and allow cells to interact with their environment. Using an interdisciplinary approach from protein biochemistry to cell biology, he analyzes the machinery and mechanisms that monitor cellular protein biogenesis. By focusing on proteins of immunological and biomedical relevance, he seeks a molecular understanding of fundamental biological processes that at the same time may help in developing new approaches for protein engineering and human therapy.

Selected Publications

  • Feige, Matthias J.; Buchner, Johannes: Principles and engineering of antibody folding and assembly. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1844 (11), 2014, 2024-2031.
  • Feige, M. J.; Grawert, M. A.; Marcinowski, M.; Hennig, J.; Behnke, J.; Auslander, D.; Herold, E. M.; Peschek, J.; Castro, C. D.; Flajnik, M.; Hendershot, L. M.; Sattler, M.; Groll, M.; Buchner, J.: The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins. Proceedings of the National Academy of Sciences 111 (22), 2014, 8155-8160.
  • Feige, Matthias J.; Hendershot, Linda M.: Quality Control of Integral Membrane Proteins by Assembly-Dependent Membrane Integration. Molecular Cell 51 (3), 2013, 297-309.
  • Feige, Matthias J.; Groscurth, Sandra; Marcinowski, Moritz; Shimizu, Yuichiro; Kessler, Horst; Hendershot, Linda M.; Buchner, Johannes: An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies. Molecular Cell 34 (5), 2009, 569-579.
  • Feige, M. J.; Groscurth, S.; Marcinowski, M.; Yew, Z. T.; Truffault, V.; Paci, E.; Kessler, H.; Buchner, J.: The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity. Proceedings of the National Academy of Sciences 105 (36), 2008, 13373-13378.

Publications as TUM-IAS-Fellow


  • Hohl, Adrian; Mideksa, Yonatan G; Karan, Ram; Akal, Anastassja; Vogler, Malvina; Groll, Michael; Rueping, Magnus; Lang, Kathrin; Feige, Matthias J; Eppinger, Jörg: Genetically encoded biotin analogs: Incorporation and application in bacterial and mammalian cells. ChemBioChem, 2019 mehr… BibTeX Volltext ( DOI )
  • Meier, Susanne; Bohnacker, Sina; Klose, Carolin J.; Lopez, Abraham; Choe, Christian A.; Schmid, Philipp W. N.; Bloemeke, Nicolas; Rührnößl, Florian; Haslbeck, Martin; Bieren, Julia Esser-von; Sattler, Michael; Huang, Po-Ssu; Feige, Matthias J.: The molecular basis of chaperone-mediated interleukin 23 assembly control. Nature Communications 10 (1), 2019 mehr… BibTeX Volltext ( DOI )
  • Müller, Stephanie I.; Aschenbrenner, Isabel; Zacharias, Martin; Feige, Matthias J.: An Interspecies Analysis Reveals Molecular Construction Principles of Interleukin 27. Journal of Molecular Biology 431 (12), 2019, 2383-2393 mehr… BibTeX Volltext ( DOI )
  • Müller, Stephanie I.; Friedl, Antonie; Aschenbrenner, Isabel; Esser-von Bieren, Julia; Zacharias, Martin; Devergne, Odile; Feige, Matthias J.: A folding switch regulates interleukin 27 biogenesis and secretion of its α-subunit as a cytokine. Proceedings of the National Academy of Sciences 116 (5), 2019, 1585-1590 mehr… BibTeX Volltext ( DOI )


  • Grötsch, Raphael K.; Angı, Arzu; Mideksa, Yonatan G.; Wanzke, Caren; Tena-Solsona, Marta; Feige, Matthias J.; Rieger, Bernhard; Boekhoven, Job: Dissipative Self-Assembly of Photoluminescent Silicon Nanocrystals. Angewandte Chemie International Edition 57 (44), 2018, 14608-14612 mehr… BibTeX Volltext ( DOI )
  • Matthias Feige: Oxidative Folding of Proteins. Royal Society of Chemistry, 2018 mehr… BibTeX Volltext ( DOI )
  • Rodriguez Camargo, Diana C.; Garg, Divita; Buday, Katalin; Franko, Andras; Rodriguez Camargo, Andres; Schmidt, Fabian; Cox, Sarah J.; Suladze, Saba; Haslbeck, Martin; Mideksa, Yonatan G.; Gemmecker, Gerd; Aichler, Michaela; Mettenleiter, Gabriele; Schulz, Michael; Walch, Axel Karl; Hrabě de Angelis, Martin; Feige, Matthias J.; Sierra, Cesar A.; Conrad, Marcus; Tripsianes, Konstantinos; Ramamoorthy, Ayyalusamy; Reif, Bernd: hIAPP forms toxic oligomers in plasma. Chemical Communications 54 (43), 2018, 5426-5429 mehr… BibTeX Volltext ( DOI )


  • Reitberger, Susanne; Haimerl, Pascal; Aschenbrenner, Isabel; Esser-von Bieren, Julia; Feige, Matthias J.: Assembly-induced folding regulates interleukin 12 biogenesis and secretion. Journal of Biological Chemistry 292 (19), 2017, 8073-8081 mehr… BibTeX Volltext ( DOI )


  • Behnke, Julia; Mann, Melissa J.; Scruggs, Fei-Lin; Feige, Matthias J.; Hendershot, Linda M.: Members of the Hsp70 Family Recognize Distinct Types of Sequences to Execute ER Quality Control. Molecular Cell 63 (5), 2016, 739-752 mehr… BibTeX Volltext ( DOI )


  • Behnke, Julia; Feige, Matthias J.; Hendershot, Linda M.: BiP and Its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions. Journal of Molecular Biology 427 (7), 2015, 1589-1608 mehr… BibTeX Volltext ( DOI )
  • Feige, Matthias J.; Behnke, Julia; Mittag, Tanja; Hendershot, Linda M.: Dimerization-dependent Folding Underlies Assembly Control of the Clonotypic αβT Cell Receptor Chains. Journal of Biological Chemistry 290 (44), 2015, 26821-26831 mehr… BibTeX Volltext ( DOI )