Jane A. McKeating

Fellowship
Hans Fischer Senior Fellow

Institution
University of Oxford

Department
Nuffield Department of Medicine

Host
Ulrike Protzer

Focus Group
Viral Hepatitis

Short CV

Jane A. McKeating received a BSc in Biological Sciences from the University of Warwick in 1982 and a PhD in Virology from the Royal Free Hospital School of Medicine at University College London in 1987. From 1987- 1992, she was a research fellow at the Institute of Cancer Research in London. From 1994-1999, she was a Research Fellow of the Lister Institute of Preventive Medicine as well as an lecturer/reader in Virology at the University of Reading. After working as as a Section Head of Anti-Virals at Pfizer Research Central Research, UK, from 1999-2000, Jane A. McKeating moved to Rockefeller University as an associate professor. From 2005 - 2017, she was a professor of Molecular Virology at the University of Birmingham, a professor of Molecular Virology at the University of Birmingham,where she was the director of the Centre of Human Virology since 2012 and the Deputy Head of the School of Immunity and Infection since 2013. In 2017, Jane A. McKeating transferred to the University of Oxford.

Awards

2015 Founders Award for academic excellence – University of Birmingham

2010 Oxford University Distinguished Virology Lecture

2006 Royal Society Wolfson Merit Award

1995 Fleming Award, Society of General Microbiology

1994 Research Fellowship of the Lister Institute of Preventive Medicine

1990 Medical Research Council Senior AIDS Research Fellowship

1988 Herpes Vaccine Research Trust Prize, Society of General Microbiology

Research Interests

Jane A. McKeating’s research focuses on understanding early infection events that define the cellular and tissue tropism of clinically important human viruses to understand viral-associated pathology and to design improved vaccines and anti-viral therapies.

Selected Publications

  • Fletcher, Nicola F.; Wilson, Garrick K.; Murray, Jacinta; Hu, Ke; Lewis, Andrew; Reynolds, Gary M.; Stamataki, Zania; Meredith, Luke W.; Rowe, Ian A.; Luo, Guangxiang; Lopez–Ramirez, Miguel A.; Baumert, Thomas F.; Weksler, Babette; Couraud, Pierre–Olivier; Kim, Kwang Sik; Romero, Ignacio A.; Jopling, Catherine; Morgello, Susan; Balfe, Peter; McKeating, Jane A.: Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier. Gastroenterology 142 (3), 2012, 634-643.e6 mehr… BibTeX Volltext ( DOI )
  • Lupberger, Joachim; Zeisel, Mirjam B; Xiao, Fei; Thumann, Christine; Fofana, Isabel; Zona, Laetitia; Davis, Christopher; Mee, Christopher J; Turek, Marine; Gorke, Sebastian; Royer, Cathy; Fischer, Benoit; Zahid, Muhammad N; Lavillette, Dimitri; Fresquet, Judith; Cosset, François-Loïc; Rothenberg, S Michael; Pietschmann, Thomas; Patel, Arvind H; Pessaux, Patrick; Doffoël, Michel; Raffelsberger, Wolfgang; Poch, Olivier; McKeating, Jane A; Brino, Laurent; Baumert, Thomas F: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nature Medicine 17 (5), 2011, 589-595 mehr… BibTeX Volltext ( DOI )
  • Harris, Helen J.; Davis, Christopher; Mullins, Jonathan G. L.; Hu, Ke; Goodall, Margaret; Farquhar, Michelle J.; Mee, Christopher J.; McCaffrey, Kitty; Young, Stephen; Drummer, Heidi; Balfe, Peter; McKeating, Jane A.: Claudin Association with CD81 Defines Hepatitis C Virus Entry. Journal of Biological Chemistry 285 (27), 2010, 21092-21102 mehr… BibTeX Volltext ( DOI )
  • Timpe, Jennifer M.; Stamataki, Zania; Jennings, Adam; Hu, Ke; Farquhar, Michelle J.; Harris, Helen J.; Schwarz, Anne; Desombere, Isabelle; Roels, Geert Leroux; Balfe, Peter; McKeating, Jane A.: Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies. Hepatology 47 (1), 2007, 17-24 mehr… BibTeX Volltext ( DOI )
  • Evans, Matthew J.; von Hahn, Thomas; Tscherne, Donna M.; Syder, Andrew J.; Panis, Maryline; Wölk, Benno; Hatziioannou, Theodora; McKeating, Jane A.; Bieniasz, Paul D.; Rice, Charles M.: Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature 446 (7137), 2007, 801-805 mehr… BibTeX Volltext ( DOI )
  • von Hahn, Thomas; Yoon, Joo Chun; Alter, Harvey; Rice, Charles M.; Rehermann, Barbara; Balfe, Peter; McKeating, Jane A.: Hepatitis C Virus Continuously Escapes From Neutralizing Antibody and T-Cell Responses During Chronic Infection In Vivo. Gastroenterology 132 (2), 2007, 667-678 mehr… BibTeX Volltext ( DOI )
  • Lindenbach, B. D.: Complete Replication of Hepatitis C Virus in Cell Culture. Science 309 (5734), 2005, 623-626 mehr… BibTeX Volltext ( DOI )
  • Logvinoff, C.; Major, M. E.; Oldach, D.; Heyward, S.; Talal, A.; Balfe, P.; Feinstone, S. M.; Alter, H.; Rice, C. M.; McKeating, J. A.: Neutralizing antibody response during acute and chronic hepatitis C virus infection. Proceedings of the National Academy of Sciences 101 (27), 2004, 10149-10154 mehr… BibTeX Volltext ( DOI )
  • Hsu, M.; Zhang, J.; Flint, M.; Logvinoff, C.; Cheng-Mayer, C.; Rice, C. M.; McKeating, J. A.: Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Proceedings of the National Academy of Sciences 100 (12), 2003, 7271-7276 mehr… BibTeX Volltext ( DOI )
  • Blight, K. J.; McKeating, J. A.; Rice, C. M.: Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication. Journal of Virology 76, 2002, 13001-13014 mehr… BibTeX
  • Moore, J.; McKeating, J.; Weiss, R.; Sattentau, Q.: Dissociation of gp120 from HIV-1 virions induced by soluble CD4. Science 250 (4984), 1990, 1139-1142 mehr… BibTeX Volltext ( DOI )
  • McKeating, Jane A.; Griffiths, Paul D.; Weiss, Robin A.: HIV susceptibility conferred to human fibroblasts by cytomegalovirus-induced Fc receptor. Nature 343 (6259), 1990, 659-661 mehr… BibTeX Volltext ( DOI )